Genomes and Genes


Yujun Shi


Affiliation: Sichuan University
Location: Chengdu, China


  1. Lu C, Xia J, Zhou Y, Lu X, Zhang L, Gou M, et al. Loss of Gsα impairs liver regeneration through a defect in the crosstalk between cAMP and growth factor signaling. J Hepatol. 2016;64:342-351 pubmed publisher
    ..Loss of Gsα leads to a breakdown of the crosstalk between cAMP and growth factor signaling and dramatically impairs liver regeneration. ..
  2. Cao X, Ji H, Zhou Y, Lu X, Shen J, Wu Z, et al. Elevated expression of Gs? in intrahepatic cholangiocarcinoma associates with poor prognosis. Hepatobiliary Pancreat Dis Int. 2017;16:638-644 pubmed publisher
    ..004 and P=0.005, respectively). High Gs? expression is correlated with poor prognosis in ICC patients. Gs? might serve as a potential prognostic indicator of ICC. ..
  3. Lu X, Cao X, Zhu Y, Wu Z, Zhuang X, Shao M, et al. Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway. Cell Death Dis. 2018;9:398 pubmed publisher
    ..Our results suggest that HDAC3 is an important regulator of STAT3-dependent cell proliferation in liver regeneration and cancer. These findings provide novel insights into the HDAC3-STAT3 pathway in liver pathophysiological processes. ..
  4. Kong L, Zhou Y, Bu H, Lv T, Shi Y, Yang J. Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice. J Exp Clin Cancer Res. 2016;35:131 pubmed publisher
    ..Our findings demonstrate that increased TAM-derived IL-6 had an amplifying effect on the inflammation response, thereby promoting the occurrence and development of HCC. ..
  5. Ji H, Lu Y, Shi Y. Seeds in the liver. Acta Histochem. 2017;119:349-356 pubmed publisher
    ..Here, we review the relevant articles, focusing on cell-lineage tracing to better understanding seed cells and their distinct fate in the liver. ..
  6. Yin X, Wu Q, Monga J, Xie E, Wang H, Wang S, et al. HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-overload Murine Models. Antioxid Redox Signal. 2017;: pubmed publisher
    ..The in vivo effects of the identified compounds were further tested in iron-overload mouse models, including Hfe-/-, Hjv-/- and hepatocyte-specific Smad4 knockout (Smad4fl/fl;Alb-Cre+) mice...

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