Canhua Huang

Summary

Affiliation: Sichuan University
Country: China

Publications

  1. pmc Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma
    Fenglian Ren
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
    Mol Cancer 9:81. 2010
  2. ncbi request reprint Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid
    Aiping Tong
    The State Key Laboratory of Biotherapy, West China Hospital, and College of Life Science, Sichuan University, Chengdu, 610041, People s Republic of China
    Cancer Chemother Pharmacol 61:791-802. 2008
  3. doi request reprint Proteomic analyses of gastric cancer cells treated with vesicular stomatitis virus matrix protein
    Dequan Zeng
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People s Republic of China
    Protein J 30:308-17. 2011
  4. pmc Proteomics identification of cyclophilin a as a potential prognostic factor and therapeutic target in endometrial carcinoma
    Zhengyu Li
    Department of Gynecology and Obstetrics, West China Second corrected Hospital, Sichuan University, Chengdu 610041, China
    Mol Cell Proteomics 7:1810-23. 2008
  5. doi request reprint Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone-mediated gastric carcinogenic signaling pathway
    Rui Liu
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Mol Cell Proteomics 8:70-85. 2009
  6. doi request reprint Frequent inactivation of RUNX3 by promoter hypermethylation and protein mislocalization in oral squamous cell carcinomas
    Feng Gao
    State Key Laboratory for Dental Medicines and West China College of Stomatology, Sichuan University, No 14 Sec 3 Renminnan Road, Chengdu, Sichuan, People s Republic of China
    J Cancer Res Clin Oncol 135:739-47. 2009
  7. ncbi request reprint Proteomic analysis of cervical cancer cells treated with suberonylanilide hydroxamic acid
    Jianxiong He
    The State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Cheng Du 610041, People s Republic of China
    J Biosci 33:715-21. 2008
  8. doi request reprint Proteomic profiling identifies aberrant epigenetic modifications induced by hepatitis B virus X protein
    Aiping Tong
    West China Hospital, Sichuan University, Chengdu, 610041, People s Republic of China
    J Proteome Res 8:1037-46. 2009
  9. doi request reprint Comprehensive proteomic analysis of host cell lipid rafts modified by HBV infection
    Na Xie
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, PR China
    J Proteomics 75:725-39. 2012
  10. ncbi request reprint Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling
    Kui Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Autophagy 7:966-78. 2011

Collaborators

Detail Information

Publications25

  1. pmc Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma
    Fenglian Ren
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
    Mol Cancer 9:81. 2010
    ..There is an urgent need to develop novel biomarkers for early diagnosis, as well as to identify new drug targets for therapeutic interventions...
  2. ncbi request reprint Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid
    Aiping Tong
    The State Key Laboratory of Biotherapy, West China Hospital, and College of Life Science, Sichuan University, Chengdu, 610041, People s Republic of China
    Cancer Chemother Pharmacol 61:791-802. 2008
    ....
  3. doi request reprint Proteomic analyses of gastric cancer cells treated with vesicular stomatitis virus matrix protein
    Dequan Zeng
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People s Republic of China
    Protein J 30:308-17. 2011
    ..Our findings are considered a significant step toward a better understanding the mechanism of MP-induced anti-cancer effect...
  4. pmc Proteomics identification of cyclophilin a as a potential prognostic factor and therapeutic target in endometrial carcinoma
    Zhengyu Li
    Department of Gynecology and Obstetrics, West China Second corrected Hospital, Sichuan University, Chengdu 610041, China
    Mol Cell Proteomics 7:1810-23. 2008
    ..01) and the inhibition of tumor growth in vivo (p < 0.01). These data suggest that cyclophilin A may serve as a novel prognostic factor and possibly an attractive therapeutic target for endometrial carcinoma...
  5. doi request reprint Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone-mediated gastric carcinogenic signaling pathway
    Rui Liu
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Mol Cell Proteomics 8:70-85. 2009
    ..Our findings are considered a significant step toward a better understanding of adaptations to metabolic stress in gastric carcinogenesis...
  6. doi request reprint Frequent inactivation of RUNX3 by promoter hypermethylation and protein mislocalization in oral squamous cell carcinomas
    Feng Gao
    State Key Laboratory for Dental Medicines and West China College of Stomatology, Sichuan University, No 14 Sec 3 Renminnan Road, Chengdu, Sichuan, People s Republic of China
    J Cancer Res Clin Oncol 135:739-47. 2009
    ..Here, we examined the expression of RUNX3 gene and protein in oral squamous cell carcinomas (OSCCs) and analyzed the methylation status of RUNX3 promoter region...
  7. ncbi request reprint Proteomic analysis of cervical cancer cells treated with suberonylanilide hydroxamic acid
    Jianxiong He
    The State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Cheng Du 610041, People s Republic of China
    J Biosci 33:715-21. 2008
    ..These changed proteins may provide some clues to a better understanding of the molecular mechanisms underlying SAHA-induced apoptosis in cervical cancer...
  8. doi request reprint Proteomic profiling identifies aberrant epigenetic modifications induced by hepatitis B virus X protein
    Aiping Tong
    West China Hospital, Sichuan University, Chengdu, 610041, People s Republic of China
    J Proteome Res 8:1037-46. 2009
    ..In summary, we profiled proteome alterations between HepG2-HBx and control cells, and found that HBx not only induces regional hypermethylation but also specific hypomethylation of host cell genes...
  9. doi request reprint Comprehensive proteomic analysis of host cell lipid rafts modified by HBV infection
    Na Xie
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, PR China
    J Proteomics 75:725-39. 2012
    ..These data will provide valuable clues for further investigation of HBV pathogenesis...
  10. ncbi request reprint Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling
    Kui Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Autophagy 7:966-78. 2011
    ....
  11. doi request reprint Proteomics-based approach identified differentially expressed proteins with potential roles in endometrial carcinoma
    Zhengyu Li
    Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu 610041, China
    Int J Gynecol Cancer 20:9-15. 2010
    ..INSTRUCTION: We used proteomic approaches to identify altered expressed proteins in endometrial carcinoma, with the aim of discovering potential biomarkers or therapeutic targets for endometrial carcinoma...
  12. doi request reprint Integrative oncoproteomics strategies for anticancer drug discovery
    Rui Liu
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People s Republic of China
    Expert Rev Proteomics 7:411-29. 2010
    ....
  13. ncbi request reprint Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells
    Jingyi Li
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, P R China
    Autophagy 6:711-24. 2010
    ..Taken together, our study identifies autophagy as a reaction to counter increased ROS and is thus involved as a cellular prosurvival mechanism in response to SAHA treatment...
  14. pmc Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells
    Yunlong Lei
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, PR China
    Mol Cell Proteomics 10:M110.005397. 2011
    ..Taken together, these studies suggest that ITGB3 plays an important role in ROS-induced migration and invasion in CRC...
  15. doi request reprint Viral proteomics: the emerging cutting-edge of virus research
    ShengTao Zhou
    Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, China
    Sci China Life Sci 54:502-12. 2011
    ..Here, we review the major areas of viral proteomics, including virion proteomics, structural proteomics, viral protein interactomics, and changes to the host cell proteome upon viral infection...
  16. doi request reprint Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model
    Aiping Tong
    The State Key Laboratory of Biotherapy, West China Hospital, College of Life Science, Sichuan University, Chengdu, People s Republic of China
    Proteomics 8:2012-23. 2008
    ..15 and HepG2 cells. The proteins identified in this study would be useful in revealing the mechanisms underlying HBV-host cell interactions and the development of HCC. This study can also provide some useful clues for antiviral research...
  17. ncbi request reprint Comparative plasma membrane-associated proteomics of immortalized human hepatocytes
    Lan tu Gou
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
    Biochemistry (Mosc) 73:1200-6. 2008
    ..The identified proteins could provide helpful reference in clinical investigations on potential candidates for diagnosis and therapy of liver cancer...
  18. doi request reprint Gene expression and methylation status of 14-3-3sigma in human renal carcinoma tissues
    Shufang Liang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    IUBMB Life 60:534-40. 2008
    ..However, the methylation frequency was gradually reinforced with the extent of malignancy from normal to para-cancerous and cancerous kidney tissues...
  19. ncbi request reprint Dissection of aberrant GPCR signaling in tumorigenesis--a systems biology approach
    Jinhua Wu
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People s Republic of China
    Cancer Genomics Proteomics 9:37-50. 2012
    ..Here, we review recent research advances in the identification of novel GPCRs and their protein interactions...
  20. ncbi request reprint Application of chemistry-based functional proteomics to screening for novel drug targets
    Kefei Yuan
    The State Key Laboratory of Biotherapy, Chengdu, Sichuan University, People s Republic of China
    Comb Chem High Throughput Screen 13:414-21. 2010
    ..This review covers major chemistry-based functional proteomic approaches and highlights their recent advances in applications for novel drug target screening...
  21. doi request reprint Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach
    Zhengyu Li
    Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, People s Republic of China
    Int J Cancer 123:2377-83. 2008
    ..CAPS might be a potential prognostic factor for survival in patients with EC. The research pattern from proteomics to clinical specimens would have widespread applications...
  22. doi request reprint Proteomics revisits the cancer metabolome
    Hao Hu
    The State Key Laboratory of Biotherapy, West China Hospital and College of Life Science, Sichuan University, Chengdu, PR China
    Expert Rev Proteomics 8:505-33. 2011
    ..This article will address recent exciting advances in the understanding of cancer cell metabolism using proteomics-based systems biology approaches...
  23. pmc Elevated inflammatory response in caveolin-1-deficient mice with Pseudomonas aeruginosa infection is mediated by STAT3 protein and nuclear factor kappaB (NF-kappaB)
    Kefei Yuan
    State Key Laboratory for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    J Biol Chem 286:21814-25. 2011
    ..Collectively, our studies indicate that Cav-1 is critical for inflammatory responses regulating the STAT3/NF-κB pathway and thereby impacting P. aeruginosa infection...
  24. doi request reprint The metabolic switch and its regulation in cancer cells
    ShengTao Zhou
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
    Sci China Life Sci 53:942-58. 2010
    ....
  25. ncbi request reprint Enhancement of cisplatin induced apoptosis by suberoylanilide hydroxamic acid in human oral squamous cell carcinoma cell lines
    Jun Shen
    Department of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, PR China
    Biochem Pharmacol 73:1901-9. 2007
    ..Our results suggest that concurrent treatment with SAHA enhances tumor cell sensitivity to subtoxic doses of cisplatin. This may be regarded as a novel strategy for treatment of OSCC...