Affiliation: Sichuan University
Location: Chengdu, China
Lu C, Xia J, Zhou Y, Lu X, Zhang L, Gou M, et al
. Loss of GsÎ± impairs liver regeneration through a defect in the crosstalk between cAMP and growth factor signaling. J Hepatol. 2016;64:342-351 pubmed publisher
..Loss of GsÎ± leads to a breakdown of the crosstalk between cAMP and growth factor signaling and dramatically impairs liver regeneration. ..
Cao X, Ji H, Zhou Y, Lu X, Shen J, Wu Z, et al
. Elevated expression of Gs? in intrahepatic cholangiocarcinoma associates with poor prognosis. Hepatobiliary Pancreat Dis Int. 2017;16:638-644 pubmed publisher
..004 and P=0.005, respectively). High Gs? expression is correlated with poor prognosis in ICC patients. Gs? might serve as a potential prognostic indicator of ICC. ..
Lu X, Cao X, Zhu Y, Wu Z, Zhuang X, Shao M, et al
. Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway. Cell Death Dis. 2018;9:398 pubmed publisher
..Our results suggest that HDAC3 is an important regulator of STAT3-dependent cell proliferation in liver regeneration and cancer. These findings provide novel insights into the HDAC3-STAT3 pathway in liver pathophysiological processes. ..
Kong L, Zhou Y, Bu H, Lv T, Shi Y, Yang J. Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice. J Exp Clin Cancer Res. 2016;35:131 pubmed publisher
..Our findings demonstrate that increased TAM-derived IL-6 had an amplifying effect on the inflammation response, thereby promoting the occurrence and development of HCC. ..
Ji H, Lu Y, Shi Y. Seeds in the liver. Acta Histochem. 2017;119:349-356 pubmed publisher
..Here, we review the relevant articles, focusing on cell-lineage tracing to better understanding seed cells and their distinct fate in the liver. ..
Yin X, Wu Q, Monga J, Xie E, Wang H, Wang S, et al
. HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-overload Murine Models. Antioxid Redox Signal. 2017;: pubmed publisher
..The in vivo effects of the identified compounds were further tested in iron-overload mouse models, including Hfe-/-, Hjv-/- and hepatocyte-specific Smad4 knockout (Smad4fl/fl;Alb-Cre+) mice...