Henry Lik Yuen Chan

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Virological response to different combination regimes of peginterferon alpha-2b and lamivudine in hepatitis B e antigen positive chronic hepatitis B
    Henry Lik Yuen Chan
    Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Antivir Ther 12:815-23. 2007
  2. ncbi request reprint Long-term follow-up of lamivudine treatment in patients with severe acute exacerbation of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B
    Vincent Wai Sun Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR
    Antivir Ther 13:571-9. 2008
  3. ncbi request reprint Genetic polymorphisms of interleukin-1-beta in association with sustained response to anti-viral treatment in chronic hepatitis B in Chinese
    H L Y Chan
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 23:1703-11. 2006
  4. ncbi request reprint Randomized trial of interferon beta-1a with or without ribavirin in Asian patients with chronic hepatitis C
    Henry L Y Chan
    The Chinese University of Hong Kong, Shatin, Hong Kong
    Hepatology 46:315-23. 2007
  5. doi request reprint Entecavir treatment in patients with severe acute exacerbation of chronic hepatitis B
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    J Hepatol 54:236-42. 2011
  6. ncbi request reprint Effects of tenofovir disoproxil fumarate in hepatitis B e antigen-positive patients with normal levels of alanine aminotransferase and high levels of hepatitis B virus DNA
    Henry L Y Chan
    Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Electronic address
    Gastroenterology 146:1240-8. 2014
  7. doi request reprint Randomized clinical trial: efficacy and safety of telbivudine and lamivudine in treatment-naïve patients with HBV-related decompensated cirrhosis
    H L Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    J Viral Hepat 19:732-43. 2012
  8. doi request reprint Use of antiviral therapy in surveillance: impact on outcome of hepatitis B-related hepatocellular carcinoma
    Stephen L Chan
    State Key Laboratory in Oncology in South China, Sir YK Pao Center for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Liver Int 32:271-8. 2012
  9. ncbi request reprint Early virological suppression is associated with good maintained response to adefovir dipivoxil in lamivudine resistant chronic hepatitis B
    H L Y Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Aliment Pharmacol Ther 25:891-8. 2007
  10. pmc Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus
    Joseph J Y Sung
    Department of Medicine and Therapeutics, 9 F Prince of Wales Hospital, The Chinese University of Hong Kong, NT, Shatin, Hong Kong
    J Virol 82:3604-11. 2008

Detail Information

Publications136 found, 100 shown here

  1. ncbi request reprint Virological response to different combination regimes of peginterferon alpha-2b and lamivudine in hepatitis B e antigen positive chronic hepatitis B
    Henry Lik Yuen Chan
    Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Antivir Ther 12:815-23. 2007
    ..To investigate whether simultaneous commencement of peginterferon alpha-2b and lamivudine treatment has more potent hepatitis B virus (HBV) DNA suppression than staggered regimes...
  2. ncbi request reprint Long-term follow-up of lamivudine treatment in patients with severe acute exacerbation of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B
    Vincent Wai Sun Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR
    Antivir Ther 13:571-9. 2008
    ..The long-term efficacy of lamivudine treatment for patients suffering from severe acute exacerbation of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B is unknown...
  3. ncbi request reprint Genetic polymorphisms of interleukin-1-beta in association with sustained response to anti-viral treatment in chronic hepatitis B in Chinese
    H L Y Chan
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 23:1703-11. 2006
    ..Interleukin-1beta is a pro-inflammatory cytokine that may influence host defence against viral infection...
  4. ncbi request reprint Randomized trial of interferon beta-1a with or without ribavirin in Asian patients with chronic hepatitis C
    Henry L Y Chan
    The Chinese University of Hong Kong, Shatin, Hong Kong
    Hepatology 46:315-23. 2007
    ..54 (95% confidence interval: 2.53, 8.13)]. In HCV genotype 1 patients, 37 of 80 patients (46.3%) treated with IFN beta-1a/ribavirin achieved an SVR versus 19 of 85 patients (22.4%) treated with IFN beta-1a (P = 0.001)...
  5. doi request reprint Entecavir treatment in patients with severe acute exacerbation of chronic hepatitis B
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    J Hepatol 54:236-42. 2011
    ..Lamivudine was used in most previous studies, but the drug was limited by the development of resistance. Our objective is to study the safety and efficacy of entecavir in patients with severe acute exacerbation...
  6. ncbi request reprint Effects of tenofovir disoproxil fumarate in hepatitis B e antigen-positive patients with normal levels of alanine aminotransferase and high levels of hepatitis B virus DNA
    Henry L Y Chan
    Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Electronic address
    Gastroenterology 146:1240-8. 2014
    ..We evaluated the effects of single and combination therapies in immune-tolerant patients with chronic hepatitis B...
  7. doi request reprint Randomized clinical trial: efficacy and safety of telbivudine and lamivudine in treatment-naïve patients with HBV-related decompensated cirrhosis
    H L Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    J Viral Hepat 19:732-43. 2012
    ..Telbivudine compared to lamivudine was associated with a higher rate of patients with both viral suppression and ALT normalization, a trend towards a higher rate of survival and significant improvement in glomerular filtration...
  8. doi request reprint Use of antiviral therapy in surveillance: impact on outcome of hepatitis B-related hepatocellular carcinoma
    Stephen L Chan
    State Key Laboratory in Oncology in South China, Sir YK Pao Center for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Liver Int 32:271-8. 2012
    ..In patients who subsequently develop HCC, the impact of antiviral therapy on the outcome of HCC remains unclear...
  9. ncbi request reprint Early virological suppression is associated with good maintained response to adefovir dipivoxil in lamivudine resistant chronic hepatitis B
    H L Y Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Aliment Pharmacol Ther 25:891-8. 2007
    ..To determine the factors affecting the virological response to adefovir dipivoxil (ADV) among patients with lamivudine resistant chronic hepatitis B...
  10. pmc Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus
    Joseph J Y Sung
    Department of Medicine and Therapeutics, 9 F Prince of Wales Hospital, The Chinese University of Hong Kong, NT, Shatin, Hong Kong
    J Virol 82:3604-11. 2008
    ..Different HBV genotypes may have different virologic mechanisms of hepatocarcinogenesis...
  11. ncbi request reprint Treatment of patients with chronic hepatitis B who have failed previous antiviral treatment with pegylated interferon alpha2a (40 kda; PEGASYS)
    Henry L Y Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Antivir Ther 13:555-62. 2008
    ..We aimed to investigate the efficacy of pegylated interferon alpha2a (PEG-IFN-alpha2a) in these difficult-to-treat patients...
  12. ncbi request reprint Epidemiological and virological characteristics of 2 subgroups of hepatitis B virus genotype C
    Henry L Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    J Infect Dis 191:2022-32. 2005
    ..We aimed to investigate the characteristics of hepatitis B virus (HBV) genotype C subgroups in Hong Kong and their relationship with HBV genotype C in other parts of Asia...
  13. ncbi request reprint Long-term follow-up of peginterferon and lamivudine combination treatment in HBeAg-positive chronic hepatitis B
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Hepatology 41:1357-64. 2005
    ..In conclusion, combination treatment of peginterferon and lamivudine has a higher sustained virological response than lamivudine monotherapy up to 3 years after treatment...
  14. ncbi request reprint Long-term lamivudine treatment is associated with a good maintained response in severe acute exacerbation of chronic HBeAg-negative hepatitis B
    Henry Lik Yuen Chan
    Department of Medicine and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Antivir Ther 11:465-71. 2006
    ..In conclusion, extended lamivudine treatment is associated with a high maintained virological response and a low rate of drug resistance in severe acute exacerbation of HBeAg-negative chronic hepatitis B...
  15. ncbi request reprint A review of the natural history of chronic hepatitis B in the era of transient elastography
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, Chinese University of Hong Kong, New Territories, Hong Kong SAR, China
    Antivir Ther 14:489-99. 2009
    ..In this review, new insights from studies using transient elastography on the natural history of chronic hepatitis B with special focus on liver fibrosis will be summarized and discussed...
  16. ncbi request reprint Serum hepatitis B surface antigen quantitation can reflect hepatitis B virus in the liver and predict treatment response
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics, and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Gastroenterol Hepatol 5:1462-8. 2007
    ....
  17. pmc Phylogenetic, virological, and clinical characteristics of genotype C hepatitis B virus with TCC at codon 15 of the precore region
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics and Institute of Digestive Diseases, 9 F Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, Hong Kong, Hong Kong
    J Clin Microbiol 44:681-7. 2006
    ..43). In summary, we report that HBV with TCC at nucleotides 1856 to 1858 of the precore region might represent a specific HBV strain associated with more aggressive liver disease than other genotype C HBV strains...
  18. ncbi request reprint Treatment of hepatitis B e antigen positive chronic hepatitis with telbivudine or adefovir: a randomized trial
    Henry L Y Chan
    The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Ann Intern Med 147:745-54. 2007
    ..The efficacy of nucleoside and nucleotide analogues for hepatitis B has been linked to the magnitude and durability of hepatitis B virus (HBV) suppression...
  19. ncbi request reprint Association of cytokine gene polymorphisms and liver fibrosis in chronic hepatitis B
    Henry L Y Chan
    Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 23:783-9. 2008
    ..We aimed to investigate the association of cytokine gene polymorphism and liver fibrosis among Chinese patients with chronic hepatitis B...
  20. ncbi request reprint Two-year lamivudine treatment for hepatitis B e antigen-negative chronic hepatitis B: a double-blind, placebo-controlled trial
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Antivir Ther 12:345-53. 2007
    ..We conducted a multicentre, double-blind, placebo-controlled, randomized study to investigate the efficacy of 2-year lamivudine treatment in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B...
  21. ncbi request reprint How should we manage patients with non-alcoholic fatty liver disease in 2007?
    Henry L Y Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Gastroenterol Hepatol 22:801-8. 2007
    ..Lifestyle changes are the first line and mainstay of management...
  22. ncbi request reprint Hepatitis B virus genotype C is associated with more severe liver fibrosis than genotype B
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Gastroenterol Hepatol 7:1361-6. 2009
    ..Histologic analyses of liver fibrosis have been limited by small sample sizes and the predominance of samples from patients with active hepatitis...
  23. pmc Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma
    H L Y Chan
    Department of Medicine and Therapeutics, 9 F Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, Hong Kong, China
    Gut 53:1494-8. 2004
    ..Our aim was to study the independent risk factors and effect of HBV genotypes on HCC development in a prospective longitudinal cohort of chronic hepatitis B patients...
  24. doi request reprint JGH Foundation emerging leadership lecture. Significance of hepatitis B virus genotypes and mutations in the development of hepatocellular carcinoma in Asia
    Henry Lik Yuen Chan
    Institute of Digestive Diseases and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Gastroenterol Hepatol 26:8-12. 2011
    ..The understanding of the carcinogenic mechanisms of these HBV strains may shed light into future therapeutics in the prevention and treatment of HBV-related HCC...
  25. pmc Use of hepatitis B virus DNA quantitation to predict hepatitis B e antigen reversion in cases of chronic hepatitis B
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China
    J Clin Microbiol 41:4793-5. 2003
    ..HBV DNA levels at HBeAg seroconversion (group I) and at initial visits (group II) were significantly lower among patients who were persistently negative for HBeAg than among those who underwent HBeAg reversion...
  26. ncbi request reprint Hepatitis B virus genotype has no impact on hepatitis B e antigen seroconversion after lamivudine treatment
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong
    World J Gastroenterol 9:2695-7. 2003
    ..To investigate the association of hepatitis B virus (HBV) genotype and HBeAg seroconversion after nucleotide analogue treatment...
  27. doi request reprint Hepatitis B surface antigen quantification: why and how to use it in 2011 - a core group report
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    J Hepatol 55:1121-31. 2011
    ..In clinical practice, serum HBsAg level should be used together with, but not as a substitute for, HBV DNA...
  28. doi request reprint Serum HBsAg quantification to predict response to peginterferon therapy of e antigen positive chronic hepatitis B
    H L Y Chan
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Aliment Pharmacol Ther 32:1323-31. 2010
    ..On-treatment predictors of response to peginterferon can guide individualization of therapy in chronic hepatitis B virus infection...
  29. doi request reprint Viral determinants of hepatitis B surface antigen seroclearance in hepatitis B e antigen-negative chronic hepatitis B patients
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong
    J Infect Dis 204:408-14. 2011
    ..We studied whether quantification of serum HBsAg and HBV DNA levels could predict spontaneous HBsAg clearance in patients with negative hepatitis B e antigen (HBeAg)...
  30. doi request reprint A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Hepatology 52:1232-41. 2010
    ..041 log IU/mL/year and 0.043 log IU/mL/year, respectively. Twenty-two (17%) patients had HBsAg reduction >1 log IU/mL at the last visit; most of them showed reduced hepatitis B virus DNA, and eight had HBsAg loss...
  31. doi request reprint Chronic hepatitis B in Asia-new insights from the past decade
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, China
    J Gastroenterol Hepatol 26:131-7. 2011
    ..Properly performed cost-effective analysis and understanding on the best timing of stopping antiviral drugs will be important to facilitate the most appropriate allocation of resources...
  32. doi request reprint Prediction of off-treatment response to lamivudine by serum hepatitis B surface antigen quantification in hepatitis B e antigen-negative patients
    Henry L Y Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Antivir Ther 16:1249-57. 2011
    ..Here, we aimed to investigate the role of HBV DNA and hepatitis B surface antigen (HBsAg) monitoring to predict off-treatment sustained response...
  33. ncbi request reprint Absence of impact of donor hepatic steatosis and posttransplantation lamivudine resistance in a patient with chronic hepatitis B
    H L Y Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China
    Transplant Proc 36:2309-10. 2004
    ..Lamivudine monoprophylaxis for hepatitis B virus-related liver diseases post liver transplantation can be used in areas where hepatitis B immunoglobulin is not affordable...
  34. doi request reprint Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B
    H L Y Chan
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
    J Viral Hepat 16:36-44. 2009
    ..In conclusion, transient elastography is a reasonable noninvasive tool to substitute liver biopsy among the lowest and highest risk patients for the assessment of liver fibrosis...
  35. pmc Evaluation of impact of serial hepatitis B virus DNA levels on development of hepatocellular carcinoma
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Clin Microbiol 47:1830-6. 2009
    ..0 +/- 1.4 log copies/ml in HCC patients versus 2.5 +/- 0.9 log copies/ml in control patients; P = 0.38). A high trough HBV DNA level was associated with a higher risk of HCC. Whether antiviral treatment could prevent HCC was uncertain...
  36. ncbi request reprint A randomized, controlled trial of combination therapy for chronic hepatitis B: comparing pegylated interferon-alpha2b and lamivudine with lamivudine alone
    Henry Lik Yuen Chan
    Chinese University of Hong Kong and Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
    Ann Intern Med 142:240-50. 2005
    ..Conventional interferon and lamivudine monotherapy are unsatisfactory in treating hepatitis B virus (HBV) infection...
  37. ncbi request reprint Factors associated with viral breakthrough in lamivudine monoprophylaxis of hepatitis B virus recurrence after liver transplantation
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    J Med Virol 68:182-7. 2002
    ..In conclusion, patients transplanted for fulminant hepatitis B and cirrhotic patients in whom HBV DNA could be rendered PCR negative before liver transplantation are unlikely to develop YMDD mutation on lamivudine monoprophylaxis...
  38. ncbi request reprint Durability of peginterferon alfa-2b treatment at 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Hepatology 51:1945-53. 2010
    ..The duration of concomitant lamivudine treatment had no impact on any long-term response...
  39. ncbi request reprint Early hepatitis B virus DNA suppression can predict virologic response to peginterferon and lamivudine treatment
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics and Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Gastroenterol Hepatol 6:1022-6. 2008
    ..We aimed to investigate the early on-treatment HBV DNA response to predict sustained virologic response for peginterferon and lamivudine combination therapy...
  40. doi request reprint Surrogate end points and long-term outcome in patients with chronic hepatitis B
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Clin Gastroenterol Hepatol 7:1113-20. 2009
    ..It is unclear whether surrogate end points reported in clinical trials correlate with long-term outcome of patients with chronic hepatitis B...
  41. ncbi request reprint Interaction of adipokines and hepatitis B virus on histological liver injury in the Chinese
    Vincent Wai Sun Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, China
    Am J Gastroenterol 105:132-8. 2010
    ..Our objective was to test whether dysregulation of adipokines contributes to liver injury. We also studied whether viral factors affected adipokines, insulin resistance, and hepatic steatosis...
  42. doi request reprint On-treatment monitoring of liver fibrosis with transient elastography in chronic hepatitis B patients
    Grace Lai Hung Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Antivir Ther 16:165-72. 2011
    ..The performance of liver stiffness measurement (LSM) to monitor the changes in the severity of liver fibrosis in chronic hepatitis B (CHB) patients on antiviral treatment is uncertain...
  43. ncbi request reprint Evaluation of alanine transaminase and hepatitis B virus DNA to predict liver cirrhosis in hepatitis B e antigen-negative chronic hepatitis B using transient elastography
    Grace Lai Hung Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Am J Gastroenterol 103:3071-81. 2008
    ....
  44. ncbi request reprint Genetic polymorphisms of adiponectin and tumor necrosis factor-alpha and nonalcoholic fatty liver disease in Chinese people
    Vincent Wai Sun Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Tseung Kwan O Hospital, Hong Kong
    J Gastroenterol Hepatol 23:914-21. 2008
    ..This study aimed to investigate the genetic polymorphisms of adiponectin and TNF-alpha in Chinese NAFLD patients and their association with disease severity...
  45. doi request reprint Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography
    Vincent Wai Sun Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
    Gut 61:409-15. 2012
    ..New non-invasive tests allow accurate and safe assessment in healthy individuals. The aim of this study was to examine the prevalence of NAFLD and advanced fibrosis in the general Hong Kong Chinese population...
  46. ncbi request reprint Fatty pancreas, insulin resistance, and β-cell function: a population study using fat-water magnetic resonance imaging
    Vincent Wai Sun Wong
    1 Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China 2 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Am J Gastroenterol 109:589-97. 2014
    ..We aimed to define the normal range of pancreatic fat and identify factors associated with fatty pancreas. In addition, the effect of fatty liver and fatty pancreas on insulin resistance (IR) and pancreatic β-cell function was studied...
  47. doi request reprint Cost-effectiveness analysis of roadmap models in chronic hepatitis B using tenofovir as the rescue therapy
    Yanni Yan Ni Lui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, New Terrritories, Hong Kong
    Antivir Ther 15:145-55. 2010
    ..The roadmap approach is recommended to guide chronic hepatitis B treatment. We evaluated the cost-effectiveness of various treatment strategies in the global market...
  48. doi request reprint High viral load and hepatitis B virus subgenotype ce are associated with increased risk of hepatocellular carcinoma
    Henry Lik Yuen Chan
    Department of Clinical Oncology, Sir YK Pao Center for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Oncol 26:177-82. 2008
    ..We aimed to investigate the impact of hepatitis B virus (HBV) DNA and HBV genotypes/subgenotypes on the risk of hepatocellular carcinoma (HCC)...
  49. doi request reprint Clinical factors associated with liver stiffness in hepatitis B e antigen-positive chronic hepatitis B patients
    Grace Lai Hung Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Gastroenterol Hepatol 7:227-33. 2009
    ..We analyzed the clinical factors associated with advanced liver fibrosis in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients...
  50. ncbi request reprint Occult HBV infection in cryptogenic liver cirrhosis in an area with high prevalence of HBV infection
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics and Microbiology, The Chinese University of Hong Kong, Shatin
    Am J Gastroenterol 97:1211-5. 2002
    ..We aimed to investigate 1) the prevalence of occult HBV infection in cryptogenic liver cirrhosis in Hong Kong and 2) the role of HBV "a" determinant mutations among these patients...
  51. pmc Hepatitis B virus genotype C takes a more aggressive disease course than hepatitis B virus genotype B in hepatitis B e antigen-positive patients
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Clin Microbiol 41:1277-9. 2003
    ..Disease activity was greater in patients infected by HBV genotype C than in those infected by HBV genotype B in the HBeAg-positive phase but not after HBeAg seroconversion...
  52. doi request reprint Liver stiffness measurement using XL probe in patients with nonalcoholic fatty liver disease
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Am J Gastroenterol 107:1862-71. 2012
    ..The aim of this study was to evaluate the performance of the new XL probe in patients with nonalcoholic fatty liver disease (NAFLD)...
  53. ncbi request reprint Non-invasive assessment of liver fibrosis with transient elastography (FibroScan®): applying the cut-offs of M probe to XL probe
    Grace Lai Hung Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
    Ann Hepatol 12:570-80. 2013
    ..The diagnostic accuracy of XL cut-offs to diagnose advanced fibrosis was evaluated...
  54. doi request reprint High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B
    Vincent Wai Sun Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Int J Cancer 124:2766-70. 2009
    ..This may assist clinicians in selecting high-risk patients for HCC surveillance program...
  55. ncbi request reprint Performance of the new MELD-Na score in predicting 3-month and 1-year mortality in Chinese patients with chronic hepatitis B
    Vincent Wai Sun Wong
    Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Republic of China
    Liver Transpl 13:1228-35. 2007
    ..72 and 0.75, respectively) (P = 0.004) in predicting mortality. In conclusion, the new MELD-Na score is a valid model to predict mortality in patients with complications of chronic hepatitis B...
  56. doi request reprint Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, 9 F, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong
    Gut 59:969-74. 2010
    ..Patients with non-alcoholic steatohepatitis (NASH) have increased mortality and liver-related complications. In contrast, simple steatosis is considered benign and non-progressive...
  57. ncbi request reprint Liver fibrosis progression is uncommon in patients with inactive chronic hepatitis B: a prospective cohort study with paired transient elastography examination
    Grace Lai Hung Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Gastroenterol Hepatol 28:1842-8. 2013
    ..This study aimed to evaluate the risk of disease progression in such patients...
  58. ncbi request reprint Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients With liver cirrhosis
    Grace Lai Hung Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Hepatology 58:1537-47. 2013
    ..Hepatology 2013;58:1537-1547). ..
  59. ncbi request reprint Treatment of nonalcoholic steatohepatitis with probiotics. A proof-of-concept study
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Ann Hepatol 12:256-62. 2013
    ..Probiotics have profound effect on nonalcoholic steatohepatitis (NASH) in animal models. We aimed to test the hypothesis that probiotics treatment was superior to usual care in reducing liver fat in NASH patients...
  60. ncbi request reprint Metabolic and adipokine profile of Chinese patients with nonalcoholic fatty liver disease
    Vincent Wai Sun Wong
    Institute of Digestive Diseases, Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Gastroenterol Hepatol 4:1154-61. 2006
    ..This cross-sectional study examined the metabolic and adipokine profiles of Chinese patients with biopsy-proven NAFLD and factors associated with severe disease...
  61. ncbi request reprint Quantitative assessment of fibrosis in liver biopsies from patients with chronic hepatitis B
    Alex Yui Hui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Liver Int 24:611-8. 2004
    ..Image analysis or morphometry has the theoretical advantage of providing truly quantitative data...
  62. doi request reprint Liver stiffness measurement by transient elastography as a predictor on posthepatectomy outcomes
    Jeff Siu Wang Wong
    Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China
    Ann Surg 257:922-8. 2013
    ..Liver stiffness measurement (LSM) using transient elastography is a new method for detection of hepatic fibrosis and cirrhosis with high accuracy. Whether LSM can predict posthepatectomy outcomes has not been studied...
  63. doi request reprint Treatment of non-alcoholic steatohepatitis with Phyllanthus urinaria: a randomized trial
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    J Gastroenterol Hepatol 28:57-62. 2013
    ..We aimed to test the hypothesis that Phyllanthus was superior to placebo in improving histological non-alcoholic fatty liver disease (NAFLD) activity score...
  64. doi request reprint Hepatitis B virus infection and fatty liver in the general population
    Vincent Wai Sun Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
    J Hepatol 56:533-40. 2012
    ..In animal studies, expression of hepatitis B virus (HBV) proteins causes hepatic steatosis. We aimed to study the prevalence of fatty liver in people with and without HBV infection in the general population...
  65. ncbi request reprint Validation of the NAFLD fibrosis score in a Chinese population with low prevalence of advanced fibrosis
    Vincent Wai Sun Wong
    Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Am J Gastroenterol 103:1682-8. 2008
    ..Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence worldwide. This study aimed to validate the NAFLD fibrosis score in the Chinese population...
  66. ncbi request reprint Outcome of lamivudine resistant hepatitis B virus mutant post-liver transplantation on lamivudine monoprophylaxis
    Henry Lik Yuen Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Transplant 18:295-300. 2004
    ..We aimed to investigate the clinical outcome of patients who develop lamivudine resistant hepatitis B virus mutants (YMDD mutants) after liver transplantation...
  67. ncbi request reprint Identification of chronic hepatitis B patients without significant liver fibrosis by a simple noninvasive predictive model
    Alex Yui Hui
    Department of Medicine and Therapeutics and Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Am J Gastroenterol 100:616-23. 2005
    ..The aim of this study was to develop a noninvasive model to assess liver fibrosis in CHB patients using clinical and routine laboratory data...
  68. ncbi request reprint A retrospective study on clinical features and prognostic factors of biopsy-proven primary biliary cirrhosis in Chinese patients
    Grace Lai Hung Wong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Am J Gastroenterol 100:2205-11. 2005
    ..Though extensive research has been performed on primary biliary cirrhosis (PBC) in Caucasian patients, little is known about the disease in the Asian population...
  69. ncbi request reprint Survival and prognostic indicators in patients with hepatitis B virus-related cirrhosis after onset of hepatic decompensation
    Alex Yui Hui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong ROC
    J Clin Gastroenterol 34:569-72. 2002
    ..To determine the 2-year survival and prognostic indicators of hepatitis B virus-related cirrhosis after the onset of hepatic decompensation...
  70. doi request reprint High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong, China
    Gut 60:829-36. 2011
    ..The aim of this study was to examine the prevalence of colorectal neoplasm in NAFLD patients and the risk of colorectal neoplasm in relation to the severity of NAFLD histology. Design Cross-sectional study...
  71. doi request reprint Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers
    Jiayun Shen
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    J Hepatol 56:1363-70. 2012
    ..We aimed at testing the accuracy of cytokeratin-18 fragment (CK-18), adipocyte fatty acid binding protein (AFABP) and fibroblast growth factor 21 (FGF21) for the diagnosis of NAFLD and NASH...
  72. ncbi request reprint Association between anthropometric parameters and measurements of liver stiffness by transient elastography
    Grace Lai Hung Wong
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China
    Clin Gastroenterol Hepatol 11:295-302.e1-3. 2013
    ..We investigated the association between anthropometric parameters and results of liver stiffness measurements (LSMs) by transient elastography in healthy subjects and patients with nonalcoholic fatty liver disease (NAFLD)...
  73. doi request reprint Antiviral drug resistance testing in patients with chronic hepatitis B
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, Hong Kong
    Dig Dis Sci 57:221-31. 2012
    ..Antiviral drugs against hepatitis B virus are limited by the emergence of drug resistance...
  74. ncbi request reprint Assessment of fibrosis by transient elastography compared with liver biopsy and morphometry in chronic liver diseases
    Grace Lai Hung Wong
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Gastroenterol Hepatol 6:1027-35. 2008
    ..We aimed to study the diagnostic performance of LSM for histologic bridging fibrosis and cirrhosis in various chronic liver diseases and to investigate the effects of liver fibrosis distribution on LSM...
  75. ncbi request reprint Effect of prostaglandin E2 and prostaglandin I2 on PDGF-induced proliferation of LI90, a human hepatic stellate cell line
    Alex Yui Hui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Prostaglandins Leukot Essent Fatty Acids 71:329-33. 2004
    ..In vivo studies using animal models are needed to elucidate the effect of COX-2 inhibition by non-steroidal anti-inflammatory drugs or COX-2 inhibitor in hepatic fibrosis...
  76. ncbi request reprint High incidence of mortality and recurrent bleeding in patients with Helicobacter pylori-negative idiopathic bleeding ulcers
    Grace Lai Hung Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Gastroenterology 137:525-31. 2009
    ..The long-term prognosis of peptic ulcers associated with neither Helicobacter pylori nor nonsteroidal anti-inflammatory drugs (NSAIDs) is unknown...
  77. doi request reprint Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Gut 60:1721-7. 2011
    ..The aim of this study was to determine the role of fatty liver in predicting coronary artery disease and clinical outcomes in patients undergoing coronary angiogram...
  78. doi request reprint The effect of caffeine and alcohol consumption on liver fibrosis - a study of 1045 Asian hepatitis B patients using transient elastography
    Arlinking Ong
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Liver Int 31:1047-53. 2011
    ..Role of caffeine consumption in chronic hepatitis B virus (HBV)-infected patients and the interaction with alcohol consumption is unclear...
  79. ncbi request reprint Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial
    Francis Ka Leung Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Lancet 369:1621-6. 2007
    ....
  80. doi request reprint Severe acute exacerbation of chronic hepatitis B: a unique presentation of a common disease
    Vincent Wai Sun Wong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    J Gastroenterol Hepatol 24:1179-86. 2009
    ..Liver transplantation, particularly living donor liver transplantation, should be considered for patients who develop hepatic failure secondary to severe acute exacerbation...
  81. pmc Glucose-regulated protein 78 is an intracellular antiviral factor against hepatitis B virus
    Yan Ma
    Stanley Ho Center for Emerging Infectious Diseases, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China
    Mol Cell Proteomics 8:2582-94. 2009
    ..Induction of hepatic GRP78 may provide a novel therapeutic approach in treating HBV infection...
  82. doi request reprint Efficacy of cap-assisted colonoscopy in comparison with regular colonoscopy: a randomized controlled trial
    Yuk Tong Lee
    Faculty of Medicine, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Am J Gastroenterol 104:41-6. 2009
    ..Colonoscopy cannot be completed in up to 10% of cases. We postulate that cap-assisted colonoscopy (CAC), by fitting a mucosectomy cap to the tip of a colonoscope, could improve the outcome...
  83. pmc The G1613A mutation in the HBV genome affects HBeAg expression and viral replication through altered core promoter activity
    Man Shan Li
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    PLoS ONE 6:e21856. 2011
    ..We also provide a possible molecular mechanism of this hotspot mutation to the increased viral load of HBV carriers, which increases the risk to HCC...
  84. ncbi request reprint Surveillance programme for hepatocellular carcinoma improves the survival of patients with chronic viral hepatitis
    Grace Lai Hung Wong
    Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Liver Int 28:79-87. 2008
    ..The survival benefit of surveillance for hepatocellular carcinoma (HCC) is controversial...
  85. ncbi request reprint Lipoprotein lipase activator ameliorates the severity of dietary steatohepatitis
    Jun Yu
    Institute of Digestive Disease, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Biochem Biophys Res Commun 356:53-9. 2007
    ..These findings indicate that NO-1886 is a potential therapeutic agent for steatohepatitis...
  86. ncbi request reprint A review of telbivudine for the management of chronic hepatitis B virus infection
    Yanni Y N Lui
    The Chinese University of Hong Kong, Department of Medicine and Therapeutics and Institute of Digestive Disease, Hong Kong SAR, China
    Expert Opin Drug Metab Toxicol 4:1351-61. 2008
    ..Research interests have focused on the development of potent and safe antiviral agents with low resistance rates. Telbivudine is a nucleoside analogue that has been approved for treatment of chronic hepatitis B...
  87. doi request reprint Lamivudine monoprophylaxis and adefovir salvage for liver transplantation in chronic hepatitis B: a seven-year follow-up study
    Jenny L Limquiaco
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
    J Med Virol 81:224-9. 2009
    ..No genotypic resistance to adefovir was detected. Lamivudine followed by adefovir salvage is effective for prophylaxis of recurrence of HBV after liver transplantation up to 7 years...
  88. doi request reprint Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease
    Vincent Wai Sun Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
    Hepatology 51:454-62. 2010
    ..Discordance of at least two stages between transient elastography and histology was observed in 33 (13.4%) patients. By multivariate analysis, liver biopsy length less than 20 mm and F0-2 disease were associated with discordance...
  89. ncbi request reprint Evaluation of model for end stage liver disease (MELD)-based systems as prognostic index for hepatocellular carcinoma
    Jenny L Limquiaco
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
    J Gastroenterol Hepatol 24:63-9. 2009
    ..The Cancer of Liver Italian Program (CLIP) and Japan Integrated Scoring System (JIS) used the Child-Turcotte-Pugh (CTP) score to evaluate the liver function...
  90. ncbi request reprint Predictors of treatment response in chronic hepatitis B
    Grace L H Wong
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, the Hong Kong SAR, China
    Drugs 69:2167-77. 2009
    ..In conclusion, predictors of response are useful to provide the most appropriate antiviral therapy to the most suitable patients, in order to achieve the best response and improve the clinical outcome of chronic hepatitis B patients...
  91. ncbi request reprint Quantitative analysis of circulating methylated DNA as a biomarker for hepatocellular carcinoma
    K C Allen Chan
    State Key Laboratory in Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Clin Chem 54:1528-36. 2008
    ..We evaluated the analysis of circulating hypermethylated RASSF1A for detecting HCC and assessing its prognosis...
  92. doi request reprint Treatment of chronic hepatitis B: focus on telbivudine
    Yanni Y N Lui
    Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Expert Rev Anti Infect Ther 7:259-68. 2009
    ..This article provides an overview of the pharmacokinetics, clinical efficacies, resistance profile and safety of telbivudine. A comparison of telbivudine with other oral antiviral agents is also highlighted...
  93. doi request reprint High level virion production and surface antigen expression with 1.5 copies of hepatitis B viral genome
    Qingming Dong
    Stanley Ho Centre for Emerging Infectious Diseases, School of Public Health, The Chinese University of Hong Kong, Hong Kong, China
    J Virol Methods 159:135-40. 2009
    ..The HBV-1.5X system may be a useful platform that assists the establishment of stable cell lines and transgenic mice for the investigation of viral pathogenesis, particularly for the various strains of HBV...
  94. pmc Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis
    Jun Yu
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Gut 56:991-9. 2007
    ..However, it is not known whether overexpression of COX-2 in the liver is sufficient to promote activation or secretion of inflammatory factors leading to hepatitis...
  95. doi request reprint Hepatocellular carcinoma in the Asia pacific region
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Gastroenterol Hepatol 24:346-53. 2009
    ..However, transmission of HCV by injection drug use, and rising prevalence of obesity and diabetes, both independent risk factors for HCC, may partly offset this decline...
  96. doi request reprint The anti-inflammatory effect of celecoxib does not prevent liver fibrosis in bile duct-ligated rats
    Jun Yu
    Department of Medicine, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Liver Int 29:25-36. 2009
    ..However, data on the progression of liver fibrosis after treatment by celecoxib are not available. This study aims to elucidate the effects of celecoxib on cholestatic liver fibrosis in rats...
  97. ncbi request reprint Effect of celecoxib on experimental liver fibrosis in rat
    Alex Yui Hui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Liver Int 26:125-36. 2006
    ..In the current study, we assessed the in vivo effect of celecoxib, a COX-2-selective inhibitor, in experimental liver fibrosis in rats...
  98. doi request reprint Heme oxygenase-1 protects against steatohepatitis in both cultured hepatocytes and mice
    Jun Yu
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Gastroenterology 138:694-704, 704.e1. 2010
    ..Heme oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against oxidant-induced tissue injury. We investigated the role of HO-1 in nutritional steatohepatitis in vitro and in vivo...
  99. doi request reprint Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab
    Winnie Yeo
    Department of Clinical Oncology, Stanley Ho Centre for Emerging Infectious Diseases, School of Public Health, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    J Clin Oncol 27:605-11. 2009
    ....
  100. ncbi request reprint A1762T/G1764A mutations of hepatitis B virus, associated with the increased risk of hepatocellular carcinoma, reduce basal core promoter activities
    Qingming Dong
    Stanley Ho Centre for Emerging Infectious Diseases and Li Ka Shing Institute of Health Sciences, School of Public Health, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Biochem Biophys Res Commun 374:773-6. 2008
    ..We also show that T1762A and G1764A double mutations synergize the reduction of the promoter activity. A mechanism of HBV evasion from host immunoresponse that may facilitate disease development is also discussed...
  101. ncbi request reprint Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cells
    Alfred S L Cheng
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, P R China
    Int J Oncol 23:113-9. 2003
    ..In conclusion, specific COX-2 inhibitor suppresses cell proliferation and induces apoptosis in HCC cell lines that express COX-2. Our finding suggests that COX-2 inhibition may offer a new approach for HCC chemoprevention...