Research Topics
| Tyk ChanSummaryAffiliation: The Chinese University of Hong Kong Country: China Publications
| Collaborators
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Detail Information
Publications
Potential risks associated with the use of herbal anti-obesity productsThomas Y K Chan
Centre for Food and Drug Safety, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
Drug Saf 32:453-6. 2009..They should warn their patients about the heterogeneous nature of these agents and the potential risks associated with their use. They should report suspected adverse reactions to their national spontaneous reporting system...- Aconite poisoning presenting as hypotension and bradycardiaThomas Y K Chan
Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
Hum Exp Toxicol 28:795-7. 2009..In patients with aconite poisoning, prolonged hypotension and sinus bradycardia may occur and supportive therapy with close monitoring of blood pressure and cardiac rhythm are essential... - Contributory factors in herb-induced fatal aconite poisoningThomas Y K Chan
Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
Forensic Sci Int 223:40-3. 2012..Good manufacturing practice to ensure adequate processing of aconite roots, use of the recommended doses, clear instructions for the patients and their compliance during decoction preparation are important preventive measures... - Aconite poisoning following the percutaneous absorption of Aconitum alkaloidsThomas Y K Chan
Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
Forensic Sci Int 223:25-7. 2012..The public should be warned of the danger in using these topical aconite preparations and the risk of systemic toxicity following percutaneous absorption of Aconitum alkaloids... - Aconitum alkaloid content and the high toxicity of aconite tinctureThomas Y K Chan
Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
Forensic Sci Int 222:1-3. 2012..Severe aconite poisoning can be complicated by fatal ventricular tachyarrhythmias and asystole. The public should be repeatedly warned of the danger of taking aconite tincture by mouth... - Life-threatening retroperitoneal bleeding due to warfarin-drug interactionsThomas Y K Chan
Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong
Pharmacoepidemiol Drug Saf 18:420-2. 2009..The over-anticoagulation and the presence of platelet dysfunction increase the risk of severe bleeding, which can be provoked by trauma... - Aconite poisoningThomas Y K Chan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
Clin Toxicol (Phila) 47:279-85. 2009..However, the use of a larger than recommended dose and inadequate processing increases the risk of poisoning... - Overdose of methyldopa, indapamide and theophylline resulting in prolonged hypotension, marked diuresis and hypokalaemia in an elderly patientThomas Y K Chan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
Pharmacoepidemiol Drug Saf 18:977-9. 2009..g. theophylline and methyldopa). Restricting access to hazardous drugs (in overdose) would be of paramount importance to reduce the number of severe acute poisoning cases and case-fatalities... 
Digital gangrene following a green pit viper biteTyk Chan
Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
Southeast Asian J Trop Med Public Health 41:192-4. 2010..She developed local pain and swelling and coagulopathy, complicated by pulp tissue necrosis and digital gangrene of left middle finger. She fully recovered after amputation of the left middle finger at the mid portion...- Vegetable-borne nitrate and nitrite and the risk of methaemoglobinaemiaThomas Y K Chan
Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
Toxicol Lett 200:107-8. 2011..Nitrate levels in some vegetables can decrease after cooking in water or blanching. Home prepared infant food containing vegetables should be avoided until the infant is 3 months or older... - Causes and prevention of herb-induced aconite poisonings in AsiaThomas Y K Chan
Faculty of Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
Hum Exp Toxicol 30:2023-6. 2011..National reporting or monitoring systems can be used to identify the causes of aconite poisonings and assess the impact of preventive measures... - Inorganic mercury poisoning associated with skin-lightening cosmetic productsThomas Y K Chan
Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
Clin Toxicol (Phila) 49:886-91. 2011..Mercury and mercury salts, including mercurous chloride and mercurous oxide, are prohibited for use in cosmetic products as skin-lightening agents because of their high toxicity. Yet, the public continue to have access to these products... - Interaction between warfarin and danshen (Salvia miltiorrhiza)T Y Chan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
Ann Pharmacother 35:501-4. 2001..To discuss the potential for an adverse interaction between the Chinese herb danshen, the dry root and rhizome of Salvia miltiorrhiza Bge, and warfarin... - A multidisciplinary approach to the toxicologic problems associated with the use of herbal medicinesThomas Y K Chan
Drug and Poisons Information Bureau, Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
Ther Drug Monit 27:53-7. 2005..Toxicological problems associated with the use of herbal medicines are complex and may be easily overlooked. A multidisciplinary team of experts should be made available to provide advice to frontline healthcare professionals... - Ingestion of medicated oils by adults: the risk of severe salicylate poisoning is related to the packaging of these productsT Y K Chan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
Hum Exp Toxicol 21:171-4. 2002..To reduce the amount of methyl salicylate that can be readily swallowed during accidental or deliberate ingestion of medicated oils, improvements are needed in the existing packaging of these products... - Incidence of herb-induced aconitine poisoning in Hong Kong: impact of publicity measures to promote awareness among the herbalists and the publicThomas Y K Chan
Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
Drug Saf 25:823-8. 2002..An information leaflet was also sent to hospital doctors. Since 1992, the topic was covered periodically in the local newspapers, medical journals and continuing medical education programmes... - Herbal medicine causing likely strychnine poisoningT Y K Chan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
Hum Exp Toxicol 21:467-8. 2002..In any patient with 'unexplained' muscle spasms or convulsions, strychnine poisoning should be included in the differential diagnosis and they should be asked about the use of herbal medicines... - Interaction between warfarin and the herbal product quilinggaoAnna L N Wong
Accident and Emergency Department, Alice Ho Miu Ling Nethersole Hospital, Tai Po, New Territories, Hong Kong
Ann Pharmacother 37:836-8. 2003..Patients on warfarin therapy should be discouraged from taking herbal medicines, especially preparations that are already known to have antiplatelet and antithrombotic effects... - Use of herbal medicines by patients receiving warfarinRaymond S M Wong
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
Drug Saf 26:585-8. 2003..Healthcare professionals play an important role in educating the patients and updating the list of herbal medicines that should be avoided by patients taking warfarin... - Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopauseJean Woo
Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong
Menopause 10:352-61. 2003..The scientific basis for its action may be its action as a phytoestrogen... - A study of the health and economic effects of influenza-like illness on the working population under different working environments of a large corporation in Hong KongKenneth K C Lee
School of Pharmacy, The Chinese University of Hong Kong, Hong Kong
J Med Econ 11:639-50. 2008..The present study was undertaken to determine the health and economic impacts of ILIs under different environmental conditions on the working population of a large corporation... - The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patientsWing Y Tam
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
J Altern Complement Med 15:415-21. 2009..Recent pharmacological studies suggest their therapeutic values. We aimed to evaluate the efficacy and safety of Salvia miltiorrhiza (danshen) and Pueraria lobata (gegen) in secondary prevention... - Relationship between patients' warfarin knowledge and anticoagulation controlElaine Othilia Y L Tang
School of Pharmacy, The Chinese University of Hong Kong, Hong Kong
Ann Pharmacother 37:34-9. 2003..20; p = 0.024). CONCLUSIONS: Patients' warfarin knowledge, a determinant of anticoagulation control, was generally poor. More attention should be given to the education of elderly and illiterate patients... - Adverse herbal interactions causing hypotensionAnna L N Wong
Accident and Emergency Department, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong, China
Ther Drug Monit 25:297-8. 2003..In traditional Chinese medicine, practitioners often use a combination of herbs in an attempt to improve the efficacy but reduce the adverse effects of treatment. The risk of adverse herbal interactions will also be higher... 
Management of Chinese patients on warfarin therapy in two models of anticoagulation service - a prospective randomized trialFredric W H Chan
School of Pharmacy, Faculty of Medicine, The Prince of Wales Hospital, Hong Kong
Br J Clin Pharmacol 62:601-9. 2006..3) (P < 0.001). CONCLUSION: The pharmacist-managed anticoagulation service was more effective and less costly than the physician-managed service in achieving target anticoagulation control for Chinese patients on warfarin therapy...- Cost-effectiveness analysis of high-dose omeprazole infusion as adjuvant therapy to endoscopic treatment of bleeding peptic ulcerKenneth K C Lee
School of Pharmacy, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Gastrointest Endosc 57:160-4. 2003.... - Mild symptoms of toxicity following deliberate ingestion of thyroxineDavid K Y Lo
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Whales Hospital, Shatin, New Territories, China
Vet Hum Toxicol 46:193. 2004 - Smoking without exception adversely affects vascular structure and function in apparently healthy Chinese: implications in global atherosclerosis preventionG Neil Thomas
The Chinese University of Hong Kong, Shatin, Hong Kong, China
Int J Cardiol 128:172-7. 2008..Both active and passive smoking are prevalent in China but cardiovascular diseases were less prevalent in the past. We studied the current relationship between surrogate atherosclerosis markers and smoking in Chinese... - Clinical features and management of herb-induced aconitine poisoningChih Chuan Lin
Emergency Department, Chang Gung Memorial Hospital, Taipei, Taiwan
Ann Emerg Med 43:574-9. 2004..We define the potential sources, clinical manifestations, and treatment of aconitine poisoning... - Deficient dietary vitamin K intake among elderly nursing home residents in Hong KongSamuel L S Tse
Department of Medicine and Extended Care, Tai Po Hospital, Hong Kong
Asia Pac J Clin Nutr 11:62-5. 2002..Elderly nursing home residents in this study generally had a poor dietary vitamin K intake and might therefore be predisposed to osteoporosis. The importance of green leafy vegetables as a rich source of vitamin K should be emphasised... - A probable case of amygdalin-induced peripheral neuropathy in a vegetarian with vitamin B12 deficiencyThomas Y K Chan
Ther Drug Monit 28:140-1. 2006