Li Wu Fu

Summary

Affiliation: Sun Yat-sen University
Country: China

Publications

  1. pmc Neratinib reverses ATP-binding cassette B1-mediated chemotherapeutic drug resistance in vitro, in vivo, and ex vivo
    Xiao qin Zhao
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, 510060, China
    Mol Pharmacol 82:47-58. 2012
  2. pmc Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma
    Jing yan Cao
    State Key Laboratory of Oncology in South China
    Mol Cancer 9:237. 2010
  3. pmc Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2
    Chun Ling Dai
    State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 68:7905-14. 2008
  4. doi request reprint Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2
    Chun Ling Dai
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Cancer Lett 279:74-83. 2009
  5. ncbi request reprint Reversal of P-gp-mediated multidrug resistance by Bromotetrandrine in vivo is associated with enhanced accumulation of chemotherapeutical drug in tumor tissue
    Li Ming Chen
    Cancer Center, Sun Yat Sen University, Guangzhou 510060, People s Republic of China
    Anticancer Res 29:4597-604. 2009
  6. pmc Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi
    Jian Ye Zhang
    State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, 510060, China
    Mar Drugs 8:1469-81. 2010
  7. pmc Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters
    Yan jun Mi
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 70:7981-91. 2010
  8. ncbi request reprint [Induction of apoptosis of tumor multidrug resistance cell by uvarigrin and its mechanism]
    Yan fang Li
    Cancer Center, Sun Yat Sen University, Guangzhou, China
    Yao Xue Xue Bao 41:252-6. 2006
  9. ncbi request reprint Experimental chemotherapy against xenografts derived from multidrug resistant KBv200 cells and parental drug-sensitive KB cells in nude mice by annonaceous acetogenin 89-2
    Li Wu Fu
    Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Yao Xue Xue Bao 38:565-70. 2003
  10. ncbi request reprint A cell-based screen for anticancer activity of 13 pyrazolone derivatives
    Xiao Hong Wang
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510060, P R China
    Chin J Cancer 29:980-7. 2010

Collaborators

Detail Information

Publications42

  1. pmc Neratinib reverses ATP-binding cassette B1-mediated chemotherapeutic drug resistance in vitro, in vivo, and ex vivo
    Xiao qin Zhao
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, 510060, China
    Mol Pharmacol 82:47-58. 2012
    ..In conclusion, neratinib can reverse ABCB1-mediated multidrug resistance in vitro, ex vivo, and in vivo by inhibiting its transport function...
  2. pmc Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma
    Jing yan Cao
    State Key Laboratory of Oncology in South China
    Mol Cancer 9:237. 2010
    ....
  3. pmc Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2
    Chun Ling Dai
    State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 68:7905-14. 2008
    ..Overall, we conclude that lapatinib reverses ABCB1- and ABCG2-mediated MDR by directly inhibiting their transport function. These findings may be useful for cancer combinational therapy with lapatinib in the clinic...
  4. doi request reprint Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2
    Chun Ling Dai
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Cancer Lett 279:74-83. 2009
    ..Overall, we conclude that sunitinib reverses ABCG2-mediated MDR through inhibiting the drug efflux function of ABCG2. These findings may be useful for cancer combinational therapy with sunitinib in the clinic...
  5. ncbi request reprint Reversal of P-gp-mediated multidrug resistance by Bromotetrandrine in vivo is associated with enhanced accumulation of chemotherapeutical drug in tumor tissue
    Li Ming Chen
    Cancer Center, Sun Yat Sen University, Guangzhou 510060, People s Republic of China
    Anticancer Res 29:4597-604. 2009
    ..5-Bromotetrandrine (Br-Tet) is a newly synthesized brominated derivative of Tet. In this study, we investigated the MDR reversal activity of Br-Tet in vitro and in vivo and the mechanism involved in this reversal...
  6. pmc Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi
    Jian Ye Zhang
    State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, 510060, China
    Mar Drugs 8:1469-81. 2010
    ..Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed...
  7. pmc Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters
    Yan jun Mi
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Res 70:7981-91. 2010
    ..Apatinib may be useful in circumventing MDR to other conventional antineoplastic drugs...
  8. ncbi request reprint [Induction of apoptosis of tumor multidrug resistance cell by uvarigrin and its mechanism]
    Yan fang Li
    Cancer Center, Sun Yat Sen University, Guangzhou, China
    Yao Xue Xue Bao 41:252-6. 2006
    ..To study the effect of uvarigrin on mitochondrial dependent pathway during the apoptosis induced by it in MDR KBv200 cells and their parental sensitive KB cells...
  9. ncbi request reprint Experimental chemotherapy against xenografts derived from multidrug resistant KBv200 cells and parental drug-sensitive KB cells in nude mice by annonaceous acetogenin 89-2
    Li Wu Fu
    Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Yao Xue Xue Bao 38:565-70. 2003
    ..Annonaceous acetogenin 89-2 was obtained from atemoya plant. To investigate the effect of 89-2 on experimental chemotherapy against xenografts derived from multidrug resistant KBv200 cells and parental drug-sensitive KB cells...
  10. ncbi request reprint A cell-based screen for anticancer activity of 13 pyrazolone derivatives
    Xiao Hong Wang
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510060, P R China
    Chin J Cancer 29:980-7. 2010
    ..Additionally, the structure-activity relationships of these compounds were discussed...
  11. ncbi request reprint Overexpression of Survivin and XIAP in MDR cancer cells unrelated to P-glycoprotein
    Zhi Shi
    State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, P R China
    Oncol Rep 17:969-76. 2007
    ..In summary, our study suggested that the overexpression of Survivin and XIAP in MDR cancer cells does not directly interact with P-gp...
  12. ncbi request reprint Lgf-YL-9 induces apoptosis in human epidermoid carcinoma KB cells and multidrug resistant KBv200 cells via reactive oxygen species-independent mitochondrial pathway
    Xiao Hong Wang
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, PR China
    Cancer Lett 249:256-70. 2007
    ..Lgf-YL-9-induced apoptosis is involved in a new ROS-independent mitochondrial dysfunction pathway, but not in intercalating to DNA...
  13. doi request reprint Euphorbia factor L1 reverses ABCB1-mediated multidrug resistance involving interaction with ABCB1 independent of ABCB1 downregualtion
    Jian Ye Zhang
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, PR China
    J Cell Biochem 112:1076-83. 2011
    ..At the same time, EFL1 inhibited the efflux of ABCB1 in KBv200 and MCF-7/adr cells. In addition, EFL1 did not downregulate expression of ABCB1 in KBv200 and MCF-7/adr cells either in mRNA or protein level...
  14. doi request reprint Prognostic value of the multidrug resistance transporter ABCG2 gene polymorphisms in Chinese patients with de novo acute leukaemia
    Fang Wang
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, 510060, China
    Eur J Cancer 47:1990-9. 2011
    ..Functional polymorphisms of the ABCG2 gene may contribute to individual variability in drug response and the prognosis of patients...
  15. pmc Anticancer effect and structure-activity analysis of marine products isolated from metabolites of mangrove fungi in the South China Sea
    Li Yang Tao
    State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, 510060, China
    Mar Drugs 8:1094-105. 2010
    ....
  16. doi request reprint Apatinib (YN968D1) enhances the efficacy of conventional chemotherapeutical drugs in side population cells and ABCB1-overexpressing leukemia cells
    Xiu zhen Tong
    Department of Hematology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Biochem Pharmacol 83:586-97. 2012
    ..These findings should be useful for the combination of apatinib and chemotherapeutic agents in the clinic...
  17. doi request reprint Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu
    Yan Yan Yan
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Mol Pharm 8:1687-97. 2011
    ..Our results provide suggestions that emodin AMAD could be promising as a new targeting therapeutic strategy in the treatment of Her2/neu-overexpressing cancers...
  18. ncbi request reprint P-glycoprotein is not involved in pathway of anti-Fas/Fas-induced apoptosis in KBv200 cells
    Qiu Liang Wu
    Department of Pathology, Cancer Center, Sun Yat Sen University, Guangzhou 510060, Guangdong Province, China
    World J Gastroenterol 11:3544-8. 2005
    ..To verify whether P-glycoprotein (P-gp) could induce cell resistance to apoptosis by inhibiting caspase-8 and caspase-3...
  19. ncbi request reprint FG020326-loaded nanoparticle with PEG and PDLLA improved pharmacodynamics of reversing multidrug resistance in vitro and in vivo
    Wen jing Deng
    State Key Laboratory of Oncology in Southern China Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Acta Pharmacol Sin 28:913-20. 2007
    ..This work was intended to evaluate the pharmacodynamics of PEDLLA-FG020326 on reversing MDR in vitro and in vivo...
  20. doi request reprint Up-regulation of ABCB1/P-glycoprotein by escaping promoter hypermethylation indicates poor prognosis in hematologic malignancy patients with and without bone marrow transplantation
    Cheng Jun Shi
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Leuk Res 35:73-9. 2011
    ..In addition, MDR1 in K562 cells elevated significantly after 5-Aza-dC treatment. In summary, MDR1 promoter hypomethylation conferred its up-regulation and indicated poor prognosis in patients with and without BMT...
  21. pmc Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function
    Chun Ling Dai
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Biochem Pharmacol 78:355-64. 2009
    ..Furthermore, FG020326 was co-localized with ABCB1 in cell membranes. Hence, FG020326 is characterized as a third generation MDR modulator that holds great promise for the treatment of cancer patients with ABCB1-mediated MDR...
  22. ncbi request reprint [Correlation between inhibitory effect of Manumycin on human hepatoma cancer cell HepG2 and Ras signal transduction pathway]
    Jun Min Zhou
    Cancer Institute, Sun Yat Sen University, Guangzhou 510060, P R China
    Ai Zheng 21:364-8. 2002
    ..This study was designed to investigate the antitumor effect of Manumycin in human hepatoma cell line HepG2 and try to clarify its influence on Ras pathway...
  23. ncbi request reprint [Detecting doxorubicin concentration in KBv200 and KB cell xenografts in nude mice by high-performance liquid chromatography]
    Wen jing Deng
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China
    Ai Zheng 27:364-8. 2008
    ..This study was to detect and compare the concentration of Dox in KBv200 and KB cell xenografts in nude mice by high-performance liquid chromatography (HPLC)...
  24. pmc The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    J Clin Invest 119:3626-36. 2009
    ..Our results provide functional and mechanistic links between the oncoprotein Bmi-1 and the tumor suppressor PTEN in the development and progression of cancer...
  25. ncbi request reprint Tetrandrine achieved plasma concentrations capable of reversing MDR in vitro and had no apparent effect on doxorubicin pharmacokinetics in mice
    Chun Ling Dai
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Cancer Chemother Pharmacol 60:741-50. 2007
    ..Our aims were to determine whether serum concentration of Tet, which was capable of blocking P-gp in vitro, could be safely achieved in mice and whether Tet induced pharmacokinetic alterations in serum doxorubicin disposition in mice...
  26. pmc Crizotinib (PF-02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P-glycoprotein
    Wen Jing Zhou
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Br J Pharmacol 166:1669-83. 2012
    ..Here, we assessed the possible reversal of multidrug resistance (MDR) by crizotinib in vitro and in vivo...
  27. ncbi request reprint [Correlation of antitumor effect of recombinant sea snake basic phospholipase A2 to its enzymatic activity]
    Yong Ju Liang
    State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong 510060, P R China
    Ai Zheng 24:1474-8. 2005
    ....
  28. doi request reprint FG020326 sensitized multidrug resistant cancer cells to docetaxel-mediated apoptosis via enhancement of caspases activation
    Xiu Wen Wang
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University of Medical Sciences, Guangzhou 510060, China
    Molecules 17:5442-58. 2012
    ..Therefore, the enhancement of caspase-8, -9 and -3 activation induced by docetaxel may be one of the key mechanisms of the reversal of P-gp mediated docetaxel resistance by FG020326...
  29. ncbi request reprint Secalonic acid D induced leukemia cell apoptosis and cell cycle arrest of G(1) with involvement of GSK-3beta/beta-catenin/c-Myc pathway
    Jian Ye Zhang
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, PR China
    Cell Cycle 8:2444-50. 2009
    ..Moreover, our data indicated that downregulation of c-Myc and cell cycle arrest of G(1) phase were caused not by formation of G-quadruplex structures but by activation of GSK-3beta followed by degradation of beta-catenin...
  30. pmc Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function
    Li sheng Zheng
    Research Department, State Key Laboratory of Oncology in South China, Cancer Center, SunYat sen University, Guangzhou, People s Republic of China
    PLoS ONE 4:e5172. 2009
    ..In this study, we evaluated the possible interaction of vandetanib, an orally administered drug inhibiting multiple receptor tyrosine kinases, with ABCC1 and ABCG2 in vitro...
  31. doi request reprint ABCG2-overexpressing S1-M1-80 cell xenografts in nude mice keep original biochemistry and cell biological properties
    Fang Wang
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510060, P R China
    Chin J Cancer 31:150-8. 2012
    ..These results suggest that S1-M1-80 cell xenografts in nude mice retain their original cytological characteristics at 9 weeks. Thus, this model could serve as a good system for further investigation of ABCG2-mediated MDR...
  32. ncbi request reprint [Advance of several types of important marine antitumor drugs]
    Jian Ye Zhang
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, 510060, China
    Yao Xue Xue Bao 43:435-42. 2008
    ..In this review, we summarized the recent research progress of the above mentioned marine antitumor drugs and their derivatives. Also, the development tendency of marine antitumor drugs was discussed...
  33. ncbi request reprint [Advances in the study of expression and regulation of P-glycoprotein]
    Cheng Jun Shi
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Yao Xue Xue Bao 42:911-6. 2007
    ..This paper summarized the advances of studies on expression and regulation of P-glycoprotein...
  34. ncbi request reprint The clinical significance of twist expression in nasopharyngeal carcinoma
    Li Bing Song
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    Cancer Lett 242:258-65. 2006
    ..These findings demonstrate that the Twist may play an important role in the invasion and metastasis of NPC. Twist protein is valuable marker for assessing the prognosis of NPC...
  35. ncbi request reprint Anthracenedione derivative 1403P-3 induces apoptosis in KB and KBv200 cells via reactive oxygen species-independent mitochondrial pathway and death receptor pathway
    Jian Ye Zhang
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, PR, China
    Cancer Biol Ther 6:1413-21. 2007
    ..In summary, 1403P-3 induced apoptosis of KB cells and KBv200 cells through mitochondrial pathway and death receptor pathway. Furthermore, the mitochondrial pathway was independent of reactive oxygen species and activation of caspase-8...
  36. ncbi request reprint Interaction of tyrosine kinase inhibitors with the MDR- related ABC transporter proteins
    Xiao Kun Wang
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, 510060, China
    Curr Drug Metab 11:618-28. 2010
    ..In this review, the interaction of several TKIs, currently in clinical use or being developed in clinical trials, with the MDR-related ABC transporters, in particular ABCB1, ABCC1 and ABCG2, will be discussed...
  37. ncbi request reprint [Progress of individualized chemotherapy guided by chemosensitivity test]
    Yan jun Mi
    State Key Laboratory of Oncology in South China, Cancer Center Sun Yat sen University Guangzhou 510060, China
    Yao Xue Xue Bao 44:1187-92. 2009
    ..This paper reviews some current methods, and their possibility for directing clinical chemotherapy...
  38. pmc Bullatacin triggered ABCB1-overexpressing cell apoptosis via the mitochondrial-dependent pathway
    Yong Ju Liang
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    J Biomed Biotechnol 2009:867123. 2009
    ..These implied that apoptosis of KBv200 cells induced by bullatacin was associated with the mitochondria-dependent pathway that was limited to activation of apical caspase-9...
  39. ncbi request reprint [Correlation of chemosensitivity measured by histoculture drug response assay to expression of multidrug resistance genes and proteins in gastric cancer]
    Shu Qiang Yuan
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China
    Ai Zheng 28:337-43. 2009
    ....
  40. ncbi request reprint [Inhibitory effect of apatinib on HL-60 cell proliferation and its mechanism]
    Shu Liang
    Department of Hematology, Yat sen University, Guangzhou 510060, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:871-4. 2011
    ..To investigate the effect of apatinib, a small-molecule vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, on the proliferation of human acute myeloid leukemia HL-60 cells and explore the possible mechanism...
  41. doi request reprint Cediranib (recentin, AZD2171) reverses ABCB1- and ABCC1-mediated multidrug resistance by inhibition of their transport function
    Li Yang Tao
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Chemother Pharmacol 64:961-9. 2009
    ..Here we investigate the ability of cediranib to reverse tumor multidrug resistance (MDR) due to overexpression of ABCB1 (P-glycoprotein) and ABCC1 (MRP1) transporters...
  42. ncbi request reprint [Correlation of chemosensitivity tested using histoculture drug response assay to expression of multidrug resistance genes and proteins in colorectal cancer tissues]
    Shu Qiang Yuan
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China
    Ai Zheng 28:932-8. 2009
    ....