Lan Tan

Summary

Country: China

Publications

  1. pmc Genome-wide microRNA profiling of rat hippocampus after status epilepticus induced by amygdala stimulation identifies modulators of neuronal apoptosis
    Zhen Sun
    Department of Neurology, Qingdao Municipal Hospital, Taishan Medical University, Qingdao, China
    PLoS ONE 8:e78375. 2013
  2. pmc Meta-analysis of peripheral blood apolipoprotein e levels in Alzheimer's disease
    Chong Wang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong, China
    PLoS ONE 9:e89041. 2014
  3. ncbi request reprint Epidemiology and etiology of Alzheimer's disease: from genetic to non-genetic factors
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province 266071, China
    Curr Alzheimer Res 10:852-67. 2013
  4. doi request reprint Association of GWAS-linked loci with late-onset Alzheimer's disease in a northern Han Chinese population
    Lan Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, PR China
    Alzheimers Dement 9:546-53. 2013
  5. doi request reprint The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations
    Lin Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China
    J Neurol Sci 323:1-8. 2012
  6. ncbi request reprint Intranasal anticonvulsive treatment: a prospective management of intractable epilepsy?
    Lan Tan
    College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, Shandong Province, PR China
    Med Hypotheses 71:542-5. 2008
  7. ncbi request reprint Resveratrol exerts pharmacological preconditioning by activating PGC-1alpha
    Lan Tan
    College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, Shandong Province, PR China
    Med Hypotheses 71:664-7. 2008
  8. ncbi request reprint The influence of cytochrome oxidase CYP2A6, CYP2B6, and CYP2C9 polymorphisms on the plasma concentrations of valproic acid in epileptic patients
    Lan Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province 266071, China
    Clin Neurol Neurosurg 112:320-3. 2010
  9. doi request reprint Association of TOMM40 polymorphisms with late-onset Alzheimer's disease in a Northern Han Chinese population
    Xiao Ying Ma
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao 266071, China
    Neuromolecular Med 15:279-87. 2013
  10. doi request reprint SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population
    Hui Fu Wang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China
    Brain Res 1448:111-6. 2012

Collaborators

Detail Information

Publications86

  1. pmc Genome-wide microRNA profiling of rat hippocampus after status epilepticus induced by amygdala stimulation identifies modulators of neuronal apoptosis
    Zhen Sun
    Department of Neurology, Qingdao Municipal Hospital, Taishan Medical University, Qingdao, China
    PLoS ONE 8:e78375. 2013
    ..Taken together, our data suggest that miRNAs are important modulators of SE-induced neuronal apoptosis. These findings also open new avenues for future studies aimed at developing strategies against neuronal apoptosis after SE. ..
  2. pmc Meta-analysis of peripheral blood apolipoprotein e levels in Alzheimer's disease
    Chong Wang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong, China
    PLoS ONE 9:e89041. 2014
    ..This meta-analysis was designed to re-examine the potential role of peripheral ApoE in AD diagnosis and its potential value as a candidate biomarker...
  3. ncbi request reprint Epidemiology and etiology of Alzheimer's disease: from genetic to non-genetic factors
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province 266071, China
    Curr Alzheimer Res 10:852-67. 2013
    ..In addition, public health campaigns targeted at modification of non-genetic risk factors should be developed among population at high risk of AD. ..
  4. doi request reprint Association of GWAS-linked loci with late-onset Alzheimer's disease in a northern Han Chinese population
    Lan Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, PR China
    Alzheimers Dement 9:546-53. 2013
    ..These studies have been conducted almost exclusively in white populations and it is unclear whether these observations generalize to populations with different ethnicities...
  5. doi request reprint The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations
    Lin Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China
    J Neurol Sci 323:1-8. 2012
    ..In this review we discuss the mechanistic and therapeutic considerations of KP in aging and the main neurodegenerative diseases and review the updated knowledge in this therapeutic field...
  6. ncbi request reprint Intranasal anticonvulsive treatment: a prospective management of intractable epilepsy?
    Lan Tan
    College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, Shandong Province, PR China
    Med Hypotheses 71:542-5. 2008
    ..Our hypothesis provides not only a new alternative treatment for intractable epilepsy but also has potential for investigating the mechanisms underlying the development of pharmacoresistance in epilepsy...
  7. ncbi request reprint Resveratrol exerts pharmacological preconditioning by activating PGC-1alpha
    Lan Tan
    College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, Shandong Province, PR China
    Med Hypotheses 71:664-7. 2008
    ..Attempts to confirm this hypothesis will provide new directions in the study of pharmaceutical preconditioning and the development of new treatment approaches for reducing the extent of ischemia/reperfusion injury...
  8. ncbi request reprint The influence of cytochrome oxidase CYP2A6, CYP2B6, and CYP2C9 polymorphisms on the plasma concentrations of valproic acid in epileptic patients
    Lan Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province 266071, China
    Clin Neurol Neurosurg 112:320-3. 2010
    ..To investigate influences of the functional polymorphisms of Cytochrome P450 isozymes 2A6 (CYP2A6), 2B6 (CYP2B6), and 2C9 (CYP2C9) on pharmacokinetics of VPA in vivo...
  9. doi request reprint Association of TOMM40 polymorphisms with late-onset Alzheimer's disease in a Northern Han Chinese population
    Xiao Ying Ma
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao 266071, China
    Neuromolecular Med 15:279-87. 2013
    ..In summary, our findings suggest that the TOMM40 polymorphisms may play a role in the pathogenesis of LOAD in Han Chinese...
  10. doi request reprint SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population
    Hui Fu Wang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China
    Brain Res 1448:111-6. 2012
    ..019, OR=0.523) and haplotype analysis (GCC: P=0.002, ATT: P=0.002, ACC: P=0.025) in this subset. Our data suggested that SORCS1 was in interaction with APOE in the development of LOAD in a Northern Han Chinese population...
  11. ncbi request reprint Complement receptor 1 polymorphisms and risk of late-onset Alzheimer's disease
    Qun Zhang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China
    Brain Res 1348:216-21. 2010
    ..03, OR=2.44). This study provides the evidence that variations in the CR1 gene play an important role in the pathogenesis of sporadic LOAD in the Han Chinese population...
  12. ncbi request reprint Common variants in toll-like receptor 4 confer susceptibility to Alzheimer's disease in a Han Chinese population
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China
    Curr Alzheimer Res 9:458-66. 2012
    ..7x10-6, Pc s1.0x10-4). Our data suggests that the TLR4 gene contributes to the susceptibility for LOAD in Han Chinese...
  13. ncbi request reprint Age-dependent association of KIBRA gene polymorphism with Alzheimer's disease in Han Chinese
    Hui Fu Wang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China
    Mol Biol Rep 40:7077-82. 2013
    ..045, OR = 0.428). Our data suggested that KIBRA might associate with younger AD patients (≤74 years) in a Northern Han Chinese population. ..
  14. doi request reprint NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese
    Meng Shan Tan
    Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China
    J Neuroimmunol 265:91-5. 2013
    ..Our data support the notion that genetic variation in NLRP3 gene may contribute to LOAD risk in Northern Han Chinese. ..
  15. ncbi request reprint Neuropeptide Y polymorphisms and ischemic stroke in Chinese population
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China
    Clin Chim Acta 411:242-5. 2010
    ..Stroke is the second most common cause of death in developed countries and a major cause of adult disability and mortality worldwide. New data strongly suggest that neuropeptide Y (NPY) may be a candidate gene for ischemic stroke...
  16. doi request reprint Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, Affiliated Hospital of Qingdao University, Shandong Province, PR China
    Brain Res 1253:169-75. 2009
    ..62, P=0.003, Power=0.97). These findings suggest that the functional polymorphisms in IL-18 promoter may be involved in the risk of developing sporadic LOAD in the Han Chinese population...
  17. doi request reprint Implication of IL-33 gene polymorphism in Chinese patients with Alzheimer's disease
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
    Neurobiol Aging 33:1014.e11-4. 2012
    ..021; additive model: OR = 0.71, p = 0.004) after adjusting for age, gender, and the apolipoprotein E (APOE) ε4 status. Our results support the evidence that genetic variants of IL-33 affect susceptibility to LOAD in Han Chinese...
  18. doi request reprint Lack of association between rs597668 polymorphism near EXOC3L2 and late-onset Alzheimer's disease in Han Chinese
    Qiu Yan Liu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, PR China
    Neurosci Lett 513:174-7. 2012
    ..This study suggests that the rs597668 polymorphism near EXOC3L2 may not play a major role in the susceptibility to LOAD in the Northern Han Chinese population...
  19. doi request reprint Single nucleotide polymorphism rs1333049 on chromosome 9p21.3 is associated with Alzheimer's disease in Han Chinese
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China
    Clin Chim Acta 411:1204-7. 2010
    ..Chromosome 9p21.3 polymorphism has been shown to affect susceptibility to Alzheimer's disease (AD) in Caucasians, while there are no studies on the association of chromosome 9p21.3 polymorphism with the risk of AD in Asians...
  20. doi request reprint NEDD9 is genetically associated with Alzheimer's disease in a Han Chinese population
    Yao Yao Xing
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province 266071, PR China
    Brain Res 1369:230-4. 2011
    ..The study demonstrated a significant association between the tested SNP and LOAD, indicating that NEDD9 polymorphism has a possible role in changing the genetic susceptibility to LOAD in a Han Chinese population...
  21. doi request reprint Lack of association between PCDH11X genetic variation and late-onset Alzheimer's disease in a Han Chinese population
    Zhong Chen Wu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China
    Brain Res 1357:152-6. 2010
    ..Our results failed to find any significant association between the tested SNP and LOAD, indicating that PCDH11X gene polymorphism does not play a major role in the genetic predisposition to LOAD in this Han Chinese population...
  22. ncbi request reprint Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China
    Clin Chim Acta 411:1516-9. 2010
    ..Recently, two genome-wide association studies have identified three variants in CLU gene encoding clusterin associated with AD risk in Caucasians, while there are no studies on the association of CLU with AD risk in Asians...
  23. ncbi request reprint Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients
    Nan Hu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China
    J Alzheimers Dis 38:497-501. 2014
    ..Our results indicate that TREM2 might serve as a novel noninvasive biomarker for AD diagnosis...
  24. pmc Toll-like receptor 9 promoter polymorphism is associated with decreased risk of Alzheimer's disease in Han Chinese
    Ying Li Wang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
    J Neuroinflammation 10:101. 2013
    ..Therefore, TLR9 might represent a reasonable functional candidate gene for AD...
  25. doi request reprint Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China
    J Neurol Sci 300:78-80. 2011
    ..68 to 1.10), even after statistical adjustment for age, gender and apolipoprotein E (APOE) status. Our results suggest that the PICALM polymorphism may not play a major role in the development of LOAD in the Han Chinese population...
  26. doi request reprint Interleukin-18 promoter polymorphisms and risk of ischemic stroke
    Na Zhang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, China
    Brain Res Bull 81:590-4. 2010
    ..341, P = 0.005, power = 100%). Our findings suggest that these functional polymorphisms in the IL-18 promoter are involved in development of IS in the Han Chinese population...
  27. doi request reprint Mitochondrial transcription factor A (TFAM) polymorphisms and risk of late-onset Alzheimer's disease in Han Chinese
    Qun Zhang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province 266071, China
    Brain Res 1368:355-60. 2011
    ..Haplotype analysis identified the haplotype CC as a protective factor of LOAD (P=0.038, OR=0.76). This study provides the evidence that variations in TFAM are involved in the pathogenesis of sporadic LOAD in the Han Chinese population...
  28. doi request reprint Anticonvulsant effect of unilateral anterior thalamic high frequency electrical stimulation on amygdala-kindled seizures in rat
    Qun Zhang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao 266071, China
    Brain Res Bull 87:221-6. 2012
    ....
  29. doi request reprint Genetic association of TLR4/11367 polymorphism with late-onset Alzheimer's disease in a Han Chinese population
    Li Zhu Wang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China
    Brain Res 1381:202-7. 2011
    ..75, 95% CI=1.73-4.37, P<0.001) after adjustment for age, gender, and the APOE ε4 carrier status. This study gives the first evidence that the TLR4/11367 polymorphism was associated with LOAD in a Han Chinese population...
  30. doi request reprint An exploratory study on STX6, MOBP, MAPT, and EIF2AK3 and late-onset Alzheimer's disease
    Qiu Yan Liu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province, China
    Neurobiol Aging 34:1519.e13-7. 2013
    ..Genotypes at MOBP and EIF2AK3 confer risk predominantly in APOE ε4-positive subjects, with indications of an interaction between APOE and MOBP or EIF2AK3 on AD risk...
  31. doi request reprint Genetic association of rs11610206 SNP on chromosome 12q13 with late-onset Alzheimer's disease in a Han Chinese population
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, China
    Clin Chim Acta 412:148-51. 2011
    ..Recently, the strongest significant association was reported for the single nucleotide polymorphism (SNP) rs11610206 on chromosome 12q13 in an independent genome-wide association study (GWAS) in Caucasians...
  32. doi request reprint Insulin-like growth factor 1 (IGF1) polymorphism is associated with Alzheimer's disease in Han Chinese
    Wei Wang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China
    Neurosci Lett 531:20-3. 2012
    ..These results suggest that IGF1 polymorphism has a possible role in changing the genetic susceptibility to LOAD in a Han Chinese population...
  33. doi request reprint Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's disease
    Yao Yao Xing
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
    J Alzheimers Dis 29:515-9. 2012
    ..001). This study indicates that the rs9331888 AD-risk variant is associated with low blood clusterin levels...
  34. doi request reprint Replication of the MTHFD1L gene association with late-onset Alzheimer's disease in a Northern Han Chinese population
    Xiao Ying Ma
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
    J Alzheimers Dis 29:521-5. 2012
    ..400; p < 0.001). Haplotype analysis revealed the "AC" haplotype increased the risk of developing LOAD (OR = 1.730; p = 0.015). Our findings support a role of MTHFD1L gene in LOAD...
  35. doi request reprint Association between late-onset Alzheimer's disease and microsatellite polymorphisms in intron II of the human toll-like receptor 2 gene
    Li Zhu Wang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China
    Neurosci Lett 489:164-7. 2011
    ..05, 95% CI=1.26-3.34), and this association was influenced by the presence of APOE ɛ4 alleles. This study demonstrates an association of microsatellite polymorphisms in intron II of the human TLR2 gene with risk for LOAD in Han Chinese...
  36. doi request reprint Association analysis of GSK3B and MAPT polymorphisms with Alzheimer's disease in Han Chinese
    Na Zhang
    Department of Neurology, Qingdao Fuwai Hospital, Qingdao, Shandong Province 266034, PR China
    Brain Res 1391:147-53. 2011
    ..383, P=0.013). Our findings suggest that the functional polymorphisms in GSK3B promoter may be involved in the risk of developing sporadic LOAD in Han Chinese...
  37. ncbi request reprint IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice
    Meng Shan Tan
    College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China
    J Alzheimers Dis 38:633-46. 2014
    ....
  38. pmc Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China
    Br J Pharmacol 171:3146-57. 2014
    ..Here, we tested the possibility that acute metformin preconditioning confers neuroprotection by pre-activation of AMPK-dependent autophagy in a rat model of permanent middle cerebral artery occlusion (pMCAO)...
  39. doi request reprint Association of LRRTM3 polymorphisms with late-onset Alzheimer's disease in Han Chinese
    Jun Wang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China
    Exp Gerontol 52:18-22. 2014
    ..However, additional independent replication groups are required to further validate this association. ..
  40. doi request reprint Circulating miR-125b as a biomarker of Alzheimer's disease
    Lin Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China
    J Neurol Sci 336:52-6. 2014
    ..This study was conducted to investigate the potential role of serum miRNAs as diagnostic biomarkers for Alzheimer's disease (AD)...
  41. doi request reprint Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China Electronic address
    Neurobiol Aging 35:937.e1-3. 2014
    ..These findings suggest that mutations in exon2 of TREM2 were unlikely to play a key role in the susceptibility of LOAD in the northern Han Chinese population. ..
  42. ncbi request reprint No association of toll-like receptor 2 polymorphisms with Alzheimer's disease in Han Chinese
    Jin Tai Yu
    College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China
    Neurobiol Aging 32:1924.e1-3. 2011
    ..TLR2 gene might not play a major role in the genetic predisposition to late-onset Alzheimer's disease in this population...
  43. doi request reprint Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese
    Nan Nan Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China
    Neurosci Lett 491:83-6. 2011
    ..78, P=0.037). This study provides the evidence that variations in the TTBK1 gene may play an important role in the pathogenesis of sporadic LOAD in a Han Chinese population...
  44. doi request reprint Association of DAPK1 genetic variations with Alzheimer's disease in Han Chinese
    Zhong Chen Wu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province 266071, PR China
    Brain Res 1374:129-33. 2011
    ..007, OR=1.33, 95% CI=1.08-1.64). This study provides the evidence that variation in DAPK1 gene influences susceptibility to LOAD in the Northern Han Chinese population...
  45. ncbi request reprint Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: a systematic review and meta-analysis
    Chen Chen Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
    J Alzheimers Dis 41:615-31. 2014
    ....
  46. ncbi request reprint Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China
    Neuropharmacology 85:121-30. 2014
    ..These findings highlight temsirolimus administration as a potential therapeutic strategy for neurodegenerative tauopathies. ..
  47. ncbi request reprint Exploring the value of plasma BIN1 as a potential biomarker for alzheimer's disease
    Lei Sun
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
    J Alzheimers Dis 37:291-5. 2013
    ..Although this is a pilot study requiring corroboration on a larger cohort of patients, our results highlight the possible use of plasma BIN1 as a biomarker for AD diagnosis. ..
  48. doi request reprint Genetic variation in clusterin gene and Alzheimer's disease risk in Han Chinese
    Jin Tai Yu
    College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China
    Neurobiol Aging 34:1921.e17-23. 2013
    ..274; dominant model: p = 0.039, odds ratio = 1.239; recessive model: p = 0.002, OR = 1.975) after adjusting for sex, age, and APOE ε4 status. Our findings implicate CLU as a susceptibility gene for LOAD in Han Chinese...
  49. doi request reprint Polymorphisms at the beta2-adrenergic receptor gene influence Alzheimer's disease susceptibility
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, Affiliated Hospital of Qingdao University Medical College, Shandong Province, PR China
    Brain Res 1210:216-22. 2008
    ..004). Our results suggest that variations in the beta2-AR gene play an important role in the pathogenesis of sporadic LOAD, and interact with the epsilon4 allele to markedly increase the LOAD risk...
  50. doi request reprint Decreased expression of CD33 in peripheral mononuclear cells of Alzheimer's disease patients
    Nan Hu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China
    Neurosci Lett 563:51-4. 2014
    ..05). According to receiver operating characteristic (ROC) curve analysis, the diagnostic accuracy for CD33 alone is relatively lower, while, combining with additional parameters might further improve the diagnostic value for AD...
  51. ncbi request reprint Genetic association of SLC2A14 polymorphism with Alzheimer's disease in a Han Chinese population
    Wei Wang
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, 266071, People s Republic of China
    J Mol Neurosci 47:481-4. 2012
    ..These results suggested that SLC2A14 polymorphism has a possible role in changing the genetic susceptibility to LOAD in a Han Chinese population...
  52. pmc Toll-like receptor 2 -196 to -174 del polymorphism influences the susceptibility of Han Chinese people to Alzheimer's disease
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, China
    J Neuroinflammation 8:136. 2011
    ..The -196 to -174 del polymorphism affects the TLR2 gene and alters its promoter activity...
  53. doi request reprint Common variant in GAB2 is associated with late-onset Alzheimer's disease in Han Chinese
    Xiao ling Zhong
    Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Shandong Province, China
    Clin Chim Acta 412:446-9. 2011
    ..While there are no studies on the association of rs10793294 polymorphism with AD risk in the Chinese population...
  54. ncbi request reprint Autophagy modulation for Alzheimer's disease therapy
    Xi Chen Zhu
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China
    Mol Neurobiol 48:702-14. 2013
    ..However, to date, little of the researches on autophagy have been performed to investigate the modulation in AD; more investigations need to be confirmed in the future. ..
  55. ncbi request reprint Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease
    Lin Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Shandong, China
    J Alzheimers Dis 40:1017-27. 2014
    ..This study identified six serum miRNAs that distinguish AD patients from healthy controls with high sensitivity and specificity. Serum miRNA panel (or miR-342-3p alone) may serve as a novel, noninvasive biomarker for AD. ..
  56. ncbi request reprint Lack of association between COMT Val158Met polymorphism and late-onset Alzheimer's disease in Han Chinese
    Jing Zhou
    Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, China
    Neurosci Lett 554:162-6. 2013
    ..Our results indicated that the COMT Val158Met polymorphism may not play a major role in the development of LOAD in Han Chinese. ..
  57. doi request reprint Genetic variation in PICALM and Alzheimer's disease risk in Han Chinese
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China
    Neurobiol Aging 35:934.e1-3. 2014
    ..These findings implicate that PICALM might not play a major role in the genetic predisposition to LOAD in Han Chinese...
  58. doi request reprint Increased expressions of TLR2 and TLR4 on peripheral blood mononuclear cells from patients with Alzheimer's disease
    Wei Zhang
    Department of Neurology, Shandong University, Jinan, Shandong Province, China
    J Neurol Sci 315:67-71. 2012
    ..Therefore, we hypothesize that there may be significant changes in TLR2 and TLR4 expressions on peripheral blood mononuclear cells (PBMCs) from patients with AD when compared to healthy control subjects...
  59. doi request reprint Blocking beta2-adrenergic receptor attenuates acute stress-induced amyloid beta peptides production
    Nan Nan Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province 266071, PR China
    Brain Res 1317:305-10. 2010
    ..The findings indicate that new therapeutic strategies designed to blocking beta(2)-AR might be valuable for the prevention and treatment of AD...
  60. ncbi request reprint [Effect of UGT1A6 genetic polymorphisms on the metabolism of sodium valproate]
    Yan Ping Sun
    Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China
    Zhonghua Yi Xue Za Zhi 87:2033-5. 2007
    ..To investigate the effect of UGT1A6 genetic polymorphisms on the serum concentration of sodium valproate so as to help better individualize the medication for patients with epilepsy...
  61. ncbi request reprint Interleukin-23 receptor polymorphisms are associated with Alzheimer's disease in Han Chinese
    Ying Liu
    Department of Neurology, Dalian Medical University, Qingdao Municipal Hospital, China
    J Neuroimmunol 271:43-8. 2014
    ..The G allele of rs1884444 polymorphism is significantly associated with a higher risk of AD in APOE ɛ4 carriers. Our results demonstrate that IL23R genetic polymorphisms are associated with AD in a Northern Han Chinese population. ..
  62. ncbi request reprint Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China
    Pharmacol Res 81:54-63. 2014
    ..Meanwhile, these findings emphasize the notion that many therapeutic agents possess pleiotropic actions aside from their main applications. ..
  63. pmc Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy
    Meng Meng Li
    1 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China 2
    Sci Rep 4:4734. 2014
    ..Collectively, our findings suggest that miRNAs may exert anti-apoptotic effects in chronic TLE. ..
  64. pmc Nutrition and the risk of Alzheimer's disease
    Nan Hu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Number 5 Donghai Middle Road, Qingdao 266071, China
    Biomed Res Int 2013:524820. 2013
    ..Adherence to a healthy diet, the Japanese diet, and the Mediterranean diet is associated with a lower risk of AD. This paper will focus on the evidence linking many nutrients, foods, and dietary patterns to AD. ..
  65. doi request reprint Genetic association between ADAM10 gene polymorphism and Alzheimer's disease in a Northern Han Chinese population
    Jing Hui Song
    Department of Neurology, Qilu Hospital of Shandong University, 44 West Wenhua Road, 250012, Jinan, Shandong Province, PR China
    Brain Res 1421:78-81. 2011
    ..611, 95% CI=0.408-0.931, P=0.023). This study suggests that the rs2305421 polymorphism in ADAM10 gene could modify the risk for LOAD in a Northern Han Chinese population...
  66. doi request reprint Roles of β-adrenergic receptors in Alzheimer's disease: implications for novel therapeutics
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China
    Brain Res Bull 84:111-7. 2011
    ....
  67. doi request reprint Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, People s Republic of China
    Neurobiol Aging 35:1243-51. 2014
    ..Meanwhile, more obvious neuronal and synaptic losses and cognitive impairment were observed. These findings indicate that TREM2 may play a protective role against aging-related neuroinflammation and cognitive impairment. ..
  68. doi request reprint Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy
    Chen Chen Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
    Neurobiol Aging 35:941-57. 2014
    ..This review will discuss the cellular and molecular mechanisms of autophagy and its important role in the pathogenesis of aging and neurodegenerative diseases, and the ongoing drug discovery strategies for therapeutic modulation. ..
  69. ncbi request reprint CD33 in Alzheimer's Disease
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China
    Mol Neurobiol 49:529-35. 2014
    ..Based on the contributing effects of CD33 in AD pathogenesis, targeting CD33 may provide new opportunities for AD therapeutic strategies. ..
  70. ncbi request reprint Novel disease-modifying therapies for Alzheimer's disease
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China
    J Alzheimers Dis 31:475-92. 2012
    ..Some typical therapies with disease-modifying effects have also been discussed...
  71. ncbi request reprint Clusterin in Alzheimer's disease
    Zhong Chen Wu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province, China
    Adv Clin Chem 56:155-73. 2012
    ..This review focuses on the characteristics of clusterin and possible mechanisms of its relationship to AD...
  72. doi request reprint Low-frequency stimulation of bilateral anterior nucleus of thalamus inhibits amygdale-kindled seizures in rats
    Xiao ling Zhong
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao 266071, China
    Brain Res Bull 86:422-7. 2011
    ..Our study demonstrated that bilateral LFS in ANT could significantly inhibit amygdala-kindled seizures by preventing both afterdischarge generation and propagation. It provided further evidence for clinical use of LFS in ANT...
  73. doi request reprint Deep brain stimulation for epilepsy in clinical practice and in animal models
    Xiao ling Zhong
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao 266071, PR China
    Brain Res Bull 85:81-8. 2011
    ..Here, we endeavor to review mainly the animal studies and clinical studies of ANT DBS to further explore the more reliable target...
  74. doi request reprint TREM2 in Alzheimer's disease
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China
    Mol Neurobiol 48:180-5. 2013
    ..Based on the potential protective actions of TREM2 in AD pathogenesis, targeting TREM2 might provide new opportunities for AD treatment...
  75. ncbi request reprint Single nucleotide polymorphism rs7294919 on chromosome 12q24.22 is associated with late-onset Alzheimer's disease in Han Chinese
    Ling Li Ma
    Department of Neurology, Qingdao Municipal Hospital, Weifang Medical University, China
    Neurosci Lett 560:67-70. 2014
    ..In conclusion, our study demonstrates an association of rs7294919 polymorphism locus on chromosome 12q24.22 with risk for LOAD in Han Chinese. ..
  76. ncbi request reprint The clinical and pathological phenotypes of frontotemporal dementia with C9ORF72 mutations
    Ying Liu
    Department of Neurology, Qingdao Municipal Hospital, Dalian Medical University, China
    J Neurol Sci 335:26-35. 2013
    ....
  77. doi request reprint Missense variants in CR1 are associated with increased risk of Alzheimer' disease in Han Chinese
    Xiao Ying Ma
    Department of Neurology, Guiyang Hospital of Guizhou Aviation Industry Group, Guizhou, China Department of Neurology, Affiliated Guizhou Aviation Industry Group 300 Hospital of Zunyi Medical University, Guizhou, China Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
    Neurobiol Aging 35:443.e17-21. 2014
    ..These findings provide the evidence that missense variants in the CR1 gene may be involved in LOAD pathologic process in Han Chinese...
  78. doi request reprint Angiotensin-(1-7) inhibits autophagy in the brain of spontaneously hypertensive rats
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China
    Pharmacol Res 71:61-8. 2013
    ..These findings suggest that treatment with Ang-(1-7) may be useful to prevent hypertension-induced excessive autophagic activation in brain...
  79. ncbi request reprint Β-arrestins as potential therapeutic targets for Alzheimer's disease
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China
    Mol Neurobiol 48:812-8. 2013
    ..Based on the role of β-arrestins in AD pathogenesis, genetically or pharmacologically targeting β-arrestins might provide new opportunities for AD treatment...
  80. ncbi request reprint The NLRP3 inflammasome in Alzheimer's disease
    Meng Shan Tan
    College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China
    Mol Neurobiol 48:875-82. 2013
    ..So, we further discuss the recent advances and challenges in targeting NLRP3 inflammasome for AD therapy...
  81. ncbi request reprint Calcium dysregulation in Alzheimer's disease: from mechanisms to therapeutic opportunities
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province 266071, China
    Prog Neurobiol 89:240-55. 2009
    ..The review aims to provide an overview of the current understanding of the molecular mechanisms involved in calcium dysregulation in AD, and an insight on how to exploit calcium regulation as therapeutic opportunities in AD...
  82. ncbi request reprint Elevated plasma levels of soluble TNFRs and TACE activity in Alzheimer's disease patients of Northern Han Chinese descent
    Lin Bai
    Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines Physiology, Medical College of Qingdao University, Qingdao, 266071, China
    Curr Alzheimer Res 10:57-62. 2013
    ..However, whether the plasma levels of soluble TNF receptors (sTNFRs) are changed is still unclear in AD patients of Han descent...
  83. doi request reprint Non-coding RNAs in Alzheimer's disease
    Lin Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province, 266071, China
    Mol Neurobiol 47:382-93. 2013
    ..Here, we review current findings regarding ncRNA research in human and mouse models to provide a strong basis for future study aiming at promising contributions of ncRNA in AD...
  84. doi request reprint The role of clusterin in Alzheimer's disease: pathways, pathogenesis, and therapy
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao, Shandong Province 266071, China
    Mol Neurobiol 45:314-26. 2012
    ..Emerging knowledge of the contribution of clusterin to the pathogenesis of AD presents new opportunities for AD therapy...
  85. doi request reprint Role of the mTOR signaling pathway in epilepsy
    Xiang fei Meng
    Department of Neurology, School of Medicine, Qingdao Municipal Hospital, Qingdao University, China
    J Neurol Sci 332:4-15. 2013
    ..Limited clinical studies in human epilepsy, some paradoxical experimental data and outstanding questions have also been discussed. ..
  86. ncbi request reprint Diffusion-weighted magnetic resonance imaging demonstrates parenchymal pathophysiological changes in epilepsy
    Jin Tai Yu
    Department of Neurology, Qingdao Municipal Hospital, Affiliated Hospital of Qingdao University Medical College, Shandong Province, PR China
    Brain Res Rev 59:34-41. 2008
    ....