Affiliation: Sun Yat-sen University
Lin Y, Zhang H, Liang J, Li K, Zhu W, Fu L, et al
. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. Proc Natl Acad Sci U S A. 2014;111:E4504-12 pubmed publisher
..Additionally, M1 killed cancer cells by inducing endoplasmic reticulum stress-mediated apoptosis. Our report provides novel insights into potentially personalized cancer therapy using oncolytic viruses. ..
Zhang H, Li K, Lin Y, Xing F, Xiao X, Cai J, et al
. Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma. Sci Transl Med. 2017;9: pubmed publisher
..Our study identifies combined VCP inhibition and oncolytic virus as a potential treatment for HCC and demonstrates promising therapeutic potential. ..
Ou Y, Zheng X, Gao Y, Shu M, Leng T, Li Y, et al
. Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics. Urol Oncol. 2014;32:47.e21-8 pubmed publisher
..Our results indicated that the cAMP/PKA signaling pathway might inhibit bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics, which could be exploited for the therapy of invasive bladder cancer. ..