F F Hou

Summary

Affiliation: Sun Yat-sen University
Country: China

Publications

  1. ncbi Beta 2-microglobulin modified with advanced glycation end products modulates collagen synthesis by human fibroblasts
    W F Owen
    Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 53:1365-73. 1998
  2. ncbi Beta 2-microglobulin amyloidosis: role of monocytes/macrophages
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, Guangzhou, People s Republic of China
    Curr Opin Nephrol Hypertens 11:417-21. 2002
  3. ncbi [Cardiovascular disease in Chinese chronic renal insufficiency patients-epidemiology survey]
    Fan Fan Hou
    Department of Nephrology, Nanfang Hospital, Guangzhou 510515, China
    Zhonghua Yi Xue Za Zhi 85:458-63. 2005
  4. doi Induction treatment of proliferative lupus nephritis with leflunomide combined with prednisone: a prospective multi-centre observational study
    H Y Wang
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
    Lupus 17:638-44. 2008
  5. ncbi [Epidemiology of cardiovascular risk in Chinese chronic kidney disease patients]
    Fan Fan Hou
    Department of Nephrology, Nanfang Hospital, Guangzhou 510515, China
    Zhonghua Yi Xue Za Zhi 85:753-9. 2005
  6. ncbi Efficacy and safety of benazepril for advanced chronic renal insufficiency
    Fan Fan Hou
    Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China
    N Engl J Med 354:131-40. 2006
  7. ncbi Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study: a randomized controlled study of benazepril and losartan in chronic renal insufficiency
    Fan Fan Hou
    Renal Division, Nanfang Hospital, 1838 North Guangzhou Avenue, Guangzhou 510515, People s Republic of China
    J Am Soc Nephrol 18:1889-98. 2007
  8. ncbi Enhanced expression of receptor for advanced glycation end products in chronic kidney disease
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, Guangzhou, People s Republic of China
    J Am Soc Nephrol 15:1889-96. 2004
  9. ncbi Pharmacological intervention of hypertension in proteinuric chronic kidney disease: how and what?
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
    Chin Med J (Engl) 121:840-3. 2008
  10. doi Optimal dose of angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker for renoprotection
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, Southern Medical University, Key Laboratory for Organ Failure Research, Ministry of Education, Guangzhou, China
    Nephrology (Carlton) 15:57-60. 2010

Collaborators

Detail Information

Publications38

  1. ncbi Beta 2-microglobulin modified with advanced glycation end products modulates collagen synthesis by human fibroblasts
    W F Owen
    Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 53:1365-73. 1998
    ..These findings support the hypothesis that beta 2m-AGE actively participates in connective tissue and bone remodeling via a pathway involving fibroblast RAGE, and at least one interposed mediator, the growth factor EGF...
  2. ncbi Beta 2-microglobulin amyloidosis: role of monocytes/macrophages
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, Guangzhou, People s Republic of China
    Curr Opin Nephrol Hypertens 11:417-21. 2002
    ..Studies reported during the past years have helped to clarify the role of monocytes/macrophages in the fibrillar precipitation of beta2-microglobulin and in the pathogenesis of osteoarticular pathology...
  3. ncbi [Cardiovascular disease in Chinese chronic renal insufficiency patients-epidemiology survey]
    Fan Fan Hou
    Department of Nephrology, Nanfang Hospital, Guangzhou 510515, China
    Zhonghua Yi Xue Za Zhi 85:458-63. 2005
    ..The study was performed to investigate the prevalence and the spectrum of CVD in Chinese chronic kidney disease (CKD) patients...
  4. doi Induction treatment of proliferative lupus nephritis with leflunomide combined with prednisone: a prospective multi-centre observational study
    H Y Wang
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
    Lupus 17:638-44. 2008
    ..Leflunomide, compared with cyclophosphamide, in combination with prednisone was effective in the induction therapy of proliferative lupus nephritis and was generally well-tolerated...
  5. ncbi [Epidemiology of cardiovascular risk in Chinese chronic kidney disease patients]
    Fan Fan Hou
    Department of Nephrology, Nanfang Hospital, Guangzhou 510515, China
    Zhonghua Yi Xue Za Zhi 85:753-9. 2005
    ..To identify the risk factors associated with cardiovascular disease (CVD) in Chinese chronic kidney disease (CKD) patients...
  6. ncbi Efficacy and safety of benazepril for advanced chronic renal insufficiency
    Fan Fan Hou
    Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China
    N Engl J Med 354:131-40. 2006
    ..0 mg per deciliter or less). We assessed the efficacy and safety of benazepril in patients without diabetes who had advanced renal insufficiency...
  7. ncbi Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study: a randomized controlled study of benazepril and losartan in chronic renal insufficiency
    Fan Fan Hou
    Renal Division, Nanfang Hospital, 1838 North Guangzhou Avenue, Guangzhou 510515, People s Republic of China
    J Am Soc Nephrol 18:1889-98. 2007
    ..It is concluded that uptitration of benazepril or losartan against proteinuria conferred further benefit on renal outcome in patients who did not have diabetes and had proteinuria and renal insufficiency...
  8. ncbi Enhanced expression of receptor for advanced glycation end products in chronic kidney disease
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, Guangzhou, People s Republic of China
    J Am Soc Nephrol 15:1889-96. 2004
    ..It was concluded that RAGE expression was upregulated on monocytes from patients with CKD. Enhanced RAGE may amplify AGE-induced monocytes perturbation and contribute to monocyte-mediated systemic inflammation in progressive CKD...
  9. ncbi Pharmacological intervention of hypertension in proteinuric chronic kidney disease: how and what?
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
    Chin Med J (Engl) 121:840-3. 2008
  10. doi Optimal dose of angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker for renoprotection
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, Southern Medical University, Key Laboratory for Organ Failure Research, Ministry of Education, Guangzhou, China
    Nephrology (Carlton) 15:57-60. 2010
    ..Because patients who would benefit from higher doses are not identifiable a priori, a titration process might be cogent in order to provide more robust anti-proteinuric benefit to such patients...
  11. ncbi Phenotypic and functional characteristics of macrophage-like cells differentiated in pro-inflammatory cytokine-containing cultures
    F F Hou
    Renal Division, Division of Immunology and Rheumatology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Immunol Cell Biol 78:205-13. 2000
    ..Elevated levels of IL-1beta and TNF-alpha in the inflammatory tissues may therefore not only prolong the survival of recruited monocytes, but maintain them in an inflammatory state...
  12. ncbi Receptor for advanced glycation end products on human synovial fibroblasts: role in the pathogenesis of dialysis-related amyloidosis
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, Guangzhou, People s Republic of China
    J Am Soc Nephrol 13:1296-306. 2002
    ..These data provide evidence of RAGE-mediated perturbation of human synoviocytes, which may be involved in the pathogenesis of inflammatory processes associated with DRA...
  13. ncbi beta(2)-Microglobulin modified with advanced glycation end products delays monocyte apoptosis
    F F Hou
    Duke Institute of Renal Outcomes Research and Health Policy, Division of Nephrology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 59:990-1002. 2001
    ..CONCLUSIONS: These findings support a novel role for AGE-modified proteins such as AGE-beta(2)m that may contribute to the development of a local inflammatory response, with predominant accumulation of monocytes/macrophages, in DRA...
  14. ncbi Advanced glycation end products upregulate C-reactive protein synthesis by human hepatocytes through stimulation of monocyte IL-6 and IL-1 beta production
    J T Li
    Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Scand J Immunol 66:555-62. 2007
    ..These results suggest that AGE cannot directly stimulate hepatocytes to produce CRP, but rather indirectly enhance CRP expression via stimulation of IL-6 and IL-1 beta production by human monocytes...
  15. ncbi Natural history and impact on outcomes of acute kidney injury in patients with road traffic injury
    F Yuan
    1Division of Nephrology, Nanfang Hospital, and 2Department of Biostatistics, Southern Medical University, Guangzhou, P R China
    Clin Nephrol 71:669-79. 2009
    ..The natural history of AKI after road traffic injury (RTI) has not been studied...
  16. ncbi Restricted intake of dietary advanced glycation end products retards renal progression in the remnant kidney model
    J X Feng
    Department of Medicine, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China
    Kidney Int 71:901-11. 2007
    ..These results demonstrated that restriction of dietary AGEs intake retards progression of renal fibrosis and dysfunction in the remnant kidney model...
  17. ncbi Pathogenesis of beta(2)-microglobulin amyloidosis: role of monocytes/macrophages
    F F Hou
    Division of Nephrology, Nanfang Hospital, Guangzhou, Peoples Republic of China
    Semin Dial 14:135-9. 2001
    ..Thus through regulation of their survival and differentiation, AGE beta(2)M in amyloid deposits may be able to influence the presence and quantity of infiltrated monocytes, and hence their biologic effects...
  18. doi Successful treatment of massive ascites with intraperitoneal administration of a steroid in a case of systemic lupus erythematosus
    Q G Zhou
    Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Lupus 18:740-2. 2009
    ..Intraperitoneal injection of triamcinolone, an insoluble glucocorticoid, induced dramatic remission of massive ascites, with no adverse event or recurrence...
  19. doi High level of proteinuria during treatment with renin-angiotensin inhibitors is a strong predictor of renal outcome in nondiabetic kidney disease
    Di Xie
    Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, P R China
    J Clin Pharmacol 51:1025-34. 2011
    ..Therefore, minimization of proteinuria at least to less than 1.0 g/d should be a therapeutic goal in the management of nondiabetic patients with heavy proteinuria and renal insufficiency...
  20. ncbi Cardiovascular risk in Chinese patients with chronic kidney diseases: where do we stand?
    Fan Fan Hou
    Chin Med J (Engl) 118:883-6. 2005
  21. ncbi [Inflammatory status in patients with end-stage renal disease: role of monocyte activation]
    Min Liang
    Department of Nephrology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 23:781-4. 2003
    ..To study the association of monocyte activation and the inflammatory status in patients with end-stage renal disease (ESRD)...
  22. ncbi Preparation of monoclonal antibodies against different epitopes on extracellular domain of human receptor for advanced glycation end product
    Ping Zhu
    Department of Immunology, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:129-32. 2004
    ..To prepare and characterize monoclonal antibodies (mAb) against recombinant human receptor for advanced glycation end product (rhRAGE)...
  23. ncbi [Hyperhomocysteinemia, oxidative stress and microinflammation in chronic renal failure: their roles in atherogene]
    Yue Ming Yu
    Division of Nephrology, Nanfang Hospital, Guangzhou 510515, China
    Zhonghua Nei Ke Za Zhi 43:292-5. 2004
    ..To investigate the relationship between hyperhomocysteinemia, oxidative stress and microinflammation in patients with chronic renal failure (CRF), and its role in the pathogenesis of atherosclerosis seen in these patients...
  24. ncbi [Activation of receptor for advanced glycation end products: a mechanism for monocyte-mediated inflammation in chronic renal failure]
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Zhonghua Yi Xue Za Zhi 84:1614-9. 2004
    ..To investigate the expression of receptor for advanced glycation end products (RAGE) in chronic renal failure (CRF) and its role in monocyte-mediated inflammation associated with chronic renal failure (CRF)...
  25. ncbi How should renin-angiotensin system blockade be applied in chronic kidney disease for optimal renal protection?
    Xun Zhang
    Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Chin Med J (Engl) 120:243-5. 2007
  26. ncbi [Improvement of left ventricular hypertrophy by anemic-correcting erythropoietin therapy in chronic renal insufficiency]
    Jian Ping Jiang
    Division of Nephrology, Nanfang Hospital, Guangzhou 510515, China
    Zhonghua Nei Ke Za Zhi 44:25-9. 2005
    ..This prospective multi-center Chinese cohort study evaluates left ventricular mass index (LVMI) evolution in anemic CRI patients with or without recombinant human erythropoietin (rHuEPO) therapy...
  27. ncbi Level of asymmetric dimethylarginine and carotid atherosclerosis in patients with chronic kidney disease
    Wei Ru Zhang
    Division of Nephrology, Xiangya Hospital, Central South University, Changsha 410078, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:621-8. 2006
    ..To determine the association between asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthase, with atherosclerosis in patients with chronic kidney disease (CKD)...
  28. ncbi [Can angiotensin-converting enzyme inhibitor be used in chronic kidney disease patients with serum creatinine level greater than 266 micromol/L?]
    Guo Hua Zhang
    Division of Nephrology, Nanfang Hospital, The Nanfang Medical University, Guangzhou 510515, China
    Zhonghua Nei Ke Za Zhi 44:592-6. 2005
    ..A prospective, randomized controlled trial was performed to evaluate the renal protective effect and safety of ACEI in patients whose serum creatinine (Scr) levels were higher than 265 micromol/L...
  29. ncbi [Increased levels of advanced oxidation protein products are associated with atherosclerosis in chronic kidney disease]
    Xiao Bing Yang
    Department of Nephrology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Zhonghua Nei Ke Za Zhi 44:342-6. 2005
    ..Accumulation of advanced oxidation protein products (AOPP) has been found in patients with chronic kidney disease (CKD). The study was performed to investigate the association between serum levels of AOPP and atherosclerosis in CKD...
  30. ncbi Comparisons between oral pulse alfacalcidol therapy and daily therapy in maintenance hemodialysis patients with secondary hyperparathyroidism: a randomized, controlled, and multicenter study
    Y Gu
    Ren Fail 27:205-12. 2005
    ..To investigate the efficacy and safety of 1alpha-(OH)-D3 high-dose pulse therapy or daily low-dose therapy in secondary hyperthyroidism in maintenance hemodialysis patients in China...
  31. ncbi [The structure and function of RAGE]
    Shan Chao Zhao
    Sheng Li Ke Xue Jin Zhan 34:71-3. 2003
  32. ncbi [Vector construction for the intracellular domain of human receptor for advanced glycation end- products and expression of the fusion protein]
    Shan Chao Zhao
    Key Laboratory of Shock and Microcirculation of PLA, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 23:1314-6. 2003
    ..To construct a eukaryotic expression vector for GST-tagged intracellular domain of human receptor for advanced glycation end-products (hRAGE), and to study the function of the expressed fusion protein and identify its interacting proteins...
  33. ncbi [Proteins modified with glycation or oxidation products accelerate atherosclerosis in experimental hypercholesterolemic rabbits]
    Zhi Jian Guo
    Division of Nephrology, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China
    Beijing Da Xue Xue Bao 36:127-30. 2004
    ..To investigate whether advanced glycation end products (AGE) or advanced oxidative protein products (AOPP) contributes to atherogenesis in experimental hypercholesterolemic rabbits...
  34. ncbi [Prokaryotic expression and activity identification of recombinant human soluble receptor for advanced glycation end products]
    Shan Chao Zhao
    Institute of Renal Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 25:769-73. 2005
    ..To construct a eukaryotic expression vector for His-tagged human soluble receptor for advanced glycation end products (hsRAGE), and study the function and biological activity of the fusion protein...
  35. ncbi [Treatment of proliferative lupus nephritis with leflunomide and steroid: a prospective multi-center controlled clinical trial]
    Tai Gen Cui
    Renal Division and Institute of Nephrology, First Hospital, Peking University, Beijing 100034, China
    Zhonghua Nei Ke Za Zhi 44:672-6. 2005
    ..To evaluate the efficacy and safety of LEF in the treatment of proliferative lupus nephritis, a prospective multi-center controlled clinical trial was conducted...
  36. ncbi [The protective effects to the function of kidney and long by clearing of cytokines in patients with open-heart surgery]
    Guo Hua Zhang
    Division of Nephrology, Nanfang Hospital, Nanfang Medical University, Guangzhou 510515, China
    Zhonghua Yi Xue Za Zhi 85:3194-8. 2005
    ..To observe the effect of cytokines absorption on renal and respiratory function in patients with open-heart surgery...
  37. ncbi Advanced glycation end products induce actin rearrangement and subsequent hyperpermeability of endothelial cells
    Xiao Hua Guo
    Department of Pathophysiology, Southern Medical University, Guangzhou, PR China
    APMIS 114:874-83. 2006
    ..The results indicate that ERK and p38 MAPK play important roles in the mediation of AGE-induced EC barrier dysfunction associated with morphological changes of the F-actin...
  38. ncbi [Advanced oxidation protein products-induced tumor necrosis factor alpha secretion in monocytes via reactive oxygen species generation]
    Zhi Hui Zhang
    Department of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 25:493-7. 2005
    ..To investigate the effect of advanced oxidation protein products (AOPP) on the secretion of tumor necrosis factor alpha eTNFalphae in monocytes and its possible mechanism...