Research Topics
Genomes and Genes | Jin Qiu ZhouSummaryAffiliation: Shanghai Institutes for Biological Sciences Country: China Publications
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Detail Information
Publications
Recent transcription-induced histone H3 lysine 4 (H3K4) methylation inhibits gene reactivationBo O Zhou
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
J Biol Chem 286:34770-6. 2011..Taken together, our data present a new mechanism by which H3K4 methylation regulates gene transcription...
Def1p is involved in telomere maintenance in budding yeastYong Bin Chen
Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
J Biol Chem 280:24784-91. 2005..Our novel findings of the functions of Def1p in telomere and mitochondria suggested that Def1p plays multiple roles in yeast...
Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongationMing liang Zhang
The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
Nat Struct Mol Biol 17:202-9. 2010..Cells carrying Est1p mutants deficient in G-quadruplex formation in vitro showed gradual telomere shortening and cellular senescence, indicating a positive regulatory role for G-quadruplex in the maintenance of telomere length...- Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoterShan Shan Wang
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Mol Cell Biol 31:3171-81. 2011..We propose that the restriction of aberrant nucleosome remodeling contributes to strict control of gene transcription by the transactivators... - Est1 protects telomeres and inhibits subtelomeric y'-element recombinationXia Jing Tong
The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
Mol Cell Biol 31:1263-74. 2011..Our results demonstrate that one major functional role that Est1 brings to the telomerase complex is the capping or protection of telomeres... - Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiaeBo O Zhou
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
PLoS Genet 7:e1001272. 2011..Together, these data shed light on a potential histone acetylation mark within telomeric heterochromatin that contributes to telomere plasticity... - The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenanceJing Peng
The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
Nucleic Acids Res 40:581-93. 2012..Our study reveals a specific role of Mediator complex at the heterochromatic telomere and this function is specific to telomeres as it has no effect on the HMR locus... - SWR1 complex poises heterochromatin boundaries for antisilencing activity propagationBo O Zhou
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, 320 Yue Yang Road, Shanghai 200031, China
Mol Cell Biol 30:2391-400. 2010..Our results support a model where SWR1-C resides at the heterochromatin boundary to maintain and amplify antisilencing activity of histone H4 acetylation through incorporating H2A.Z into chromatin... - Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeastXin Hua Liao
Max Planck Junior Research Group in the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
Biochem J 390:169-76. 2005.... - Candida albicans, a distinctive fungal model for cellular aging studyXiao Hong Fu
Max Planck Junior Research Group in the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of Chinese Academy of Sciences, Shanghai, China
Aging Cell 7:746-57. 2008..cerevisiae... - Telomerase-null survivor screening identifies novel telomere recombination regulatorsYan Hu
The State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
PLoS Genet 9:e1003208. 2013..Our data provide an independent line of evidence supporting the idea that these genes play important roles in telomere dynamics... - The N-terminus of histone H3 is required for de novo DNA methylation in chromatinJia Lei Hu
The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
Proc Natl Acad Sci U S A 106:22187-92. 2009..These findings establish the N terminus of histone H3 tail with an unmethylated lysine 4 as a chromatin determinant for DNA methylation... - Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivoCui Ping Yang
Max Planck Junior Research Group in the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, China
Nucleic Acids Res 34:407-16. 2006..These data suggested that dimerization is important for Est3p function in vivo... - Saccharomyces cerevisiae MHF complex structurally resembles the histones (H3-H4)₂ heterotetramer and functions as a heterotetramerHui Yang
State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Structure 20:364-70. 2012..These results provide, to the best of our knowledge, new mechanistic insights into the function of the MHF complex... - Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replicationFei Long Meng
The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
EMBO J 28:1466-78. 2009..Thus, Sua5p represents a novel ssTG DNA-binding protein and positively regulates the telomere length in vivo... - Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagationJing Zhou
The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School, Shanghai 200031, China
Nucleic Acids Res 37:3699-713. 2009..Together, these data provide insight into the molecular mechanisms for the anti-silencing functions of Rpd3p during the formation of heterochromatin boundaries... - Telomere recombination accelerates cellular aging in Saccharomyces cerevisiaeXiao Fen Chen
The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
PLoS Genet 5:e1000535. 2009..These results suggest that telomere recombination accelerates cellular aging in telomerase-null type II survivors and that telomerase is likely a superior telomere maintenance pathway in sustaining yeast replicative life span... - Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanismYuanyuan Chang
Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Biochem J 433:295-302. 2011..Taken together, our structural and biological data provide insights into the molecular basis of the histone demethylase activity and the substrate specificity of Rph1... - The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activityDeng Hong Zhang
Max Planck Junior Research Group in the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, The Graduate School, Chinese Academy of Sciences, Shanghai 200031, PR China
Nucleic Acids Res 34:1393-404. 2006..We propose that the mechanism of hPif1's inhibition on telomerase involves unwinding of the DNA/RNA duplex formed by telomerase RNA and telomeric DNA, and RecD homologues in eukaryotes may have evolved gaining additional functions... - Characterization of the intramolecular G-quadruplex promoting activity of Est1Qian Jin Li
The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
FEBS Lett 587:659-65. 2013..Therefore, it remains possible that the intramolecular G-quadruplex promoting activity of Est1 is biologically relevant in telomere replication in vivo... - Immortalization of normal human cytotrophoblast cells by reconstitution of telomeric reverse transcriptase activityYan Ling Wang
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Mol Hum Reprod 12:451-60. 2006..The cells will provide an ideal in vitro model for the study of human extravillous trophoblast (EVT) functions and consequently the mechanisms of embryonic implantation and placentation... - Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulationWei Qian
The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School of Chinese Academy of Sciences, Shanghai, China
Cell Res 19:849-63. 2009..These results suggest that Ten1p enhances the telomeric DNA-binding activity of Cdc13p to negatively regulate telomere length...