Huichang Bi

Summary

Affiliation: Sun Yat-sen University
Country: China

Publications

  1. pmc Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity
    Huichang Bi
    School of Pharmaceutical Sciences, Sun Yat Sen University, 132 Waihuandong Road, University City, Guangzhou 510006, China Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Evid Based Complement Alternat Med 2013:985257. 2013
  2. pmc Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells
    Huichang Bi
    School of Pharmaceutical Sciences, Sun Yat Sen University, 132 Waihuandong Road, Guangzhou University City, Guangzhou 510006, China
    Anal Bioanal Chem 405:5279-89. 2013
  3. doi request reprint Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine
    Xiaomei Fan
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China X F, Y J, Yi W, H T, H Z, Yo W, M H, H B The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China P C and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD A Q, F J G
    Drug Metab Dispos 43:317-24. 2015
  4. doi request reprint Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways
    Ying Wang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Toxicol Lett 236:82-9. 2015
  5. pmc Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration
    Yiming Jiang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Toxicol Sci 143:107-15. 2015
  6. doi request reprint Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation
    Yiming Jiang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Chem Biol Interact 231:83-9. 2015
  7. pmc Metabolomics reveals that tumor xenografts induce liver dysfunction
    Fei Li
    Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Proteomics 12:2126-35. 2013
  8. doi request reprint Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways
    Xiaomei Fan
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China X F, Y J, Yo W, H T, H Z, Yi W, M H, H B The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China P C and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland A Q, F J G
    Drug Metab Dispos 42:1982-90. 2014

Collaborators

  • Yiming Jiang
  • Xiaomei Fan
  • Ying Wang
  • Huasen Tan
  • Min Huang
  • Hang Zeng
  • Pan Chen
  • Frank J Gonzalez
  • Yongtao Wang
  • Aijuan Qu
  • Fei Li
  • James B Mitchell
  • Changtao Jiang
  • Anastasia L Sowers
  • John A Cook
  • Kristopher W Krausz
  • Andrew D Patterson

Detail Information

Publications9

  1. pmc Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity
    Huichang Bi
    School of Pharmaceutical Sciences, Sun Yat Sen University, 132 Waihuandong Road, University City, Guangzhou 510006, China Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Evid Based Complement Alternat Med 2013:985257. 2013
    ..Taken together, the current study provides new insights into understanding the hepatoprotective effect of WZ against APAP-induced liver toxicity...
  2. pmc Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells
    Huichang Bi
    School of Pharmaceutical Sciences, Sun Yat Sen University, 132 Waihuandong Road, Guangzhou University City, Guangzhou 510006, China
    Anal Bioanal Chem 405:5279-89. 2013
    ....
  3. doi request reprint Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine
    Xiaomei Fan
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China X F, Y J, Yi W, H T, H Z, Yo W, M H, H B The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China P C and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD A Q, F J G
    Drug Metab Dispos 43:317-24. 2015
    ..Thus WZ may represent a new therapy for APAP-induced acute liver injury. ..
  4. doi request reprint Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways
    Ying Wang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Toxicol Lett 236:82-9. 2015
    ..This study demonstrated that RES prevents APAP-induced hepatotoxicity by inhibition of CYP-mediated APAP bioactivation and regulation of SIRT1, p53, cyclin D1 and PCNA to facilitate liver regeneration following APAP-induced liver injury...
  5. pmc Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration
    Yiming Jiang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Toxicol Sci 143:107-15. 2015
    ....
  6. doi request reprint Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation
    Yiming Jiang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Chem Biol Interact 231:83-9. 2015
    ..This study demonstrated that SinA, SinB, SinC, SolA, SolB and SthA exhibited significant protective actions toward APAP-induced liver injury, which was partially associated with the inhibition of CYP-mediated APAP bioactivation. ..
  7. pmc Metabolomics reveals that tumor xenografts induce liver dysfunction
    Fei Li
    Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Proteomics 12:2126-35. 2013
    ....
  8. doi request reprint Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways
    Xiaomei Fan
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China X F, Y J, Yo W, H T, H Z, Yi W, M H, H B The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China P C and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland A Q, F J G
    Drug Metab Dispos 42:1982-90. 2014
    ....