Xuan Xian Peng


Affiliation: Sun Yat-sen University
Country: China


  1. Su Y, Peng B, Li H, Cheng Z, Zhang T, Zhu J, et al. Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria. Proc Natl Acad Sci U S A. 2018;115:E1578-E1587 pubmed publisher
  2. Cheng Z, Ma Y, Li H, Peng X. N-acetylglucosamine enhances survival ability of tilapias infected by Streptococcus iniae. Fish Shellfish Immunol. 2014;40:524-30 pubmed publisher
    ..iniae. Exogenous N-acetylglucosamine significantly elevates survival ability of tilapia against the infection caused by S. iniae. Our findings highlight the importance of metabolic strategy against bacterial infections. ..
  3. Zhao X, Han Y, Ren S, Ma Y, Li H, Peng X. L-proline increases survival of tilapias infected by Streptococcus agalactiae in higher water temperature. Fish Shellfish Immunol. 2015;44:33-42 pubmed publisher
    ..Our findings provide a potential metabolic modulator for controlling the disease, and shed some light on host metabolic prevention to infectious diseases. ..
  4. Ma Y, Yang M, Wang S, Li H, Peng X. Liver functional metabolomics discloses an action of L-leucine against Streptococcus iniae infection in tilapias. Fish Shellfish Immunol. 2015;45:414-21 pubmed publisher
    ..The present study establishes an alternative way, metabolic modulation, to cope with bacterial infections. ..
  5. Wu C, Zhao X, Wu X, Wen C, Li H, Chen X, et al. Exogenous glycine and serine promote growth and antifungal activity of Penicillium citrinum W1 from the south-west Indian Ocean. FEMS Microbiol Lett. 2015;362:fnv040 pubmed publisher
    ..citrinum W1 growth and increased antifungal activity, but also highlight the way to utilize metabolomics for an understanding of metabolic mechanism manipulated by an exogenous compound. ..
  6. Liu X, Zhu W, Su Y, Guo C, Zeng Z, Zhu H, et al. Characterization of ampicillin-stressed proteomics and development of a direct method for detecting drug-binding proteins in Edwardsiella tarda. J Proteomics. 2015;116:97-105 pubmed publisher
    ..tarda. ETAE_3367 is closely interacted with proteins of the TCA cycle and glycolysis/gluconeogenesis, suggesting the drug-resistant mechanism. ..
  7. Peng B, Su Y, Li H, Han Y, Guo C, Tian Y, et al. Exogenous alanine and/or glucose plus kanamycin kills antibiotic-resistant bacteria. Cell Metab. 2015;21:249-61 pubmed publisher
    ..This study establishes a functional metabolomics-based strategy to manage infection by antibiotic-resistant bacteria. ..
  8. Li H, Chu X, Li D, Zeng Z, Peng X. Construction and immune protection evaluation of recombinant polyvalent OmpAs derived from genetically divergent ompA by DNA shuffling. Fish Shellfish Immunol. 2016;49:230-6 pubmed publisher
    ..Thus, the present study highlights the way to develop polyvalent vaccines against microbial infections by DNA shuffling. ..
  9. Wang S, Cheng Z, Ling X, Chu X, Peng X, Li H. Construction, immune protection and innate immune response of shuffled polyvalent ompAs vaccines. Fish Shellfish Immunol. 2018;74:325-331 pubmed publisher
    ..These results indicate that use of different primers to construct a DNA library selects new evolution of polyvalent vaccines with desired traits, and polyvalent ompA vaccines elicit high innate immune response. ..


More Information


  1. Cheng Z, Chu X, Wang S, Peng X, Li H. Six genes of ompA family shuffling for development of polyvalent vaccines against Vibrio alginolyticus and Edwardsiella tarda. Fish Shellfish Immunol. 2018;75:308-315 pubmed publisher
    ..These results indicate the expansion of polyvalent vaccine reservoir with the same shuffling genes but different primers, and promote the understanding of the mechanisms of polyvalent vaccines based on vaccine-induced innate immunity. ..
  2. Zhang D, Ye J, Dai H, Lin X, Li H, Peng X. Identification of ethanol tolerant outer membrane proteome reveals OmpC-dependent mechanism in a manner of EnvZ/OmpR regulation in Escherichia coli. J Proteomics. 2018;179:92-99 pubmed publisher
    ..This is the first report of OM proteomics in E. coli exposed to ethanol. Our findings reveal an unknown OmpC-dependent mechanism of ethanol tolerance in a manner of EnvZ/OmpR regulation. ..
  3. Li H, Zhang D, Lin X, Peng X. Outer membrane proteomics of kanamycin-resistant Escherichia coli identified MipA as a novel antibiotic resistance-related protein. FEMS Microbiol Lett. 2015;362: pubmed publisher
  4. Lin X, Yang M, Li H, Wang C, Peng X. Decreased expression of LamB and Odp1 complex is crucial for antibiotic resistance in Escherichia coli. J Proteomics. 2014;98:244-53 pubmed publisher
    ..Our findings indicate that interaction of outer membrane protein with energy metabolic enzyme constructs an efficient pathway to resist antibiotics and provides novel insights into the mechanisms of antibiotic resistance. ..