Research Topics
Genomes and GenesSpecies | Larry W BaumSummaryAffiliation: The Chinese University of Hong Kong Country: China Publications
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Publications
Curcumin effects on blood lipid profile in a 6-month human studyLarry Baum
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
Pharmacol Res 56:509-14. 2007..Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol...- Polymorphisms and vascular cognitive impairment after ischemic strokeLarry Baum
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
J Geriatr Psychiatry Neurol 20:93-9. 2007..Testing the GCLM genotype in an independent group of stroke patients may determine whether this association with vascular cognitive impairment is genuine... - Apolipoprotein E epsilon4 allele is associated with vascular dementiaLarry Baum
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
Dement Geriatr Cogn Disord 22:301-5. 2006..The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study... - Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarctionLarry Baum
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
Clin Chem Lab Med 44:274-81. 2006.... - Paraoxonase 1 gene Q192R polymorphism affects stroke and myocardial infarction riskLarry Baum
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
Clin Biochem 39:191-5. 2006..Paraoxonase (PON1), an enzyme associated with high-density lipoprotein (HDL) particles, inhibits oxidation and atherogenesis. We sought to investigate the association of the PON1 Q192R polymorphism with stroke and heart disease... - Sex, hormones, and Alzheimer's diseaseLarry W Baum
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
J Gerontol A Biol Sci Med Sci 60:736-43. 2005..Further study is required to discern by which of several possible mechanisms HRT increases dementia risk... - Developing the use of mismatch binding proteins for discovering rare somatic mutationsLarry Baum
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, China
Mol Cell Probes 19:163-8. 2005.... - Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive abilityLarry Baum
School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
Biometals 23:173-9. 2010..The arsenic correlation might be caused by the major contribution of seafood consumption to intake of both arsenic and docosahexaenoic acid, of which the latter may delay AD... - Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal modelsLarry Baum
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin
J Alzheimers Dis 6:367-77; discussion 443-9. 2004.... - APOA5-1131T>C polymorphism is associated with triglyceride levels in Chinese menL Baum
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Clin Genet 63:377-9. 2003..The C allele is more common in Chinese than in Caucasians (26-40% vs. 8% of alleles), suggesting that the impact of this polymorphism on triglyceride levels in the population and therefore on public health is greater among Chinese... - EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetesHaitao Li
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong, China
Mol Vis 14:1698-704. 2008..We tested the hypothesis that genetic variants in vasoactive and angiogenic factors regulating the retina vasculature contribute to the development of diabetic retinopathy (DR)... - Apolipoprotein E polymorphism and expression in type 2 diabetic patients with nephropathy: clinicopathological correlationJing Guan
Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
Nephrol Dial Transplant 24:1889-95. 2009..There have been clinical reports on the risk association of diabetic nephropathy with an apolipoprotein E (ApoE) exon 4 polymorphism although its correlations with renal histopathological changes have not been explored... - Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han ChineseCeleste B L Man
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 48:1015-8. 2007..Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals... - Effect of hepatic lipase -514C->T polymorphism and its interactions with apolipoprotein C3 -482C->T and apolipoprotein E exon 4 polymorphisms on the risk of nephropathy in chinese type 2 diabetic patientsLarry Baum
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
Diabetes Care 28:1704-9. 2005..We hypothesized that the HL -514C-->T polymorphism, which reduces HL expression, and its interactions with polymorphisms in apolipoprotein (apo) E and apoC3 increase the risk of diabetic nephropathy... - Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong ChineseZhi Kai Liu
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
Atherosclerosis 208:427-32. 2010..We examined these associations with FCH in Hong Kong Chinese... - Gene-wide tagging study of association between ABCB1 polymorphisms and multidrug resistance in epilepsy in Han ChinesePatrick Kwan
Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong, China
Pharmacogenomics 10:723-32. 2009..To further study the potential association, we genotyped a broad set of tagging SNPs, and explored whether any associations were affected by other host factors. We correlated any association with cerebral mRNA expression of ABCB1... - Amyloid oligomers in diabetic and nondiabetic human pancreasHai Lu Zhao
Department of Medicine and Therapeutics, Department of Anatomical and Cellular Pathology, Hong Kong Institute of Diabetes and Obesity, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
Transl Res 153:24-32. 2009..The observations warrant function studies to investigate the clinical implications of the amyloid oligomerization in the pathogenesis of type 2 diabetes... - Higher islet amyloid load in men than in women with type 2 diabetes mellitusHai Lu Zhao
Departments of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Pancreas 37:e68-73. 2008..Type 2 diabetes mellitus is characterized histopathologically by islet amyloid deposits formed from islet amyloid polypeptide. The aim of this study was to investigate sex difference in islet amyloid of type 2 diabetic patients... - Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsyChunbo Zhang
School of Pharmacy, The Chinese University of Hong Kong, Hong Kong, China
Epilepsia 51:1878-81. 2010..The results do not suggest that SCN1A SNPs are susceptibility factors for FS in Han Chinese... - Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expressionPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China
Pharmacogenet Genomics 18:989-98. 2008..We investigated the association of AED responsiveness with genetic polymorphisms and correlated any association with mRNA expression of the neuronal sodium channels... - Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han ChinesePatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsy Behav 11:112-7. 2007..5, 95% confidence interval=1.4-4.6, P=0.0009). Our results contrast with those of studies of Caucasians, and highlight the complexity of the possible role of this polymorphism in AED response in different ethnic populations... - Genotype-phenotype studies of six novel LPL mutations in Chinese patients with hypertriglyceridemiaLisa Y S Chan
Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, China
Hum Mutat 20:232-3. 2002..The heterogeneity in phenotypic effects of these mutations is a likely consequence of their variable effects on proteoglycan binding, conformation and interactions with other secondary genetic or environmental factors... - A case-control study of apoA5 -1131T-->C polymorphism that examines the role of triglyceride levels in diabetic nephropathyLarry Baum
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
J Diabetes Complications 21:158-63. 2007..The strong association between TG level and DN may be due to a factor that is usually closely linked to TG level but that is not affected by the apoA5 polymorphism... - Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic strokeLarry Baum
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, PR China
Clin Chem Lab Med 42:1370-6. 2004..Perhaps folate supplementation for stroke prevention would particularly benefit VV individuals in such high-risk regions... - TIGR/MYOC gene sequence alterations in individuals with and without primary open-angle glaucomaChi Pui Pang
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
Invest Ophthalmol Vis Sci 43:3231-5. 2002..To discover sequence alterations in the TIGR/MYOC gene associated with primary open-angle glaucoma (POAG) in Chinese subjects... - Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's diseaseSuk Ling Ma
Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Neurosci Lett 332:216-8. 2002..The latter was found in four AD patients (2.0%) and 11 controls (6.0%), a significant difference (P = 0.042). Further study is needed to confirm this possible association of LRP8 with AD... - ABCA4 sequence variants in Chinese patients with age-related macular degeneration or Stargardt's diseaseLarry Baum
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
Ophthalmologica 217:111-4. 2003..T1428M and R2040X occurred in STGD patients. Control subjects displayed all the above missense alterations but no splicing or nonsense changes. Therefore, ABCA4 splicing mutations may be associated with a small proportion of AMD cases... - Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in ChineseYouling Guo
Department of Psychiatry and The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China
Hum Mol Genet 21:1184-9. 2012..Our results suggest that common genetic variants may increase the susceptibility to epilepsy in Chinese... - In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoproteinChunbo Zhang
School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
Life Sci 86:899-905. 2010..We evaluated AEDs as P-gp substrates using cell monolayers... - Familial high myopia linkage to chromosome 18pDennis S C Lam
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
Ophthalmologica 217:115-8. 2003..4 at D18S476. While multiple genetic and environmental factors likely contribute to myopia, these data are consistent with the possibility of a locus on chromosome 18p...