Larry W Baum

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Apolipoprotein E epsilon4 allele is associated with vascular dementia
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
    Dement Geriatr Cogn Disord 22:301-5. 2006
  2. ncbi request reprint Curcumin effects on blood lipid profile in a 6-month human study
    Larry Baum
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Pharmacol Res 56:509-14. 2007
  3. ncbi request reprint Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy
    Larry Baum
    School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Hum Genet 133:651-9. 2014
  4. ncbi request reprint Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Chem Lab Med 44:274-81. 2006
  5. ncbi request reprint Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Biochem 39:191-5. 2006
  6. ncbi request reprint Sex, hormones, and Alzheimer's disease
    Larry W Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    J Gerontol A Biol Sci Med Sci 60:736-43. 2005
  7. ncbi request reprint Developing the use of mismatch binding proteins for discovering rare somatic mutations
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Mol Cell Probes 19:163-8. 2005
  8. ncbi request reprint Polymorphisms and vascular cognitive impairment after ischemic stroke
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    J Geriatr Psychiatry Neurol 20:93-9. 2007
  9. ncbi request reprint Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin
    J Alzheimers Dis 6:367-77; discussion 443-9. 2004
  10. ncbi request reprint APOA5-1131T>C polymorphism is associated with triglyceride levels in Chinese men
    L Baum
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin Genet 63:377-9. 2003

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Apolipoprotein E epsilon4 allele is associated with vascular dementia
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
    Dement Geriatr Cogn Disord 22:301-5. 2006
    ..The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study...
  2. ncbi request reprint Curcumin effects on blood lipid profile in a 6-month human study
    Larry Baum
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Pharmacol Res 56:509-14. 2007
    ..Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol...
  3. ncbi request reprint Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy
    Larry Baum
    School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Hum Genet 133:651-9. 2014
    ..10). SCN1A rs2298771 was associated in Indians (OR = 0.56, p = 0.005) and SCN2B rs602594 with idiopathic epilepsy (OR = 0.62, p = 0.002). Therefore, sodium channel polymorphisms are associated with epilepsy. ..
  4. ncbi request reprint Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Chem Lab Med 44:274-81. 2006
    ....
  5. ncbi request reprint Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction risk
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Biochem 39:191-5. 2006
    ..Paraoxonase (PON1), an enzyme associated with high-density lipoprotein (HDL) particles, inhibits oxidation and atherogenesis. We sought to investigate the association of the PON1 Q192R polymorphism with stroke and heart disease...
  6. ncbi request reprint Sex, hormones, and Alzheimer's disease
    Larry W Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    J Gerontol A Biol Sci Med Sci 60:736-43. 2005
    ..Further study is required to discern by which of several possible mechanisms HRT increases dementia risk...
  7. ncbi request reprint Developing the use of mismatch binding proteins for discovering rare somatic mutations
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Mol Cell Probes 19:163-8. 2005
    ....
  8. ncbi request reprint Polymorphisms and vascular cognitive impairment after ischemic stroke
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    J Geriatr Psychiatry Neurol 20:93-9. 2007
    ..Testing the GCLM genotype in an independent group of stroke patients may determine whether this association with vascular cognitive impairment is genuine...
  9. ncbi request reprint Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin
    J Alzheimers Dis 6:367-77; discussion 443-9. 2004
    ....
  10. ncbi request reprint APOA5-1131T>C polymorphism is associated with triglyceride levels in Chinese men
    L Baum
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin Genet 63:377-9. 2003
    ..The C allele is more common in Chinese than in Caucasians (26-40% vs. 8% of alleles), suggesting that the impact of this polymorphism on triglyceride levels in the population and therefore on public health is greater among Chinese...
  11. doi request reprint Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability
    Larry Baum
    School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
    Biometals 23:173-9. 2010
    ..The arsenic correlation might be caused by the major contribution of seafood consumption to intake of both arsenic and docosahexaenoic acid, of which the latter may delay AD...
  12. pmc EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes
    Haitao Li
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong, China
    Mol Vis 14:1698-704. 2008
    ..We tested the hypothesis that genetic variants in vasoactive and angiogenic factors regulating the retina vasculature contribute to the development of diabetic retinopathy (DR)...
  13. ncbi request reprint Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese
    Celeste B L Man
    Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Epilepsia 48:1015-8. 2007
    ..Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals...
  14. doi request reprint Apolipoprotein E polymorphism and expression in type 2 diabetic patients with nephropathy: clinicopathological correlation
    Jing Guan
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
    Nephrol Dial Transplant 24:1889-95. 2009
    ..There have been clinical reports on the risk association of diabetic nephropathy with an apolipoprotein E (ApoE) exon 4 polymorphism although its correlations with renal histopathological changes have not been explored...
  15. ncbi request reprint Effect of hepatic lipase -514C->T polymorphism and its interactions with apolipoprotein C3 -482C->T and apolipoprotein E exon 4 polymorphisms on the risk of nephropathy in chinese type 2 diabetic patients
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    Diabetes Care 28:1704-9. 2005
    ..We hypothesized that the HL -514C-->T polymorphism, which reduces HL expression, and its interactions with polymorphisms in apolipoprotein (apo) E and apoC3 increase the risk of diabetic nephropathy...
  16. doi request reprint Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese
    Zhi Kai Liu
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
    Atherosclerosis 208:427-32. 2010
    ..We examined these associations with FCH in Hong Kong Chinese...
  17. doi request reprint Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in Chinese
    Youling Guo
    Department of Psychiatry and The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China
    Hum Mol Genet 21:1184-9. 2012
    ..Our results suggest that common genetic variants may increase the susceptibility to epilepsy in Chinese...
  18. ncbi request reprint A case-control study of apoA5 -1131T-->C polymorphism that examines the role of triglyceride levels in diabetic nephropathy
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    J Diabetes Complications 21:158-63. 2007
    ..The strong association between TG level and DN may be due to a factor that is usually closely linked to TG level but that is not affected by the apoA5 polymorphism...
  19. doi request reprint Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsy
    Chunbo Zhang
    School of Pharmacy, The Chinese University of Hong Kong, Hong Kong, China
    Epilepsia 51:1878-81. 2010
    ..The results do not suggest that SCN1A SNPs are susceptibility factors for FS in Han Chinese...
  20. ncbi request reprint TIGR/MYOC gene sequence alterations in individuals with and without primary open-angle glaucoma
    Chi Pui Pang
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Invest Ophthalmol Vis Sci 43:3231-5. 2002
    ..To discover sequence alterations in the TIGR/MYOC gene associated with primary open-angle glaucoma (POAG) in Chinese subjects...
  21. doi request reprint Gene-wide tagging study of association between ABCB1 polymorphisms and multidrug resistance in epilepsy in Han Chinese
    Patrick Kwan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong, China
    Pharmacogenomics 10:723-32. 2009
    ..To further study the potential association, we genotyped a broad set of tagging SNPs, and explored whether any associations were affected by other host factors. We correlated any association with cerebral mRNA expression of ABCB1...
  22. ncbi request reprint Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease
    Suk Ling Ma
    Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Neurosci Lett 332:216-8. 2002
    ..The latter was found in four AD patients (2.0%) and 11 controls (6.0%), a significant difference (P = 0.042). Further study is needed to confirm this possible association of LRP8 with AD...
  23. doi request reprint Amyloid oligomers in diabetic and nondiabetic human pancreas
    Hai Lu Zhao
    Department of Medicine and Therapeutics, Department of Anatomical and Cellular Pathology, Hong Kong Institute of Diabetes and Obesity, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
    Transl Res 153:24-32. 2009
    ..The observations warrant function studies to investigate the clinical implications of the amyloid oligomerization in the pathogenesis of type 2 diabetes...
  24. doi request reprint Higher islet amyloid load in men than in women with type 2 diabetes mellitus
    Hai Lu Zhao
    Departments of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Pancreas 37:e68-73. 2008
    ..Type 2 diabetes mellitus is characterized histopathologically by islet amyloid deposits formed from islet amyloid polypeptide. The aim of this study was to investigate sex difference in islet amyloid of type 2 diabetic patients...
  25. doi request reprint Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China
    Pharmacogenet Genomics 18:989-98. 2008
    ..We investigated the association of AED responsiveness with genetic polymorphisms and correlated any association with mRNA expression of the neuronal sodium channels...
  26. ncbi request reprint Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China
    Clin Chem Lab Med 42:1370-6. 2004
    ..Perhaps folate supplementation for stroke prevention would particularly benefit VV individuals in such high-risk regions...
  27. ncbi request reprint Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Epilepsy Behav 11:112-7. 2007
    ..5, 95% confidence interval=1.4-4.6, P=0.0009). Our results contrast with those of studies of Caucasians, and highlight the complexity of the possible role of this polymorphism in AED response in different ethnic populations...
  28. ncbi request reprint Genotype-phenotype studies of six novel LPL mutations in Chinese patients with hypertriglyceridemia
    Lisa Y S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, China
    Hum Mutat 20:232-3. 2002
    ..The heterogeneity in phenotypic effects of these mutations is a likely consequence of their variable effects on proteoglycan binding, conformation and interactions with other secondary genetic or environmental factors...
  29. ncbi request reprint ABCA4 sequence variants in Chinese patients with age-related macular degeneration or Stargardt's disease
    Larry Baum
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
    Ophthalmologica 217:111-4. 2003
    ..T1428M and R2040X occurred in STGD patients. Control subjects displayed all the above missense alterations but no splicing or nonsense changes. Therefore, ABCA4 splicing mutations may be associated with a small proportion of AMD cases...
  30. ncbi request reprint Familial high myopia linkage to chromosome 18p
    Dennis S C Lam
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
    Ophthalmologica 217:115-8. 2003
    ..4 at D18S476. While multiple genetic and environmental factors likely contribute to myopia, these data are consistent with the possibility of a locus on chromosome 18p...
  31. doi request reprint In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein
    Chunbo Zhang
    School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Life Sci 86:899-905. 2010
    ..We evaluated AEDs as P-gp substrates using cell monolayers...