Wu L, Chen Y, Liu H, Zhan Z, Liang Z, Zhang T, et al
. Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2. Toxicol Appl Pharmacol. 2018;359:91-101 pubmed publisher
Wu L, Zhong W, Liu J, Han W, Zhong S, Wei Q, et al
. Human microsomal cyttrochrome P450-mediated reduction of oxysophocarpine, an active and highly toxic constituent derived from Sophora flavescens species, and its intestinal absorption and metabolism in rat. Fitoterapia. 2015;105:26-36 pubmed publisher
..In conclusion, the liver was the main organ responsible for OSC metabolism. First-pass metabolism via CYP3A4/5, 2B6, 2D6, and 2C9 may be the main reason for the poor OSC bioavailability. ..
He J, Lu X, Wei T, Dong Y, Cai Z, Tang L, et al
. Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. Int J Mol Sci. 2018;19: pubmed publisher
Chen R, He J, Tong X, Tang L, Liu M. The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics. Molecules. 2016;21: pubmed publisher
..The present review aims to provide up-to-date and comprehensive information on the phytochemistry, pharmacology, quality control and pharmacokinetic characteristics of H. diffusa for its clinical use and further development. ..
He J, Li J, Liu H, Yang Z, Zhou F, Wei T, et al
. Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-?B and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. Int J Mol Sci. 2018;19: pubmed publisher
Hou C, Liu W, Liang Z, Han W, Li J, Ye L, et al
. UGT-mediated metabolism plays a dominant role in the pharmacokinetic behavior and the disposition of morusin in vivo and in vitro. J Pharm Biomed Anal. 2018;154:339-353 pubmed publisher
..In conclusion, glucuronidation was confirmed to be the crucial metabolic pathway for morusin in vivo, and M-4'-G was the main metabolite. ..
Zhong S, Han W, Hou C, Liu J, Wu L, Liu M, et al
. Relation of Transcriptional Factors to the Expression and Activity of Cytochrome P450 and UDP-Glucuronosyltransferases 1A in Human Liver: Co-Expression Network Analysis. AAPS J. 2017;19:203-214 pubmed publisher
..We detected several novel TFs involved in the regulatory network of hepatic CYPs and UGTs in humans. Further validation and investigation may reveal their exact mechanism of CYPs/UGTs regulation. ..
Liu J, Yu X, Zhong S, Han W, Liang Z, Ye L, et al
. Hepatic and renal metabolism of genistein: An individual-based model to predict glucuronidation behavior of genistein in different organs. J Pharm Biomed Anal. 2017;139:252-262 pubmed publisher
..In conclusion, the individual-based model can be employed for predicting individual glucuronidation behavior of genistein in different organs. ..
Liang Z, Xu C, Dong L, Fu Y, Wu Q, Zhao J, et al
. Involvement of UDP-glucuronosyltransferases in higenamine glucuronidation and the gender and species differences in liver. Biomed Pharmacother. 2017;93:172-179 pubmed publisher
..UGT1A9 is a major isoenzyme responsible for the glucuronidation of HG in Human liver microsomes (HLMs). Dog may be an appropriate animal model to evaluate HG metabolism. ..