Jun Cui


Affiliation: Sun Yat-sen University
Country: China


  1. Meng Q, Cai C, Sun T, Wang Q, Xie W, Wang R, et al. Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch. J Cell Biol. 2015;211:1025-40 pubmed publisher
    ..Collectively, our results provide the regulatory mechanisms of reversible NLRC5 ubiquitination and its role in the dynamic control of innate immunity. ..
  2. Jin S, Tian S, Chen Y, Zhang C, Xie W, Xia X, et al. USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1. EMBO J. 2016;35:866-80 pubmed publisher
    ..Our findings reveal novel dual functions of theUSP19-Beclin-1 axis by balancing autophagy and the production of type IIFNs. ..
  3. Du Y, Duan T, Feng Y, Liu Q, Lin M, Cui J, et al. LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation. EMBO J. 2018;37:351-366 pubmed publisher
  4. Zhang C, Ye S, Ni J, Cai T, Liu Y, Huang D, et al. STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion. Cell Death Differ. 2019;: pubmed publisher
    ..Our findings reveal a novel mechanism linking STING to tumor microenvironmental cytokine production and MDSC induction. ..
  5. Liu K, Zhang C, Li B, Xie W, Zhang J, Nie X, et al. Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression. Cell Rep. 2018;23:838-851 pubmed publisher
  6. Sun T, Cui J. Dynamics of P53 in response to DNA damage: Mathematical modeling and perspective. Prog Biophys Mol Biol. 2015;119:175-82 pubmed publisher
    ..From theoretical perspective, we focus on the dynamical patterns of p53 and how such complex dynamics relate to cell fate leading to a better knowledge about its regulation and function. ..
  7. Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, et al. TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses. Mol Cell. 2016;64:105-119 pubmed publisher
    ..Taken together, our findings reveal a positive feedback loop of cGAS signaling generated by TRIM14-USP14 and provide insights into the crosstalk between autophagy and type I IFN signaling in innate immunity. ..
  8. Lin M, Zhao Z, Yang Z, Meng Q, Tan P, Xie W, et al. USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome. Mol Cell. 2016;64:267-281 pubmed publisher
    ..Our findings identify an essential role for USP38 in negatively regulating type I IFN signaling, and they provide insights into the mechanisms by which USP38 regulates TBK1 ubiquitination through the NLRP4 signalosome. ..
  9. Qin Y, Su Z, Wu Y, Wu C, Jin S, Xie W, et al. NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis. EMBO Rep. 2017;18:2160-2171 pubmed publisher
    ..Using MAVS as a platform, NLRP11 degrades TRAF6 to attenuate the production of type I IFNs as well as virus-induced apoptosis. Our findings reveal the regulatory role of NLRP11 in antiviral immunity by disrupting MAVS signalosome. ..

More Information


  1. Wu C, Su Z, Lin M, Ou J, Zhao W, Cui J, et al. NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A. Nat Commun. 2017;8:1977 pubmed publisher
    ..Therefore, our findings identify NLRP11 as a conserved negative regulator of TLR signalling in primate cells and reveal a mechanism by which the NLRP11-RNF19A axis targets TRAF6 for degradation. ..
  2. Wu C, Yang Y, Ou J, Zhu L, Zhao W, Cui J. LRRC14 attenuates Toll-like receptor-mediated NF-?B signaling through disruption of IKK complex. Exp Cell Res. 2016;347:65-73 pubmed publisher
    ..In addition, our data showed that TLR signaling led to lower expression of LRRC14. Together, LRRC14 may function as a checkpoint to prevent overzealous inflammation. ..
  3. Liu T, Tang Q, Liu K, Xie W, Liu X, Wang H, et al. TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy. Cell Rep. 2016;16:1988-2002 pubmed publisher
    ..These findings identify a role for TRIMs in AIM2 inflammasome activation where TRIM11 acts as a secondary receptor to deliver AIM2 to the autophagosomes for degradation in a p62-dependent manner. ..
  4. Jin S, Tian S, Luo M, Xie W, Liu T, Duan T, et al. Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells. Mol Cell. 2017;68:308-322.e4 pubmed publisher
  5. Feng Y, Duan T, Du Y, Jin S, Wang M, Cui J, et al. LRRC25 Functions as an Inhibitor of NF-?B Signaling Pathway by Promoting p65/RelA for Autophagic Degradation. Sci Rep. 2017;7:13448 pubmed publisher
    ..Our study has not only identified LRRC25 as a novel inhibitor of NF-?B signaling pathway, but also uncovers a new mechanism of crosstalk between NF-?B signaling and autophagy pathways. ..