George G Chen

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Decreased expression of Bid in human hepatocellular carcinoma is related to hepatitis B virus X protein
    G G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Eur J Cancer 37:1695-702. 2001
  2. pmc Differential functions of C- and N-terminal hepatitis B x protein in liver cells treated with doxorubicin in normoxic or hypoxic condition
    Davor Kin Fan Chau
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong, China
    PLoS ONE 7:e50118. 2012
  3. ncbi request reprint Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid induces apoptosis of human malignant cancer cells
    Ming yue Li
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Curr Drug Targets 13:1730-7. 2012
  4. doi request reprint Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα
    George G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Invest New Drugs 30:2210-8. 2012
  5. ncbi request reprint Pioglitazone prevents smoking carcinogen-induced lung tumor development in mice
    M Y Li
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Curr Cancer Drug Targets 12:597-606. 2012
  6. ncbi request reprint Heme oxygenase-1 protects against apoptosis induced by tumor necrosis factor-alpha and cycloheximide in papillary thyroid carcinoma cells
    George G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR, China
    J Cell Biochem 92:1246-56. 2004
  7. ncbi request reprint Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B-related pathway
    G G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Apoptosis 9:619-27. 2004
  8. pmc ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest
    George G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Cancer Lett 283:52-8. 2009
  9. ncbi request reprint Differential role of hydrogen peroxide and staurosporine in induction of cell death in glioblastoma cells lacking DNA-dependent protein kinase
    G G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Apoptosis 10:185-92. 2005
  10. ncbi request reprint Increased thromboxane B(2) levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma
    George G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, Shatin, Hong Kong
    Cancer Lett 234:193-8. 2006

Collaborators

Detail Information

Publications91

  1. ncbi request reprint Decreased expression of Bid in human hepatocellular carcinoma is related to hepatitis B virus X protein
    G G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Eur J Cancer 37:1695-702. 2001
    ..Therefore, this study suggests that a deficiency in the expression of Bid may contribute to the development of such an imbalance in HCC...
  2. pmc Differential functions of C- and N-terminal hepatitis B x protein in liver cells treated with doxorubicin in normoxic or hypoxic condition
    Davor Kin Fan Chau
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong, China
    PLoS ONE 7:e50118. 2012
    ..The acute hypoxia may overcome the HBx-induced resistance and facilitate the chemotherapy...
  3. ncbi request reprint Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid induces apoptosis of human malignant cancer cells
    Ming yue Li
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Curr Drug Targets 13:1730-7. 2012
    ..The good ability of 5F to inhibit cancer cells makes it in line with the successful development of other anti-tumor agents...
  4. doi request reprint Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα
    George G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Invest New Drugs 30:2210-8. 2012
    ..5F did not damage liver and renal functions. In conclusion, 5F is effective against HCC with minimal side effects. It induces apoptosis in HCC cells via inhibiting NF-kB, leading to the decrease of Bcl-2 but the increase of Bax and Bak...
  5. ncbi request reprint Pioglitazone prevents smoking carcinogen-induced lung tumor development in mice
    M Y Li
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Curr Cancer Drug Targets 12:597-606. 2012
    ..The early application of PGZ is able to prevent NNK-induced lung tumor development through maintaining the level of endogenous PPARγ ligands 15(S)-HETE and 13(S)-HODE and activation of PPARγ...
  6. ncbi request reprint Heme oxygenase-1 protects against apoptosis induced by tumor necrosis factor-alpha and cycloheximide in papillary thyroid carcinoma cells
    George G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR, China
    J Cell Biochem 92:1246-56. 2004
    ..The HO-1 pathway of apoptosis resistance is associated with an increase in the levels of p21, involves a p38 MAPK and ERK-mediated mechanism and can be suppressed by inhibiting NF-kappaB...
  7. ncbi request reprint Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B-related pathway
    G G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Apoptosis 9:619-27. 2004
    ..Bcl-2, and to the less extent, Bcl-xL, were able to increase the activity of NF-kappa B, which was a known anti-apoptotic molecule in human colon cancer cells...
  8. pmc ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest
    George G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Cancer Lett 283:52-8. 2009
    ..ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells...
  9. ncbi request reprint Differential role of hydrogen peroxide and staurosporine in induction of cell death in glioblastoma cells lacking DNA-dependent protein kinase
    G G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Apoptosis 10:185-92. 2005
    ..Such differential roles in the induction of glioblastoma cell death can be of significant value in selecting and/or optimizing the treatment for this malignant brain tumor...
  10. ncbi request reprint Increased thromboxane B(2) levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma
    George G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, Shatin, Hong Kong
    Cancer Lett 234:193-8. 2006
    ..In conclusion, our study demonstrates that the production of TXB(2) is increased in lung tumor tissues and that such an increase can result in lipid peroxidation which may be met by an elevation in Bcl-2 expression...
  11. ncbi request reprint Regulation of cell growth by estrogen signaling and potential targets in thyroid cancer
    George G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Curr Cancer Drug Targets 8:367-77. 2008
    ..The modulation of ERalpha and ERbeta and the intervention of their pathways may open up new potential targets for the treatment of thyroid cancer...
  12. ncbi request reprint Identification of hepatitis B virus X gene mutation in Hong Kong patients with hepatocellular carcinoma
    G G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Room 306 Cancer Center, Shatin, New Territories, Hong Kong
    J Clin Virol 34:7-12. 2005
    ..Chronic infection by hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) in man. The viral transactivator HBV X (HBx) gene plays a critical role in the molecular pathogenesis of HBV-related HCC...
  13. ncbi request reprint Increased inducible nitric oxide synthase in lung carcinoma of smokers
    George G Chen
    Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Cancer 112:372-81. 2008
    ..The relation between cigarette smoking and iNOS in human lung cancer is unknown...
  14. ncbi request reprint The expression of Bcl-2 family proteins and spontaneous apoptosis in laryngeal carcinomas
    George G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Oncol Res 16:273-80. 2006
    ..The lack of correlation between apoptosis and the expression of Bcl-2 family proteins suggests that spontaneous apoptosis in laryngeal carcinoma is a complex process and that molecules other than Bak, Bax, and Bcl-2 participate in it...
  15. doi request reprint Estrogen and its receptors in cancer
    George G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR, China
    Med Res Rev 28:954-74. 2008
    ..We will also review some novel treatments aiming to interfere with relevant pathways mediated by estrogens and its receptors...
  16. ncbi request reprint Single nucleotide polymorphism in the promoter region of human alpha-fetoprotein (AFP) gene and its significance in hepatocellular carcinoma (HCC)
    G G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Eur J Surg Oncol 33:882-6. 2007
    ..To understand the potential mechanism underlying the differential expression of AFP, we have examined the sequence of the AFP promoter in HCC...
  17. ncbi request reprint Reduction of double-stranded RNA-activated protein kinase in hepatocellular carcinoma associated with hepatitis B virus
    George G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T Hong Kong
    J Med Virol 73:187-94. 2004
    ..HBV may participate in altering the level of PKR, but factors other than HBV should play a more determining role in the regulation of PKR in HCC. The association between PKR and AFP levels may offer an alternative tumor marker for HCC...
  18. ncbi request reprint Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer
    George G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT
    Life Sci 70:2631-46. 2002
    ..This study suggested that a PPARgamma-Bcl-2 feedback loop may function to control the life-death continuum in colonic cells and that a deficiency in generation of PPARgamma ligands may precede the development of human colon cancer...
  19. ncbi request reprint Induction of apoptosis in glioma cells by molecules released from activated macrophages
    George G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin
    J Neurooncol 57:179-86. 2002
    ..In conclusion, the present study indicates that molecules released from the activated macrophages provide significant signals to stimulate the expression of Fas/FasL and caspase-3, which function to induce apoptosis in glioma cells...
  20. ncbi request reprint Glioma apoptosis induced by macrophages involves both death receptor-dependent and independent pathways
    George G Chen
    Department of Surgery, the Sir Y K Pao Center for Cancer at Prince of Wales Hospital, and the Chinese University of Hong Kong, Shatin, NT
    J Lab Clin Med 141:190-9. 2003
    ..Apoptosis of glioma induced by the activated macrophage is executed by way of both death receptor-dependent and independent pathways, and such an apoptosis-induced approach can effectively inhibit the growth of glioma in vivo...
  21. ncbi request reprint Activation of Kupffer cells inhibits tumor growth in a murine model system
    George G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Int J Cancer 99:713-20. 2002
    ....
  22. ncbi request reprint The nuclear localization of NFkappaB and p53 is positively correlated with HPV16 E7 level in laryngeal squamous cell carcinoma
    Jing Du
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T Hong Kong
    J Histochem Cytochem 51:533-9. 2003
    ..In conclusion, this study suggests that the nuclear localization of NFkappaB and p53 may play a role in the development of human laryngeal squamous cell carcinoma infected with HPV16...
  23. ncbi request reprint Glioblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death
    George G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    J Cell Physiol 203:127-32. 2005
    ..The aberrant expression of Bcl-2 family members and Fas was, at least in part, responsible for decreased sensitivity of DNA-PK deficient glioblastoma cells to cell death stimuli...
  24. ncbi request reprint 15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway
    George G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Int J Cancer 107:837-43. 2003
    ..Treatment of colon cancer cells with 15S-HETE inhibits cell proliferation and induces apoptosis in a PPARgamma-dependent pathway involving augmentation of TIEG and reduction of Bcl-2 expression...
  25. ncbi request reprint Increased apoptosis in infiltrating mononuclear cells of colorectal cancer: a mechanism for tumor escape
    George G Chen
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Arch Pathol Lab Med 126:686-91. 2002
    ..Disturbance in apoptosis has been proposed as one of the mechanisms involved in the immune response targeting tumor outgrowth. How colorectal cancer cells escape from attack by the immune system is not yet fully understood...
  26. ncbi request reprint Immunohistochemical analysis of pro-apoptotic Bid level in chronic hepatitis, hepatocellular carcinoma and liver metastases
    G G Chen
    Department of Surgery, Room 306, Cancer Center, Prince of Wales Hospital, The Chinese University of Hong Kong, Shantin, N T Hong Kong
    Cancer Lett 172:75-82. 2001
    ..The existence of gradient tumor-development center in chronic hepatitis, liver cirrhosis and non-tumorous tissues from HCC may serve as a pathologic marker of a carcinogenic change of cell phenotypes...
  27. ncbi request reprint Negative correlation between the ratio of Bax to Bcl-2 and the size of tumor treated by culture supernatants from Kupffer cells
    George G Chen
    Department of Surgery, Sir Yue Kong Pao Centre for Cancer, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Clin Exp Metastasis 19:457-64. 2002
    ..The ratio of Bax to Bcl-2 is a useful index to evaluate tumor apoptosis induced by Kupffer cells. Our experiment also suggests that alteration of the ratio of Bax to Bcl-2 may result from increased levels of iNOS and TNF alpha...
  28. doi request reprint PPARgamma activation extinguishes smoking carcinogen by inhibiting NNK-mediated proliferation
    Ming yue Li
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Am J Respir Cell Mol Biol 42:113-22. 2010
    ..The findings reveal a novel molecular pathway of PPARgamma activation against cigarette smoking-related lung cancer...
  29. doi request reprint Anticancer efficacy of 5F in NNK-induced lung cancer development of A/J mice and human lung cancer cells
    Ming yue Li
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Mol Med (Berl) 88:1265-76. 2010
    ..Collectively, 5F is effective against lung cancer in vivo with minimal side effects. It induces apoptosis in lung cancer through the mitochondrial-mediated pathway, in which the activation of ERK is critical...
  30. ncbi request reprint Apoptosis induced by troglitazone is both peroxisome proliferator-activated receptor-gamma- and ERK-dependent in human non-small lung cancer cells
    Mingyue Li
    Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Cell Physiol 209:428-38. 2006
    ..In conclusion, our study has demonstrated that TGZ, a synthetic PPARgamma ligand, induced apoptosis in NCI-H23 lung cancer cells via a mitochondrial pathway and this pathway was PPARgamma and ERK1/2 dependent...
  31. ncbi request reprint Cell death induced by Pteris semipinnata L. is associated with p53 and oxidant stress in gastric cancer cells
    Zhimin Liu
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    FEBS Lett 579:1477-87. 2005
    ..We conclude that the expression of Bax and its downstream molecules requires the presentation of a wild-type p53 in the cells treated by 5F...
  32. doi request reprint Induction of cell cycle arrest and apoptosis by 5-fluorouracil in laryngeal cancer cells containing HPV16 E6 and E7 oncoproteins
    Han Ching Liu
    Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Clin Biochem 41:1117-25. 2008
    ..To investigate the cytotoxic effect of 5-fluorouracil (5Fu) on HPV16-associated laryngeal cancer cells...
  33. doi request reprint HER2 expression predicts improved survival in patients with cervical node-positive head and neck squamous cell carcinoma
    Gary M Tse
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Otolaryngol Head Neck Surg 141:467-73. 2009
    ..To investigate the prognostic value of HER2 and p63 expression in head and neck squamous cell carcinoma (HNSCC)...
  34. ncbi request reprint Adenovirus-mediated tBid overexpression results in therapeutic effects on p53-resistant hepatocellular carcinoma
    Ji Miao
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Int J Cancer 119:1985-93. 2006
    ..The cell death induced by Ad/AFPtBid in HCC cells is via an apoptotic pathway that can be independent of p53 status...
  35. ncbi request reprint Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas
    Ji Miao
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Apoptosis 12:1691-701. 2007
    ..In conclusion, Bim alpha isoforms appears to have a role in the regulation of apoptosis in HCC cells, which may contribute to not only the growth of tumor cells but also the sensitivity of HCC cells to chemotherapy...
  36. doi request reprint Roles of peroxisome proliferator-activated receptor-alpha and -gamma in the development of non-small cell lung cancer
    Ming yue Li
    Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Am J Respir Cell Mol Biol 43:674-83. 2010
    ..Our findings may also reveal the possibility of using the level of endogenous PPARγ ligands and the activities of PPARγ or PPARα as tumor markers for lung cancer...
  37. doi request reprint Thromboxane synthase suppression induces lung cancer cell apoptosis via inhibiting NF-κB
    Kin Chung Leung
    Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Exp Cell Res 316:3468-77. 2010
    ..Collectively, apoptosis induced by 1-BI is associated with the over-production of ROS and the reduction of NF-κB. Antioxidants can significantly block the inhibitory effect of 1-BI...
  38. ncbi request reprint Differential expression of inducible nitric oxide synthase and peroxisome proliferator-activated receptor gamma in non-small cell lung carcinoma
    Tak W Lee
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Eur J Cancer 39:1296-301. 2003
    ....
  39. ncbi request reprint Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth
    Mingyue Li
    Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    J Cell Biochem 96:760-74. 2005
    ..The mechanism of TGZ is associated with the activation of ERK and p38, the reduction of SAPK/JNK activity, and the alteration of Bcl-w and Bcl-2...
  40. doi request reprint 15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer
    Huiling Yuan
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Thorax 65:321-6. 2010
    ..The activation of PPARgamma inhibits cell growth and induces apoptosis in some cancers. The role of 15(S)-HETE) and 13(S)-HODE in the development of lung cancer is not clear...
  41. doi request reprint Expression of functional metallothionein isoforms in papillary thyroid cancer
    Zhi Min Liu
    Department of Surgery, Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Mol Cell Endocrinol 302:92-8. 2009
    ..The elevation of the MT isoforms contributes to the decreased G0/G1 but increased G2-M phase. These results reveal a novel pathway for the expression of the functional MT in papillary thyroid cancer...
  42. ncbi request reprint Bid sensitizes apoptosis induced by chemotherapeutic drugs in hepatocellular carcinoma
    Ji Miao
    Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China
    Int J Oncol 25:651-9. 2004
    ..These results indicate the level of Bid expression is closely associated with the sensitivity of HCC cells to chemotherapeutic drugs, suggesting that Bid plays an important role in HCC management...
  43. ncbi request reprint Induction of colon cancer cell death by 7-hydroxystaurosporine (UCN-01) is associated with increased p38 MAPK and decreased Bcl-xL
    Ursula P F Chan
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
    Anticancer Drugs 14:761-6. 2003
    ..The mechanism responsible appeared to be related to reduction of Bcl-xL and increased p38 MAPK. The overexpression of Bcl-xL can significantly prevent apoptosis induced by UCN-01...
  44. doi request reprint Iodine induces apoptosis via regulating MAPKs-related p53, p21, and Bcl-xL in thyroid cancer cells
    Xiao Hong Liu
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Mol Cell Endocrinol 320:128-35. 2010
    ..The findings provide solid molecular evidence to explain the potential pathway for iodine to influence thyroid cancer development. It may also reveal some novel molecular targets for the treatment of thyroid cancer...
  45. pmc Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89
    George G Chen
    Department of Surgery and the Sir Y K Pao Center for Cancer, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Am J Pathol 162:1823-9. 2003
    ..Therefore, co-localization of p53 protein with ZBP-89 may define a subgroup of recurrent HCC that is more sensitive to treatment...
  46. pmc Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma
    Chris Z Y Zhang
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT Hong Kong
    Cell Cycle 11:322-34. 2012
    ....
  47. ncbi request reprint Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression
    Ji Miao
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
    Cancer Lett 236:115-24. 2006
    ....
  48. doi request reprint Inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27
    Kin Chung Leung
    Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Exp Cell Res 315:2974-81. 2009
    ..Collectively, lung cancer cells produce high levels of TXB(2) but their nuclear p27 is markedly reduced. The inhibition of TXS results in the p27-related induction of cell death in lung cancer cells...
  49. doi request reprint Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma
    Cai Guo Ye
    Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong China America Cancer Research Institute, Guangdong Medical College, Dongguan 523808, PR China
    Biochim Biophys Acta 1833:2970-9. 2013
    ..Conclusively, zinc-binding protein-89 upregulates the expression of Bak by targeting multiple components of the epigenetic pathway in hepatocellular carcinoma. ..
  50. doi request reprint Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment
    Chris Z Y Zhang
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Apoptosis 16:683-95. 2011
    ..Collectively, HBx reduces the sensitivity of HCC cells to chemotherapy. TSA in combination with etoposide can significantly overcome the increased resistance of HBx-expressing HCC cells to chemotherapy...
  51. ncbi request reprint 5-fluorouracil mediates apoptosis and G1/S arrest in laryngeal squamous cell carcinoma via a p53-independent pathway
    Han Ching Liu
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Cancer J 12:482-93. 2006
    ..In this study, we aim to investigate the role that p53 plays in the cytotoxic effect of 5-FU on laryngeal squamous carcinoma cells...
  52. pmc ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular carcinoma cells
    Ann K Y To
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Biochim Biophys Acta 1813:222-30. 2011
    ..In conclusion, this study demonstrated that ZBP-89 significantly induced apoptosis of HCC cells via promoting Bak level...
  53. ncbi request reprint The cross-talk between estrogen receptor and peroxisome proliferator-activated receptor gamma in thyroid cancer
    Ryan Chu
    Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Hong Kong, China
    Cancer 120:142-53. 2014
    ..Estrogen receptor (ER) and peroxisome proliferator-activated receptor gamma (PPARγ) are associated with thyroid tumorigenesis and treatment. However, the interaction between them has not been studied...
  54. doi request reprint Bid exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to etoposide-induced DNA damage in hepatocellular carcinoma cells
    Gang Song
    Department of Surgery, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Apoptosis 13:693-701. 2008
    ..The elucidation of these intricate mechanisms of Bid points to the development of a possible therapeutic option that combines cytotoxic therapies to treat HCC...
  55. doi request reprint Susceptibility of Hep3B cells in different phases of cell cycle to tBid
    Shi hong Ma
    Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong
    Biochim Biophys Acta 1813:179-85. 2011
    ..The elucidation of the phase-specific effect of tBid points to a possible therapeutic option that combines different phase specific agents to overcome resistance of HCC...
  56. ncbi request reprint Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells
    Zhi Min Liu
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Oncogene 23:503-13. 2004
    ....
  57. doi request reprint Induction of autophagy in hepatocellular carcinoma cells by SB203580 requires activation of AMPK and DAPK but not p38 MAPK
    Haitao Zhang
    Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, China
    Apoptosis 17:325-34. 2012
    ..The induction of autophagy can thus account for the antiproliferative effect of SB203580 in HCC cells...
  58. ncbi request reprint Induction of functional MT1 and MT2 isoforms by calcium in anaplastic thyroid carcinoma cells
    Zhi Min Liu
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    FEBS Lett 581:2465-72. 2007
    ....
  59. doi request reprint Increased expression of ZBP-89 and its prognostic significance in hepatocellular carcinoma
    Chris Z Y Zhang
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Histopathology 60:1114-24. 2012
    ..ZBP-89 plays a role in cell growth and death. Its expression in hepatocellular carcinoma (HCC) is not well documented. This study aimed to analyse ZBP-89 expression in HCC...
  60. doi request reprint Induction of laryngeal cancer cell death by Ent-11-hydroxy-15-oxo-kaur-16-en-19-oic acid
    Alexander C Vlantis
    Department of Otorhinolaryngology Head and Neck Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Head Neck 32:1506-18. 2010
    ..Ent-11-hydroxy-15-oxo-kaur-16-en-19-oic acid (5F) is known to exhibit antitumor activity, but its mechanism is not completely understood. 5F has not been tested in laryngeal cancer...
  61. doi request reprint Correlation of biomarkers in head and neck squamous cell carcinoma
    Gary M Tse
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Otolaryngol Head Neck Surg 143:795-800. 2010
    ....
  62. ncbi request reprint Inhibition of apoptosis in human laryngeal cancer cells by E6 and E7 oncoproteins of human papillomavirus 16
    Han Ching Liu
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Cell Biochem 103:1125-43. 2008
    ....
  63. ncbi request reprint Different levels of p53 induced either apoptosis or cell cycle arrest in a doxycycline-regulated hepatocellular carcinoma cell line in vitro
    Paul B S Lai
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Apoptosis 12:387-93. 2007
    ..Bax may participate, at least in part, in inducing p53-dependent apoptosis and the induction of p21 alone was able to cause cell cycle arrest but not apoptosis...
  64. ncbi request reprint Function of PPARgamma and its ligands in lung cancer
    Ming yue Li
    Department of Surgery, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Crit Rev Clin Lab Sci 43:183-202. 2006
    ..Prospects for future research leading to new therapies for lung cancer are also discussed...
  65. pmc Lovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis
    David Y L Chan
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    J Neurooncol 86:273-83. 2008
    ..We conclude that the combination of lovastatin and TRAIL enhances apoptosis synergistically. Moreover, lovastatin sensitized glioblastoma cells to TRAIL, suggesting a new strategy to treat glioblastoma...
  66. doi request reprint Thromboxane A2 receptor α promotes tumor growth through an autoregulatory feedback pathway
    Run Yue Huang
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin N T, Hong Kong SAR, China
    J Mol Cell Biol 5:380-90. 2013
    ..This study suggests that TPα and TxAS are the ideal targets against smoking-related lung cancer. ..
  67. doi request reprint Iodine mediated mechanisms and thyroid carcinoma
    Xiao Hong Liu
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, China
    Crit Rev Clin Lab Sci 46:302-18. 2009
    ..Elucidating the roles of iodine may generate novel diagnostic and therapeutic approaches to thyroid cancer and improve current strategies for its treatment and prevention...
  68. ncbi request reprint Chemotherapy for laryngeal cancer--an apoptotic approach
    Han Ching Liu
    Department of Surgery, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Curr Drug Targets 9:878-86. 2008
    ..Systemically analysis of these targets will not only help to optimize the treatment but also provide a rationale for the best combination of two or more agents for the chemotherapy of laryngeal cancer...
  69. ncbi request reprint Transcription factor ZBP-89 in cancer growth and apoptosis
    Chris Z Y Zhang
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Biochim Biophys Acta 1806:36-41. 2010
    ..Moreover, ZBP-89 is capable of enhancing killing effects of several anti-cancer drugs. Therefore, ZBP-89 may be served as a potential target in cancer therapy...
  70. ncbi request reprint Analysis of differentially expressed genes in hepatocellular carcinoma with hepatitis C virus by suppression subtractive hybridization
    Masayo Kotaka
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T Hong Kong
    Oncol Res 13:161-7. 2002
    ..Most of these genes have not been reported in HCC. Further characterization of these differentially expressed known and unknown genes will provide useful information in understanding the genes responsible for the development of HCC...
  71. ncbi request reprint Strong immunohistochemical expression of vascular endothelial growth factor predicts overall survival in head and neck squamous cell carcinoma
    Gary M Tse
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Ngan Shing Street, Shatin, NT, Hong Kong
    Ann Surg Oncol 14:3558-65. 2007
    ....
  72. ncbi request reprint Induction of Fas and Fas ligand expression on malignant glioma cells by Kupffer cells, a potential pathway of antiliver metastases
    W Y Lau
    Department of Surgery, Prince of Wales Hospital, Shatin, N T, Hong Kong
    J Surg Res 101:44-51. 2001
    ..Therefore, this study supports a novel pathway of Kupffer cells against liver metastases, in which tumor cells were apoptotic via the Fas-Fas ligand system induced by TNFalpha released from Kupffer cells...
  73. ncbi request reprint Mechanisms of lymphocyte loss in SARS coronavirus infection
    P K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Hong Kong Med J 14:21-6. 2008
    ..4. Lymphopaenia in SARS patients is likely to result from indirect mechanisms secondary to the viral infection...
  74. pmc Increased expression of nucleophosmin/B23 in hepatocellular carcinoma and correlation with clinicopathological parameters
    J P Yun
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Br J Cancer 96:477-84. 2007
    ..05). Our results suggest that NPM may play an important role in the progression of tumorigenesis and that NPM may serve as a potential marker for HCC...
  75. ncbi request reprint Association of p53 with Bid induces cell death in response to etoposide treatment in hepatocellular carcinoma
    G Song
    Department of Surgery, The Chinese University of Hong Kong, Hong Kong
    Curr Cancer Drug Targets 9:871-80. 2009
    ..These findings reveal a novel mechanism by which p53 is associated with Bid in the nucleus to facilitate exportation of Bid to the mitochondria and induce apoptosis in response to etoposide-induced DNA damage in HCC...
  76. ncbi request reprint Migration of bone marrow stem cells in ischaemic brain
    W S Poon
    Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Acta Neurochir Suppl 99:123-4. 2006
    ..This could also occur in clusters of cells. Preferential migration of these cells took place in lesioned areas...
  77. ncbi request reprint Association of molecular marker O(6)Methylguanine DNA methyltransferase and concomitant chemoradiotherapy with survival in Southern Chinese glioblastoma patients
    Danny T M Chan
    The CUHK Brain Tumour Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Kong Med J 17:184-8. 2011
    ..2) To determine the methylation status of O(6)Methylguanine DNA methyltransferase in Chinese primary glioblastoma, and to assess the prognostic value of O(6)Methylguanine DNA methyltransferase methylation status in such patients...
  78. ncbi request reprint Eicosapentaenoic acid induces Fas-mediated apoptosis through a p53-dependent pathway in hepatoma cells
    Tian Yi Chi
    Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Cancer J 10:190-200. 2004
    ..It appears that the effects of EPA on hepatoma cells are determined by the status of p53 and that wild-type p53 is a prerequisite for the anticancer effect of EPA...
  79. ncbi request reprint Effects of the Chinese herbal formula Shi-Bi-Lin on cytokine release from the human mast cell line
    Yu Zhao
    Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China
    Ann Allergy Asthma Immunol 95:79-85. 2005
    ..The traditional Chinese herbal formula Cang Er Zi San has been used for the treatment of rhinitis, paranasal sinusitis, and allergic rhinitis for several centuries. However, its therapeutic mechanisms remain largely unclear...
  80. doi request reprint Therapeutic effect of alpha-fetoprotein promoter-mediated tBid and chemotherapeutic agents on orthotopic liver tumor in mice
    S H Ma
    Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Gene Ther 17:905-12. 2010
    ....
  81. ncbi request reprint Cell death induced by ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid in anaplastic thyroid carcinoma cells is via a mitochondrial-mediated pathway
    Z M Liu
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Apoptosis 10:1345-56. 2005
    ....
  82. ncbi request reprint Resistance to apoptosis of HPV 16-infected laryngeal cancer cells is associated with decreased Bak and increased Bcl-2 expression
    J Du
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Sir Y K Pao Center for Cancer, Shatin, N T, Hong Kong, China
    Cancer Lett 205:81-8. 2004
    ..These results suggest that the dysregulation of apoptotic molecules Bak and Bcl-2 by HPV 16 E6 and E7 plays a role in the prolongation of cell survival, which may subsequently contribute to the development of human laryngeal cancer...
  83. ncbi request reprint Blocking BRE expression in Leydig cells inhibits steroidogenesis by down-regulating 3beta-hydroxysteroid dehydrogenase
    J Miao
    Department of Surgery, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    J Endocrinol 185:507-17. 2005
    ..Our results suggest that BRE influences steroidogenesis through its effects on 3beta-HSD action, probably affecting its transcription...
  84. ncbi request reprint Induction of thyroid papillary carcinoma cell proliferation by estrogen is associated with an altered expression of Bcl-xL
    M L Lee
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR, China
    Cancer J 11:113-21. 2005
    ..The aim of this study was to explore the mechanism by which sex hormones contribute to the development of thyroid carcinoma, which is not well understood at present...
  85. doi request reprint Haem oxygenase-1 plays a central role in NNK-mediated lung carcinogenesis
    M Y Li
    Dept of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Eur Respir J 32:911-23. 2008
    ..Nuclear factor-kappaB and extracellular signal-regulated kinase 1/2 function upstream of haem oxygenase-1. Therefore, haem oxygenase-1 is likely to be a potential target in the treatment of smoking-related lung cancer...
  86. ncbi request reprint Bid stands at the crossroad of stress-response pathways
    G Song
    Cancer Research Center, Medical College, Xiamen University, Xiamen 361005, China
    Curr Cancer Drug Targets 10:584-92. 2010
    ..This review surveys recent developments in understanding the molecular mechanisms of Bid activation and its roles in regulating the cross-talk of cell cycle arrest and apoptosis...
  87. ncbi request reprint Calcium-mediated activation of PI3K and p53 leads to apoptosis in thyroid carcinoma cells
    Z M Liu
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Cell Mol Life Sci 64:1428-36. 2007
    ..These results suggested that apoptosis induced by cadmium in FRO cells was initiated by the rapid elevation of intracellular calcium, followed by calcium-mediated activation of PI3K/Akt and mitochondrial impairment...
  88. ncbi request reprint Oestrogen mediates the growth of human thyroid carcinoma cells via an oestrogen receptor-ERK pathway
    Q Zeng
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Cell Prolif 40:921-35. 2007
    ..In this study, it has been investigated how 17beta-oestradiol (E2) influenced proliferation and growth of thyroid cancer cells...
  89. doi request reprint The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle
    Guo Hua Qiu
    Department of Physiology, Faculty of Medicine, National University of Singapore, Singapore
    J Hepatol 48:433-41. 2008
    ..The 35 genes mapped to the AP20 subregion of this locus were screened for their expression to identify candidate tumor suppressor genes. DLEC1 was selected for further characterization in primary hepatocellular carcinomas and cell lines...
  90. ncbi request reprint Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma
    Guo Hua Qiu
    Department of Physiology, Faculty of Medicine, National University of Singapore, Block MD9, 2 Medical Drive, Singapore 117597, Singapore
    J Hepatol 46:655-63. 2007
    ..hDAB2IP is a candidate tumor suppressor gene. We studied the expression of its two variants, hDAB2IPA and hDAB2IPB, in normal tissues, and the expression and methylation status of hDAB2IPA in hepatocellular carcinomas (HCC) and cell lines...
  91. ncbi request reprint Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis
    Yu Zhao
    Department of Otolaryngology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Ann Allergy Asthma Immunol 96:844-50. 2006
    ..Jia Wei Cang Er Zi San, a traditional Chinese herbal formula, has been used to treat allergic rhinitis (AR) for several centuries. However, its effect on experimental animal models and its therapeutic mechanism remain unclear...