Francis K L Chan

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint The David Y. Graham lecture: use of nonsteroidal antiinflammatory drugs in a COX-2 restricted environment
    Francis K L Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Am J Gastroenterol 103:221-7. 2008
  2. doi request reprint Effects of Helicobacter pylori infection on long-term risk of peptic ulcer bleeding in low-dose aspirin users
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Gastroenterology 144:528-35. 2013
  3. doi request reprint Burden of nonsteroidal anti-inflammatory and antiplatelet drug use in Asia: a multidisciplinary working party report
    Francis Ka Leung Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Clin Gastroenterol Hepatol 10:753-60. 2012
  4. doi request reprint Editorial: single-tablet ibuprofen/double-dose famotidine for reduction of gastric and duodenal ulcers (REDUCE Trials): what can be reduced?
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China
    Am J Gastroenterol 107:387-8. 2012
  5. doi request reprint Anti-platelet therapy and managing ulcer risk
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 27:195-9. 2012
  6. pmc Lack of benefits for prevention of cardiovascular disease with aspirin therapy in type 2 diabetic patients--a longitudinal observational study
    Wilson Y Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, PR China
    Cardiovasc Diabetol 8:57. 2009
  7. ncbi request reprint Helicobacter pylori, NSAIDs and gastrointestinal haemorrhage
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Eur J Gastroenterol Hepatol 14:1-3. 2002
  8. ncbi request reprint Does eradication of Helicobacter pylori impair healing of nonsteroidal anti-inflammatory drug associated bleeding peptic ulcers? A prospective randomized study
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    Aliment Pharmacol Ther 12:1201-5. 1998
  9. ncbi request reprint Helicobacter pylori and nonsteroidal anti-inflammatory drugs
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Gastroenterol Clin North Am 30:937-52. 2001
  10. ncbi request reprint Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial
    Francis Ka Leung Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Lancet 369:1621-6. 2007

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint The David Y. Graham lecture: use of nonsteroidal antiinflammatory drugs in a COX-2 restricted environment
    Francis K L Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Am J Gastroenterol 103:221-7. 2008
    ..g., recent myocardial infarction). In contrast, combination of low-dose COX-2 inhibitor, low-dose aspirin, and a PPI or misoprostol is preferred if GI risk outweighs CV risk (e.g., recent ulcer bleeding and stable CV disease)...
  2. doi request reprint Effects of Helicobacter pylori infection on long-term risk of peptic ulcer bleeding in low-dose aspirin users
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Gastroenterology 144:528-35. 2013
    ..However, it is not clear whether this strategy affects long-term risk of ulcer bleeding. We assessed the utility of testing ASA users with a high risk of ulcer bleeding for H pylori infection...
  3. doi request reprint Burden of nonsteroidal anti-inflammatory and antiplatelet drug use in Asia: a multidisciplinary working party report
    Francis Ka Leung Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Clin Gastroenterol Hepatol 10:753-60. 2012
    ..We established a working group to examine the burden of atherothrombotic and musculoskeletal diseases in Asia and made recommendations for safer prescribing of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin...
  4. doi request reprint Editorial: single-tablet ibuprofen/double-dose famotidine for reduction of gastric and duodenal ulcers (REDUCE Trials): what can be reduced?
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China
    Am J Gastroenterol 107:387-8. 2012
    ..How the study findings may influence clinical practice deserves further consideration...
  5. doi request reprint Anti-platelet therapy and managing ulcer risk
    Francis K L Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 27:195-9. 2012
    ..In the future, management of patients on dual anti-platelet therapy needs to be individualized according to their thrombotic and bleeding risks...
  6. pmc Lack of benefits for prevention of cardiovascular disease with aspirin therapy in type 2 diabetic patients--a longitudinal observational study
    Wilson Y Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, PR China
    Cardiovasc Diabetol 8:57. 2009
    ..This study examined the benefit and harm of low-dose aspirin (daily dose < 300 mg) in patients with type 2 diabetes...
  7. ncbi request reprint Helicobacter pylori, NSAIDs and gastrointestinal haemorrhage
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Eur J Gastroenterol Hepatol 14:1-3. 2002
    ..Among H. pylori-positive patients with a history of ulcer bleeding who are taking low-dose aspirin, the eradication of H. pylori has been shown to be comparable to omeprazole in preventing recurrent bleeding...
  8. ncbi request reprint Does eradication of Helicobacter pylori impair healing of nonsteroidal anti-inflammatory drug associated bleeding peptic ulcers? A prospective randomized study
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    Aliment Pharmacol Ther 12:1201-5. 1998
    ..We investigated the effects of H. pylori eradication on the healing of NSAID-associated bleeding peptic ulcers...
  9. ncbi request reprint Helicobacter pylori and nonsteroidal anti-inflammatory drugs
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Gastroenterol Clin North Am 30:937-52. 2001
    ..Given the significant role of H. pylori in the latter condition, screen-and-treat H. pylori might be a useful strategy for the prevention of ulcer complications in high-risk patients receiving low-dose aspirin in the future...
  10. ncbi request reprint Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial
    Francis Ka Leung Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Lancet 369:1621-6. 2007
    ....
  11. ncbi request reprint Primer: managing NSAID-induced ulcer complications--balancing gastrointestinal and cardiovascular risks
    Francis K L Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Nat Clin Pract Gastroenterol Hepatol 3:563-73. 2006
    ..Naproxen is the preferred NSAID because it is not associated with excess cardiovascular risk. Patients with a high cardiovascular risk and a very high gastrointestinal risk should avoid using NSAIDs or COX2 inhibitors...
  12. ncbi request reprint Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial
    Francis K L Chan
    Departments of Medicine and Therapeutics, The Chinese University of Hong Kong, Special Administrative Region of China, Hong Kong
    Lancet 359:9-13. 2002
    ..We hypothesised that eradication of H pylori infection would reduce the risk of ulcers for patients starting long-term NSAID treatment...
  13. ncbi request reprint Management of high-risk patients on non-steroidal anti-inflammatory drugs or aspirin
    Francis K L Chan
    Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, People s Republic of China
    Drugs 66:23-8; discussion 29-33. 2006
    ..In patients with increased cardiovascular risk requiring anti-inflammatory analgesics, the combination of a non-selective NSAID, low-dose aspirin and a PPI is the preferred treatment...
  14. ncbi request reprint Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    N Engl J Med 347:2104-10. 2002
    ..We assessed whether celecoxib would be similar to diclofenac plus omeprazole in reducing the risk of recurrent ulcer bleeding in patients at high risk for bleeding...
  15. ncbi request reprint NSAID-induced peptic ulcers and Helicobacter pylori infection: implications for patient management
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Shatin, Hong Kong SAR
    Drug Saf 28:287-300. 2005
    ..In light of potential cardiovascular risk with COX-2 selective NSAIDs, it is important to weigh the potential adverse effects against the benefits for an individual patient...
  16. ncbi request reprint Should we eradicate Helicobacter pylori infection in patients receiving nonsteroidal anti-inflammatory drugs or low-dose aspirin?
    Francis K L Chan
    Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Chin J Dig Dis 6:1-5. 2005
    ..There is no convincing evidence that eradication of H. pylori has any clinically important adverse effect on the healing and prevention of ulcers in NSAIDs users...
  17. ncbi request reprint COX-2 inhibition, H. pylori infection and the risk of gastrointestinal complications
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong
    Curr Pharm Des 9:2213-9. 2003
    ..Limited data showed that COX-2 expression was also increased in human gastric ulcer regardless of the H. pylori status. The functional significance of COX-2 in human gastric ulcer is unknown...
  18. ncbi request reprint Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China
    N Engl J Med 352:238-44. 2005
    ..guidelines also recommend clopidrogel for patients who have major gastrointestinal intolerance of aspirin. We compared clopidogrel with aspirin plus esomeprazole for the prevention of recurrent bleeding from ulcers in high-risk patients...
  19. ncbi request reprint Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Gastroenterology 127:1038-43. 2004
    ..We studied the ulcer incidence and factors predicting ulcer recurrence in a prospective, double-blinded trial...
  20. ncbi request reprint Randomized trial of low-dose misoprostol and naproxen vs. nabumetone to prevent recurrent upper gastrointestinal haemorrhage in users of non-steroidal anti-inflammatory drugs
    F K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 15:19-24. 2001
    ..Prophylactic misoprostol or non-steroidal anti-inflammatory drugs (NSAIDs) with low gastric toxicity (nabumetone) has been shown to reduce mucosal injury...
  21. ncbi request reprint Protein-losing enteropathy in congestive heart failure: diagnosis by means of a simple method
    F K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong
    Hepatogastroenterology 46:1816-8. 1999
    ..The use of this simple and non-invasive diagnostic technique in protein-losing enteropathy is discussed...
  22. ncbi request reprint Salvage therapies after failure of Helicobacter pylori eradication with ranitidine bismuth citrate-based therapies
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong
    Aliment Pharmacol Ther 14:91-5. 2000
    ..Salvage therapies after initial Helicobacter pylori eradication failure of ranitidine bismuth citrate (RBC)-based regimens remain undefined...
  23. ncbi request reprint Peptic-ulcer disease
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    Lancet 360:933-41. 2002
    ..With the fall in rates of H pylori infection, the proportion of ulcers not related to this organism and NSAIDs has risen, which will affect the management of peptic ulcer...
  24. ncbi request reprint Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen
    F K Chan
    Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    N Engl J Med 344:967-73. 2001
    ..It is uncertain whether infection with Helicobacter pylori is a risk factor for bleeding in such patients...
  25. doi request reprint A novel composite endpoint to evaluate the gastrointestinal (GI) effects of nonsteroidal antiinflammatory drugs through the entire GI tract
    Francis K L Chan
    The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    J Rheumatol 37:167-74. 2010
    ..The objective of this report is to introduce a novel composite endpoint that measures damage to the entire GI tract - clinically significant upper and lower GI events (CSULGIE) - in patients with NSAID-induced GI damage...
  26. ncbi request reprint Expression and cellular localization of COX-1 and -2 in Helicobacter pylori gastritis
    F K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 15:187-93. 2001
    ..There are conflicting reports on the expression of cyclooxygenase in Helicobacter pylori infection...
  27. doi request reprint Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial
    Francis K L Chan
    Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Lancet 376:173-9. 2010
    ..We aimed to compare risk of gastrointestinal events associated with celecoxib versus diclofenac slow release plus omeprazole...
  28. doi request reprint Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial
    Joseph J Y Sung
    Institute of Digestive Disease, Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong
    Ann Intern Med 152:1-9. 2010
    ..It is uncertain whether aspirin therapy should be continued after endoscopic hemostatic therapy in patients who develop peptic ulcer bleeding while receiving low-dose aspirin...
  29. ncbi request reprint Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer
    Wai K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
    Am J Gastroenterol 100:2274-9. 2005
    ....
  30. ncbi request reprint Effects of long-term rofecoxib on gastric intestinal metaplasia: results of a randomized controlled trial
    Wai K Leung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Cancer Res 12:4766-72. 2006
    ..Gastric cancer and its premalignant gastric lesion, intestinal metaplasia (IM), frequently express cyclooxygenase-2 (COX-2) at high levels. We tested whether long-term use of specific COX-2 inhibitors regress gastric IM...
  31. ncbi request reprint The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots: a randomized comparison
    Joseph J Y Sung
    Endoscopy Center, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Ann Intern Med 139:237-43. 2003
    ..The optimal treatment of ulcers with nonbleeding visible vessels and adherent clots is unclear...
  32. ncbi request reprint Long-term outcome of Helicobacter pylori-negative idiopathic bleeding ulcers: a prospective cohort study
    Lawrence C T Hung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Gastroenterology 128:1845-50. 2005
    ..Helicobacter pylori-negative idiopathic ulcers are increasingly recognized. The secular trend and long-term outcome of this condition are unknown...
  33. doi request reprint Increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer
    Siew C Ng
    Department of Medicine and Therapeutics, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Gastroenterology 144:544-50. 2013
    ..Relatives of patients with CRC have an increased risk of colorectal neoplasm. We assessed the prevalence of advanced neoplasms among asymptomatic siblings of patients with CRC...
  34. doi request reprint Predicting mortality in patients with bleeding peptic ulcers after therapeutic endoscopy
    Philip W Y Chiu
    Department of Surgery, Institute of Digestive Disease, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    Clin Gastroenterol Hepatol 7:311-6; quiz 253. 2009
    ..Despite advances in management of patients with bleeding peptic ulcers, mortality is still 10%. This study aimed to identify predictive factors and to develop a prediction model for mortality among patients with bleeding peptic ulcers...
  35. ncbi request reprint Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells
    Michael W Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PR China
    Oncol Rep 18:1557-62. 2007
    ..RNA interference may be a promising alternative to specific COX-2 inhibitors in the prevention and treatment of gastric cancer...
  36. doi request reprint Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer
    Jun Yu
    Institute of Digestive Disease and Department of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Gastroenterology 136:640-51.e1. 2009
    ..We analyzed its epigenetic inactivation, biological effects, and prognostic significance in gastric cancer...
  37. ncbi request reprint Initial treatment with lansoprazole in young dyspeptic patients with negative urea breath test result: a randomized controlled trial with 12-month follow-up
    Wai K Leung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Am J Gastroenterol 102:1483-8. 2007
    ..We evaluated the long-term effects of an initial 12-wk course of lansoprazole in young dyspeptic patients without Helicobacter pylori (H. pylori) infection...
  38. pmc FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells
    Shun X Ren
    School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 8:e63641. 2013
    ..Our study also uncovered previously unknown reciprocal regulation between these two cell death pathways...
  39. doi request reprint Long-term follow-up of ulcerative colitis in the Chinese population
    Dorothy K L Chow
    Department of Medicine and Therapeutics, Institute of Digestive Disease, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, China
    Am J Gastroenterol 104:647-54. 2009
    ..We set out determine the incidence, prevalence, and survival rate of UC in the Chinese population and phenotypic stability by longitudinal follow-up...
  40. ncbi request reprint Anti-sense trefoil factor family-3 (intestinal trefoil factor) inhibits cell growth and induces chemosensitivity to adriamycin in human gastric cancer cells
    Michael W Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Life Sci 76:2581-92. 2005
    ..Our results demonstrated that blocking the expression of ITF inhibits growth of gastric cancer cells and enhances the response to chemotherapy...
  41. doi request reprint Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis
    William K K Wu
    Institute of Digestive Disease, LKS Institute of Health Sciences and Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Crit Rev Oncol Hematol 86:251-77. 2013
    ..Understanding their relative importance and crosstalk will provide a rational basis for anticancer drug development...
  42. ncbi request reprint Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer
    Wai K Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Mol Carcinog 37:91-7. 2003
    ..These results suggest that HLTF promoter hypermethylation is frequently demonstrated in human gastric cancer, and inactivation of HLTF or the chromatin-remodeling complex may play a crucial role in gastric carcinogenesis...
  43. pmc MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer
    Chung Wah Wu
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 8:e57036. 2013
    ..miR-18a is one of the most up-regulated miRNAs in colorectal cancers (CRC) based on miRNA profiling. In this study, we examined the functional significance of miR-18a in CRC...
  44. pmc MicroRNA-218 inhibits cell cycle progression and promotes apoptosis in colon cancer by downregulating BMI1 polycomb ring finger oncogene
    Xinqi He
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China
    Mol Med 18:1491-8. 2012
    ..05) and promoted cell cycle arrest in the G2 phase (P < 0.01). In conclusion, miR-218 plays a pivotal role in CRC development through inhibiting cell proliferation and cycle progression and promoting apoptosis by downregulating BMI-1...
  45. ncbi request reprint Omeprazole before endoscopy in patients with gastrointestinal bleeding
    James Y Lau
    Institute of Digestive Disease, Chinese University of Hong Kong, Shatin, Hong Kong, China
    N Engl J Med 356:1631-40. 2007
    ..A neutral gastric pH is critical for the stability of clots over bleeding arteries. We investigated the effect of preemptive infusion of omeprazole before endoscopy on the need for endoscopic therapy...
  46. ncbi request reprint Comparison of EUS and ERCP in the investigation with suspected biliary obstruction caused by choledocholithiasis: a randomized study
    Yuk Tong Lee
    Institute of Digestive Disease, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Gastrointest Endosc 67:660-8. 2008
    ..EUS may be used to reduce the need of diagnostic ERCP...
  47. doi request reprint Upper gastrointestinal tract phenotype of Crohn's disease is associated with early surgery and further hospitalization
    Dorothy K L Chow
    Institute of Digestive Disease, Chinese University of Hong Kong, Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong
    Inflamm Bowel Dis 15:551-7. 2009
    ..We studied the clinical course of CD in Chinese patients presenting with the L4 phenotype and factors predicting its occurrence upon longitudinal follow-up...
  48. ncbi request reprint Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma
    Wai K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Int J Oncol 23:1317-22. 2003
    ..Future studies should evaluate the potential anti-angiogenic effect of COX-2 inhibitors on human gastric cancer...
  49. doi request reprint Changes in the choice of colorectal cancer screening tests in primary care settings from 7,845 prospectively collected surveys
    Martin C S Wong
    School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, 4 F, School of Public Health and Primary Care, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China
    Cancer Causes Control 23:1541-8. 2012
    ..This study examined factors influencing the choice of participants between colonoscopy and fecal immunochemical test (FIT) in a screening program and the impact of an unbiased educational session on influencing this decision...
  50. doi request reprint Interaction of Helicobacter pylori infection and low-dose aspirin in the upper gastrointestinal tract: implications for clinical practice
    En Ling Leung Ki
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, S A R, PR China
    Best Pract Res Clin Gastroenterol 26:163-72. 2012
    ..pylori in upper gastrointestinal tract injury in low-dose ASA users and on the effectiveness of H. pylori eradication in reducing the risk of complications such as rebleeding in high-risk patients...
  51. doi request reprint The efficacy of cap-assisted colonoscopy in polyp detection and cecal intubation: a meta-analysis of randomized controlled trials
    Siew C Ng
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Am J Gastroenterol 107:1165-73. 2012
    ..The role of cap-assisted colonoscopy (CAC) in polyp detection and cecal intubation is unclear. We conducted a meta-analysis to compare the efficacy of CAC vs. standard colonoscopy (SC)...
  52. doi request reprint The risk of peptic ulcer bleeding mortality in relation to hospital admission on holidays: a cohort study on 8,222 cases of peptic ulcer bleeding
    Kelvin K F Tsoi
    Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Am J Gastroenterol 107:405-10. 2012
    ..This study sets to investigate whether mortality among patients with PUB differs between holiday and weekday admissions, and also to investigate the association between mortality and the waiting time for endoscopy...
  53. doi request reprint Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer
    Xin Liu
    Institute of Digestive Disease, Department of Medicine and Therapeutics, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Tumour Biol 30:242-8. 2009
    ..In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development...
  54. doi request reprint Comparing the Blatchford and pre-endoscopic Rockall score in predicting the need for endoscopic therapy in patients with upper GI hemorrhage
    Sandy H Pang
    Institute of Digestive Diseases, Chinese University of Hong Kong, Shatin NT, Hong Kong
    Gastrointest Endosc 71:1134-40. 2010
    ..The need for therapeutic endoscopy in patients with upper GI hemorrhage is important in determining the risk and disposition of these patients. Pre-endoscopic risk scores may be helpful in predicting this need...
  55. doi request reprint Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer
    Jun Yu
    Institute of Digestive Disease, Department of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
    Cancer 115:49-60. 2009
    ..In this study, the authors investigated the promoter methylation of the dickkopf homolog 3 gene Dkk-3 in these cancers and its prognostic significance in gastric cancer...
  56. ncbi request reprint Levofloxacin-resistant Helicobacter pylori in Hong Kong
    Ching Ching Lee
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China
    Chemotherapy 54:50-3. 2008
    ..In this study we investigate the resistance mechanism and the antimicrobial susceptibilities of clarithromycin, metronidazole, amoxicillin, tetracycline and telithromycin against levofloxacin-resistant H. pylori in Hong Kong...
  57. ncbi request reprint Risk factors associated with the development of intestinal metaplasia in first-degree relatives of gastric cancer patients
    Wai K Leung
    Department of Medicine and Therapeutics, 9th Floor, Clinical Sciences Building, Prince of Wales Hospital, Ngan Shing Street, Shatin, Hong Kong, P R China
    Cancer Epidemiol Biomarkers Prev 14:2982-6. 2005
    ..In conclusion, we have identified risk factors associated with gastric intestinal metaplasia in stomach cancer relatives, which may be useful in the understanding of gastric carcinogenesis in these high-risk individuals...
  58. pmc The knowledge of colorectal cancer symptoms and risk factors among 10,078 screening participants: are high risk individuals more knowledgeable?
    Martin C S Wong
    Institute of Digestive Disease, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 8:e60366. 2013
    ..We tested the a priori hypothesis that self-perceived and real presences of risks for colorectal cancer (CRC) are associated with better knowledge of the symptoms and risk factors for CRC, respectively...
  59. ncbi request reprint EUS in the management of uninvestigated dyspepsia
    Yuk Tong Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, China
    Gastrointest Endosc 56:842-8. 2002
    ..Management of dyspepsia often involves multiple diagnostic tests. By virtue of luminal and extraluminal imaging, EUS may be a satisfactory single test for the evaluation of patients with dyspepsia...
  60. ncbi request reprint Treatment of diarrhea-predominant irritable bowel syndrome with traditional Chinese herbal medicine: a randomized placebo-controlled trial
    Wai K Leung
    Institute of Digestive Disease, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Am J Gastroenterol 101:1574-80. 2006
    ..We investigated the therapeutic efficacy of an ancient herbal Chinese formula in patients with diarrhea-predominant IBS...
  61. doi request reprint Effect of amlodipine on platelet inhibition by clopidogrel in patients with ischaemic heart disease: a randomised, controlled trial
    Andrew Y W Li
    Department of Medicine and Geriatrics, Ruttonjee Hospital, Hong Kong, China
    Heart 99:468-73. 2013
    ..Amlodipine inhibits cytochrome P450 (CYP) enzyme and has the potential to reduce clopidogrel bioactivation in vivo. Reports in previous retrospective studies described greater platelet reactivity in patients on amlodipine...
  62. doi request reprint Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis
    Alfred S L Cheng
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Gastroenterology 144:122-133.e9. 2013
    ..Promoter hypermethylation occurs during Helicobacter pylori-induced gastritis. We investigated whether the deregulated genes contribute to gastric tumorigenesis...
  63. doi request reprint Capsule endoscopy or angiography in patients with acute overt obscure gastrointestinal bleeding: a prospective randomized study with long-term follow-up
    Wai K Leung
    Institute of Digestive Disease, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Am J Gastroenterol 107:1370-6. 2012
    ..However, no studies have directly compared the two modalities in patients with overt OGIB. We compared the diagnostic yield and long-term outcomes of patients with overt OGIB randomized to CE or angiogram...
  64. doi request reprint Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps
    Chung Wah Wu
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Gut 61:739-45. 2012
    ..The detection of molecular markers in stool samples is a potential strategy for colorectal cancer (CRC) screening. This study evaluated the feasibility of detecting miR-21 and miR-92a in stool samples of patients with CRC or polyps...
  65. doi request reprint Nonsteroid anti-inflammatory drug-induced gastroduodenal injury
    Larry H Lai
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong S A R, China
    Curr Opin Gastroenterol 25:544-8. 2009
    ..This article reviews selected publications related to nonsteroid anti-inflammatory drug (NSAID)-induced gastroduodenal toxicity in recent years...
  66. ncbi request reprint Detection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer: a feasibility study
    Wai K Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Chem 50:2179-82. 2004
  67. ncbi request reprint Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer
    Anthony W H Chan
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, SAR
    Oncol Rep 13:937-41. 2005
    ..041), advance stage of disease (p=0.029) and a poorer event-free survival (log-rank test p=0.0141). DAP-kinase promoter methylation as a potential prognostic marker for gastric cancer patients deserved further evaluation...
  68. doi request reprint NSAID-induced gastrointestinal and cardiovascular injury
    Siew C Ng
    Institute of Digestive Disease, Chinese University of Hong Kong, Department of Medicine and Therapeutics, Prince of Wales Hospital, Shalin, NT, Hong Kong
    Curr Opin Gastroenterol 26:611-7. 2010
    ..To review recent publications related to NSAID-induced adverse effects on the gastrointestinal and cardiovascular systems...
  69. pmc Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells
    Ya C Wu
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    PLoS ONE 7:e37572. 2012
    ..Collectively, we demonstrate that H(2)S inhibits colon epithelial cell proliferation and induces protective autophagy via the AMPK pathway...
  70. doi request reprint Endoscopic submucosal dissection versus local excision for early rectal neoplasms: a comparative study
    Sophie S F Hon
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Surg Endosc 25:3923-7. 2011
    ..To date, no report comparing the two approaches can be found in the literature. This study aimed to compare the short-term clinical outcomes between ESD and LE for early rectal neoplasms...
  71. ncbi request reprint Magnetic resonance colonography in the detection of colonic neoplasm in high-risk and average-risk individuals
    Wai K Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Am J Gastroenterol 99:102-8. 2004
    ..However, the use of MRC in the detection of colorectal neoplasm in average-risk individuals remains unknown. This study determined the performance and the patient's preference of MRC in the detection of colorectal neoplasm...
  72. doi request reprint Asia-Pacific Working Group consensus on non-variceal upper gastrointestinal bleeding
    Joseph J Y Sung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Gut 60:1170-7. 2011
    ..Aspirin should be resumed soon after stabilisation and clopidogrel alone is no safer than aspirin plus a PPI. When dual antiplatelet agents are used, prophylactic use of a PPI reduces the risk of adverse gastrointestinal events...
  73. ncbi request reprint Obstacles to colorectal cancer screening in Chinese: a study based on the health belief model
    Joseph J Y Sung
    School of Public Health, Faculty of Medicine of the Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Am J Gastroenterol 103:974-81. 2008
    ..Colorectal cancer (CRC) has emerged as the second most common cancer in Asia. This study uses the Health Belief Model (HBM) to examine the factors associated with the uptake of CRC testing...
  74. ncbi request reprint Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues
    Wai K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Pathol 197:582-8. 2002
    ..Progressive loss of TFF1 and TFF2, together with the induction of TFF3, is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway...
  75. ncbi request reprint Screening for colorectal cancer in Chinese: comparison of fecal occult blood test, flexible sigmoidoscopy, and colonoscopy
    Joseph J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Gastroenterology 124:608-14. 2003
    ..The aim of this study was to compare the accuracy and safety of these 3 screening procedures in a general population of ethnic Chinese...
  76. doi request reprint Increased liver stiffness measurement by transient elastography in severe acute exacerbation of chronic hepatitis B
    Grace L H Wong
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Gastroenterol Hepatol 24:1002-7. 2009
    ..We aimed to assess the effect of necroinflammatory activity on LSM in this condition...
  77. doi request reprint Management of patients on nonsteroidal anti-inflammatory drugs: a clinical practice recommendation from the First International Working Party on Gastrointestinal and Cardiovascular Effects of Nonsteroidal Anti-inflammatory Drugs and Anti-platelet Agents
    Francis K L Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong
    Am J Gastroenterol 103:2908-18. 2008
    ..Prescribing nonsteroidal antiinflammatory drugs (NSAIDs) is challenging because physicians have to consider gastrointestinal (GI) and cardiovascular (CV) safety issues...
  78. ncbi request reprint Empirical treatment based on "typical" reflux symptoms is inappropriate in a population with a high prevalence of Helicobacter pylori infection
    Justin C Y Wu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Gastrointest Endosc 55:461-5. 2002
    ..The objective of this study was to determine whether diagnosis and empirical treatment based on reflux symptoms alone are appropriate as initial management for patients with gastroesophageal reflux...
  79. ncbi request reprint Small bowel enteropathy associated with chronic low-dose aspirin therapy
    Wai K Leung
    Institute of Digestive Disease, The Chinese University of Hong Kong and Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong, China
    Lancet 369:614. 2007
  80. ncbi request reprint Intestinal trefoil factor promotes invasion in non-tumorigenic Rat-2 fibroblast cell
    Victor Y W Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Regul Pept 127:87-94. 2005
    ..5-37.8%) in TFF3-transfected cells compared to controls during 48-h incubation. Our results suggested that TFF3 possesses malignant potential through promotion of cell invasiveness and alteration of invasion-related genes...
  81. ncbi request reprint Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy
    Wai K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong, China
    World J Gastroenterol 11:4865-8. 2005
    ..To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy...
  82. doi request reprint Cigarette smoking and the risk of colorectal cancer: a meta-analysis of prospective cohort studies
    Kelvin K F Tsoi
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, PRC
    Clin Gastroenterol Hepatol 7:682-688.e1-5. 2009
    ..Smoking has been implicated in many malignant diseases, but its association with colorectal cancer (CRC) is controversial. We quantitatively evaluated the relation between smoking and incidence of CRC in a meta-analysis of cohort studies...
  83. ncbi request reprint Changes in Crohn's disease phenotype over time in the Chinese population: validation of the Montreal classification system
    Dorothy K L Chow
    Institute of Digestive Disease, Chinese University of Hong Kong, Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong
    Inflamm Bowel Dis 14:536-41. 2008
    ..The aim of this study was to validate the Montreal classification through a longitudinal sensitivity analysis in detecting phenotypic variation compared to the Vienna classification...
  84. ncbi request reprint Role of acid suppressants in prophylaxis of NSAID damage
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong
    Best Pract Res Clin Gastroenterol 15:433-45. 2001
    ..pylori -infected NSAID users. The efficacy of PPIs for the prevention of ulcer complications in H. pylori-negative NSAID users remains uncertain...
  85. ncbi request reprint Non-invasive serological detection of Helicobacter pylori antigens in adult Hong Kong Chinese non-ulcer dyspepsia patients
    Vivian W Y Lee
    School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Curr Microbiol 54:249-53. 2007
    ..pylori test), an office-based serological test and to compare relative performances with endoscopy, including biopsy urease tests (Clotest), histology, and culture when applied to dyspeptic adult patients in Hong Kong Chinese...
  86. ncbi request reprint EUS-guided injection of cyanoacrylate for bleeding gastric varices
    Y T Lee
    Departments of Medicine and Therapeutics and Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, China
    Gastrointest Endosc 52:168-74. 2000
    ..Our aim was to investigate the use of endosonography (EUS) in monitoring cyanoacrylate injection to obliterate gastric varices...
  87. ncbi request reprint Validation of a new immunoblot assay for the diagnosis of Helicobacter pylori in the Asian population
    W K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 15:423-8. 2001
    ..Currently available serology tests often show sub-optimal accuracy when used for Asian patients...
  88. pmc Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions
    J J Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Am J Pathol 157:729-35. 2000
    ..Both premalignant and malignant gastric lesions demonstrate strong COX-2 expression. Successful eradication of H. pylori leads to down-regulation of COX-2 expression but failed to reverse IM at 1 year...
  89. ncbi request reprint One-week ranitidine bismuth citrate in combinations with metronidazole, amoxycillin and clarithromycin in the treatment of Helicobacter pylori infection: the RBC-MACH study
    J J Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 13:1079-84. 1999
    ..We have previously shown that ranitidine bismuth citrate (RBC)-based triple therapy is comparable to proton pump inhibitor-based triple therapy in eradicating Helicobacter pylori infection...
  90. ncbi request reprint Non-steroidal anti-inflammatory drug toxicity in the upper gastrointestinal tract
    J Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT
    J Gastroenterol Hepatol 15:G58-68. 2000
    ..The use of potent anti-ulcer therapy, treatment of H. pylori infection and the development of Cox-II inhibitor will change the scenario of NSAID/aspirin-related gastrointestinal toxicity in the next millennium...
  91. ncbi request reprint Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer
    K F To
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, People s Republic of China
    Life Sci 70:483-9. 2001
    ..Our results suggested that alterations of FzE3 or hsFRP were frequent in gastric cancer. These provide alternative mechanisms leading to activation of Wnt signaling pathway in gastric carcinogenesis...
  92. ncbi request reprint Apoptosis and proliferation in Helicobacter pylori-associated gastric intestinal metaplasia
    W K Leung
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Aliment Pharmacol Ther 15:1467-72. 2001
    ..Imbalance between apoptosis and proliferation may be one of the mechanisms underlying H. pylori associated gastric carcinogenesis...
  93. ncbi request reprint Comparison of two new rapid serology tests for diagnosis of Helicobacter pylori infection in Chinese patients
    C T Hung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Dig Liver Dis 34:111-5. 2002
    ..Rapid serology test is a simple and convenient way for diagnosing Helicobacter pylori infection. However performances of these tests are usually less satisfactory than expected, particularly in developing countries...
  94. ncbi request reprint Inverse association between cyclooxygenase-2 overexpression and microsatellite instability in gastric cancer
    T L Lee
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Cancer Lett 168:133-40. 2001
    ..07). The results from this study suggest that gastric cancer with microsatellite instability or COX-2 overexpression present with diverse clinicopathological features...
  95. ncbi request reprint Helicobacter pylori infection in Chinese subjects with type 2 diabetes
    G T Ko
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Pirnce of Wales Hospital, Shatin
    Endocr Res 27:171-7. 2001
    ..No association was found between HP infection, glycaemic status, and duration of diabetes and upper gastrointestinal symptoms in these diabetic subjects...
  96. ncbi request reprint Is non-Helicobacter pylori, non-NSAID peptic ulcer a common cause of upper GI bleeding? A prospective study of 977 patients
    H L Chan
    Departments of Medicine and Therapeutics, Surgery, and Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China
    Gastrointest Endosc 53:438-42. 2001
    ..Whether it is a significant problem in the Orient is unclear. The aim of this study was to investigate the incidence of non-H pylori, non-NSAID ulcers presenting with GI bleeding...
  97. ncbi request reprint Effect of Helicobacter pylori eradication on expression of cyclin D2 and p27 in gastric intestinal metaplasia
    J Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Aliment Pharmacol Ther 15:1505-11. 2001
    ..pylori-associated intestinal metaplasia. Eradication of H. pylori infection reverses the aberrant expression of cyclin D2 and p27 in intestinal metaplasia...
  98. ncbi request reprint Dysfunction of oesophageal motility in Helicobacter pylori-infected patients with reflux oesophagitis
    J C Wu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 15:1913-9. 2001
    ..Helicobacter pylori infection has been suggested to be protective against gastro-oesophageal reflux disease. However, a significant proportion of patients with gastro-oesophageal reflux disease are infected by H. pylori...
  99. ncbi request reprint Ulcers and gastritis
    W K Leung
    Institute of Digestive Diseases and Dept of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Endoscopy 38:2-4. 2006
  100. pmc Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer
    W K Leung
    Departments of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Br J Cancer 84:335-9. 2001
    ..3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer...
  101. ncbi request reprint Incidence of gastroesophageal malignancy in patients with dyspepsia in Hong Kong: implications for screening strategies
    J J Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Gastrointest Endosc 54:454-8. 2001
    ..This finding raises concerns as to the safety of the "test-and-treat" strategy for the management of patients with dyspepsia in Asia...