Cheng Zhang

Summary

Affiliation: Sun Yat-sen University
Country: China

Publications

  1. pmc MLPA-based genotype-phenotype analysis in 1053 Chinese patients with DMD/BMD
    Juan Yang
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhong Shaner Road, Guangzhou City, 510080, People s Republic of China
    BMC Med Genet 14:29. 2013
  2. doi request reprint [Study on Duchenne muscular dystrophy gene mutation and prenatal diagnosis]
    Shan Wei Feng
    Institute of Population Research, Peking University, Beijing, People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30:36-9. 2013
  3. pmc Neurospheres from rat adipose-derived stem cells could be induced into functional Schwann cell-like cells in vitro
    Yongfeng Xu
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, PR China
    BMC Neurosci 9:21. 2008
  4. doi request reprint Myelin-forming ability of Schwann cell-like cells induced from rat adipose-derived stem cells in vitro
    Yongfeng Xu
    Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, No 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, PR China
    Brain Res 1239:49-55. 2008
  5. pmc Enhanced effect of microdystrophin gene transfection by HSV-VP22 mediated intercellular protein transport
    Fu Xiong
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, PR China
    BMC Neurosci 8:50. 2007
  6. pmc Comparative study of mesenchymal stem cells from C57BL/10 and mdx mice
    Yong Li
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, PROC
    BMC Cell Biol 9:24. 2008
  7. ncbi request reprint [Dystrophin expression in mdx mice after bone marrow stem cells transplantation]
    Shan Wei Feng
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:178-81. 2006
  8. ncbi request reprint [Comparison of transduction efficiencies of various gene vectors in human bone-marrow-derived mesenchymal stem cells]
    Zheng Shan Liu
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 30:569-73. 2008
  9. doi request reprint Decorin promotes myogenic differentiation and mdx mice therapeutic effects after transplantation of rat adipose-derived stem cells
    Jia Geng
    Neurology Department, The First Affiliated Hospital, Kunming Medical University, Kunming, PR China
    Cytotherapy 14:877-86. 2012
  10. doi request reprint Inhibition of myostatin promotes myogenic differentiation of rat bone marrow-derived mesenchymal stromal cells
    Jia Geng
    Neurology Department, The First Affiliated Hospital, Sun Yat Sen University, Guang Zhou, PR China
    Cytotherapy 11:849-63. 2009

Collaborators

Detail Information

Publications56

  1. pmc MLPA-based genotype-phenotype analysis in 1053 Chinese patients with DMD/BMD
    Juan Yang
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhong Shaner Road, Guangzhou City, 510080, People s Republic of China
    BMC Med Genet 14:29. 2013
    ....
  2. doi request reprint [Study on Duchenne muscular dystrophy gene mutation and prenatal diagnosis]
    Shan Wei Feng
    Institute of Population Research, Peking University, Beijing, People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30:36-9. 2013
    ..To explore the characteristics of DNA mutations underlying Duchenne muscular dystrophy and provide prenatal diagnosis...
  3. pmc Neurospheres from rat adipose-derived stem cells could be induced into functional Schwann cell-like cells in vitro
    Yongfeng Xu
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, PR China
    BMC Neurosci 9:21. 2008
    ..However, it is difficult to obtain sufficient large number of SC for clinical use, so alternative cell systems are desired...
  4. doi request reprint Myelin-forming ability of Schwann cell-like cells induced from rat adipose-derived stem cells in vitro
    Yongfeng Xu
    Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, No 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, PR China
    Brain Res 1239:49-55. 2008
    ..Our data further demonstrated that SC-like cells from ADSC were able to form myelins and these cells may benefit the treatment of peripheral and central nerve injuries...
  5. pmc Enhanced effect of microdystrophin gene transfection by HSV-VP22 mediated intercellular protein transport
    Fu Xiong
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, PR China
    BMC Neurosci 8:50. 2007
    ....
  6. pmc Comparative study of mesenchymal stem cells from C57BL/10 and mdx mice
    Yong Li
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, PROC
    BMC Cell Biol 9:24. 2008
    ..To understand the role of dystrophin in MSCs, we compared MSCs from mdx and C57BL/10 mice, focusing particularly on the aspects of light and electron microscopic morphology, immunophenotyping, and differentiation potential...
  7. ncbi request reprint [Dystrophin expression in mdx mice after bone marrow stem cells transplantation]
    Shan Wei Feng
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:178-81. 2006
    ..To investigate the dynamic changes of dystrophin expression in mdx mice after bone marrow stem cells transplantation...
  8. ncbi request reprint [Comparison of transduction efficiencies of various gene vectors in human bone-marrow-derived mesenchymal stem cells]
    Zheng Shan Liu
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 30:569-73. 2008
    ..To compare the transduction efficiencies of adenoviral vector, adeno-associated viral vector, baculoviral vector, and plasmid vector in human bone-marrow-derived mesenchymal stem cells (hBMSCs)...
  9. doi request reprint Decorin promotes myogenic differentiation and mdx mice therapeutic effects after transplantation of rat adipose-derived stem cells
    Jia Geng
    Neurology Department, The First Affiliated Hospital, Kunming Medical University, Kunming, PR China
    Cytotherapy 14:877-86. 2012
    ..Decorin could bind Mstn and deactivate it. Decorin has been shown to improve myogenic differentiation in mdx mice. We hypothesized that inhibition of Mstn by using decorin may ameliorate myogenic differentiation of ADSC...
  10. doi request reprint Inhibition of myostatin promotes myogenic differentiation of rat bone marrow-derived mesenchymal stromal cells
    Jia Geng
    Neurology Department, The First Affiliated Hospital, Sun Yat Sen University, Guang Zhou, PR China
    Cytotherapy 11:849-63. 2009
    ..We hypothesized that inhibition of Mstn by using anti-Mstn antibody (Ab) would ameliorate the myogenic differentiation of MSC in vitro and in vivo...
  11. doi request reprint Improved motor function in dko mice by intravenous transplantation of bone marrow-derived mesenchymal stromal cells
    Zhong Li
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Cytotherapy 13:69-77. 2011
    ..We explored the potential therapeutic value of transplanting bone marrow (BM)-derived mesenchymal stromal cells (MSC) into utrophin/dystrophin-deficient double knock-out (dko) mice, a murine model of Duchenne muscular dystrophy...
  12. ncbi request reprint [Carrier genetic diagnosis of intron and/or exon-deletion Duchenne muscular dystrophy by microsatellite analysis and quantitative polymerase chain reaction]
    Wen Huang
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510080 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:72-5. 2007
    ..To detect the female carriers from the intron and/or exon-deletion Duchenne/Becker musclular dystrophy (DMD) familial members for prenatal or preimplantation genetic diagnosis...
  13. ncbi request reprint Wnt3a signaling promotes proliferation, myogenic differentiation, and migration of rat bone marrow mesenchymal stem cells
    Yan chang Shang
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Acta Pharmacol Sin 28:1761-74. 2007
    ..To investigate the effects of the wingless-related MMTV integration site 3A (Wnt3a) signaling on the proliferation, migration, and the myogenic and adipogenic differentiation of rat bone marrow mesenchymal stem cells (rMSC)...
  14. ncbi request reprint [Identification of disease-causing point mutations in DMD patients' dystrophin gene without large deletions/duplications]
    Ben chang Shen
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510080 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:392-6. 2006
    ..To detect the disease-causing point mutations in the dystrophin gene of Duchenne muscular dystrophy (DMD) patients...
  15. ncbi request reprint [Mutation analysis of small heat shock protein 27 gene in Chinese patients with Charcot-Marie-Tooth disease]
    Xiao Min Liu
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:510-3. 2005
    ..To investigate the features of small heat shock protein 27 (HSP27) gene mutation in Chinese patients with Charcot-Marie-Tooth disease (CMT)...
  16. ncbi request reprint [Detection of duplications or deletions of the PMP22 gene using real-time quantitative PCR]
    Fu feng Zhang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:537-40. 2005
    ....
  17. ncbi request reprint [Transduction of rhesus bone marrow mesenchymal stem cells by recombinant baculovirus]
    Zhengshan Liu
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Wei Sheng Wu Xue Bao 48:539-44. 2008
    ....
  18. ncbi request reprint [The experimental study on bone marrow stem cell transplantition combinated with bushen fang therapy for DMD]
    Xi Lin Lu
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Zhong Yao Cai 29:1056-8. 2006
    ..To investigate the effect on bone marrow stem cell transplantition (BMST) combinated with Bushen fang therapy in mdx mice...
  19. ncbi request reprint Herpes simplex virus VP22 enhances adenovirus-mediated microdystrophin gene transfer to skeletal muscles in dystrophin-deficient (mdx) mice
    Fu Xiong
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
    Hum Gene Ther 18:490-501. 2007
    ....
  20. doi request reprint Comparative study of myocytes from normal and mdx mice iPS cells
    Fei Chen
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, People s Republic of China
    J Cell Biochem 113:678-84. 2012
    ..More importantly, treatment of a pan-caspase inhibitor (Z-VAD) produced a significant decrease in apoptotic cells. This study might add some insight to the biology study of dystrophin gene...
  21. doi request reprint Rat bone marrow stromal cells could be induced into Schwann cell precursor-like cells in vitro
    Yongfeng Xu
    Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China
    Neurosci Lett 488:229-33. 2011
    ..SCP-like cells were flattened in shape, p75(+)GFAP(-)S-100(-)nestin(-), and could differentiate into SC-like cells, similar to genuine SCP. Our data suggested that MSCs could be induced into SCP-like cells...
  22. ncbi request reprint A method comparison in monitoring disease progression of G93A mouse model of ALS
    Chang Zhou
    Department of Neurology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Amyotroph Lateral Scler 8:366-72. 2007
    ....
  23. doi request reprint Baculovirus-transduced mouse amniotic fluid-derived stem cells maintain differentiation potential
    Zheng Shan Liu
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    Ann Hematol 88:565-72. 2009
    ..Thus, baculovirus vector effective and safe transduction is an attractive promise for genetic modification of mAFSs. Baculovirus genetically modified mAFSs will probably be more suitable as vehicles for regenerative medicine...
  24. doi request reprint Restoration of muscle fibers and satellite cells after isogenic MSC transplantation with microdystrophin gene delivery
    Shan Wei Feng
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, PR China Institute of Population Research, Peking University, PR China
    Biochem Biophys Res Commun 419:1-6. 2012
    ..Simultaneous coexpression of human microdystrophin and desmin showed that implanted mMSCs are capable of long-term survival as muscle satellite cells...
  25. ncbi request reprint Signals in pathological CNS extracts of ALS mice promote hMSCs neurogenic differentiation in vitro
    Cui ping Zhao
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, PR China
    Cell Biol Int 31:1428-35. 2007
    ..These results show that pathological condition of ALS is endowed with capacity to induce hMSCs neurogenic differentiation and hMSCs have shown a potential candidate in cellular therapy for ALS...
  26. doi request reprint Preimplantation genetic diagnosis for Duchenne muscular dystrophy by multiple displacement amplification
    Zi Ren
    Department of Obstetrics and Gynecology, Guangdong Provincial People s Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    Fertil Steril 91:359-64. 2009
    ..To evaluate the use of multiple displacement amplification (MDA) in preimplantation genetic diagnosis (PGD) for female carriers with Duchenne muscular dystrophy (DMD)...
  27. ncbi request reprint [Association between angiotensin-converting enzyme and polymorphisms of N5, N10-methylenetetrahydrofolic acid reductase gene in patients with ischemic stroke]
    Cai ming Li
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 29:359-63. 2007
    ..To explore the association between angiotensin-converting enzyme (ACE) and the polymorphisms of N5, N10-methylenetetrahydrofolic acid reductase (MTHFR) gene in patients with ischemic stroke (IS)...
  28. doi request reprint [Correlation between genotypes and phenotypes in pseudohypertrophic muscular dystrophy]
    Shan Wei Feng
    Institute of Population Research, Peking University, Beijing 100078, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:653-7. 2012
    ..To explore the correlation between genotypes and phenotypes in Chinese patients with pseudohypertrophic muscular dystrophy...
  29. doi request reprint Human adipose-derived stem cells enhance the glutamate uptake function of GLT1 in SOD1(G93A)-bearing astrocytes
    Ran Gu
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, PR China
    Biochem Biophys Res Commun 393:481-6. 2010
    ..Our results suggest that hADSCs may be a potential candidate in cellular therapy for ALS...
  30. ncbi request reprint [Brain-derived neurotrophic factor induces rat bone marrow stromal cells to differentiate into neuron-like cells in vitro]
    Wen Huang
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Di Yi Jun Yi Da Xue Xue Bao 24:854-8. 2004
    ....
  31. doi request reprint A comparative study of bone marrow mesenchymal stem cell functionality in C57BL and mdx mice
    Yan Leng
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, No 58 Zhongshan Road 2, Guangzhou 510080, China
    Neurosci Lett 523:139-44. 2012
    ..Because mutations in dystrophin gene cause DMD, our results demonstrate that dystrophin deficiency leads to dysfunction in the differentiation and proliferation of BMSCs...
  32. ncbi request reprint [Transduction of various mammalian bone marrow-derived mesenchymal stem cells by baculovirus]
    Zheng Shan Liu
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Sheng Li Xue Bao 60:431-6. 2008
    ..Due to the high transduction efficiency for primate and human BMSCs, baculovirus is possibly a more suitable gene vector to genetically modify BMSCs of human and primates...
  33. ncbi request reprint [Transplantation of 3H-thymidine-labeled human bone marrow-derived mesenchymal stem cells in mdx mice]
    Tai yun Liu
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510089, China
    Di Yi Jun Yi Da Xue Xue Bao 25:498-502. 2005
    ..To investigate the feasibility of using human bone marrow-derived mesenchymal stem cells (hBM- MSCs) for repairing the skeletal muscle sarcolemma lesions in mdx mice and characterize the distribution of the transplanted hBM-MSCs...
  34. doi request reprint [Genotypic and clinical features of spinal muscular atrophy type 3]
    Yan Yun Wang
    Department of Neurology, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:218-21. 2012
    ..To explore the genotypic and clinical features and laboratory examinations of spinal muscular atrophy type 3 (SMA III)...
  35. ncbi request reprint [Establishment of transgenic mouse model of familial amyotrophic lateral sclerosis and identification of the filial generation]
    Hui Huang
    Neurology Department, First Affiliated Hospital, Sun Yat Sen University, 510080, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:258-60, 265. 2006
    ..To establish transgenic mouse models of familial amyotrophic lateral sclerosis (FALS) and identify the genotype of the first filial generation...
  36. pmc Efficient retrograde transport of adeno-associated virus type 8 to spinal cord and dorsal root ganglion after vector delivery in muscle
    Hui Zheng
    Department of Neurology, the First Affiliated Hospital of Sun Yat Sen University, Sun Yat Sen University, Guangzhou 510080, China
    Hum Gene Ther 21:87-97. 2010
    ..These results support the mechanism of vector retrograde transport and suggest that AAV8 crosses blood-nerve barrier poorly. Our finding should have important implications in gene therapy for peripheral neurological disorders...
  37. ncbi request reprint [Transfection and in vitro expression of human microdystrophin gene in rat mesenchymal stem cells]
    Shu Hui Wang
    Department of Neurology, First Affiliated Hospital1, Sun Yat Sen University, Guangzhou 510080, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:261-5. 2006
    ..To construct the eukaryotic expression vector of human microdystrophin gene and observe its expression in rat mesenchymal stem cells (rMSCs) in vitro...
  38. ncbi request reprint [Preliminary study of the spatial structural and functional changes of dystrophin after exon-3 deletion]
    Ying Yin Liang
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510700, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:938-41. 2008
    ..To explore the structural and functional changes of dystrophin molecule after exon 3 deletion...
  39. doi request reprint The absence of dystrophin rather than muscle degeneration causes acetylcholine receptor cluster defects in dystrophic muscle
    Jie Kong
    The First Affiliated Hospital, Sun Yet Sen University, Guangdong Province, People s Republic of China
    Neuroreport 23:82-7. 2012
    ..Fragmentation of AChR and muscle degeneration are separate events, and both are secondary results of destabilization on the sarcolemma and the cytoskeleton...
  40. doi request reprint [Study of dystrophin gene non-deletion/duplication mutations causing Becker muscular dystrophy]
    Ji qing Cao
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510080 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 28:308-12. 2011
    ..To identify potential mutations in patients featuring Becker muscular dystrophy (BMD) and to enhance the understanding of non-deletion/duplication mutations of the dystrophin gene causing BMD...
  41. doi request reprint Multiple administrations of human marrow stromal cells through cerebrospinal fluid prolong survival in a transgenic mouse model of amyotrophic lateral sclerosis
    Chen Zhang
    Department of Neurology, First Affiliated Hospital of Sun Yat sen University, Guangzhou, Guangdong, corrected PR China
    Cytotherapy 11:299-306. 2009
    ..We investigated the effects of human marrow stromal cells (hMSC) delivered through cerebrospinal fluid (CSF) in a transgenic mouse model of ALS...
  42. ncbi request reprint [Effects of granulocyte colony-stimulating factor on focal cerebral ischemia-reperfusion injury in rats]
    Song Lin Chen
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Di Yi Jun Yi Da Xue Xue Bao 25:503-7. 2005
    ..To study the therapeutic effects of granulocyte colony-stimulating factor (G-CSF) on focal cerebral ischemia-reperfusion injury in rats...
  43. doi request reprint [Study on clinical manifestation, genotype and genetic characteristics of two Kennedy disease pedigrees]
    Juan Yang
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:125-31. 2010
    ..To investigate the clinical manifestations, genotypes, and genetic characteristics of two pedigrees with Kennedy disease...
  44. doi request reprint [Clinical, familial and hereditary analysis of myotonic dystrophy]
    Zhenfu Wu
    Department of Neurology, First Affilicated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:520-4. 2011
    ..To analyze the clinical, familial and hereditary features of myotonic dystrophy to improve the knowledge and provide molecule evidence for gene diagnosis and prenatal diagnosis of myotonic dystrophy or dystrophia myotonia (DM) families...
  45. ncbi request reprint [Relationship between methylenetrahydrofolate reductase gene and ischemic stroke]
    Cai ming Li
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, Guangdong, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 18:264-7. 2006
    ..To study the relationship between methylenetrahydrofolate reductase (MTHFR) gene and ischemic stroke...
  46. ncbi request reprint [Application of the Bgl II-Bln I dosage test to gene diagnosis of facioscapulohumeral muscular dystrophy 1A gene]
    Quan xi Su
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510080 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:245-7. 2004
    ..To increase the sensitivity and specificity of conventional gene diagnosis of facioscapulohumeral muscular dystrophy 1A(FSHD1A) by analyzing the distribution of translocation between chromosomes 4q35 and 10q26 in suspected FSHD cases...
  47. ncbi request reprint Mutation analysis of the small heat shock protein 27 gene in chinese patients with Charcot-Marie-Tooth disease
    Beisha Tang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, People s Republic of China
    Arch Neurol 62:1201-7. 2005
    ..Recently, mutations in small heat shock protein 27 (Hsp27) were reported to cause CMT disease type 2F and distal hereditary motor neuropathy...
  48. ncbi request reprint [Cell therapy for Duchenne muscular dystrophy]
    Chang Zhou
    Department of Neurology, Affiliated Hospital for Sun Yat sen University, Guangzhou, Guangdong, 510080, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:659-61. 2006
    ..Compared with them, the injection of postnatal muscle-derived stem cells (MDSC) results in a superior regeneration of dystrophin-expressing myofibers...
  49. ncbi request reprint [The genes change of hMSC before and after the differentation into neuron-like cells]
    Xiaoli Yao
    Department of Neurology, The First Affiliated Hospital, Guangzhou
    Zhong Yao Cai 28:476-81. 2005
    ..To study the genes change of hMSC before and after differentiation into neuron-like cells...
  50. pmc Human marrow stromal cells reduce microglial activation to protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis
    Chang Zhou
    Department of Neurology, the Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, Qingdao, Shandong 266003, PR China
    J Neuroinflammation 10:52. 2013
    ..In addition, we also focused on the mode of hMSCs inhibiting microglial activation...
  51. doi request reprint [Advances of treatment for Duchenne muscular dystrophy with exon skipping]
    Juan Yang
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510080, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 28:406-8. 2011
    ..However, a new method named exon-skipping mediated by antisense oligonucleotides has considerable potential for DMD therapy. In this review, the principle, basic research and clinical research of exon-skipping are mainly summarized...
  52. ncbi request reprint [Comparison and analysis of the molecular character of breakpoints in introns of deletion hotspots of dystrophin gene]
    Wen li Sheng
    Department of Neurology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510080 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:376-80. 2003
    ..To study the exons deletion mechanisms for dystrophin gene, the molecular characters of breakpoints of junction fragments for deletion-type Duchenne muscular dystrophy (DMD) patients with 46 and 51 exons deletion were compared and analyzed...
  53. ncbi request reprint Distinct novel mutations affecting the same base in the NIPA1 gene cause autosomal dominant hereditary spastic paraplegia in two Chinese families
    Suqin Chen
    Department of Medical Genetics, Zhongshan Medical College, Sun Yat Sen University, Guangzhou, People s Republic of China
    Hum Mutat 25:135-41. 2005
    ..G106R disrupts this structure, causing the intramembrane loop to descend into the cytoplasm. Our results identify two novel mutations responsible for HSP and suggest that c.316 of theNIPA1 gene may be a mutational hotspot...
  54. ncbi request reprint [Carrier detection of Duchenne/Becker muscular dystrophy in Chinese families by microsatellite analysis]
    Wen Huang
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510080 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:224-8. 2004
    ..To screen and detect the female carriers from the DMD/BMD family members for prenatal or preimplantation genetic diagnosis...
  55. ncbi request reprint [Ultrastructural changes in muscular tissues of dystrophin/utrophin double-knockout mice after bone marrow-derived mesenchymal stem cell transplantation]
    Zhong Li
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Di Yi Jun Yi Da Xue Xue Bao 24:501-4. 2004
    ..To observe the ultrastructural changes in the muscular tissues of Duchenne muscular dystrophy mouse models with dystrophin/utrophin double-knockout (DKO) after transplantation of bone marrow-derived mesenchymal stem cells (MSCs)...
  56. doi request reprint Human corneal basal epithelial cells express an embryonic stem cell marker OCT4
    Shi you Zhou
    Zhongshan Ophthalmic Center, The State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, China
    Curr Eye Res 35:978-85. 2010
    ..OCT4 expression is down-regulated in all differentiated somatic cell types in vitro and in vivo. Our aim is to investigate whether the human corneal epithelium expresses OCT4...