Xiaoming Feng

Summary

Affiliation: Sichuan University
Country: China

Publications

  1. Yao Q, Yu H, Zhang H, Dong S, Chang F, Lin L, et al. Lewis acid catalyzed asymmetric [4+2] cycloaddition of cyclobutenones to synthesize α,β-unsaturated δ-lactones. Chem Commun (Camb). 2018;54:3375-3378 pubmed publisher
    ..Moreover, based on the control experiments and previous reports, a possible catalytic cycle was proposed. ..
  2. Zhao X, Liu X, Xiong Q, Mei H, Ma B, Lin L, et al. The asymmetric synthesis of polycyclic 3-spirooxindole alkaloids via the cascade reaction of 2-isocyanoethylindoles. Chem Commun (Camb). 2015;51:16076-9 pubmed publisher
  3. Zhao X, Mei H, Xiong Q, Fu K, Lin L, Liu X, et al. Highly enantioselective construction of carbazole derivatives via [4+2] cycloaddition of silyloxyvinylindoles and ?,?-unsaturated ?-ketoesters. Chem Commun (Camb). 2016;52:10692-5 pubmed publisher
    ..A widespread range of carbazole derivatives were obtained in 47-98% yield with 86-99% ee under mild reaction conditions. ..
  4. Zhou Y, Lu Y, Hu X, Mei H, Lin L, Liu X, et al. Highly diastereo- and enantioselective synthesis of spirooxindole-cyclohexaneamides through N,N'-dioxide/Ni(ii)-catalyzed Diels-Alder reactions. Chem Commun (Camb). 2017;53:2060-2063 pubmed publisher
    ..New kinds of spirooxindole-cyclohexaneamides were achieved in up to 99% yield, >95 : 5 dr, and 99% ee. ..
  5. Lian X, Lin L, Fu K, Ma B, Liu X, Feng X. A new approach to the asymmetric Mannich reaction catalyzed by chiral N,N'-dioxide-metal complexes. Chem Sci. 2017;8:1238-1242 pubmed publisher
    ..A possible transition state was proposed based on these experiments and previous reports. ..
  6. Zhong X, Tang Q, Zhou P, Zhong Z, Dong S, Liu X, et al. Asymmetric synthesis of polysubstituted methylenecyclobutanes via catalytic [2+2] cycloaddition reactions of N-allenamides. Chem Commun (Camb). 2018;54:10511-10514 pubmed publisher
    ..The utility of the donor-acceptor cyclobutane product was demonstrated as a masked 1,4-dipole in the formal [4+2] annulation reaction with a silyl enol ether. ..
  7. Zheng H, Wang Y, Xu C, Xu X, Lin L, Liu X, et al. Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones. Nat Commun. 2018;9:1968 pubmed publisher
    ..A possible catalytic model was proposed to explain the origin of the asymmetric induction. ..
  8. Zhou Y, Lin L, Yin C, Wang Z, Liu X, Feng X. The N,N'-dioxide/Ni(II)-catalyzed asymmetric inverse-electron-demand hetero-Diels-Alder reaction of methyleneindolinones with hetero-substituted alkenes. Chem Commun (Camb). 2015;51:11689-92 pubmed publisher
    ..In the presence of chiral N,N'-dioxide/Ni(II) complexes, a wide range of optically active dihydropyran-fused indoles were obtained in up to 99% yield, >95 : 5 dr and 99% ee. ..
  9. Xiao X, Mei H, Chen Q, Zhao X, Lin L, Liu X, et al. Direct asymmetric vinylogous Michael addition of 3-alkylidene oxindoles to chalcones catalyzed by a chiral N,N'-dioxide ytterbium(III) complex. Chem Commun (Camb). 2015;51:580-3 pubmed publisher

Collaborators

More Information

Publications29

  1. Hu H, Liu Y, Guo J, Lin L, Xu Y, Liu X, et al. Enantioselective synthesis of dihydrocoumarin derivatives by chiral scandium(III)-complex catalyzed inverse-electron-demand hetero-Diels-Alder reaction. Chem Commun (Camb). 2015;51:3835-7 pubmed publisher
    ..A concerted reaction pathway was confirmed by Operando IR and control experiments. ..
  2. Chen W, Xia Y, Lin L, Yuan X, Guo S, Liu X, et al. Asymmetric Synthesis of Furo[3,4-b]indoles by Catalytic [3+2] Cycloaddition of Indoles with Epoxides. Chemistry. 2015;21:15104-7 pubmed publisher
    ..It provided a promising approach for chiral furo[3,4-b]indoles in up to 98% yield with up to 91% enantiomeric excess (ee) and >95:5 diastereomeric ratio (d.r.). ..
  3. Wu W, Liu X, Zhang Y, Ji J, Huang T, Lin L, et al. Chiral N,N'-dioxide-FeCl3 complex-catalyzed asymmetric intramolecular Cannizzaro reaction. Chem Commun (Camb). 2015;51:11646-9 pubmed publisher
    ..Aryl and alkyl glyoxal monohydrates were applied to obtain α-hydroxy acid esters with excellent results. Deuterium-label and control experiments shed light on the reaction mechanism. ..
  4. Luo W, Zhao J, Ji J, Lin L, Liu X, Mei H, et al. A catalytic asymmetric carbonyl-ene reaction of β,γ-unsaturated α-ketoesters with 5-methyleneoxazolines. Chem Commun (Camb). 2015;51:10042-5 pubmed publisher
    ..Based on the experimental investigations and previous reports, a possible transition state was proposed. ..
  5. Zhang Y, Yang N, Liu X, Guo J, Zhang X, Lin L, et al. Reversal of enantioselective Friedel-Crafts C3-alkylation of pyrrole by slightly tuning the amide units of N,N'-dioxide ligands. Chem Commun (Camb). 2015;51:8432-5 pubmed publisher
    ..A dramatic reversal of enantioselectivity is realized with ligands derived from the same type of chiral source of l-ramipril, by slightly tuning the amide units. ..
  6. Zheng H, Liu X, Xu C, Xia Y, Lin L, Feng X. Regio- and Enantioselective Aza-Diels-Alder Reactions of 3-Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609. Angew Chem Int Ed Engl. 2015;54:10958-62 pubmed publisher
    ..6 %. Control experiments and operando IR experiments imply a concerted reaction pathway. The regioselectivity and exo selectivity result from π-π interactions between the two indoline rings of the two reactants. ..
  7. Xia Y, Lin L, Chang F, Fu X, Liu X, Feng X. Asymmetric Ring-Opening of Cyclopropyl Ketones with Thiol, Alcohol, and Carboxylic Acid Nucleophiles Catalyzed by a Chiral N,N'-Dioxide-Scandium(III) Complex. Angew Chem Int Ed Engl. 2015;54:13748-52 pubmed publisher
    ..This is also the first example of one catalytic system working for the ring-opening reaction of donor-acceptor cyclopropanes with three different nucleophiles, let alone in an asymmetric version. ..
  8. Zhang J, Zhang Y, Lin L, Yao Q, Liu X, Feng X. Catalytic asymmetric desymmetrization of N-arylmaleimides: efficient construction of both atom chirality and axial chirality. Chem Commun (Camb). 2015;51:10554-7 pubmed publisher
    ..r. ..
  9. Huang T, Lin L, Hu X, Zheng J, Liu X, Feng X. Kinetic resolution of 2,3-epoxy 3-aryl ketones via catalytic asymmetric ring-opening with pyrazole derivatives. Chem Commun (Camb). 2015;51:11374-7 pubmed publisher
    ..A wide variety of substrates were readily scoped, and the selectivity factors obtained were excellent (up to >300). ..
  10. Fu K, Zheng J, Lin L, Liu X, Feng X. Chiral N,N'-dioxide-In(OTf)3-catalyzed asymmetric vinylogous Mukaiyama aldol reactions. Chem Commun (Camb). 2015;51:3106-8 pubmed publisher
    ..The corresponding δ-hydroxy-α,β-unsaturated esters were obtained in up to 99% yield and 98% ee. Moreover, the obtained (R)-3v can be easily transformed to natural bioactive products. ..
  11. Xia Y, Lin L, Chang F, Liao Y, Liu X, Feng X. Asymmetric Ring Opening/Cyclization/Retro-Mannich Reaction of Cyclopropyl Ketones with Aryl 1,2-Diamines for the Synthesis of Benzimidazole Derivatives. Angew Chem Int Ed Engl. 2016;55:12228-32 pubmed publisher
    ..This method also provides efficient access to chiral benzimidazole-substituted amide and cycloheptene derivatives. ..
  12. Peng R, Lin L, Zhang Y, Wu W, Lu Y, Liu X, et al. The assignment of the configuration for ?-hydroxy acid esters using a CEC strategy. Org Biomol Chem. 2016;14:5258-62 pubmed publisher
    ..A mnemonic is presented to aid the assignment of the absolute configuration of the substrates. ..
  13. Feng J, Yuan X, Luo W, Lin L, Liu X, Feng X. Chiral N,N'-Dioxide-Organocatalyzed Regio-, Diastereo- and Enantioselective Michael Addition-Alkylation Reaction. Chemistry. 2016;22:15650-15653 pubmed publisher
    ..A variety of substrates performed well in this reaction, and the corresponding multifunctionalized chiral 2,3-dihydrofurans were obtained in up to 95?% yield with 95:5?dr and 93?% ee. ..
  14. Hu H, Liu Y, Lin L, Zhang Y, Liu X, Feng X. Kinetic Resolution of 2H-Azirines by Asymmetric Imine Amidation. Angew Chem Int Ed Engl. 2016;55:10098-101 pubmed publisher
    ..It is rare to find an example of N1 of an oxindole participating in a reaction over C3. Moreover, chiral 2H-azirines were stereospecifically transformed into an unprotected aziridine and ?-amino ketone. ..
  15. Zhang Y, Liao Y, Liu X, Yao Q, Zhou Y, Lin L, et al. Catalytic Michael/Ring-Closure Reaction of ?,?-Unsaturated Pyrazoleamides with Amidomalonates: Asymmetric Synthesis of (-)-Paroxetine. Chemistry. 2016;22:15119-15124 pubmed publisher
    ..A plausible transition state was proposed to explain the origin of the asymmetric induction. ..
  16. Li J, Lin L, Hu B, Lian X, Wang G, Liu X, et al. Bimetallic Gold(I)/Chiral N,N'-Dioxide Nickel(II) Asymmetric Relay Catalysis: Chemo- and Enantioselective Synthesis of Spiroketals and Spiroaminals. Angew Chem Int Ed Engl. 2016;55:6075-8 pubmed publisher
    ..r., and more than 99?% ee under mild reaction conditions. Control experiments suggest that the N,N'-dioxide ligand was essential for the formation of the spiro products. ..
  17. Kang T, Ge S, Lin L, Lu Y, Liu X, Feng X. A Chiral N,N'-Dioxide-Zn(II) Complex Catalyzes the Enantioselective [2+2] Cycloaddition of Alkynones with Cyclic Enol Silyl Ethers. Angew Chem Int Ed Engl. 2016;55:5541-4 pubmed publisher
    ..Meanwhile, the desired cyclobutene product can easily be transformed into fused cyclobutane derivatives. ..
  18. Liu Y, Liu X, Hu H, Guo J, Xia Y, Lin L, et al. Synergistic Kinetic Resolution and Asymmetric Propargyl Claisen Rearrangement for the Synthesis of Chiral Allenes. Angew Chem Int Ed Engl. 2016;55:4054-8 pubmed publisher
    ..The complete chirality transfer and facially selective rearrangement enabled the simultaneous construction of an axially chiral allenic unit and a quaternary carbon stereocenter. ..
  19. Yao Q, Liao Y, Lin L, Lin X, Ji J, Liu X, et al. Efficient Synthesis of Chiral Trisubstituted 1,2-Allenyl Ketones by Catalytic Asymmetric Conjugate Addition of Malonic Esters to Enynes. Angew Chem Int Ed Engl. 2016;55:1859-63 pubmed publisher
    ..Moreover, the products could be easily transformed into chiral furan and 5-hydroxypyrazoline derivatives, both of which are important skeletons of many biologically active compounds and pharmacologicals. ..
  20. Lian X, Lin L, Wang G, Liu X, Feng X. Chiral N,N'-Dioxide-Scandium(III)-Catalyzed Asymmetric Dearomatization of 2-Naphthols through an Amination Reaction. Chemistry. 2015;21:17453-8 pubmed publisher
    ..The reaction could be scaled up to a gram-scale with the yield and ee maintained. Based on these experiments and on previous reports, a possible transition state was proposed. ..