Lan Wang


Affiliation: Shanxi University
Country: China


  1. Jing W, Lang L, Lin Z, Liu N, Wang L. Cadmium bioaccumulation and elimination in tissues of the freshwater mussel Anodonta woodiana. Chemosphere. 2019;219:321-327 pubmed publisher
    ..Thus, we concluded that the kidney, gills and digestive gland of A. woodiana are target tissues for subchronic Cd toxicity. ..
  2. Li Y, Wu H, Wei X, He Y, Li B, Li Y, et al. Subcellular distribution of Cd and Zn and MT mRNA expression in the hepatopancreas of Sinopotamon henanense after single and co-exposure to Cd and Zn. Comp Biochem Physiol C Toxicol Pharmacol. 2015;167:117-30 pubmed publisher
    ..MT mRNA expression was also determined in our report, the results showed that both Cd and Zn had the ability of inducing MT mRNA expression. Additionally, the MT mRNA transcription level was enhanced when Cd was mixed with Zn. ..
  3. Yang J, Liu D, He Y, Wang L. Mitochondrial energy metabolism in the hepatopancreas of freshwater crabs (Sinopotamon henanense) after cadmium exposure. Environ Sci Process Impacts. 2015;17:156-65 pubmed publisher
    ..Our findings suggest that energy-related parameters could be used as biomarkers in the monitoring of metal pollution and quantitative risk assessments of pollutant exposure. ..
  4. Luo J, Pei S, Jing W, Zou E, Wang L. Cadmium inhibits molting of the freshwater crab Sinopotamon henanense by reducing the hemolymph ecdysteroid content and the activities of chitinase and N-acetyl-β-glucosaminidase in the epidermis. Comp Biochem Physiol C Toxicol Pharmacol. 2015;169:1-6 pubmed publisher
    ..This work provides new insights into the mechanisms underlying the molting inhibition effect of cadmium on the crabs. ..
  5. Li N, Hou Y, Ma D, Jing W, Dahms H, Wang L. Lead accumulation, oxidative damage and histopathological alteration in testes and accessory glands of freshwater crab, Sinopotamon henanense, induced by acute lead exposure. Ecotoxicol Environ Saf. 2015;117:20-7 pubmed publisher
    ..These results showed that acute Pb exposure led to a reduction of survival rate of sperm and harmful effects at the cellular level of crab testes and accessory glands, which are most likely linked to Pb-induced oxidative stress. ..
  6. Wang L, Xu T, Lei W, Liu D, Li Y, Xuan R, et al. Cadmium-induced oxidative stress and apoptotic changes in the testis of freshwater crab, Sinopotamon henanense. PLoS ONE. 2011;6:e27853 pubmed publisher
  7. Zhou Y, Dahms H, Dong F, Jing W, Wang L. Immune-associated parameters and antioxidative responses to cadmium in the freshwater crab Sinopotamon henanense. Ecotoxicol Environ Saf. 2016;129:235-41 pubmed publisher
    ..Our results suggest that Cd exposure caused immunomodulation, a potentially harmful immunity function and damage in the antioxidant system of Sinopotamon henanense. ..
  8. Li N, Hou Y, Jing W, Dahms H, Wang L. Quality decline and oxidative damage in sperm of freshwater crab Sinopotamon henanense exposed to lead. Ecotoxicol Environ Saf. 2016;130:193-8 pubmed publisher
    ..Our findings document that Pb can induce harmful effects on several reproductive endpoints in a freshwater crab. ..
  9. Xu P, Wu Z, Xi Y, Wang L. Epigenetic regulation of placental glucose transporters mediates maternal cadmium-induced fetal growth restriction. Toxicology. 2016;372:34-41 pubmed publisher
    ..Collectively, our results suggest that changes in DNMT3B and DNMT3L expressions and site-specific DNA methylation may be involved in the etiology of Cd-induced fetal growth restriction through downregulation of GLUT3. ..

More Information


  1. Zhou Y, Jing W, Dahms H, Hwang J, Wang L. Oxidative damage, ultrastructural alterations and gene expressions of hemocytes in the freshwater crab Sinopotamon henanense exposed to cadmium. Ecotoxicol Environ Saf. 2017;138:130-138 pubmed publisher
    ..The expression levels of LSZ and MT were up-regulated to some extent. Our findings suggest these parameters could be used as biomarkers in the monitoring of heavy metal pollution and quantitative risk assessments of pollutant exposure. ..
  2. Lang X, Wang L, Zhang Z. Stability evaluation of reference genes for real-time PCR in zebrafish (Danio rerio) exposed to cadmium chloride and subsequently infected by bacteria Aeromonas hydrophila. Aquat Toxicol. 2016;170:240-250 pubmed publisher
    ..It emphasized the importance of reference gene evaluation for studies using qPCR, in particular when investigations involve factors not explored previously. ..
  3. Xu P, Wu Z, Yang W, Wang L. Dysregulation of DNA methylation and expression of imprinted genes in mouse placentas of fetal growth restriction induced by maternal cadmium exposure. Toxicology. 2017;390:109-116 pubmed publisher
    ..Therefore, our results suggest that changes of the DNA methylation levels of the promoter regions and the expression patterns of Cdkn1c and Peg10 may be involved in the etiology of Cd-induced fetal growth restriction. ..
  4. request reprint
    Yang Y, Pessin J, Wang L. [High frequency electrical stimulation of sciatic nerve enhances skeletal muscle autophagy in mice]. Sheng Li Xue Bao. 2017;69:422-428 pubmed
    ..These results suggest that electrical stimulation of sciatic nerve may induce the skeletal muscle autophagy, and this may be regulated through AMPK/ULK1-mediated signaling pathway. ..
  5. Lang L, Zhang Z, Jing W, Hwang J, Lee S, Wang L. Identification of a novel toll gene (Shtoll3) from the freshwater crab Sinopotamon henanense and its expression pattern changes in response to cadmium followed by Aeromonas hydrophila infection. Fish Shellfish Immunol. 2017;71:177-190 pubmed publisher
    ..hydrophila infection in gills and midguts. This suggest that Shtoll3 may contribute to the innate immune defense of S. henanense to A. hydrophila and Cd can modify the immune function in epithelium. ..
  6. Li B, Li D, Jing W, Fan J, Dahms H, Lee S, et al. Biogenic selenium and its hepatoprotective activity. Sci Rep. 2017;7:15627 pubmed publisher
    ..BioSeNPs may have the potential to be used as a trace element food supplement inducing antioxidant bioactivities. ..
  7. Wang L, Yan B, Liu N, Li Y, Wang Q. Effects of cadmium on glutathione synthesis in hepatopancreas of freshwater crab, Sinopotamon yangtsekiense. Chemosphere. 2008;74:51-6 pubmed publisher
  8. Luo J, Li D, Wei D, Wang X, Wang L, Zeng X. RhoA and RhoC are involved in stromal cell-derived factor-1-induced cell migration by regulating F-actin redistribution and assembly. Mol Cell Biochem. 2017;436:13-21 pubmed publisher
    ..This work will contribute to a clearer insight into the migration mechanism of acute lymphoblastic leukemia. ..
  9. Li N, Xu P, Jing W, Hwang J, Wang L. Toxic effects of Pb2+ entering sperm through Ca2+ channels in the freshwater crab Sinopotamon henanense. Aquat Toxicol. 2017;192:24-29 pubmed publisher
    ..Our results indicate that Pb enters the sperm of the crab S. henanense through calcium channels, the inhibition of which blocks Pb-induced stresses such as sperm quality decline and oxidative damage. ..