Leshuai W Zhang
Affiliation: Suzhou University
Zhang S, Pang G, Chen C, Qin J, Yu H, Liu Y, et al
. Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response. Carbohydr Polym. 2019;205:192-202 pubmed publisher
..This work suggests that polysaccharides from natural herbs can be incorporated into nanocomposites with immunoregulatory characteristics for enhanced efficacy on tumor therapy. ..
Zhang X, Yang L, Liu Y, Song Z, Zhao J, Chen D, et al
. Detection of nanocarrier potentiation on drug induced phospholipidosis in cultured cells and primary hepatocyte spheroids by high content imaging and analysis. Toxicol Appl Pharmacol. 2018;348:54-66 pubmed publisher
..Therefore, evidences were provided by us that nanocarriers may increase the adverse drug effects and guidance by regulatory agencies need to be drafted for the safe use of nanotechnology in drug delivery. ..
Pang G, Wang F, Zhang L. Dose matters: Direct killing or immunoregulatory effects of natural polysaccharides in cancer treatment. Carbohydr Polym. 2018;195:243-256 pubmed publisher
..Therefore, understanding the sophisticated mechanisms of the immunoregulatory function of natural polysaccharides with refined doses for clinical use will help the standardization of traditional medicine. ..
Lv X, Chen D, Yang L, Zhu N, Li J, Zhao J, et al
. Comparative studies on the immunoregulatory effects of three polysaccharides using high content imaging system. Int J Biol Macromol. 2016;86:28-42 pubmed publisher
Zhu N, Lv X, Wang Y, Li J, Liu Y, Lu W, et al
. Comparison of immunoregulatory effects of polysaccharides from three natural herbs and cellular uptake in dendritic cells. Int J Biol Macromol. 2016;93:940-951 pubmed publisher
Liu Y, Zhuang J, Zhang X, Yue C, Zhu N, Yang L, et al
. Autophagy associated cytotoxicity and cellular uptake mechanisms of bismuth nanoparticles in human kidney cells. Toxicol Lett. 2017;275:39-48 pubmed publisher
..With our novel finding of bismuth induced autophagy and endocytic mechanisms, potential approaches may be applied to reduce the toxicity by bismuth. ..