Genomes and Genes
Affiliation: Sun Yat-sen University
- Wu C, Su Z, Lin M, Ou J, Zhao W, Cui J, et al. NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A. Nat Commun. 2017;8:1977 pubmed publisher..Therefore, our findings identify NLRP11 as a conserved negative regulator of TLR signalling in primate cells and reveal a mechanism by which the NLRP11-RNF19A axis targets TRAF6 for degradation. ..
- Wu C, Yang Y, Ou J, Zhu L, Zhao W, Cui J. LRRC14 attenuates Toll-like receptor-mediated NF-?B signaling through disruption of IKK complex. Exp Cell Res. 2016;347:65-73 pubmed publisher..In addition, our data showed that TLR signaling led to lower expression of LRRC14. Together, LRRC14 may function as a checkpoint to prevent overzealous inflammation. ..
- Liu T, Tang Q, Liu K, Xie W, Liu X, Wang H, et al. TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy. Cell Rep. 2016;16:1988-2002 pubmed publisher..These findings identify a role for TRIMs in AIM2 inflammasome activation where TRIM11 acts as a secondary receptor to deliver AIM2 to the autophagosomes for degradation in a p62-dependent manner. ..
- Feng Y, Duan T, Du Y, Jin S, Wang M, Cui J, et al. LRRC25 Functions as an Inhibitor of NF-?B Signaling Pathway by Promoting p65/RelA for Autophagic Degradation. Sci Rep. 2017;7:13448 pubmed publisher..Our study has not only identified LRRC25 as a novel inhibitor of NF-?B signaling pathway, but also uncovers a new mechanism of crosstalk between NF-?B signaling and autophagy pathways. ..