Juliana Cn Chan

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. pmc Diabetes-related distress and physical and psychological health in chinese type 2 diabetic patients
    Rose Z W Ting
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong S A R, China
    Diabetes Care 34:1094-6. 2011
  2. pmc Additive effects of blood glucose lowering drugs, statins and renin-angiotensin system blockers on all-site cancer risk in patients with type 2 diabetes
    Alice P S Kong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, China
    BMC Med 12:76. 2014
  3. pmc Associations of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese Universityof Hong Kong, Hong Kong, People s Republic of China
    Diabetes 59:1254-60. 2010
  4. pmc Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese
    Ronald Ching Wan Ma
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People s Republic of China Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, People s Republic of China Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People s Republic of China
    PLoS ONE 9:e84770. 2014
  5. pmc Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations
    Vincent Kwok Lim Lam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People s Republic of China
    PLoS ONE 8:e62378. 2013
  6. doi request reprint Diabetes in the Western pacific region--past, present and future
    Juliana C N Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China Electronic address
    Diabetes Res Clin Pract 103:244-55. 2014
  7. doi request reprint Prospective study on the incidences of cardiovascular-renal complications in chinese patients with young-onset type 1 and type 2 diabetes
    Andrea O Y Luk
    Corresponding author Juliana C N Chan
    Diabetes Care 37:149-57. 2014
  8. pmc Using a multi-staged strategy based on machine learning and mathematical modeling to predict genotype-phenotype risk patterns in diabetic kidney disease: a prospective case-control cohort analysis
    Ross K K Leung
    Hong Kong Bioinformatics Centre, The Chinese University of Hong Kong, Hong Kong, SAR, China
    BMC Nephrol 14:162. 2013
  9. pmc Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression
    Hai Lu Zhao
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    Diabetes 61:933-43. 2012
  10. pmc Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy: a multicentre, randomised, placebo-controlled study
    E Imai
    Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Diabetologia 54:2978-86. 2011

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. pmc Diabetes-related distress and physical and psychological health in chinese type 2 diabetic patients
    Rose Z W Ting
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong S A R, China
    Diabetes Care 34:1094-6. 2011
    ..To validate a Chinese version of the Diabetes Distress Scale (CDDS)...
  2. pmc Additive effects of blood glucose lowering drugs, statins and renin-angiotensin system blockers on all-site cancer risk in patients with type 2 diabetes
    Alice P S Kong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, China
    BMC Med 12:76. 2014
    ..We examined the joint associations of optimal glycemic control (HbA1c <7%), RAS inhibitors and HMGCR inhibitors on cancer incidence in patients with type 2 diabetes...
  3. pmc Associations of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese Universityof Hong Kong, Hong Kong, People s Republic of China
    Diabetes 59:1254-60. 2010
    ..CONCLUSIONS In Chinese patients with type 2 diabetes, hyperglycemia predicts cancer, whereas insulin usage was associated with a reduced cancer risk...
  4. pmc Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese
    Ronald Ching Wan Ma
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People s Republic of China Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, People s Republic of China Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People s Republic of China
    PLoS ONE 9:e84770. 2014
    ..Bioinformatics analysis revealed that rs1408888 lies within regulatory elements of DACH1 implicated in islet development and insulin secretion. The T allele of rs1408888 of DACH1 was associated with YOD, prediabetes and CVD in Chinese...
  5. pmc Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations
    Vincent Kwok Lim Lam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People s Republic of China
    PLoS ONE 8:e62378. 2013
    ..Taken together, these results support the importance of dysregulation of IAPP metabolism in T2D in East Asians...
  6. doi request reprint Diabetes in the Western pacific region--past, present and future
    Juliana C N Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China Electronic address
    Diabetes Res Clin Pract 103:244-55. 2014
    ..Despite these challenges, the WP Region has provided notable examples to prevent and control diabetes. ..
  7. doi request reprint Prospective study on the incidences of cardiovascular-renal complications in chinese patients with young-onset type 1 and type 2 diabetes
    Andrea O Y Luk
    Corresponding author Juliana C N Chan
    Diabetes Care 37:149-57. 2014
    ..The increased risk was driven primarily by accompanying metabolic risk factors. ..
  8. pmc Using a multi-staged strategy based on machine learning and mathematical modeling to predict genotype-phenotype risk patterns in diabetic kidney disease: a prospective case-control cohort analysis
    Ross K K Leung
    Hong Kong Bioinformatics Centre, The Chinese University of Hong Kong, Hong Kong, SAR, China
    BMC Nephrol 14:162. 2013
    ..In a database with comprehensive collection of phenotypes and genotypes, we compared the performance of common machine learning methods to generate mathematical models to predict diabetic kidney disease (DKD)...
  9. pmc Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression
    Hai Lu Zhao
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    Diabetes 61:933-43. 2012
    ..These novel findings suggest that multicomponent TCM may be a useful tool to unravel genome regulation and expression in complex diseases...
  10. pmc Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy: a multicentre, randomised, placebo-controlled study
    E Imai
    Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Diabetologia 54:2978-86. 2011
    ..The renal and cardiovascular protective effects of angiotensin receptor blocker (ARB) remain controversial in type 2 diabetic patients treated with a contemporary regimen including an angiotensin converting enzyme inhibitor (ACEI)...
  11. pmc Lipid control and use of lipid-regulating drugs for prevention of cardiovascular events in Chinese type 2 diabetic patients: a prospective cohort study
    Rose Z W Ting
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Cardiovasc Diabetol 9:77. 2010
    ..Yet, the effectiveness of lipid regulating drugs in Asians is lacking. We examined the effects of lipid control and treatment with lipid regulating drugs on new onset of CVD in Chinese type 2 diabetic patients...
  12. pmc Lack of benefits for prevention of cardiovascular disease with aspirin therapy in type 2 diabetic patients--a longitudinal observational study
    Wilson Y Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, PR China
    Cardiovasc Diabetol 8:57. 2009
    ..This study examined the benefit and harm of low-dose aspirin (daily dose < 300 mg) in patients with type 2 diabetes...
  13. pmc Impacts of chronic kidney disease and albuminuria on associations between coronary heart disease and its traditional risk factors in type 2 diabetic patients - the Hong Kong diabetes registry
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Diabetol 6:37. 2007
    ..We used novel statistical analyses to examine how albuminuria and chronic kidney disease (CKD) may influence the effects of other risk factors on coronary heart disease (CHD)...
  14. pmc Development and validation of a risk score for hospitalization for heart failure in patients with Type 2 diabetes mellitus
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Diabetol 7:9. 2008
    ..Based on the Hong Kong Diabetes Registry, this study aimed to develop and validate a risk score for predicting heart failure that needs hospitalisation in T2DM...
  15. pmc Hong Kong Chinese school children with elevated urine melamine levels: a prospective follow up study
    Alice P S Kong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    BMC Public Health 11:354. 2011
    ..We identified Hong Kong school children with elevated urine melamine level from a community-based school survey in 2007-08 and reviewed their clinical status in 2009...
  16. pmc Association between physical activity and cardiovascular risk in Chinese youth independent of age and pubertal stage
    Alice P S Kong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    BMC Public Health 10:303. 2010
    ..We examined the association of self-reported level of physical activity and cardiovascular risk in Hong Kong Chinese youth of school-age...
  17. pmc The problem of obesity among adolescents in Hong Kong: a comparison using various diagnostic criteria
    Gary T C Ko
    The Hong Kong Institute of Diabetes and Obesity, Hong Kong SAR, China
    BMC Pediatr 8:10. 2008
    ..Obesity is now a global epidemic. In this study, we aimed to assess the rates of obesity using several major diagnostic criteria in Chinese school adolescents in Hong Kong...
  18. pmc From design to implementation--the Joint Asia Diabetes Evaluation (JADE) program: a descriptive report of an electronic web-based diabetes management program
    Gary T Ko
    Asia Diabetes Foundation, Flat 4B, Block B, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    BMC Med Inform Decis Mak 10:26. 2010
    ..The Joint Asia Diabetes Evaluation (JADE) Program is a web-based program incorporating a comprehensive risk engine, care protocols, and clinical decision support to improve ambulatory diabetes care...
  19. pmc Genome-wide linkage scan for factors of metabolic syndrome in a Chinese population
    Claudia H T Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    BMC Genet 11:14. 2010
    ..Shared genetic factors may contribute to the phenotypic clustering of different components of the metabolic syndrome (MES). This study aims to identify genetic loci that contribute to individual or multiple factors related to MES...
  20. ncbi request reprint The Joint Asia Diabetes Evaluation (JADE) Program: a web-based program to translate evidence to clinical practice in Type 2 diabetes
    J Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    Diabet Med 26:693-9. 2009
    ..The aim was to validate the risk stratification system of the JADE Program using a large prospective cohort...
  21. ncbi request reprint Role of metformin in the initiation of pharmacotherapy for type 2 diabetes: an Asian-Pacific perspective
    Juliana C N Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hongkong
    Diabetes Res Clin Pract 75:255-66. 2007
    ..These recommendations can serve as templates for development of local guidelines for Asian people with diabetes, given the ethnic and cultural diversity within the region...
  22. doi request reprint Diabetes in Asia: epidemiology, risk factors, and pathophysiology
    Juliana C N Chan
    Hong Kong Institute of Diabetes and Obesity, Department of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    JAMA 301:2129-40. 2009
    ..With increasing globalization and East-West exchanges, the increasing epidemic of type 2 diabetes in Asia has far-reaching public health and socioeconomic implications...
  23. ncbi request reprint The central roles of obesity-associated dyslipidaemia, endothelial activation and cytokines in the Metabolic Syndrome--an analysis by structural equation modelling
    J C N Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Int J Obes Relat Metab Disord 26:994-1008. 2002
    ..To test this hypothesis, we used confirmatory factor analysis and structural equation modelling to fit these data to a model designed on theoretical grounds...
  24. ncbi request reprint Renin angiotensin aldosterone system blockade and renal disease in patients with type 2 diabetes. An Asian perspective from the RENAAL Study
    Juliana C N Chan
    Department of Medicine and Therapeutics, The Chinese University Hong Kong, The Prince of Wales Hospital, Hong Kong, Shatin, China
    Diabetes Care 27:874-9. 2004
    ..In this subgroup analysis, we examined the characteristics, response, and adherence to treatment of the Asian population, as well as their baseline predictors of risk of renal end points...
  25. pmc Multifaceted determinants for achieving glycemic control: the International Diabetes Management Practice Study (IDMPS)
    Juliana C N Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Diabetes Care 32:227-33. 2009
    ..The International Diabetes Mellitus Practice Study is a 5-year survey documenting changes in diabetes treatment practice in developing regions...
  26. ncbi request reprint Lessons learned from young-onset diabetes in China
    Juliana C N Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong, China
    Curr Diab Rep 3:101-7. 2003
    ..Understanding the molecular basis of diabetes in these subjects may also eventually lead to improvement in diagnosis, classification, and treatment...
  27. pmc Effects of structured versus usual care on renal endpoint in type 2 diabetes: the SURE study: a randomized multicenter translational study
    Juliana C Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Diabetes Care 32:977-82. 2009
    ..Multifaceted care has been shown to reduce mortality and complications in type 2 diabetes. We hypothesized that structured care would reduce renal complications in type 2 diabetes...
  28. ncbi request reprint Accuracy, precision and user-acceptability of self blood glucose monitoring machines
    J C Chan
    Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Diabetes Res Clin Pract 36:91-104. 1997
    ..One Touch II yielded the most reproducible results with a mean CV of 2.7% and was considered the most user friendly machine. More studies are required to examine the performance of these machines in the hands of patients...
  29. ncbi request reprint An Asian multicenter clinical trial to assess the efficacy and tolerability of acarbose compared with placebo in type 2 diabetic patients previously treated with diet. Asian Acarbose Study Group
    J C Chan
    Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
    Diabetes Care 21:1058-61. 1998
    ..To assess the efficacy, safety, and tolerability of acarbose versus placebo during a 24-week treatment period in Asian type 2 diabetic patients with dietary failure...
  30. ncbi request reprint Long-term effects of angiotensin-converting enzyme inhibition and metabolic control in hypertensive type 2 diabetic patients
    J C Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong
    Kidney Int 57:590-600. 2000
    ..Long-term effects of angiotensin-converting enzyme inhibition and metabolic control in hypertensive type 2 diabetic patients...
  31. doi request reprint Diabetic dyslipidaemia in Asian populations in the Western Pacific Region: what we know and don't know
    Juliana C N Chan
    Hong Kong Institute of Diabetes and Obesity and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong Special Administrative Region
    Diabetes Res Clin Pract 94:1-13. 2011
    ..The group recommends conducting randomized studies, strengthening of the health care system to promote early detection, and intervention of diabetic dyslipidaemia to prevent end organ damage...
  32. ncbi request reprint Diabetes mellitus--a special medical challenge from a Chinese perspective
    J C Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong
    Diabetes Res Clin Pract 54:S19-27. 2001
    ....
  33. ncbi request reprint Contribution of gene polymorphisms in the renin-angiotensin system to macroangiopathy in patients with diabetic nephropathy
    T Y Wong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, China
    Am J Kidney Dis 38:9-17. 2001
    ..The association is dependent on its effect on serum ACE activity, which is an independent risk factor for the development of macroangiopathy...
  34. ncbi request reprint Outcomes of screening for diabetes in high-risk Hong Kong Chinese subjects
    G T Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin
    Diabetes Care 23:1290-4. 2000
    ..To examine the significance of individual risk factors on the development of diabetes in subjects who underwent screening for diabetes...
  35. ncbi request reprint Cardiovascular disease in chinese type 2 diabetic women is associated with a prolonged QTc interval
    G T Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, N T, Shatin, Hong Kong
    Int J Cardiol 76:75-80. 2000
    ..Age, systolic blood pressure and female gender are independently correlated to QTc interval...
  36. ncbi request reprint Diabetes in Hong Kong Chinese: evidence for familial clustering and parental effects
    S C Lee
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, SAR
    Diabetes Care 23:1365-8. 2000
    ..To investigate transmission patterns of diabetes and their relationships with clinical characteristics in Hong Kong Chinese patients with late-onset (age > or =35 years) type 2 diabetes...
  37. ncbi request reprint Urinary epinephrine and norepinephrine interrelations with obesity, insulin, and the metabolic syndrome in Hong Kong Chinese
    Z S Lee
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories
    Metabolism 50:135-43. 2001
    ..Based on these findings, we postulate that complex interactions between the insulin and sympathoadrenal systems may lead to the development of obesity and the metabolic syndrome...
  38. ncbi request reprint Change of glycaemic status in Chinese subjects with impaired fasting glycaemia
    G T Ko
    Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Tai Po, NT, Hong Kong
    Diabet Med 18:745-8. 2001
    ..To examine the risk of progression to diabetes in Chinese subjects with impaired fasting glycaemia (IFG) or normal fasting glucose (NFG)...
  39. ncbi request reprint The islet amyloid polypeptide (amylin) gene S20G mutation in Chinese subjects: evidence for associations with type 2 diabetes and cholesterol levels
    S C Lee
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Clin Endocrinol (Oxf) 54:541-6. 2001
    ..In the present study, we investigated the distribution of the mutation in Hong Kong Chinese, and examined whether there was evidence for associations between the mutation and type 2 diabetes and/or metabolic profiles...
  40. ncbi request reprint Factors predicting the age when type 2 diabetes is diagnosed in Hong Kong Chinese subjects
    S C Lee
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, SAR
    Diabetes Care 24:646-9. 2001
    ..To examine the factors predicting age at diagnosis of type 2 diabetes in Hong Kong Chinese...
  41. ncbi request reprint Glycaemic control and obesity are the major determinants of diabetic dyslipidaemia in Hong Kong Chinese
    G T Ko
    Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, 11 Chuen On Road, Tai Po, Hong Kong, ROC
    Diabetes Metab 27:637-44. 2001
    ..Dyslipidaemia plays a major role in the increased mortality in diabetes. Our aim was to address the quantitative abnormalities and determinants for lipid abnormalities in Chinese Type 2 diabetic patients...
  42. ncbi request reprint Association of retinopathy with a microsatellite at 5' end of the aldose reductase gene in Chinese patients with late-onset Type 2 diabetes
    S C Lee
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Ophthalmic Genet 22:63-7. 2001
    ..The aldose reductase gene may be implicated, but is not likely to play a major role...
  43. ncbi request reprint Prediction of hypertension, diabetes, dyslipidaemia or albuminuria using simple anthropometric indexes in Hong Kong Chinese
    G T Ko
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Int J Obes Relat Metab Disord 23:1136-42. 1999
    ..In this analysis, we aimed to assess which anthropometric cutoff values are best at predicting the likelihood of diabetes, hypertension, dyslipidaemia and albuminuria in Hong Kong Chinese...
  44. ncbi request reprint Lower BMI cut-off value to define obesity in Hong Kong Chinese: an analysis based on body fat assessment by bioelectrical impedance
    G T Ko
    Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, 11, Chuen On Road, Tai Po, Hong Kong
    Br J Nutr 85:239-42. 2001
    ..We suggest a BMI of 23 kg/m(2) and 26 kg/m(2) as the cut-off values to define overweight and obesity respectively in Hong Kong Chinese...
  45. ncbi request reprint Gastrointestinal symptoms in Chinese patients with Type 2 diabetes mellitus
    G T Ko
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Diabet Med 16:670-4. 1999
    ..To examine and compare gastrointestinal (GI) symptoms in Hong Kong Chinese Type 2 diabetic outpatients and non-diabetic control subjects...
  46. ncbi request reprint Obesity, insulin resistance and isolated low high-density-lipoprotein cholesterol in Chinese subjects
    G T Ko
    Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Tai Po, NT, Hong Kong
    Diabet Med 18:663-6. 2001
    ..2 mmol/l) was similar to those with hypercholesterolaemia. We examined the prevalence of isolated low HDL-C in Hong Kong Chinese and its relationship with insulin resistance and triglyceride (TG) level...
  47. ncbi request reprint Factor analysis of the metabolic syndrome: obesity vs insulin resistance as the central abnormality
    P J Anderson
    Division of Clinical Pharmacology, The Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, New Territories, Hong Kong SAR
    Int J Obes Relat Metab Disord 25:1782-8. 2001
    ..To evaluate whether there is one central abnormality contributing to the conditions associated with the metabolic syndrome (MES), or whether one abnormality is contributing on multiple levels...
  48. ncbi request reprint Combined use of fasting plasma glucose and HbA1c predicts the progression to diabetes in Chinese subjects
    G T Ko
    Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong, China
    Diabetes Care 23:1770-3. 2000
    ..In this article, we followed up on 208 nondiabetic subjects and examined their rates of progression to diabetes. We analyzed their likelihood of becoming diabetic according to their baseline FPG and HbA1c concentrations...
  49. ncbi request reprint Hypoadiponectinaemia enhances waist circumference as a predictor of glucose intolerance and clustering of risk factors in Chinese men
    G T C Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Flat D, 4th Floor, Block B, Staff Quarter, The Prince of Wales Hospital, Shatin, Hong Kong, China
    Diabetes Metab 36:192-7. 2010
    ..This study aimed to confirm the hypothesis that adiponectin levels can enhance the discriminative value of waist circumference (WC) in predicting impaired glycaemic status and clustering of risk factors...
  50. ncbi request reprint Risk factors for cataract in Chinese patients with type 2 diabetes: evidence for the influence of the aldose reductase gene
    S C Lee
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Clin Genet 59:356-9. 2001
    ..In conclusion, our data indicate that the occurrence of cataract is common in the Chinese type 2 diabetes population, with age and the aldose reductase gene as important determinants...
  51. ncbi request reprint Relationships between the taqI polymorphism of the dopamine D2 receptor and blood pressure in hyperglycaemic and normoglycaemic Chinese subjects
    G N Thomas
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, SAR
    Clin Endocrinol (Oxf) 55:605-11. 2001
    ..Hypertension is also a common feature of patients with type 2 diabetes, with up to 50% being hypertensive...
  52. ncbi request reprint Dexfenfluramine in obese Chinese NIDDM patients. A placebo-controlled investigation of the effects on body weight, glycemic control, and cardiovascular risk factors
    C C Chow
    Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T
    Diabetes Care 20:1122-7. 1997
    ..To investigate the safety, efficacy, and metabolic effects of dexfenfluramine in obese Chinese NIDDM patients...
  53. ncbi request reprint How to minimize missing those subjects with high 2HR plasma glucose but 'normal' fasting plasma glucose levels?
    G T Ko
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Med 32:53-65. 2001
    ..This clinical approach may improve the detection of those subjects with glucose intolerance, who will be otherwise missed by using fasting plasma glucose alone...
  54. ncbi request reprint Familial early-onset type 2 diabetes in Chinese patients: obesity and genetics have more significant roles than autoimmunity
    M C Ng
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, SAR
    Diabetes Care 24:663-71. 2001
    ..We examined the prevalence of different forms of diabetes in Hong Kong Chinese patients with familial early-onset type 2 diabetes and compared their clinical features with patients with familial late-onset type 2 diabetes...
  55. ncbi request reprint Renin-angiotensin system gene polymorphisms, blood pressure, dyslipidemia, and diabetes in Hong Kong Chinese: a significant association of tne ACE insertion/deletion polymorphism with type 2 diabetes
    G N Thomas
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin
    Diabetes Care 24:356-61. 2001
    ....
  56. ncbi request reprint Albuminuria and the renin-angiotensin system gene polymorphisms in type-2-diabetic and in normoglycemic hypertensive Chinese
    G N Thomas
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, SAR
    Clin Nephrol 55:7-15. 2001
    ..We have previously suggested that the angiotensinogen 235T variant may be associated with nephropathy in diabetic Chinese...
  57. ncbi request reprint Obesity, independent of insulin resistance, is a major determinant of blood pressure in normoglycemic Hong Kong Chinese
    G N Thomas
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People s Republic of China
    Metabolism 49:1523-8. 2000
    ..13). These relationships persisted after adjustment for age, gender, and FIGP. Obesity, therefore, appears to have a predominant role compared with insulin resistance in determining blood pressure in these normoglycemic Chinese...
  58. ncbi request reprint Hyperfibrinogenaemia did not improve after treating hyperglycaemia in Chinese type 2 diabetic patients
    G T Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT
    Ann Clin Biochem 37:655-61. 2000
    ..282, P = 0.011) was identified as the only independent variable that predicted the changes in the fibrinogen concentrations. Improved glycaemic control was not accompanied by a reduction in plasma fibrinogen concentration...
  59. ncbi request reprint Mitochondrial DNA A3243G mutation in patients with early- or late-onset type 2 diabetes mellitus in Hong Kong Chinese
    M C Ng
    Department of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Endocrinol (Oxf) 52:557-64. 2000
    ..7% prevalence of this mutation in a cohort of young patients with either type 1 or type 2 diabetes. In this study, we aimed to confirm this finding by examining for the prevalence of this mutation in a large-scale study...
  60. ncbi request reprint Use of indapamide in hospital and community clinics and its effect on plasma potassium in Chinese patients
    S Chang
    Department of Pharmacy, The Chinese University of Hong Kong, Shatin, New Territories
    J Clin Pharm Ther 23:295-302. 1998
    ..The plasma potassium concentrations of patients receiving indapamide and other diuretics were also examined...
  61. ncbi request reprint Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY
    M C Ng
    Department of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Diabet Med 16:956-63. 1999
    ....
  62. ncbi request reprint An insulin receptor gene polymorphism is associated with diastolic blood pressure in Chinese subjects with components of the metabolic syndrome
    G N Thomas
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, People s Republic of China
    Am J Hypertens 13:745-52. 2000
    ..018. Age, gender, and body mass index (BMI) were also included in the analysis and were all significantly associated with diastolic DBP. To conclude, the insulin receptor gene NsiI RFLP is associated with DBP in these Chinese subjects...
  63. ncbi request reprint The Trp64Arg polymorphism of the beta3-adrenergic receptor gene and obesity in Chinese subjects with components of the metabolic syndrome
    G N Thomas
    Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Prince of Wales Hospital, Shatin, Hong Kong SAR, People s Republic of China
    Int J Obes Relat Metab Disord 24:545-51. 2000
    ..These changes have been associated with a dramatic increase in the prevalence of diabetes and related diseases of the metabolic syndrome...
  64. pmc Validation of methods to control for immortal time bias in a pharmacoepidemiologic analysis of Renin-Angiotensin system inhibitors in type 2 diabetes
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital
    J Epidemiol 24:267-73. 2014
    ....
  65. pmc Glucose lowering effect of transgenic human insulin-like growth factor-I from rice: in vitro and in vivo studies
    Stanley Ck Cheung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    BMC Biotechnol 11:37. 2011
    ..In the present study, an efficient plant expression system was developed to produce biologically active recombinant hIGF-I (rhIGF-I) in transgenic rice grains...
  66. pmc Renal carcinogenesis after uninephrectomy
    Yi Sui
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
    Transl Oncol 2:258-63. 2009
    ..These findings indicate a unique rat model of UNX-induced renal cancer associated with enhanced IGF-1 signaling pathway...
  67. pmc Smoking and diabetes in Chinese men
    G T Ko
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Postgrad Med J 77:240-3. 2001
    ..7. The prevalence of smoking in Hong Kong Chinese women is low and its association with diabetes is inconclusive...
  68. ncbi request reprint A low socio-economic status is an additional risk factor for glucose intolerance in high risk Hong Kong Chinese
    G T Ko
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, NT, PR China
    Eur J Epidemiol 17:289-95. 2001
    ..These subjects should have increased priority for health education and regular diabetes screening. Our findings further emphasise the complex relationships between societal affluence, personal income and educational level...
  69. ncbi request reprint Treatment of Chinese acromegaly with a combination of bromocriptine and octreotide
    J K Li
    Department of Medicine, Yan Chai Hospital, New Territories, Hong Kong
    Aust N Z J Med 30:457-61. 2000
    ..Good results have been reported with combined use of octreotide and bromocriptine in acromegalic Caucasians. Data concerning the efficacy and tolerability of this combination treatment in Chinese acromegalic patients are scanty...
  70. ncbi request reprint Hairy cell leukemia in Hong Kong Chinese: a 12-year retrospective survey
    W Y Au
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Hematol Oncol 18:155-159. 2000
    ..There have been few reports of HCL from oriental countries...
  71. doi request reprint Development and validation of a total coronary heart disease risk score in type 2 diabetes mellitus
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Am J Cardiol 101:596-601. 2008
    ..External validations are required in other Chinese populations...
  72. ncbi request reprint The lipoprotein lipase gene HindIII polymorphism is associated with lipid levels in early-onset type 2 diabetic patients
    Yan Qin Ma
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
    Metabolism 52:338-43. 2003
    ..We conclude that the H+ allele of the LPL gene HindIII polymorphism is associated with higher plasma triglyceride and lower HDL-cholesterol levels in Chinese patients with early-onset diabetes...
  73. ncbi request reprint Weight management and current options in pharmacotherapy: orlistat and sibutramine
    Wilson Y S Leung
    Department of Medicine and Therapeutics, Division of Clinical Pharmacology, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong
    Clin Ther 25:58-80. 2003
    ..Pharmacotherapy with antiobesity agents is an important management strategy in conjunction with lifestyle interventions...
  74. ncbi request reprint Acarbose improves glycemic control in insulin-treated Asian type 2 diabetic patients: results from a multinational, placebo-controlled study
    Chii Min Hwu
    Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taiwan
    Diabetes Res Clin Pract 60:111-8. 2003
    ..6% vs. 16.4% for placebo). Adjunctive acarbose therapy offers an efficacious and safe means for improvement of glycemic control in Asian type 2 diabetic patients insufficiently controlled by insulin...
  75. ncbi request reprint Associations between dietary habits and risk factors for cardiovascular diseases in a Hong Kong Chinese working population--the "Better Health for Better Hong Kong" (BHBHK) health promotion campaign
    Gary T C Ko
    Department of Medicine, Alice HML Nethersole Hospital, 11 Chuen On Road, Tai Po, NT, Hong Kong
    Asia Pac J Clin Nutr 16:757-65. 2007
    ..In conclusion, there were close associations between dietary habits and risk factors for cardiovascular diseases in Hong Kong. More effective community education about healthy lifestyle is required in Hong Kong...
  76. ncbi request reprint Risk factors in V-shaped risk associations with all-cause mortality in type 2 diabetes-The Hong Kong Diabetes Registry
    Wing Yee So
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, China
    Diabetes Metab Res Rev 24:238-46. 2008
    ..Body mass index (BMI) is associated with death in a V-shaped manner in general populations but it is unknown whether BMI or other risk factors also exhibit V-shaped relationships with death in type 2 diabetic patients...
  77. ncbi request reprint Low levels of awareness of suboptimal health conditions in a high-risk working population: the "better health for better Hong Kong" health promotion campaign
    Gary T C Ko
    Department of Medicine, Alice HML Nethersole Hospital, 11 Chuen On Road, Tai Po, NT, Hong Kong
    Int J Behav Med 14:63-9. 2007
    ..Massive public education is an important and essential, although it may not be self-sufficient, factor to reduce the socioeconomic impacts of this epidemic...
  78. ncbi request reprint High prevalence of insulin resistance and metabolic syndrome in overweight/obese preadolescent Hong Kong Chinese children aged 9-12 years
    Rita Y T Sung
    Diabetes Care 26:250-1. 2003
  79. ncbi request reprint Independent associations of alanine aminotransferase (ALT) levels with cardiovascular risk factor clustering in Chinese adolescents
    Alice P S Kong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR, China
    J Hepatol 49:115-22. 2008
    ..To establish the prevalence of elevated serum alanine aminotransferase (ALT) concentrations in Chinese adolescents, and to explore the nature of associations amongst ALT, obesity and cardiovascular risk factors...
  80. pmc Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
    Maggie C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Diabetes 57:2226-33. 2008
    ..However, the implications of these genes in Asians are unclear...
  81. pmc EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes
    Haitao Li
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong, China
    Mol Vis 14:1698-704. 2008
    ..We tested the hypothesis that genetic variants in vasoactive and angiogenic factors regulating the retina vasculature contribute to the development of diabetic retinopathy (DR)...
  82. ncbi request reprint The effect of orlistat-induced weight loss, without concomitant hypocaloric diet, on cardiovascular risk factors and insulin sensitivity in young obese Chinese subjects with or without type 2 diabetes
    Peter C Y Tong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Arch Intern Med 162:2428-35. 2002
    ..We examined the weight-losing effect of orlistat treatment on insulin sensitivity and cardiovascular risk factors in a group of severely obese young Chinese patients with or without type 2 diabetes mellitus...
  83. ncbi request reprint Association of the D8S282 marker near the lipoprotein lipase gene locus with systolic blood pressure in healthy Chinese subjects
    Yan Qing Ma
    Department of Medicine and Theraputics The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
    J Hypertens 20:2199-204. 2002
    ..Eight different alleles were identified (272-286 bp) resulting in 15 genotypes in our population. We investigated the association between the common (28.8%) 278 bp allele and the anthropometric and biochemical parameters...
  84. ncbi request reprint Management of nephropathy in patients with type 2 diabetes
    Julian A J H Critchley
    Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Chin Med J (Engl) 115:129-35. 2002
    ..To review evidence-based management of nephropathy in patients with type 2 diabetes...
  85. doi request reprint Middle cerebral artery stenosis increased the risk of vascular disease mortality among type 2 diabetic patients
    G Neil Thomas
    Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong, SAR, PR China
    Cerebrovasc Dis 25:261-7. 2008
    ..We assess whether asymptomatic MCA stenosis is associated with mortality in Chinese type 2 diabetic patients...
  86. pmc Carbamazepine and false positive dexamethasone suppression tests for Cushing's syndrome
    Ronald C W Ma
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    BMJ 330:299-300. 2005
  87. ncbi request reprint The renoprotective effects of structured care in a clinical trial setting in type 2 diabetic patients with nephropathy
    Wilson Y S Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, N T, Hong Kong, SAR
    Nephrol Dial Transplant 19:2519-25. 2004
    ..In this subgroup analysis from the RENAAL Study, we hypothesized that the intensive care received by patients in a clinical trial setting also reduced the rate of decline in renal function through optimization of all risk factors...
  88. ncbi request reprint Abnormal liver function test predicts type 2 diabetes: a community-based prospective study
    Nam H Cho
    Preventive Medicine, Ajou University, Suwon, Korea
    Diabetes Care 30:2566-8. 2007
  89. ncbi request reprint Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:977-83. 2007
    ..Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes...
  90. ncbi request reprint Variants conferring risk of atrial fibrillation on chromosome 4q25
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 448:353-7. 2007
    ..42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart...
  91. ncbi request reprint Association of erectile dysfunction with cardiovascular risk factors and increasing existing vascular disease in male chinese type 2 diabetic patients
    G Neil Thomas
    Department of Community Medicine, University of Hong Kong, 21 Sassoon Rd, Pokfulam, Hong Kong
    Diabetes Care 28:2051-3. 2005
  92. ncbi request reprint Effect of hepatic lipase -514C->T polymorphism and its interactions with apolipoprotein C3 -482C->T and apolipoprotein E exon 4 polymorphisms on the risk of nephropathy in chinese type 2 diabetic patients
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    Diabetes Care 28:1704-9. 2005
    ..We hypothesized that the HL -514C-->T polymorphism, which reduces HL expression, and its interactions with polymorphisms in apolipoprotein (apo) E and apoC3 increase the risk of diabetic nephropathy...
  93. ncbi request reprint Effects of body mass index, plasma glucose and cholesterol levels on isolated systolic hypertension
    Gary T C Ko
    Department of Medicine, Alice Ho Nethersole Hospital, Tai Po, Hong Kong
    Int J Cardiol 101:429-33. 2005
    ..Age, obesity, lipid and duration of diabetes were independent associated with ISH. These findings suggest that control of body weight and metabolic profile might have beneficial effects on ISH...
  94. ncbi request reprint Antihypertensive therapy and incidence of type 2 diabetes in an elderly cohort: response to Padwal et al
    Norman N Chan
    Diabetes Care 28:762; author reply 762-3. 2005
  95. ncbi request reprint Middle cerebral artery stenosis in type II diabetic Chinese patients is associated with conventional risk factors but not with polymorphisms of the renin-angiotensin system genes
    G Neil Thomas
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR
    Cerebrovasc Dis 16:217-23. 2003
    ..In Chinese, middle cerebral artery (MCA) stenosis is the most commonly identified intracranial vascular lesion. The involvement of renin-angiotensin system (RAS) gene polymorphisms in this condition has not been determined...
  96. ncbi request reprint Prognostic effect of insertion/deletion polymorphism of the ace gene on renal and cardiovascular clinical outcomes in Chinese patients with type 2 diabetes
    Ying Wang
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Diabetes Care 28:348-54. 2005
    ..The aim of the present study was to investigate the prognostic effect of I/D polymorphism on renal and cardiovascular clinical outcomes in Chinese patients with type 2 diabetes...
  97. ncbi request reprint Clinicopathologic characteristics of nodular glomerulosclerosis in Chinese patients with type 2 diabetes
    Hai Lu Zhao
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, SAR, China
    Am J Kidney Dis 44:1039-49. 2004
    ..Nodular glomerulosclerosis is a distinct entity that is highly specific for diabetic glomerulopathy. However, clinicopathologic characteristics of this nodular lesion are largely undefined in patients with type 2 diabetes...
  98. pmc Association between adherence to statin therapy and lipid control in Hong Kong Chinese patients at high risk of coronary heart disease
    Caroline W R Cheng
    School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Br J Clin Pharmacol 58:528-35. 2004
    ....
  99. ncbi request reprint Association of glomerulopathy with the 5'-end polymorphism of the aldose reductase gene and renal insufficiency in type 2 diabetic patients
    Hai Lu Zhao
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Diabetes 53:2984-91. 2004
    ..Gene mutation, cellular transdifferentiation, growth factor upregulation, extracellular matrix expansion, and glomerular filtration impairment are the primary abnormalities in type 2 diabetic patients with nephropathy...
  100. ncbi request reprint Effect of angiotensin-converting enzyme inhibition on survival in 3773 Chinese type 2 diabetic patients
    Wing Yee So
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Hypertension 44:294-9. 2004
    ..The effects of ACE inhibitors in type 2 diabetic patients with normoalbuminuria require further evaluation...