H C Chan

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm
    Xiao Fei Wang
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Nat Cell Biol 5:902-6. 2003
  2. pmc Defective CFTR-dependent CREB activation results in impaired spermatogenesis and azoospermia
    Wen Ming Xu
    Sichuan University The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Institute of Women and Children s Health, West China Second University Hospital, Sichuan University, Chengdu, People s Republic of China
    PLoS ONE 6:e19120. 2011
  3. pmc A host defense mechanism involving CFTR-mediated bicarbonate secretion in bacterial prostatitis
    Chen Xie
    Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 5:e15255. 2010
  4. pmc A protective mechanism against antibiotic-induced ototoxicity: role of prestin
    Li Yu
    Epithelial Cells Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    PLoS ONE 6:e17322. 2011
  5. pmc Lymphocytes accelerate epithelial tight junction assembly: role of AMP-activated protein kinase (AMPK)
    Xiao Xiao Tang
    Epithelial Cell Biology Research Center, School of Biomedial Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    PLoS ONE 5:e12343. 2010
  6. pmc Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation model
    Zi Huan Yang
    The School of Life Science, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 3:e3348. 2008
  7. pmc Flavonoid Myricetin Modulates GABA(A) Receptor Activity through Activation of Ca(2+) Channels and CaMK-II Pathway
    Xiao Hu Zhang
    Epithelial Cell Biology Research Centre, The Chinese University of Hong Kong, Hong Kong
    Evid Based Complement Alternat Med 2012:758097. 2012
  8. ncbi request reprint Physiology and pathophysiology of the epithelial barrier of the female reproductive tract: role of ion channels
    Hsiao Chang Chan
    Epithelial Cell Biology Research Center, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Adv Exp Med Biol 763:193-217. 2012
  9. ncbi request reprint Epithelial ion channels in the regulation of female reproductive tract fluid microenvironment: implications in fertility and infertility
    Hsiao Chang Chan
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Sheng Li Xue Bao 59:495-504. 2007
  10. doi request reprint Impaired CFTR-dependent amplification of FSH-stimulated estrogen production in cystic fibrosis and PCOS
    Hui Chen
    Epithelial Cell Biology Research Center, Room 408 Basic Medical Sciences Building, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    J Clin Endocrinol Metab 97:923-32. 2012

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm
    Xiao Fei Wang
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Nat Cell Biol 5:902-6. 2003
    ..These results are consistent with a critical role of CFTR in controlling uterine bicarbonate secretion and the fertilizing capacity of sperm, providing a link between defective CFTR and lower female fertility in CF...
  2. pmc Defective CFTR-dependent CREB activation results in impaired spermatogenesis and azoospermia
    Wen Ming Xu
    Sichuan University The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Institute of Women and Children s Health, West China Second University Hospital, Sichuan University, Chengdu, People s Republic of China
    PLoS ONE 6:e19120. 2011
    ..Altered CFTR-sAC-cAMP-CREB functional loop may also underline the pathogenesis of various CF-related diseases...
  3. pmc A host defense mechanism involving CFTR-mediated bicarbonate secretion in bacterial prostatitis
    Chen Xie
    Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 5:e15255. 2010
    ..Prostatitis is associated with a characteristic increase in prostatic fluid pH; however, the underlying mechanism and its physiological significance have not been elucidated...
  4. pmc A protective mechanism against antibiotic-induced ototoxicity: role of prestin
    Li Yu
    Epithelial Cells Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    PLoS ONE 6:e17322. 2011
    ....
  5. pmc Lymphocytes accelerate epithelial tight junction assembly: role of AMP-activated protein kinase (AMPK)
    Xiao Xiao Tang
    Epithelial Cell Biology Research Center, School of Biomedial Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    PLoS ONE 5:e12343. 2010
    ..These results suggest that signals from lymphocytes, such as cytokines, facilitate TJ assembly in epithelial cells via the activation of AMPK...
  6. pmc Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation model
    Zi Huan Yang
    The School of Life Science, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 3:e3348. 2008
    ....
  7. pmc Flavonoid Myricetin Modulates GABA(A) Receptor Activity through Activation of Ca(2+) Channels and CaMK-II Pathway
    Xiao Hu Zhang
    Epithelial Cell Biology Research Centre, The Chinese University of Hong Kong, Hong Kong
    Evid Based Complement Alternat Med 2012:758097. 2012
    ..The present results suggest that myricetin enhances GABA(A) receptor activity via calcium channel/CaMK-II dependent mechanism, which is distinctively different from that of most existing BZ-binding site agonists of GABA(A) receptor...
  8. ncbi request reprint Physiology and pathophysiology of the epithelial barrier of the female reproductive tract: role of ion channels
    Hsiao Chang Chan
    Epithelial Cell Biology Research Center, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Adv Exp Med Biol 763:193-217. 2012
    ....
  9. ncbi request reprint Epithelial ion channels in the regulation of female reproductive tract fluid microenvironment: implications in fertility and infertility
    Hsiao Chang Chan
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Sheng Li Xue Bao 59:495-504. 2007
    ....
  10. doi request reprint Impaired CFTR-dependent amplification of FSH-stimulated estrogen production in cystic fibrosis and PCOS
    Hui Chen
    Epithelial Cell Biology Research Center, Room 408 Basic Medical Sciences Building, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    J Clin Endocrinol Metab 97:923-32. 2012
    ....
  11. pmc The cystic fibrosis transmembrane conductance regulator in reproductive health and disease
    Hsiao Chang Chan
    Epithelial Cell Biology Research Center, Li Ka Shing Institute of Health Sciences, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Physiol 587:2187-95. 2009
    ..The evidence presented is consistent with an important role of CFTR in reproductive health and disease, suggesting that CFTR might be a potential target for the diagnosis and treatment of reproductive diseases including infertility...
  12. ncbi request reprint Critical role of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm
    Hsiao Chang Chan
    Epithelial Cell Biology Research Center, Department of Physiology, The Chinese University of Hong Kong, Room 410, Basic Medical Sciences Building, Shatin, Hong Kong
    Mol Cell Endocrinol 250:106-13. 2006
    ..These results are consistent with a critical role of CFTR in controlling uterine HCO3- secretion and sperm fertilizing capacity, suggesting that CFTR may be a potential target for post-meiotic regulation of fertility...
  13. ncbi request reprint Effect of melatonin on chloride secretion by human colonic T84 cells
    H C Chan
    Department of Physiology, The Chinese University of Hong Kong, Shatin
    Life Sci 62:2151-8. 1998
    ..Our data suggest that melatonin may play a role in regulating colonic Cl- secretion via melatonin receptors; however, the signal transduction pathway(s) involved remains to be elucidated...
  14. ncbi request reprint Expression of sperm Ca2+-activated K+ channels in Xenopus oocytes and their modulation by extracellular ATP
    H C Chan
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin
    FEBS Lett 438:177-82. 1998
    ..These results suggest that sperm possess Ca2+-activated K+ channels which may be involved in the process of sperm activation...
  15. ncbi request reprint Inhibition of amiloride-sensitive Na(+) absorption by activation of CFTR in mouse endometrial epithelium
    L N Chan
    Epithelial Cell Biology Research Centre, Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong
    Pflugers Arch 443:S132-6. 2001
    ..Our data suggest an interaction between CFTR and ENaC, which may be the underlying mechanism for balancing Na(+) absorption and Cl(-) secretion across the mouse endometrial epithelium...
  16. ncbi request reprint Enhanced epithelial Na(+) channel (ENaC) activity in mouse endometrial epithelium by upregulation of gammaENaC subunit
    L L Tsang
    Epithelial Cell Biology Research Center, Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong
    Jpn J Physiol 51:539-43. 2001
    ..The results indicated an important role of gammaENaC subunit in determining ENaC activity, and a possible role of the gammaENaC subunit in interacting with CFTR was also discussed...
  17. ncbi request reprint Suppression of ATP-induced Cl(-)secretion by enhanced expression of epithelial Na(+)channels in mouse endometrial epithelium
    X F Wang
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong
    Cell Biol Int 25:1017-20. 2001
    ....
  18. ncbi request reprint Expression, immunolocalization, and functional activity of Na+/H+ exchanger isoforms in mouse endometrial epithelium
    X F Wang
    Department of Physiology, The Chinese University of Hong Kong, Shatin, China
    Biol Reprod 68:302-8. 2003
    ..The apically located NHEs may be involved in mediating Na(+) absorption as alternatives of or complementary to epithelial Na(+) channels...
  19. ncbi request reprint cGMP-regulated store-operated calcium entry in human hepatoma cells
    J L Jiang
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Cell Biol Int 25:993-5. 2001
    ..Application of 8-Br-cGMP reduced the [Ca(2+)](i)in hepatoma 7721 cells by 80%. These data demonstrated for the first time that store-operated Ca(2+)entry pathway is present in human hepatoma cells, which is regulated by cGMP...
  20. ncbi request reprint Effect of phenol red and steroid hormones on cystic fibrosis transmembrane conductance regulator in mouse endometrial epithelial cells
    L L Tsang
    Epithelial Cell Biology Research Center, Department of Physiology, The Chinese University of Hong Kong
    Cell Biol Int 25:1021-4. 2001
    ..Our study demonstrates the need for carefully choosing the culture media and supplements due to the effect of steroid hormones...
  21. ncbi request reprint Local regulation of anion secretion by pituitary adenylate cyclase-activating polypeptide in human colonic T84 cells
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Cell Biol Int 25:123-9. 2001
    ..Moreover, the regulation of anion secretion by T84 cells may be mediated by locally formed PACAP in an autocrine or paracrine fashion...
  22. ncbi request reprint Cellular signaling mechanisms underlying pharmacological action of Bak Foong Pills on gastrointestinal secretion
    J X Zhu
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR
    Jpn J Physiol 52:129-34. 2002
    ..The effect of BFP may be explored to treat GI disorders such as constipation...
  23. ncbi request reprint Upregulation of cystic fibrosis transmembrane conductance regulator expression by oestrogen and Bak Foong Pill in mouse uteri
    D K Rowlands
    Epithelial Cell Biology Research Center, Department of Physiology, Chinese University of Hong Kong, Shatin, Hong Kong
    Cell Biol Int 25:1033-5. 2001
    ..Regulation of CFTR expression by both oestrogen and gynaecological medication BFP indicates an important role of CFTR in reproductive functions...
  24. ncbi request reprint Testicular hormonal regulation of the renin-angiotensin system in the rat epididymis
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT
    Life Sci 66:1317-24. 2000
    ....
  25. pmc Anion secretion induced by capacitative Ca2+ entry through apical and basolateral membranes of cultured equine sweat gland epithelium
    W H Ko
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    J Physiol 497:19-29. 1996
    ....
  26. ncbi request reprint Adrenergic receptors on cultured rat epididymal cells: regulation of Cl- conductances
    H C Chan
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N T
    Biol Reprod 51:1040-5. 1994
    ....
  27. ncbi request reprint Differential gene expression of angiotensin II receptor subtypes in the epididymides of mature and immature rats
    P S Leung
    Department of Physiology, The Chinese University of Hong Kong, Shatin, NT
    Life Sci 62:461-8. 1998
    ..Type-1 subtype may play a role in regulation of electrolyte and fluid transport in mature rat whereas type-2 subtype may be important in growth and development in the immature rat...
  28. ncbi request reprint Quantification of apoptotic DNA fragmentation in a transformed uterine epithelial cell line, HRE-H9, using capillary electrophoresis with laser-induced fluorescence detector (CE-LIF)
    R R Fiscus
    The Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Cell Biol Int 25:1007-11. 2001
    ..2-fold, respectively, above the 0 h or plus-serum controls. This ultrasensitive CE-LIF technique provides a novel method for accurately measuring the actions of pro- or anti-apoptotic agents or conditions on uterine epithelial cell lines...
  29. ncbi request reprint Localization and distribution of pituitary adenylate cyclase-activating polypeptide in the rat epididymis
    P S Leung
    Department of Physiology, Chinese University of Hong Kong, Shatin
    Cell Biol Int 22:193-8. 1998
    ....
  30. ncbi request reprint Involvement of Na+-HCO3- cotransporter in mediating cyclic adenosine 3',5'-monophosphate-dependent HCO3- secretion by mouse endometrial epithelium
    X F Wang
    Epithelial Cell Biology Research Center, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong
    Biol Reprod 66:1846-52. 2002
    ..The results suggest that basolaterally located Na+-HCO3- cotransporter is involved in mediating cAMP-stimulated HCO3- secretion across the mouse endometrial epithelium...
  31. pmc Regulation of anion secretion by cyclo-oxygenase and prostanoids in cultured epididymal epithelia from the rat
    P Y Wong
    Department of Physiology, The Chinese University of Hong Kong, Shatin, NT, Hong
    J Physiol 514:809-20. 1999
    ..8. The role of COX in the formation of the epididymal microenvironment and the implication of long term administration of non-steroidal anti-inflammatory drugs (NSAIDs) on male fertility are discussed...
  32. ncbi request reprint The involvement of HAb18G/CD147 in regulation of store-operated calcium entry and metastasis of human hepatoma cells
    J L Jiang
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Biol Chem 276:46870-7. 2001
    ..These results suggest that HAb18G/CD147 enhances metastatic potentials in human hepatoma cells by disrupting the regulation of store-operated Ca(2+) entry by NO/cGMP...
  33. pmc Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility
    Wen Ming Xu
    Epithelial Cell Biology Research Center, Li Ka Shing Institute of Health Sciences, Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Proc Natl Acad Sci U S A 104:9816-21. 2007
    ....
  34. ncbi request reprint Distribution and regulation of ENaC subunit and CFTR mRNA expression in murine female reproductive tract
    L N Chan
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong, SAR
    J Membr Biol 185:165-76. 2002
    ..Variations in the fluid profiles may be dictated by the regional and cyclic variations in expression of ENaC and CFTR and are likely to contribute to various reproductive events in different regions of the female reproductive tract...
  35. doi request reprint CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer
    C Xie
    Epithelial Cell Biology Research Center, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong
    Oncogene 32:2282-91, 2291.e1-7. 2013
    ..Taken together, the present study has demonstrated a previously undefined tumor-suppressing role of CFTR and its involvement in regulation of miR-193b in prostate cancer development...
  36. ncbi request reprint Androgen dependent expression of AT1 receptor and its regulation of anion secretion in rat epididymis
    P S Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Cell Biol Int 26:117-22. 2002
    ..This androgen-dependent expression of AT(1)receptor could have a role in the control of AT(1)receptor-mediated anion secretion and thus fluid secretion by the rat epididymis...
  37. doi request reprint Abnormally up-regulated cystic fibrosis transmembrane conductance regulator expression and uterine fluid accumulation contribute to Chlamydia trachomatis-induced female infertility
    Qiong He
    Epithelial Cell Biology Research Center, Key Laboratory for Regenerative Medicine of Ministry of Education of China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People s Republic of China
    Fertil Steril 93:2608-14. 2010
    ..trachomatis-induced female infertility...
  38. ncbi request reprint Differential expression and localization of CFTR and ENaC in mouse endometrium during pre-implantation
    Jian Zhi Yang
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    Cell Biol Int 28:433-9. 2004
    ....
  39. ncbi request reprint Epididymial defensins and sperm maturation
    H C Chan
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, HKSAR
    Andrologia 37:200-1. 2005
  40. ncbi request reprint Increased cystic fibrosis transmembrane conductance regulator (CFTR) expression in the human hydrosalpinx
    Louis Chukwuemeka Ajonuma
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin
    Hum Reprod 20:1228-34. 2005
    ..The present study investigated the possible involvement of cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent chloride channel, in the pathogenesis of hydrosalpinx...
  41. ncbi request reprint Regulation of ion transport by 5-hydroxytryptamine in rat colon
    Yang Ning
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Exp Pharmacol Physiol 31:424-8. 2004
    ..5. In conclusion, the present study has demonstrated that 5-HT can elicit Cl(-)- and HCO3- anion secretion and Na+ absorption by acting directly on colonic epithelial cells via 5-HT4 receptors...
  42. ncbi request reprint Altered cyclic expression of epithelial Na+ channel subunits and cystic fibrosis transmembrane conductance regulator in mouse endometrium by a low sodium diet
    Lai Ling Tsang
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Cell Biol Int 28:549-55. 2004
    ..The altered cyclic expression of uterine ENaC and CFTR by a low sodium diet suggests that these ion channels may be affected by elevated circulating aldosterone, which may disrupt reproductive events in the uterus...
  43. ncbi request reprint An epididymis-specific beta-defensin is important for the initiation of sperm maturation
    Chen Xi Zhou
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Nat Cell Biol 6:458-64. 2004
    ..Thus, beta-defensin is important for the acquisition of sperm motility and the initiation of sperm maturation...
  44. ncbi request reprint Activation of apical CFTR and basolateral Ca(2+)-activated K+ channels by tetramethylpyrazine in Caco-2 cell line
    Jin Xia Zhu
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, PR China
    Eur J Pharmacol 510:187-95. 2005
    ..2 fold higher than that of Ca(2+)-activated Cl- channel (CACC). In conclusion, TMP stimulates Cl- secretion by activating cAMP and [Ca2+]i signaling pathways leading to subsequent activation of apical CFTR and basolateral K+ channels...
  45. ncbi request reprint Estrogen-induced abnormally high cystic fibrosis transmembrane conductance regulator expression results in ovarian hyperstimulation syndrome
    Louis Chukwuemeka Ajonuma
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territory, Hong Kong
    Mol Endocrinol 19:3038-44. 2005
    ..These findings confirm a critical role of CFTR in the pathogenesis of OHSS and may provide grounds for better assisted reproduction treatment strategy to reduce the risk of OHSS and improve in vitro fertilization outcome...
  46. ncbi request reprint The role of inducible nitric oxide synthase in gamete interaction and fertilization: a comparative study on knockout mice of three NOS isoforms
    Jian Zhi Yang
    Epithelial Cell Biology Research Center, Department of Physiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong Special Administrative Region, PR China
    Cell Biol Int 29:785-91. 2005
    ..While all three types of NOS do not seem to play a significant role in pre-ejaculated sperm function, iNOS may play an inhibitory role in sperm and oocyte functions affecting the process of fertilization and early embryo development...
  47. doi request reprint Involvement of cystic fibrosis transmembrane conductance regulator in infection-induced edema
    Louis Chukwuemeka Ajonuma
    Epithelial Cell Biology Research Center, Li Ka Shing Institute of Health Science, Department of Physiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Cell Biol Int 32:801-6. 2008
    ..trachomatis infection-induced CFTR upregulation, enhanced CFTR channel activity and fluid accumulation, further confirming the involvement of CFTR in infection-induced tissue fluid secretion...
  48. ncbi request reprint Differentiation of adult rat bone marrow stem cells into epithelial progenitor cells in culture
    Chang Shu
    Epithelial Cell Biology Research Center, Li Ka Shing Institute of Health Sciences, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Cell Biol Int 30:823-8. 2006
    ....
  49. doi request reprint CFTR is required for cellular entry and internalization of Chlamydia trachomatis
    Louis Chukwuemeka Ajonuma
    Epithelial Cell Biology Research Center, Department of Physiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, People s Republic of China
    Cell Biol Int 34:593-600. 2010
    ..trachomatis and these findings may lead to the development of new treatment strategies to curtail the spread of chlamydial infections...
  50. doi request reprint Traditional Chinese medicine Bak Foong Pills alters uterine quiescence - possible role in alleviation of dysmenorrhoeal symptoms
    Dewi Kenneth Rowlands
    Epithelial Cell Biology Research Centre, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Cell Biol Int 33:1207-11. 2009
    ..The ability of Bak Foong Pills to alleviate menstrual pain may be due to direct regulation of uterine tone...
  51. ncbi request reprint Dopamine stimulates Cl(-) absorption coupled with HCO(3)(-) secretion in rat late distal colon
    Gui Hong Zhang
    Epithelial Cell Biology Research Center, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, PR China
    Eur J Pharmacol 570:188-95. 2007
    ..The present findings reveal a previously unreported dopamine-regulated anion transport process in rat late distal colon, which may have implication in Parkinson's disease...
  52. ncbi request reprint Differential effects of Matrigel and its components on functional activity of CFTR and ENaC in mouse endometrial epithelial cells
    Jian Zhi Yang
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, HKSAR, Hong Kong
    Cell Biol Int 27:543-8. 2003
    ..The information obtained may be useful for designing future in vitro culture models to investigate the functional roles of these ion channels in the endometrium...
  53. doi request reprint Involvement of cystic fibrosis transmembrane conductance regulator (CFTR) in the pathogenesis of hydrosalpinx induced by Chlamydia trachomatis infection
    Louis Chukwuemeka Ajonuma
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    J Obstet Gynaecol Res 34:923-30. 2008
    ....
  54. ncbi request reprint YWK-II protein as a novel G(o)-coupled receptor for Müllerian inhibiting substance in cell survival
    Xueqian Yin
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China
    J Cell Sci 120:1521-8. 2007
    ..Taken together, the present study has demonstrated a new G(o)-coupled receptor for MIS in mediating ERK1/2 activation leading to anti-apoptotic activity or cell survival...