Sheng Chen

Summary

Affiliation: The Hong Kong Polytechnic University
Country: China

Publications

  1. pmc Characterization of a novel zinc transporter ZnuA acquired by Vibrio parahaemolyticus through horizontal gene transfer
    Ming Liu
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hong Kong, China Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute Shenzhen, China
    Front Cell Infect Microbiol 3:61. 2013
  2. pmc Clinical uses of botulinum neurotoxins: current indications, limitations and future developments
    Sheng Chen
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Toxins (Basel) 4:913-39. 2012
  3. doi request reprint Engineering Clostridia Neurotoxins with elevated catalytic activity
    Jiubiao Guo
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region
    Toxicon 74:158-66. 2013
  4. pmc Unique substrate recognition mechanism of the botulinum neurotoxin D light chain
    Jiubiao Guo
    From the Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
    J Biol Chem 288:27881-7. 2013
  5. pmc A simple, rapid and sensitive FRET assay for botulinum neurotoxin serotype B detection
    Jiubiao Guo
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR
    PLoS ONE 9:e114124. 2014
  6. pmc Emergence of clinical Salmonella enterica serovar Typhimurium isolates with concurrent resistance to ciprofloxacin, ceftriaxone, and azithromycin
    Marcus Ho Yin Wong
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, SAR Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 58:3752-6. 2014
  7. doi request reprint Molecular characterisation of a multidrug resistance conjugative plasmid from Vibrio parahaemolyticus
    Ming Liu
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, PR China
    Int J Antimicrob Agents 42:575-9. 2013
  8. doi request reprint Expression and biochemical characterization of light chains of Botulinum neurotoxin subtypes F5 and F7
    Jiubiao Guo
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, PR China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Protein Expr Purif 111:87-90. 2015
  9. doi request reprint Increasing prevalence of hydrogen sulfide negative Salmonella in retail meats
    Dachuan Lin
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, PR China
    Food Microbiol 43:1-4. 2014
  10. pmc Insights into the different catalytic activities of Clostridium neurotoxins
    Sheng Chen
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR
    Biochemistry 51:3941-7. 2012

Collaborators

  • Xuechen Li
  • Yanxiang Zhao
  • Jiubiao Guo
  • Ming Liu
  • Marcus Ho Yin Wong
  • Meiying Yan
  • Dachuan Lin
  • Edward Wai Chi Chan
  • Song Lin
  • Kan Biao
  • Ci Xu
  • Xuehua Pan
  • Lizhang Liu

Detail Information

Publications11

  1. pmc Characterization of a novel zinc transporter ZnuA acquired by Vibrio parahaemolyticus through horizontal gene transfer
    Ming Liu
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hong Kong, China Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute Shenzhen, China
    Front Cell Infect Microbiol 3:61. 2013
    ..These results suggest that the horizontally acquired znuA subfamily gene, vpa1307, contributes to the fitness and virulence of Vibrio species. ..
  2. pmc Clinical uses of botulinum neurotoxins: current indications, limitations and future developments
    Sheng Chen
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Toxins (Basel) 4:913-39. 2012
    ..Much research still needs to be done to improve and extend the medical uses of BoNTs...
  3. doi request reprint Engineering Clostridia Neurotoxins with elevated catalytic activity
    Jiubiao Guo
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region
    Toxicon 74:158-66. 2013
    ..The LC/B derivative with elevated activity has the potential to be developed into novel therapy to minimize the impact of immunoresistance during BoNT/B therapy. ..
  4. pmc Unique substrate recognition mechanism of the botulinum neurotoxin D light chain
    Jiubiao Guo
    From the Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
    J Biol Chem 288:27881-7. 2013
    ..In conclusion, in this study, we identified a unique multistep substrate recognition mechanism by LC/D and provide insights for LC/D engineering and antitoxin development. ..
  5. pmc A simple, rapid and sensitive FRET assay for botulinum neurotoxin serotype B detection
    Jiubiao Guo
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR
    PLoS ONE 9:e114124. 2014
    ..Importantly, FVP-B showed the potential to be scaled up and used in high throughput screening of LC/B inhibitor. The currently developed FRET assay is one of the most economic and rapid FRET assays for LC/B detection. ..
  6. pmc Emergence of clinical Salmonella enterica serovar Typhimurium isolates with concurrent resistance to ciprofloxacin, ceftriaxone, and azithromycin
    Marcus Ho Yin Wong
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, SAR Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, People s Republic of China
    Antimicrob Agents Chemother 58:3752-6. 2014
    ..The dissemination of resistance genes, such as those encoding ESBLs and the OqxAB pump, among Salmonella organisms will speed up the selection of XDR Salmonella, posing a huge threat to public health and Salmonella infection control...
  7. doi request reprint Molecular characterisation of a multidrug resistance conjugative plasmid from Vibrio parahaemolyticus
    Ming Liu
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, PR China
    Int J Antimicrob Agents 42:575-9. 2013
    ..Transmission of this multidrug resistance conjugative plasmid among Vibrio spp. would compromise the effectiveness of Vibrio infection control and pose a huge threat to public health...
  8. doi request reprint Expression and biochemical characterization of light chains of Botulinum neurotoxin subtypes F5 and F7
    Jiubiao Guo
    Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, PR China State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Protein Expr Purif 111:87-90. 2015
    ....
  9. doi request reprint Increasing prevalence of hydrogen sulfide negative Salmonella in retail meats
    Dachuan Lin
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region Food Safety and Technology Research Center, Hong Kong PolyU Shenzhen Research Institute, Shenzhen, PR China
    Food Microbiol 43:1-4. 2014
    ..Such finding warrants the development of an improved method for effective coverage of H2S negative Salmonella. ..
  10. pmc Insights into the different catalytic activities of Clostridium neurotoxins
    Sheng Chen
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR
    Biochemistry 51:3941-7. 2012
    ..This analysis explains the molecular basis underlying the VAMP2 recognition and cleavage by LC/B and LC/T and provides insight that may extend the pharmacologic utility of these neurological reagents...