Tyk Chan

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. doi request reprint Potential risks associated with the use of herbal anti-obesity products
    Thomas Y K Chan
    Centre for Food and Drug Safety, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Drug Saf 32:453-6. 2009
  2. doi request reprint Aconite poisoning presenting as hypotension and bradycardia
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Hum Exp Toxicol 28:795-7. 2009
  3. ncbi request reprint Large outbreaks of ciguatera after consumption of brown marbled grouper
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Toxins (Basel) 6:2041-9. 2014
  4. doi request reprint Ciguatera caused by consumption of humphead wrasse
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China Centre for Food and Drug Safety, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China Prince of Wales Hospital Poison Treatment Centre, Shatin, New Territories, Hong Kong, China Electronic address
    Toxicon 76:255-9. 2013
  5. doi request reprint Severe bradycardia and prolonged hypotension in ciguatera
    Thomas Yan Keung Chan
    Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Singapore Med J 54:e120-2. 2013
  6. doi request reprint Contributory factors in herb-induced fatal aconite poisoning
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Forensic Sci Int 223:40-3. 2012
  7. doi request reprint Aconite poisoning following the percutaneous absorption of Aconitum alkaloids
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Forensic Sci Int 223:25-7. 2012
  8. ncbi request reprint Aconitum alkaloid content and the high toxicity of aconite tincture
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Forensic Sci Int 222:1-3. 2012
  9. doi request reprint Aconite poisoning
    Thomas Y K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Clin Toxicol (Phila) 47:279-85. 2009
  10. doi request reprint Overdose of methyldopa, indapamide and theophylline resulting in prolonged hypotension, marked diuresis and hypokalaemia in an elderly patient
    Thomas Y K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Pharmacoepidemiol Drug Saf 18:977-9. 2009

Collaborators

Detail Information

Publications34

  1. doi request reprint Potential risks associated with the use of herbal anti-obesity products
    Thomas Y K Chan
    Centre for Food and Drug Safety, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Drug Saf 32:453-6. 2009
    ..They should warn their patients about the heterogeneous nature of these agents and the potential risks associated with their use. They should report suspected adverse reactions to their national spontaneous reporting system...
  2. doi request reprint Aconite poisoning presenting as hypotension and bradycardia
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Hum Exp Toxicol 28:795-7. 2009
    ..In patients with aconite poisoning, prolonged hypotension and sinus bradycardia may occur and supportive therapy with close monitoring of blood pressure and cardiac rhythm are essential...
  3. ncbi request reprint Large outbreaks of ciguatera after consumption of brown marbled grouper
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Toxins (Basel) 6:2041-9. 2014
    ..The public should realize that consumption of the high-risk fish (especially the ciguatoxin-rich parts and together with alcohol use) and repeated ciguatoxin exposures will result in more severe and chronic illness. ..
  4. doi request reprint Ciguatera caused by consumption of humphead wrasse
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China Centre for Food and Drug Safety, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China Prince of Wales Hospital Poison Treatment Centre, Shatin, New Territories, Hong Kong, China Electronic address
    Toxicon 76:255-9. 2013
    ..They should realise that consumption of the high-risk fish may result in more severe and chronic illness, including life-threatening complications and neuropsychiatric features. ..
  5. doi request reprint Severe bradycardia and prolonged hypotension in ciguatera
    Thomas Yan Keung Chan
    Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Singapore Med J 54:e120-2. 2013
    ..Physicians should recognise the possible cardiovascular complications of ciguatera and promptly initiate treatment with intravenous atropine, intravenous fluid replacement and inotropic therapy if such complications are observed. ..
  6. doi request reprint Contributory factors in herb-induced fatal aconite poisoning
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Forensic Sci Int 223:40-3. 2012
    ..Good manufacturing practice to ensure adequate processing of aconite roots, use of the recommended doses, clear instructions for the patients and their compliance during decoction preparation are important preventive measures...
  7. doi request reprint Aconite poisoning following the percutaneous absorption of Aconitum alkaloids
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Forensic Sci Int 223:25-7. 2012
    ..The public should be warned of the danger in using these topical aconite preparations and the risk of systemic toxicity following percutaneous absorption of Aconitum alkaloids...
  8. ncbi request reprint Aconitum alkaloid content and the high toxicity of aconite tincture
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Forensic Sci Int 222:1-3. 2012
    ..Severe aconite poisoning can be complicated by fatal ventricular tachyarrhythmias and asystole. The public should be repeatedly warned of the danger of taking aconite tincture by mouth...
  9. doi request reprint Aconite poisoning
    Thomas Y K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Clin Toxicol (Phila) 47:279-85. 2009
    ..However, the use of a larger than recommended dose and inadequate processing increases the risk of poisoning...
  10. doi request reprint Overdose of methyldopa, indapamide and theophylline resulting in prolonged hypotension, marked diuresis and hypokalaemia in an elderly patient
    Thomas Y K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Pharmacoepidemiol Drug Saf 18:977-9. 2009
    ..g. theophylline and methyldopa). Restricting access to hazardous drugs (in overdose) would be of paramount importance to reduce the number of severe acute poisoning cases and case-fatalities...
  11. ncbi request reprint Digital gangrene following a green pit viper bite
    Tyk Chan
    Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Southeast Asian J Trop Med Public Health 41:192-4. 2010
    ..She developed local pain and swelling and coagulopathy, complicated by pulp tissue necrosis and digital gangrene of left middle finger. She fully recovered after amputation of the left middle finger at the mid portion...
  12. doi request reprint Vegetable-borne nitrate and nitrite and the risk of methaemoglobinaemia
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Toxicol Lett 200:107-8. 2011
    ..Nitrate levels in some vegetables can decrease after cooking in water or blanching. Home prepared infant food containing vegetables should be avoided until the infant is 3 months or older...
  13. doi request reprint Causes and prevention of herb-induced aconite poisonings in Asia
    Thomas Y K Chan
    Faculty of Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Hum Exp Toxicol 30:2023-6. 2011
    ..National reporting or monitoring systems can be used to identify the causes of aconite poisonings and assess the impact of preventive measures...
  14. doi request reprint Inorganic mercury poisoning associated with skin-lightening cosmetic products
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Clin Toxicol (Phila) 49:886-91. 2011
    ..Mercury and mercury salts, including mercurous chloride and mercurous oxide, are prohibited for use in cosmetic products as skin-lightening agents because of their high toxicity. Yet, the public continue to have access to these products...
  15. doi request reprint Life-threatening retroperitoneal bleeding due to warfarin-drug interactions
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong
    Pharmacoepidemiol Drug Saf 18:420-2. 2009
    ..The over-anticoagulation and the presence of platelet dysfunction increase the risk of severe bleeding, which can be provoked by trauma...
  16. ncbi request reprint Interaction between warfarin and danshen (Salvia miltiorrhiza)
    T Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Ann Pharmacother 35:501-4. 2001
    ..To discuss the potential for an adverse interaction between the Chinese herb danshen, the dry root and rhizome of Salvia miltiorrhiza Bge, and warfarin...
  17. ncbi request reprint Ingestion of medicated oils by adults: the risk of severe salicylate poisoning is related to the packaging of these products
    T Y K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Hum Exp Toxicol 21:171-4. 2002
    ..To reduce the amount of methyl salicylate that can be readily swallowed during accidental or deliberate ingestion of medicated oils, improvements are needed in the existing packaging of these products...
  18. ncbi request reprint Incidence of herb-induced aconitine poisoning in Hong Kong: impact of publicity measures to promote awareness among the herbalists and the public
    Thomas Y K Chan
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Drug Saf 25:823-8. 2002
    ..An information leaflet was also sent to hospital doctors. Since 1992, the topic was covered periodically in the local newspapers, medical journals and continuing medical education programmes...
  19. ncbi request reprint Herbal medicine causing likely strychnine poisoning
    T Y K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Hum Exp Toxicol 21:467-8. 2002
    ..In any patient with 'unexplained' muscle spasms or convulsions, strychnine poisoning should be included in the differential diagnosis and they should be asked about the use of herbal medicines...
  20. ncbi request reprint A multidisciplinary approach to the toxicologic problems associated with the use of herbal medicines
    Thomas Y K Chan
    Drug and Poisons Information Bureau, Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Ther Drug Monit 27:53-7. 2005
    ..Toxicological problems associated with the use of herbal medicines are complex and may be easily overlooked. A multidisciplinary team of experts should be made available to provide advice to frontline healthcare professionals...
  21. ncbi request reprint Interaction between warfarin and the herbal product quilinggao
    Anna L N Wong
    Accident and Emergency Department, Alice Ho Miu Ling Nethersole Hospital, Tai Po, New Territories, Hong Kong
    Ann Pharmacother 37:836-8. 2003
    ..To describe a patient with loss of anticoagulation control and bleeding after consumption of the combination herbal product quilinggao...
  22. ncbi request reprint Use of herbal medicines by patients receiving warfarin
    Raymond S M Wong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Drug Saf 26:585-8. 2003
    ..Patients receiving warfarin therapy are discouraged from taking herbal medicines. Whether patients adhere to this advice and, if they do not, the types of products they use, are not known...
  23. ncbi request reprint Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause
    Jean Woo
    Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong
    Menopause 10:352-61. 2003
    ..The scientific basis for its action may be its action as a phytoestrogen...
  24. doi request reprint A study of the health and economic effects of influenza-like illness on the working population under different working environments of a large corporation in Hong Kong
    Kenneth K C Lee
    School of Pharmacy, The Chinese University of Hong Kong, Hong Kong
    J Med Econ 11:639-50. 2008
    ..The present study was undertaken to determine the health and economic impacts of ILIs under different environmental conditions on the working population of a large corporation...
  25. ncbi request reprint Relationship between patients' warfarin knowledge and anticoagulation control
    Elaine Othilia Y L Tang
    School of Pharmacy, The Chinese University of Hong Kong, Hong Kong
    Ann Pharmacother 37:34-9. 2003
    ..To evaluate patients' knowledge of warfarin and its relationship to anticoagulation control...
  26. doi request reprint The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients
    Wing Y Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Altern Complement Med 15:415-21. 2009
    ..Recent pharmacological studies suggest their therapeutic values. We aimed to evaluate the efficacy and safety of Salvia miltiorrhiza (danshen) and Pueraria lobata (gegen) in secondary prevention...
  27. ncbi request reprint Adverse herbal interactions causing hypotension
    Anna L N Wong
    Accident and Emergency Department, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong, China
    Ther Drug Monit 25:297-8. 2003
    ..In traditional Chinese medicine, practitioners often use a combination of herbs in an attempt to improve the efficacy but reduce the adverse effects of treatment. The risk of adverse herbal interactions will also be higher...
  28. pmc Management of Chinese patients on warfarin therapy in two models of anticoagulation service - a prospective randomized trial
    Fredric W H Chan
    School of Pharmacy, Faculty of Medicine, The Prince of Wales Hospital, Hong Kong
    Br J Clin Pharmacol 62:601-9. 2006
    ..To compare the treatment outcomes of a clinical pharmacist-managed anticoagulation service with physician-managed service in Chinese patients...
  29. ncbi request reprint Cost-effectiveness analysis of high-dose omeprazole infusion as adjuvant therapy to endoscopic treatment of bleeding peptic ulcer
    Kenneth K C Lee
    School of Pharmacy, Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Gastrointest Endosc 57:160-4. 2003
    ..Yet there is a relative lack of formal assessment of this practice. The aim of this study was to examine the cost-effectiveness of this therapy by using standard pharmacoeconomic methods...
  30. ncbi request reprint Mild symptoms of toxicity following deliberate ingestion of thyroxine
    David K Y Lo
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Whales Hospital, Shatin, New Territories, China
    Vet Hum Toxicol 46:193. 2004
  31. doi request reprint Smoking without exception adversely affects vascular structure and function in apparently healthy Chinese: implications in global atherosclerosis prevention
    G Neil Thomas
    The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Int J Cardiol 128:172-7. 2008
    ..Both active and passive smoking are prevalent in China but cardiovascular diseases were less prevalent in the past. We studied the current relationship between surrogate atherosclerosis markers and smoking in Chinese...
  32. ncbi request reprint A probable case of amygdalin-induced peripheral neuropathy in a vegetarian with vitamin B12 deficiency
    Thomas Y K Chan
    Ther Drug Monit 28:140-1. 2006
  33. ncbi request reprint Deficient dietary vitamin K intake among elderly nursing home residents in Hong Kong
    Samuel L S Tse
    Department of Medicine and Extended Care, Tai Po Hospital, Hong Kong
    Asia Pac J Clin Nutr 11:62-5. 2002
    ..Elderly nursing home residents in this study generally had a poor dietary vitamin K intake and might therefore be predisposed to osteoporosis. The importance of green leafy vegetables as a rich source of vitamin K should be emphasised...
  34. ncbi request reprint Clinical features and management of herb-induced aconitine poisoning
    Chih Chuan Lin
    Emergency Department, Chang Gung Memorial Hospital, Taipei, Taiwan
    Ann Emerg Med 43:574-9. 2004
    ..We define the potential sources, clinical manifestations, and treatment of aconitine poisoning...