Mei Lin Xie
Affiliation: Suzhou University
Zhu Z, Gao T, Huang Y, Xue J, Xie M. Apigenin ameliorates hypertension-induced cardiac hypertrophy and down-regulates cardiac hypoxia inducible factor-l? in rats. Food Funct. 2016;7:1992-8 pubmed publisher
Wang J, Shen W, Zhang J, Jia C, Xie M. Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway. Food Funct. 2019;10:1179-1190 pubmed publisher
Wang J, Gao T, Wang F, Xue J, Ye H, Xie M. Luteolin improves myocardial cell glucolipid metabolism by inhibiting hypoxia inducible factor-1α expression in angiotensin II/hypoxia-induced hypertrophic H9c2 cells. Nutr Res. 2019;: pubmed publisher
Zhao X, Xue J, Xie M. Osthole inhibits oleic acid/lipopolysaccharide-induced lipid accumulation and inflammatory response through activating PPARα signaling pathway in cultured hepatocytes. Exp Gerontol. 2019;119:7-13 pubmed publisher
..These findings demonstrate that osthole activates PPARα signaling pathway to inhibit lipid accumulation and inflammatory response in OA/LPS-stimulated hepatocytes. ..
Zhang Y, Cui Y, Wang X, Shang X, Qi Z, Xue J, et al
. PPARÎ±/Î³ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats. Cytokine. 2015;75:127-35 pubmed publisher
..It was concluded that the integrative application of PPARÎ± and PPARÎ³ agonists might exert a synergic inhibitory effect on NASH formation through the modulation of PPARÎ±/Î³-mediated lipogenic and inflammatory gene expressions. ..
Zhao X, Wang F, Zhou R, Zhu Z, Xie M. PPAR?/? antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats. Inflammopharmacology. 2018;26:425-433 pubmed publisher
..These findings demonstrated that the ameliorative effect of osthole on nonalcoholic steatohepatitis was mediated by PPAR?/? activation, and osthole might be a natural dual PPAR?/? activator. ..
Wang F, Liu J, Zhou R, Zhao X, Liu M, Ye H, et al
. Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPAR?-mediated lipogenic gene expression. Chem Biol Interact. 2017;275:171-177 pubmed publisher
Zhou R, Ye H, Wang F, Wang J, Xie M. Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPAR? expressions in mice. Biochem Biophys Res Commun. 2017;493:625-630 pubmed publisher