Ziniu Yu

Summary

Affiliation: South China Sea Institute of Oceanology
Country: China

Publications

  1. Mao F, Lin Y, Zhou Y, He Z, Li J, Zhang Y, et al. Structural and functional analysis of interferon regulatory factors (IRFs) reveals a novel regulatory model in an invertebrate, Crassostrea gigas. Dev Comp Immunol. 2018;89:14-22 pubmed publisher
    ..Taken together, one novel regulatory model of IRF signaling pathways has been raised one paralog of IRF has evolved and appears to be a regulator of IRF. ..
  2. Xiang Z, Qu F, Qi L, Ying T, Li J, Shu X, et al. Cloning and characterization of an apoptosis-related DNA fragmentation factor (DFF) from oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 2014;38:119-26 pubmed publisher
    ..These results suggest that ChDFFA may be involved in immune response reactions in the Hong Kong oyster C. hongkongensis. ..
  3. Li J, Zhang Y, Zhang Y, Mao F, Xiao S, Xiang Z, et al. A Lysin motif (LysM)-containing protein from Hong Kong oyster, Crassostrea hongkongensis functions as a pattern recognition protein and an antibacterial agent. Gene. 2018;674:134-142 pubmed publisher
    ..Collectively, these results indicate that ChLysM is a pattern recognition molecule with bacterial growth-inhibiting activity in immune defense of C. hongkongensis. ..
  4. Li J, Zhang Y, Mao F, Lin Y, Xiao S, Xiang Z, et al. The first morphologic and functional characterization of hemocytes in Hong Kong oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 2018;81:423-429 pubmed publisher
    ..Our results provide the basic information of hemocytes population of Hong Kong oyster for further investigations associated with innate immunity. ..
  5. Xiang Z, Qu F, Wang F, Li J, Zhang Y, Yu Z. Characteristic and functional analysis of a ficolin-like protein from the oyster Crassostrea hongkongensis. Fish Shellfish Immunol. 2014;40:514-23 pubmed publisher
    ..coli K-12 and enhance the phagocytosis of C. hongkongensis hemocytes in vitro. These results indicate that ChFCN might play an important role in the immunity response of oysters. ..
  6. Qu F, Xiang Z, Zhang Y, Li J, Zhang Y, Yu Z. The identification of the first molluscan Akirin2 with immune defense function in the Hong Kong oyster Crassostrea hongkongensis. Fish Shellfish Immunol. 2014;41:455-65 pubmed publisher
    ..Altogether, this report provided the first experimental demonstration that mollusks possess a functional Akirin2 that is involved in the innate defense and embryogenesis processes of the oyster. ..
  7. Yu Z, He X, Fu D, Zhang Y. Two superoxide dismutase (SOD) with different subcellular localizations involved in innate immunity in Crassostrea hongkongensis. Fish Shellfish Immunol. 2011;31:533-9 pubmed publisher
    ..alginolyticus infection highlights their important functions in eliminating toxic reactive oxygen species (ROS) and protecting organisms from bacterial invasion in C. hongkongensis. ..
  8. Qu F, Xiang Z, Wang F, Zhang Y, Li J, Zhang Y, et al. Identification and function of an evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) from Crassostrea hongkongensis. Dev Comp Immunol. 2015;53:244-52 pubmed publisher
    ..These findings suggest that ChECSIT might be involved in embryogenesis processes and immune responses in C. hongkongensis. ..
  9. Qu F, Xiang Z, Wang F, Zhang Y, Tong Y, Li J, et al. A novel molluscan Fos gene with immune defense function identified in the Hong Kong oyster, Crassostrea hongkongensis. Dev Comp Immunol. 2015;51:194-201 pubmed publisher
    ..Overall, this study presents the first experimental evidence of the presence and functional characteristics of Fos in mollusks, which reveals its involvement in host protection against immune challenge in the oyster. ..

More Information

Publications30

  1. Xiang Z, Qu F, Wang F, Xiao S, Jun L, Zhang Y, et al. ChBax/Bak as key regulators of the mitochondrial apoptotic pathway: cloned and characterized in Crassostrea hongkongensis. Fish Shellfish Immunol. 2015;42:225-32 pubmed publisher
    ..These results indicate that ChBax and ChBak may play important roles in the mitochondrial apoptotic pathway in oysters. ..
  2. Qu F, Xiang Z, Wang F, Qi L, Xu F, Xiao S, et al. Prostaglandin E receptor 4 (PTGER4) involved in host protection against immune challenge in oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 2015;42:316-24 pubmed publisher
    ..In summary, this study provides the first experimental evidence of a functional PTGER4 in mollusks, which suggests its involvement in the innate immune response in oyster. ..
  3. Mao F, Lin Y, He Z, Li J, Xiang Z, Zhang Y, et al. Dual roles of cystatin A in the immune defense of the pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2018;75:190-197 pubmed publisher
    ..Therefore, CgCytA plays dual roles in protection of host hemocytes from apoptosis and control of bacterial clearance, which may server as one of key endogenous balancer between apoptosis and innate immunity in oyster. ..
  4. Wang F, Xiao S, Zhang Y, Zhang Y, Liu Y, Yan Y, et al. ChAkt1 involvement in orchestrating the immune and heat shock responses in Crassostrea hongkongensis: Molecular cloning and functional characterization. Fish Shellfish Immunol. 2015;47:1015-23 pubmed publisher
    ..Taken together, our results indicate that ChAkt1 most likely plays a central role in response to various stimuli in oysters and has a particular response to microbial pathogens and high temperature. ..
  5. Li J, Zhang Y, Liu Y, Zhang Y, Xiang Z, Qu F, et al. A thymosin beta-4 is involved in production of hemocytes and immune defense of Hong Kong oyster, Crassostrea hongkongensis. Dev Comp Immunol. 2016;57:1-9 pubmed publisher
    ..These results suggest that ChTβ4 is a thymosin beta-4 homolog and plays a vital role in the immune defense of C. hongkongensis. ..
  6. Ma H, Xiao S, Zhang Y, Li X, Li J, Yu Z. Polymorphic microsatellite loci developed from the Hong Kong oyster (Crassostrea hongkongensis). Genet Mol Res. 2016;15: pubmed publisher
    ..Of the 40 loci, 28 were found to conform to Hardy-Weinberg equilibrium (HWE), whereas the remaining 12 showed a significant departure from HWE. The availability of these markers will aid future genetic studies in C. hongkongensis. ..
  7. Liu Y, Li J, Wang F, Mao F, Zhang Y, Zhang Y, et al. The first molluscan TRIM9 is involved in the negative regulation of NF-?B activity in the Hong Kong oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 2016;56:106-110 pubmed publisher
    ..Furthermore, ChTRIM9 was found to be localized mainly in the cytoplasm, and its over-expression inhibited the transcriptional activity of the NF-?B gene in HEK293T cells, demonstrating its negative role in regulating NF-?B signaling. ..
  8. Li J, Zhang Y, Liu Y, Zhang Y, Xiao S, Yu Z. Co-expression of heat shock protein (HSP) 40 and HSP70 in Pinctada martensii response to thermal, low salinity and bacterial challenges. Fish Shellfish Immunol. 2016;48:239-43 pubmed publisher
  9. Qu F, Xiang Z, Zhang Y, Li J, Xiao S, Zhang Y, et al. A novel p38 MAPK indentified from Crassostrea hongkongensis and its involvement in host response to immune challenges. Mol Immunol. 2016;79:113-124 pubmed publisher
    ..Altogether, these results provide the first experimental evidence of a functional p38 in oysters and suggest its involvement in the innate immunity of C. hongkongensis. ..
  10. Yu Z, Wei Z, Kong X, Shi W. Complete mitochondrial DNA sequence of oyster Crassostrea hongkongensis-a case of "Tandem duplication-random loss" for genome rearrangement in Crassostrea?. BMC Genomics. 2008;9:477 pubmed publisher
  11. Xu F, Li J, Zhang Y, Li X, Zhang Y, Xiang Z, et al. CgIκB3, the third novel inhibitor of NF-kappa B (IκB) protein, is involved in the immune defense of the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2015;46:648-55 pubmed publisher
    ..gigas. The discovery of the third IκB emphasizes the complexity and importance of the regulation on NF-κB activation. ..
  12. Qu F, Xiang Z, Xiao S, Wang F, Li J, Zhang Y, et al. c-Jun N-terminal kinase (JNK) is involved in immune defense against bacterial infection in Crassostrea hongkongensis. Dev Comp Immunol. 2017;67:77-85 pubmed publisher
    ..In summary, this study provided the first experimental demonstration that oysters possess a functional JNK that participates in host defense against bacterial infection in C. hongkongensis. ..
  13. Qu F, Xiang Z, Li J, Xiao S, Mao F, Qin Y, et al. A molluscan extracellular signal-regulated kinase is involved in host response to immune challenges in vivo and in vitro. Fish Shellfish Immunol. 2017;62:311-319 pubmed publisher
    ..Moreover, ChERK was mainly located in the cytoplasm of HEK293T cells. Taken together, these findings may provide novel insights into the functions of molluscan ERKs, especially their roles in response to immune challenge in oyster. ..
  14. Qu F, Xiang Z, Zhang Y, Li J, Xiao S, Zhang Y, et al. Molecular identification and functional characterization of a tumor necrosis factor (TNF) gene in Crassostrea hongkongensis. Immunobiology. 2017;222:751-758 pubmed publisher
    ..Altogether, these findings may provide valuable information regarding oyster TNFs and its role in innate immunity. ..
  15. Li J, Zhang Y, Zhang Y, Mao F, Xiang Z, Xiao S, et al. The first invertebrate NFIL3 transcription factor with role in immune defense identified from the Hong Kong oyster, Crassostrea hongkongensis. Dev Comp Immunol. 2017;76:1-8 pubmed publisher
    ..In conclusion, our findings revealed that NFIL3 in molluscs, plays a conserved role in host defense, similar to its mammalian homolog. ..
  16. Zhang Y, Yu F, Li J, Tong Y, Zhang Y, Yu Z. The first invertebrate RIG-I-like receptor (RLR) homolog gene in the pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 2014;40:466-71 pubmed publisher
    ..In summary, this report provides the first CgRIG-I sequence of a mollusk, but its function in the antiviral immune response requires further investigation. ..
  17. Zhang Y, Li J, Yu F, Tong Y, Zhang Y, Xiang Z, et al. Identification and functional characterization of SIMPL in Crassostrea gigas reveals its ancient origin and involvement in the regulation of Rel/NF-?B transcription activity. Fish Shellfish Immunol. 2014;40:239-44 pubmed publisher
    ..Altogether, our studies reveal that SIMPL is reserved and co-evolved with NF-?B in chordate and mollusk, supporting its ancient origin and involvement in regulation of NF-?B signaling pathway. ..
  18. Li J, Zhang Y, Zhang Y, Liu Y, Xiang Z, Qu F, et al. Cloning and characterization of three suppressors of cytokine signaling (SOCS) genes from the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2015;44:525-32 pubmed publisher
    ..Collectively, these results demonstrated that the CgSOCS might play an important role in the innate immune responses of the Pacific oyster. ..
  19. Xiang Z, Xiao S, Wang F, Qin Y, Wu J, Ma H, et al. Cloning, characterization and comparative analysis of four death receptorTNFRs from the oyster Crassostrea hongkongensis. Fish Shellfish Immunol. 2016;59:288-297 pubmed publisher
    ..Over-expression of the ChDRs activated the NF-?B-Luc reporter in HEK293T cells in a dose-dependent manner. These results indicate that the ChDRs may play important roles in the extrinsic apoptotic pathways in oysters. ..
  20. Mao F, Li J, Zhang Y, Xiang Z, Zhang Y, Yu Z. Molecular cloning and functional analysis of tumor necrosis factor receptor-associated factor 6 (TRAF6) in Crossastrea gigas. Fish Shellfish Immunol. 2017;68:37-45 pubmed publisher
    ..These results collectively indicate that CgTRAF6 is a member of TRAF6 sub-family and is potentially involved in immune defense system against invading bacteria and viruses in Crassostrea gigas. ..
  21. Li J, Zhang Y, Zhang Y, Xiang Z, Tong Y, Qu F, et al. Genomic characterization and expression analysis of five novel IL-17 genes in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2014;40:455-65 pubmed publisher
    ..These findings suggest that CgIL-17s are involved in innate immune responses and further supports their conserved function in mollusks immunity. ..