Paul Ks Chan

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. pmc Inaccurate identification of rotavirus genotype G9 as genotype G3 strains due to primer mismatch
    Marcelo Takahiro Mitui
    Department of Microbiology, School of Medicine, Oita University, Yufu, Oita, Japan
    Virol J 9:144. 2012
  2. pmc Antagonist-mediated down-regulation of Toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus
    Shui Lian Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China
    Arthritis Res Ther 14:R80. 2012
  3. pmc Effect of avian influenza A H5N1 infection on the expression of microRNA-141 in human respiratory epithelial cells
    Wai Yip Lam
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong Special Administration Region, Shatin, People s Republic of China
    BMC Microbiol 13:104. 2013
  4. doi request reprint Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    Int J Cancer 132:2528-36. 2013
  5. doi request reprint Influenza B lineage circulation and hospitalization rates in a subtropical city, Hong Kong, 2000-2010
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, 1 F Clinical Sciences Bldg, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SpecialAdministrative Region, People s Republic of China
    Clin Infect Dis 56:677-84. 2013
  6. pmc Laboratory and clinical aspects of human papillomavirus testing
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    Crit Rev Clin Lab Sci 49:117-36. 2012
  7. pmc Human papillomavirus type 58: the unique role in cervical cancers in East Asia
    Paul Ks Chan
    Department of Microbiology, The Chinese University of Hong Kong, 1 F Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    Cell Biosci 2:17. 2012
  8. doi request reprint Attribution of human papillomavirus types to cervical intraepithelial neoplasia and invasive cancers in Southern China
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    Int J Cancer 131:692-705. 2012
  9. pmc Apoptosis, cytokine and chemokine induction by non-structural 1 (NS1) proteins encoded by different influenza subtypes
    W Y Lam
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administration Region, People s Republic of China
    Virol J 8:554. 2011
  10. pmc Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses
    W Y Lam
    Department of Microbiology, The Chinese University of Hong Kong, New Territories, Hong Kong Special Administration Region, People s Republic of China
    Virol J 7:344. 2010

Detail Information

Publications115 found, 100 shown here

  1. pmc Inaccurate identification of rotavirus genotype G9 as genotype G3 strains due to primer mismatch
    Marcelo Takahiro Mitui
    Department of Microbiology, School of Medicine, Oita University, Yufu, Oita, Japan
    Virol J 9:144. 2012
    ..Moreover, of 300 rotaviruses tested, 28.3% were untypable by set A primers whereas only 12.3% were untypable by set B primers. Our findings reinforce the need to periodically monitor the primers used for RVA genotyping...
  2. pmc Antagonist-mediated down-regulation of Toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus
    Shui Lian Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China
    Arthritis Res Ther 14:R80. 2012
    ..This study evaluated whether abnormal host innate immune response in lupus patients may enhance HPV persistence...
  3. pmc Effect of avian influenza A H5N1 infection on the expression of microRNA-141 in human respiratory epithelial cells
    Wai Yip Lam
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong Special Administration Region, Shatin, People s Republic of China
    BMC Microbiol 13:104. 2013
    ..This study aims at elucidating how avian influenza infection perturbs the host's miRNA regulatory pathways that may lead to adverse pathological events, such as cytokine storm, using the miRNA microarray approach...
  4. doi request reprint Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    Int J Cancer 132:2528-36. 2013
    ..These substitutions are more commonly found in Asia and the Americas, which may account for the higher disease attribution of HPV58 in these areas...
  5. doi request reprint Influenza B lineage circulation and hospitalization rates in a subtropical city, Hong Kong, 2000-2010
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, 1 F Clinical Sciences Bldg, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SpecialAdministrative Region, People s Republic of China
    Clin Infect Dis 56:677-84. 2013
    ..This retrospective study revealed the situation in a subtropical city over a 10-year period...
  6. pmc Laboratory and clinical aspects of human papillomavirus testing
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    Crit Rev Clin Lab Sci 49:117-36. 2012
    ..Finally, apart from technical and cost-effectiveness considerations, one should also keep in mind the psycho-social impact of using sexually-transmitted agents as a marker for cancer screening...
  7. pmc Human papillomavirus type 58: the unique role in cervical cancers in East Asia
    Paul Ks Chan
    Department of Microbiology, The Chinese University of Hong Kong, 1 F Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    Cell Biosci 2:17. 2012
    ..abstract:..
  8. doi request reprint Attribution of human papillomavirus types to cervical intraepithelial neoplasia and invasive cancers in Southern China
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    Int J Cancer 131:692-705. 2012
    ..4% for CIN3, 22.6% for CIN2 and 17.7% for CIN1. The attribution of HPV types in southern China is different from elsewhere, which should be considered in prioritizing HPV types for vaccine and screening assay development...
  9. pmc Apoptosis, cytokine and chemokine induction by non-structural 1 (NS1) proteins encoded by different influenza subtypes
    W Y Lam
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administration Region, People s Republic of China
    Virol J 8:554. 2011
    ..This study aims at improving our understanding on the pathogenic mechanism of influenza viruses, in particular the role of non-structural (NS1) protein in inducing pro-inflammatory and apoptotic responses...
  10. pmc Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses
    W Y Lam
    Department of Microbiology, The Chinese University of Hong Kong, New Territories, Hong Kong Special Administration Region, People s Republic of China
    Virol J 7:344. 2010
    ..The potential of using these cytokines/chemokines as prognostic markers or targets of therapy is worth exploring...
  11. pmc Willingness to accept H1N1 pandemic influenza vaccine: a cross-sectional study of Hong Kong community nurses
    Samuel Y S Wong
    School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, PR China
    BMC Infect Dis 10:316. 2010
    ..Our study aims to assess the willingness of nurses who work for the community nursing service (CNS) in Hong Kong on their acceptance of influenza A (H1N1) influenza vaccination...
  12. pmc Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study
    K C Allen Chan
    The Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    BMC Infect Dis 5:26. 2005
    ..Thus, we have investigated the association between ACE insertion/deletion (I/D) polymorphism and the progression to ARDS or requirement of intensive care in SARS patients...
  13. pmc A simple and rapid approach for screening of SARS-coronavirus genotypes: an evaluation study
    Grace T Y Chung
    Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    BMC Infect Dis 5:87. 2005
    ..We present here a simple and rapid assay for the screening of SARS-coronavirus genotypes based on the use of fluorogenic oligonucleotide probes for allelic discrimination...
  14. ncbi request reprint HLA-DQB1 polymorphisms and risk for cervical cancer: a case-control study in a southern Chinese population
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, PR China
    Gynecol Oncol 105:736-41. 2007
    ..In this study, the HLA DQB1 alleles among 221 southern Chinese women with cervical intraepithelial neoplasia grade III (CIN III)/invasive cervical carcinoma (ICC) were compared to 191 controls...
  15. ncbi request reprint Association between HLA-DRB1 polymorphism, high-risk HPV infection and cervical neoplasia in southern Chinese
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, Hong Kong, China
    J Med Virol 79:970-6. 2007
    ..The current study shows that, among southern Chinese, the outcome of HPV-infected cervical lesions is associated with HLA-DRB1 polymorphism. These associations often vary with the type of HPV infection...
  16. ncbi request reprint Profile of viral load, integration, and E2 gene disruption of HPV58 in normal cervix and cervical neoplasia
    Paul K S Chan
    Department of Microbiology, School of Public Health, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    J Infect Dis 196:868-75. 2007
    ..Routinely collected cervical samples contain a heterogeneous population of viruses, hampering the application of viral load and integration testing in clinical settings...
  17. ncbi request reprint SARS: clinical presentation, transmission, pathogenesis and treatment options
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    Clin Sci (Lond) 110:193-204. 2006
    ..Although SARS led to more than 700 deaths worldwide, the lessons learnt have prepared healthcare systems worldwide to face future emerging and re-emerging infections...
  18. ncbi request reprint Mechanisms of lymphocyte loss in SARS coronavirus infection
    P K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Hong Kong Med J 14:21-6. 2008
    ..4. Lymphopaenia in SARS patients is likely to result from indirect mechanisms secondary to the viral infection...
  19. ncbi request reprint Biases in human papillomavirus genotype prevalence assessment associated with commonly used consensus primers
    Paul K S Chan
    Department of Microbiology, School of Public Health, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Int J Cancer 118:243-5. 2006
    ..Biases in HPV type-specific sensitivity may result in misprioritization of vaccine candidates...
  20. ncbi request reprint Antibody avidity maturation during severe acute respiratory syndrome-associated coronavirus infection
    Paul K S Chan
    Centre for Emerging Infectious Diseases, Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    J Infect Dis 192:166-9. 2005
    ..Measurement of antibody avidity can be used to differentiate primary infection from reexposure and to assess humoral responses to candidate vaccines...
  21. ncbi request reprint Detection and quantitation of human papillomavirus DNA in primary tumour and lymph nodes of patients with early stage cervical carcinoma
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    J Clin Virol 33:201-5. 2005
    ..The HPV DNA detected from lymph nodes may have originated from circulating necrotic tumour cells or those internalized by scavengers, which was easier to be detected when the viral load per tumour cell was high...
  22. ncbi request reprint Evaluation of a recombinant nucleocapsid protein-based assay for anti-SARS-CoV IgG detection
    Paul K S Chan
    Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 75:181-4. 2005
    ..In contrast, a minority (4 of 105 patients) never developed these antibodies. The implication of differences in antibody response to the nucleocapsid protein deserves further investigation...
  23. ncbi request reprint Evaluation of a peptide-based enzyme immunoassay for anti-SARS coronavirus IgG antibody
    Paul K S Chan
    Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 74:517-20. 2004
    ..The high degree of sensitivity together with the high-throughput nature makes it advantageous as a screening assay for studies where handling of a large number of specimens is required...
  24. doi request reprint Distribution of human papillomavirus types in anogenital warts of men
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    J Clin Virol 44:111-4. 2009
    ..An HPV vaccine covering HPV6 and 11 is now available. Detailed data on the distribution of these two types in anogenital warts is needed to assess the potential benefits of the vaccine...
  25. doi request reprint A review on human influenza A H5N1 infections in Hong Kong
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, 1 F Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Sci China C Life Sci 52:412-8. 2009
    ..The experience and lessons learnt provide important information for controlling further outbreaks caused by avian influenza viruses...
  26. pmc Polymerase activity of hybrid ribonucleoprotein complexes generated from reassortment between 2009 pandemic H1N1 and seasonal H3N2 influenza A viruses
    Wai Y Lam
    Department of Microbiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administration Region, People s Republic of China
    Virol J 8:528. 2011
    ..This study compared the polymerase activity of recombinant viral ribonucleoprotein (vRNP) complexes derived from 2009 pdmH1N1 and the co-circulating seasonal H3N2, and their possible reassortants...
  27. doi request reprint Identification of human papillomavirus type 58 lineages and the distribution worldwide
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Infect Dis 203:1565-73. 2011
    ..Human papillomavirus type 58 (HPV-58) accounts for a much higher proportion of cervical cancers in East Asia than other types. A classification system of HPV-58, which is essential for molecular epidemiological study, is lacking...
  28. doi request reprint T-cell response to human papillomavirus type 52 L1, E6, and E7 peptides in women with transient infection, cervical intraepithelial neoplasia, and invasive cancer
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    J Med Virol 83:1023-30. 2011
    ..This study provides the first set of T-cell epitopes mapped for HPV 52, which can be considered for further evaluation as targets for immunotherapy...
  29. doi request reprint Clinical and virological course of infection with haemagglutinin D222G mutant strain of 2009 pandemic influenza A (H1N1) virus
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong SAR, China
    J Clin Virol 50:320-4. 2011
    ..Aspartic acid to glycine substitution (D222G) of haemagglutinin subunit (HA1) was associated with adverse outcomes in 2009 pandemic influenza A (H1N1) infections...
  30. ncbi request reprint Prevalence and genotype distribution of cervical human papillomavirus infection: Comparison between pregnant women and non-pregnant controls
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 67:583-8. 2002
    ..HPV positive results in pregnant women per se should be managed conservatively...
  31. pmc T-cell response to human papillomavirus type 58 L1, E6, And E7 peptides in women with cleared infection, cervical intraepithelial neoplasia, or invasive cancer
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Clin Vaccine Immunol 17:1315-21. 2010
    ..In summary, this study has identified a few immunogenic epitopes for HPV-58 E6 and E7 proteins. It is worthwhile to further investigate whether responses to these epitopes have a role in clearing an established cervical lesion...
  32. doi request reprint Lancet conference: influenza in the Asia-Pacific and the international scientific symposium on influenza pandemic response and preparedness
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Expert Rev Anti Infect Ther 7:1165-6. 2009
    ..Several highlights are described here...
  33. doi request reprint Seasonal influenza activity in Hong Kong and its association with meteorological variations
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    J Med Virol 81:1797-806. 2009
    ..Further study on the effects of climate change and global warming on the activity of influenza is warranted...
  34. doi request reprint Epidemiologic risk profile of infection with different groups of human papillomaviruses
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China
    J Med Virol 81:1635-44. 2009
    ..These data are useful for formulating preventative strategy for HPV-related diseases. Catch-up vaccination program in Hong Kong should cover a wider age group as the first peak of infection occurred relatively late...
  35. doi request reprint Age distribution of human papillomavirus infection and cervical neoplasia reflects caveats of cervical screening policies
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    Int J Cancer 126:297-301. 2010
    ..Bimodal peaks of HPV infection and cervical cancer are seen in many countries and the analysis of population-specific age distribution of CIN2/3 should be an integral exercise in evaluating the effectiveness of a screening program...
  36. doi request reprint Distribution of human papillomavirus types in cervical cancers in Hong Kong: current situation and changes over the last decades
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    Int J Cancer 125:1671-7. 2009
    ..Multiple infections are commonly revealed by sensitive broad-catching methods such as those used in this study. However, their implication on vaccine efficacy and cost-effective analyses should be taken cautiously...
  37. ncbi request reprint Persistent infection of SARS coronavirus in colonic cells in vitro
    Paul K S Chan
    Centre for Emerging Infectious Diseases, and Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 74:1-7. 2004
    ....
  38. ncbi request reprint Risk factors and clinical consequences of human herpesvirus 7 infection in paediatric haematopoietic stem cell transplant recipients
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 72:668-74. 2004
    ..The administration of colony stimulating factor, occurrence of acute graft versus host disease, time to neutrophil and platelet engraftment showed no significant association with the occurrence of HHV-7 DNAaemia...
  39. ncbi request reprint High carriage rate of TT virus in the cervices of pregnant women
    P K Chan
    Department of Microbiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Clin Infect Dis 32:1376-7. 2001
    ..In this study, a high rate of cervical carriage (66%) of TTV DNA was found by polymerase chain reaction, which suggests that perinatal and sexual transmission is possible...
  40. ncbi request reprint Prevalence and genotype distribution of TT virus in various specimen types from thalassaemic patients
    P K Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Viral Hepat 8:304-9. 2001
    ..TTV-infected patients often harbour multiple genotypes suggesting infection with one genotype does not necessarily confer protection against the others. No correlation between TTV infection and liver dysfunction was observed...
  41. ncbi request reprint Determinants of cervical human papillomavirus infection: differences between high- and low-oncogenic risk types
    Paul K S Chan
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Infect Dis 185:28-35. 2002
    ..Barrier contraception was protective for low-risk HPVs; current vaginal discharge had a negative association with unknown-risk HPVs. The results indicate that different risk profiles exist for infections with different HPV groups...
  42. ncbi request reprint Case report: human herpesvirus 7 associated fatal encephalitis in a peripheral blood stem cell transplant recipient
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 66:493-6. 2002
    ..All microbiological investigations were negative, except for the presence of HHV-7 DNA in cerebrospinal fluid and brain stem tissue samples...
  43. ncbi request reprint Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Clin Infect Dis 34:S58-64. 2002
    ..The experience of the H5N1 outbreak in Hong Kong underscores the importance of continuous surveillance of influenza virus strains in humans and in other animal species...
  44. ncbi request reprint Association of human papillomavirus type 58 variant with the risk of cervical cancer
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    J Natl Cancer Inst 94:1249-53. 2002
    ..038, two-sided Mann-Whitney U test). Thus, HPV58 variants carrying E7 T20I/G63S substitutions may be associated with an increased risk for cervical cancer...
  45. ncbi request reprint Genetic variation of glycoproteins B and H of human herpesvirus 7 in Hong Kong
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 71:429-33. 2003
    ..4%) Hong Kong isolates were of the gH allele group B, and all others were of the gH allele group C. These data indicate the possibility of using gB or gH alleles as markers for studying world-wide population movements and genetics...
  46. pmc Human metapneumovirus detection in patients with severe acute respiratory syndrome
    Paul K S Chan
    Faculty of Medicine of the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Emerg Infect Dis 9:1058-63. 2003
    ..These widely available HEp-2 cells should be included in conjunction with a molecular method for cell culture followup to detect HMPV, particularly in patients with SARS...
  47. pmc Severe acute respiratory syndrome-associated coronavirus infection
    Paul K S Chan
    The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Emerg Infect Dis 9:1453-4. 2003
    ..None of these healthcare workers had antibody to SARS CoV, indicating that subclinical or mild infection attributable to SARS-CoV in adults is rare...
  48. ncbi request reprint Human papillomavirus type 16 intratypic variant infection and risk for cervical neoplasia in southern China
    Paul K S Chan
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    J Infect Dis 186:696-700. 2002
    ..The epidemiology and risk implication of HPV-16 variant infection in Hong Kong differ markedly from other parts of the world...
  49. ncbi request reprint Genotype spectrum of cervical human papillomavirus infection among sexually transmitted disease clinic patients in Hong Kong
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 68:273-7. 2002
    ..This together with previous reports of the high prevalence of HPV58 among Chinese cervical cancer patients accentuate the importance of developing vaccines targeting at this otherwise uncommon genotype...
  50. pmc Association of human beta-herpesviruses with the development of cervical cancer: bystanders or cofactors
    P K Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong SAR, China
    J Clin Pathol 54:48-53. 2001
    ..In addition, CMV and HHV-6 can interact with HPVs in vivo. This study examined the possible role of beta-herpesviruses in cervical cancer development...
  51. ncbi request reprint Clearance of TT virus after allogeneic bone marrow transplantation
    P K Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, SAR
    J Pediatr Hematol Oncol 23:57-8. 2001
    ..Thus, the conditioning regimen may have depleted the hemic cells and the hematologically compartmentalized TTV. The potential of hemic tropism of TTV and its role in hematologic diseases need to be considered...
  52. pmc Laboratory diagnosis of SARS
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Emerg Infect Dis 10:825-31. 2004
    ..Positive virologic test results in patient groups were associated with mechanical ventilation or death (p < 0.001), suggesting a correlation between viral load and disease severity...
  53. ncbi request reprint High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions
    P K Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Med Virol 59:232-8. 1999
    ..6% for a cervical lesion of CIN 1 or higher severity. The high prevalence of HPV 58 among Chinese women, particularly in patients with carcinoma, has an implication on the design of HPV detection methods and the development of vaccines...
  54. pmc Immunofluorescence assay for serologic diagnosis of SARS
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, People s Republic of China
    Emerg Infect Dis 10:530-2. 2004
    ..Sensitivity and specificity of this assay were both 100%. Immunofluorescence assay can ascertain the status of SARS-CoV infection...
  55. pmc Human metapneumovirus-associated atypical pneumonia and SARS
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Emerg Infect Dis 10:497-500. 2004
    ..Human metapneumovirus was isolated from lung tissue. No other pathogen was found. Other etiologic agents should thus be sought in apparent SARS cases when coronavirus infection cannot be confirmed...
  56. ncbi request reprint Presence of human herpesviruses 6, 7, and 8 DNA sequences in normal brain tissue
    P K Chan
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    J Med Virol 59:491-5. 1999
    ..The results provide molecular evidence of the presence of the three newly identified herpesviruses in brain tissue. The pathogenic role for HHV-7 and HHV-8, as with HHV-6, in neurological diseases should not be overlooked...
  57. pmc Detection of human herpesviruses 6 and 7 genomic sequences in brain tumours
    P K Chan
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, China
    J Clin Pathol 52:620-3. 1999
    ..While HHV-6 and HHV-7 are predominantly T lymphotropic, the extent of tissue tropism in persistent infection is not known...
  58. pmc Evaluation of extraction methods from paraffin wax embedded tissues for PCR amplification of human and viral DNA
    P K Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Clin Pathol 54:401-3. 2001
    ..In addition, to assess the reliability of amplifying a housekeeping gene to indicate successful viral DNA extraction...
  59. pmc Survey for the presence and distribution of human herpesvirus 8 in healthy brain
    P K Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Clin Microbiol 38:2772-3. 2000
    ..Nineteen patients (63.3%) were positive and showed a significant increase in positivity with age (P = 0.007). The results indicate a neuroinvasive and neuropersistent potential of HHV-8...
  60. ncbi request reprint Prevalence and distribution of human herpesvirus 7 in normal brain
    P K Chan
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    J Med Virol 62:345-8. 2000
    ..Further studies to elucidate the role of this ubiquitous virus in neuropathology are warranted...
  61. ncbi request reprint Rubella immune status among healthcare workers in the Department of Obstetrics and Gynaecology of a regional hospital in Hong Kong: the need for a vaccination policy
    P K Chan
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, China
    J Hosp Infect 42:239-42. 1999
    ..There is a need to review the rubella immunization policy for healthcare workers in Hong Kong...
  62. ncbi request reprint Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis B s-antigen seropositive cancer patients undergoing cytotoxic chemotherapy
    Winnie Yeo
    MRCP, Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong winnieyeo cuhk edu hk
    J Clin Oncol 22:927-34. 2004
    ....
  63. doi request reprint Molecular epidemiology of hepatitis C genotype 6a from patients with chronic hepatitis C from Hong Kong
    Cheryl S Y Li
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 81:628-33. 2009
    ..Larger studies are required to confirm these findings...
  64. ncbi request reprint ACE2 gene polymorphisms do not affect outcome of severe acute respiratory syndrome
    Rossa W K Chiu
    The Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin
    Clin Chem 50:1683-6. 2004
  65. pmc Increase of integration events and infection loads of human papillomavirus type 52 with lesion severity from low-grade cervical lesion to invasive cancer
    Jo L K Cheung
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    J Clin Microbiol 46:1356-62. 2008
    ..In summary, the HPV-52 viral load and the integrated proportion increased with the severity of the cervical lesions but had a different pattern than that of HPV-16...
  66. doi request reprint Cytokine responses in a severe case of glandular fever treated successfully with foscarnet combined with prednisolone and intravenous immunoglobulin
    Christine Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 81:99-105. 2009
    ..Detailed immunological, virological, haematological and biochemical laboratory parameters are presented to document this patient's severe EBV disease and eventual recovery...
  67. doi request reprint Allele-specific conventional reverse-transcription polymerase chain reaction as a screening assay for discriminating influenza a H1N1 (H275Y) oseltamivir-resistant and wild-type viruses
    Karry L K Ngai
    Faculty of Medicine, Department of Microbiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administration Region, China
    J Med Virol 82:1295-8. 2010
    ..Further improvement in performance is expected when applied to cell culture isolates with a higher viral titer. These allele-specific cRT-PCR assays can be a simple, low-cost option for large-scale screening of influenza isolates...
  68. ncbi request reprint HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    Int J Cancer 118:1430-5. 2006
    ..It would also be worthwhile to assess the association between HLA-B15, HPV52 and cervical cancer in other Asian populations...
  69. ncbi request reprint Viral load, E2 gene disruption status, and lineage of human papillomavirus type 16 infection in cervical neoplasia
    Jo L K Cheung
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    J Infect Dis 194:1706-12. 2006
    ..The link between viral lineage, integration pattern, and oncogenesis deserves further study...
  70. doi request reprint Natural history of cervical papilloma virus infection in systemic lupus erythematosus - a prospective cohort study
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Rheumatol 37:330-40. 2010
    ....
  71. ncbi request reprint Hypermethylation of the tumor suppressor gene RASSFIA and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers
    Mei Y Yu
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong SAR, The People s Republic of China
    Int J Cancer 105:204-9. 2003
    ..The results supported that RASSF1A may be one of the cervical cancer-related tumor suppressor genes located at 3p21 regions...
  72. ncbi request reprint Infants born to mothers with severe acute respiratory syndrome
    Chi C Shek
    Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Lai Chi Kok, New Territories, Hong Kong
    Pediatrics 112:e254. 2003
    ..This case series is the first report to describe the clinical course of the first cohort of liveborn infants born to pregnant women with SARS...
  73. ncbi request reprint Characterizing 56 complete SARS-CoV S-gene sequences from Hong Kong
    Julian W Tang
    Department of Microbiology, School of Public Health, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Clin Virol 38:19-26. 2007
    ..The spike glycoprotein (S) gene of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) has been useful in analyzing the molecular epidemiology of the 2003 SARS outbreaks...
  74. pmc Willingness of Hong Kong healthcare workers to accept pre-pandemic influenza vaccination at different WHO alert levels: two questionnaire surveys
    Josette S Y Chor
    School of Public Health and Primary Care, Chinese University of Hong Kong, School of Public Health, Prince of Wales Hospital, Shatin, Hong Kong
    BMJ 339:b3391. 2009
    ..To assess the acceptability of pre-pandemic influenza vaccination among healthcare workers in public hospitals in Hong Kong and the effect of escalation in the World Health Organization's alert level for an influenza pandemic...
  75. doi request reprint Prevalence of diarrhea viruses in hospitalized children in Hong Kong in 2008
    Cheryl S Y Li
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    J Med Virol 81:1903-11. 2009
    ..The results support the importance of norovirus as a causative agent of diarrhea in children, which may be underestimated by the current routine diagnostic testing...
  76. ncbi request reprint Quantitative temporal-spatial distribution of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) in post-mortem tissues
    Julian W Tang
    Department of Microbiology, School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong SAR, China
    J Med Virol 79:1245-53. 2007
    ..This quantitative assessment further supports SARS-CoV has a specific tropism for the human respiratory and gastrointestinal tracts, which may be related to the density of SARS-CoV receptors...
  77. ncbi request reprint Viral etiology of acute exacerbations of COPD in Hong Kong
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong
    Chest 132:900-8. 2007
    ..Viral respiratory infections may precipitate acute exacerbations of COPD (AECOPD). However, little is known about viral etiology related to AECOPD in Asia. We aimed to study the viral etiology of AECOPD in Hong Kong...
  78. doi request reprint A one-year prospective study of infectious etiology in patients hospitalized with acute exacerbations of COPD and concomitant pneumonia
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
    Respir Med 102:1109-16. 2008
    ..This study assessed the infectious etiology of patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with concomitant pneumonia...
  79. ncbi request reprint Evaluation of Epstein-Barr virus antigen-based immunoassays for serological diagnosis of nasopharyngeal carcinoma
    Julian W Tang
    Department of Microbiology, Division of Otorhinolaryngology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, Hong Kong
    J Clin Virol 40:284-8. 2007
    ..Immunofluorescence (IF) assays based on Epstein-Barr virus (EBV)-encoded antigens have traditionally been the preferred approach for serological screening of nasopharyngeal carcinoma (NPC)...
  80. doi request reprint Prevalence and genotype distribution of cervical human papillomavirus infection in Macao
    Yuk Ching Yip
    Department of Pathology, Kiang Wu Hospital, Macao Special Administrative Region, Shatin, China
    J Med Virol 82:1724-9. 2010
    ..Further study to determine the contribution of HPV 52 in high-grade cervical neoplasia and invasive cancers in Macao is warranted...
  81. doi request reprint A wide spectrum of dengue IgM and PCR positivity post-onset of illness found in a large dengue 3 outbreak in Pakistan
    Julian W Tang
    Department of Microbiology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    J Med Virol 80:2113-21. 2008
    ..Interestingly, in this study, the dengue IgM positivity correlates more closely with significant clinical illness than the dengue RNA positivity, which may be a feature specific to this particular outbreak...
  82. doi request reprint Identification of viral and atypical bacterial pathogens in children hospitalized with acute respiratory infections in Hong Kong by multiplex PCR assays
    R Y T Sung
    Department of Paediatrics, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China
    J Med Virol 81:153-9. 2009
    ....
  83. ncbi request reprint Airflows around oxygen masks: A potential source of infection?
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, Peoples Republic of China
    Chest 130:822-6. 2006
    ..An analysis of captured digital images showed that the exhaled air at the peak of simulated exhalation reached a distance of approximately 0.40 m...
  84. ncbi request reprint Sapovirus detection by quantitative real-time RT-PCR in clinical stool specimens
    Martin C W Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
    J Virol Methods 134:146-53. 2006
    ..No cross-reactivity with norovirus and rotavirus was observed. In conclusion, the assay is a sensitive and specific method for the detection of SV from clinical stool specimens...
  85. ncbi request reprint Risk association between human leukocyte antigen-A allele and high-risk human papillomavirus infection for cervical neoplasia in Chinese women
    Denise P C Chan
    Department of Microbiology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    J Infect Dis 192:1749-56. 2005
    ..The results of the present study indicate that HLA-A polymorphism is one of the host genetic factors that alter the risk for the development of cervical cancer in Chinese women...
  86. pmc Rapid multiplex nested PCR for detection of respiratory viruses
    W Y Lam
    Department of Microbiology, The Chinese University of Hong Kong, 1 F Clinical Science Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Clin Microbiol 45:3631-40. 2007
    ..6%) in the overall positive rate. In conclusion, rapid multiplex nested PCR assays can improve the diagnostic yield for respiratory infections to allow prompt interventive actions to be taken...
  87. ncbi request reprint The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells
    Patrick T W Law
    Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    J Gen Virol 86:1921-30. 2005
    ..In vitro experiments of chromatin condensation and DNA fragmentation suggested that the 3a protein may trigger apoptosis. These data showed that overexpression of a single SARS-CoV protein can induce apoptosis in vitro...
  88. doi request reprint Emergence of adamantane-resistant influenza A(H3N2) viruses in Hong Kong between 1997 and 2006
    Julian W Tang
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    J Med Virol 80:895-901. 2008
    ..The underlying reasons for these findings are unclear and similar studies are required elsewhere to elucidate these and prevent this spread of drug-resistance happening again in future...
  89. ncbi request reprint Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS)
    Wai S Chan
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Mod Pathol 18:1432-9. 2005
    ..These antipeptide antibodies can be useful for the diagnosis of SARS at the tissue level...
  90. ncbi request reprint Increased prevalence of squamous intraepithelial lesions in systemic lupus erythematosus: association with human papillomavirus infection
    Lai Shan Tam
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Arthritis Rheum 50:3619-25. 2004
    ..The association of human papillomavirus (HPV) infection and the use of immunosuppressive agents with abnormal Pap smears in SLE was also assessed...
  91. ncbi request reprint Hospital-based study of the economic burden associated with rotavirus diarrhea in Hong Kong
    E Anthony S Nelson
    Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region
    J Infect Dis 192:S64-70. 2005
    ..Rotavirus infection is the most common cause of severe diarrhea in both developed and developing countries...
  92. ncbi request reprint Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal cases
    K F To
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Pathol 202:157-63. 2004
    ..Whereas the lung pathology was dominated by diffuse alveolar damage, the gut was relatively intact. These findings indicated that tissue responses to SARS-CoV infection are distinct in different organs...
  93. pmc Diagnostic criteria during SARS outbreak in Hong Kong
    Louis Y Chan
    Emerg Infect Dis 10:1168-70. 2004
  94. ncbi request reprint The spectrum of severe acute respiratory syndrome-associated coronavirus infection
    Timothy H Rainer
    Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Trauma and Emergency Centre, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Ann Intern Med 140:614-9. 2004
    ..Objectives: To describe the spectrum of SARS coronavirus infection in a large outbreak and to compare diagnoses based on clinical judgment with the SARS coronavirus test...
  95. ncbi request reprint Immunogenicity of a two-dose regime of varicella vaccine in children with cancers
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Eur J Haematol 72:353-7. 2004
    ..Live-attenuated varicella vaccine is effective and safe in immunocompetent children. In this study, we assess the immunogenicity and adverse events following varicella vaccination in immunosuppressed cancer children...
  96. ncbi request reprint Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital
    Kuo Ming Yeh
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, No 325, Cheng Kung Road, Sec 2, Neihu, Taipei, 114, Taiwan
    J Antimicrob Chemother 56:919-22. 2005
    ..To describe the immunological responses and clinical outcome of coronavirus (SARS) infected healthcare workers (HCW) who had been administered with convalescent plasma as a treatment...
  97. pmc Human parainfluenza virus 4 outbreak and the role of diagnostic tests
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital
    J Clin Microbiol 43:4515-21. 2005
    ..To better define the epidemiology and clinical spectrum of disease of HPIV-4 infections, HPIV-4 should be included in the routine panels of respiratory virus detection on respiratory specimens...
  98. pmc Cluster of SARS among medical students exposed to single patient, Hong Kong
    Tze Wai Wong
    Departmentof Community and Family Medicine, The Chinese University of Hong Kong, School of Public Health, Prince of Wales Hospital, Hong Kong Special Administrative Region, People s Republic of China
    Emerg Infect Dis 10:269-76. 2004
    ..Proximity to the index case-patient was associated with transmission, which is consistent with droplet spread. Transmission through fomites or small aerosols cannot be ruled out...
  99. pmc Genotypic analysis of two hypervariable human cytomegalovirus genes
    Amanda J Bradley
    MRC Virology Unit, Institute of Virology, University of Glasgow, Glasgow, United Kingdom
    J Med Virol 80:1615-23. 2008
    ..The emerging scenario is that the HCMV genotypes developed in early human populations (or even earlier), becoming established via founder or bottleneck effects, and have spread, recombined and mixed worldwide in more recent times...
  100. ncbi request reprint Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 17:275-84. 2006
    ..In summary, the data suggest that induction of IFN by mismatched dsRNA or actual treatment with exogenous IFN-alpha can inhibit SARS-CoV replication in the lungs of mice...
  101. ncbi request reprint Assessing disease burden of respiratory disorders in Hong Kong children with hospital discharge data and linked laboratory data
    Edmund A S Nelson
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 13:114-21. 2007
    ..To describe the pattern of respiratory disorders in the Hong Kong paediatric population admitted to government hospitals, and to assess the reliability of the diagnoses by linkage with laboratory data...