Affiliation: Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University
Location: Xi'an, China
Sun Z, Zhang M, Zhao X, Liu Z, Gao Y, Samartzis D, et al
. Immune cascades in human intervertebral disc: the pros and cons. Int J Clin Exp Pathol. 2013;6:1009-14 pubmed
..Further studies are needed to explore its beneficial influence. Accordingly, there are no absolutely the pros and cons in terms of immune reactions caused by NP. ..
Sun Z, Wang H, Liu Z, Chang L, Chen Y, Zhang Y, et al
. Down-regulated CK8 expression in human intervertebral disc degeneration. Int J Med Sci. 2013;10:948-56 pubmed publisher
..Consequently, CK8 positive cells might be considered as a potential option in the development of cellular treatment strategies for NP repair. ..
Liu Z, Sun Z, Wang H, Ge J, Jiang T, Chen Y, et al
. FasL expression on human nucleus pulposus cells contributes to the immune privilege of intervertebral disc by interacting with immunocytes. Int J Med Sci. 2013;10:1053-60 pubmed publisher
..Our study demonstrated that FasL expression tends to decrease in degenerated discs and FasL plays an important role in human disc immune privilege, which might provide a novel target for the treatment strategies for IDD. ..
Sun Z, Liu Z, Chen Y, Zhang Y, Wan Z, Zhang W, et al
. Molecular immunotherapy might shed a light on the treatment strategies for disc degeneration and herniation. Med Hypotheses. 2013;81:477-80 pubmed publisher
..Taken together, we hypothesize that a combined molecular immunotherapy with local and systemic immunity regulators might shed a novel light on the treatment strategies for disc degeneration and herniation. ..
Sun Z, Liu Z, Zhao X, Sun L, Chen Y, Zhang W, et al
. Impact of direct cell co-cultures on human adipose-derived stromal cells and nucleus pulposus cells. J Orthop Res. 2013;31:1804-13 pubmed publisher
..Accordingly, ADSCs might be a potential candidate in the development of cellular treatment strategies for IDD. ..
Sun Z, Wan Z, Liu Z, Guo Y, Yin J, Duan C, et al
. Expression of soluble Fas and soluble FasL in human nucleus pulposus cells. Int J Clin Exp Pathol. 2013;6:1567-73 pubmed
..Moreover, the expression of sFas and sFasL varies with culture time in vitro with different levels in degenerate and normal settings. These findings indicate that sFas and sFasL might play a role in intervertebral disc degeneration. ..
Sun Z, Luo B, Liu Z, Huang L, Liu B, Ma T, et al
. Effect of perfluorotributylamine-enriched alginate on nucleus pulposus cell: Implications for intervertebral disc regeneration. Biomaterials. 2016;82:34-47 pubmed publisher
..These findings highlight the promising application of PFTBA in further intervertebral disc regeneration. ..