Jin Qiu Zhou

Summary

Affiliation: Shanghai Institutes for Biological Sciences
Country: China

Publications

  1. pmc Recent transcription-induced histone H3 lysine 4 (H3K4) methylation inhibits gene reactivation
    Bo O Zhou
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 286:34770-6. 2011
  2. pmc The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance
    Jing Peng
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Nucleic Acids Res 40:581-93. 2012
  3. pmc Candida albicans, a distinctive fungal model for cellular aging study
    Xiao Hong Fu
    Max Planck Junior Research Group in the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of Chinese Academy of Sciences, Shanghai, China
    Aging Cell 7:746-57. 2008
  4. pmc Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiae
    Bo O Zhou
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS Genet 7:e1001272. 2011
  5. pmc The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity
    Deng Hong Zhang
    Max Planck Junior Research Group in the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, The Graduate School, Chinese Academy of Sciences, Shanghai 200031, PR China
    Nucleic Acids Res 34:1393-404. 2006
  6. pmc Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo
    Cui Ping Yang
    Max Planck Junior Research Group in the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, China
    Nucleic Acids Res 34:407-16. 2006
  7. ncbi Def1p is involved in telomere maintenance in budding yeast
    Yong Bin Chen
    Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 280:24784-91. 2005
  8. pmc Telomerase-null survivor screening identifies novel telomere recombination regulators
    Yan Hu
    The State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
    PLoS Genet 9:e1003208. 2013
  9. pmc Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter
    Shan Shan Wang
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Mol Cell Biol 31:3171-81. 2011
  10. doi Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation
    Ming liang Zhang
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Nat Struct Mol Biol 17:202-9. 2010

Collaborators

Detail Information

Publications24

  1. pmc Recent transcription-induced histone H3 lysine 4 (H3K4) methylation inhibits gene reactivation
    Bo O Zhou
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 286:34770-6. 2011
    ..Taken together, our data present a new mechanism by which H3K4 methylation regulates gene transcription...
  2. pmc The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance
    Jing Peng
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Nucleic Acids Res 40:581-93. 2012
    ..Our study reveals a specific role of Mediator complex at the heterochromatic telomere and this function is specific to telomeres as it has no effect on the HMR locus...
  3. pmc Candida albicans, a distinctive fungal model for cellular aging study
    Xiao Hong Fu
    Max Planck Junior Research Group in the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of Chinese Academy of Sciences, Shanghai, China
    Aging Cell 7:746-57. 2008
    ..cerevisiae...
  4. pmc Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiae
    Bo O Zhou
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS Genet 7:e1001272. 2011
    ..Together, these data shed light on a potential histone acetylation mark within telomeric heterochromatin that contributes to telomere plasticity...
  5. pmc The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity
    Deng Hong Zhang
    Max Planck Junior Research Group in the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, The Graduate School, Chinese Academy of Sciences, Shanghai 200031, PR China
    Nucleic Acids Res 34:1393-404. 2006
    ..We propose that the mechanism of hPif1's inhibition on telomerase involves unwinding of the DNA/RNA duplex formed by telomerase RNA and telomeric DNA, and RecD homologues in eukaryotes may have evolved gaining additional functions...
  6. pmc Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo
    Cui Ping Yang
    Max Planck Junior Research Group in the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, China
    Nucleic Acids Res 34:407-16. 2006
    ..These data suggested that dimerization is important for Est3p function in vivo...
  7. ncbi Def1p is involved in telomere maintenance in budding yeast
    Yong Bin Chen
    Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 280:24784-91. 2005
    ..Our novel findings of the functions of Def1p in telomere and mitochondria suggested that Def1p plays multiple roles in yeast...
  8. pmc Telomerase-null survivor screening identifies novel telomere recombination regulators
    Yan Hu
    The State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
    PLoS Genet 9:e1003208. 2013
    ..Our data provide an independent line of evidence supporting the idea that these genes play important roles in telomere dynamics...
  9. pmc Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter
    Shan Shan Wang
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Mol Cell Biol 31:3171-81. 2011
    ..We propose that the restriction of aberrant nucleosome remodeling contributes to strict control of gene transcription by the transactivators...
  10. doi Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation
    Ming liang Zhang
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Nat Struct Mol Biol 17:202-9. 2010
    ..Cells carrying Est1p mutants deficient in G-quadruplex formation in vitro showed gradual telomere shortening and cellular senescence, indicating a positive regulatory role for G-quadruplex in the maintenance of telomere length...
  11. pmc Est1 protects telomeres and inhibits subtelomeric y'-element recombination
    Xia Jing Tong
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Mol Cell Biol 31:1263-74. 2011
    ..Our results demonstrate that one major functional role that Est1 brings to the telomerase complex is the capping or protection of telomeres...
  12. pmc Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation
    Jing Zhou
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School, Shanghai 200031, China
    Nucleic Acids Res 37:3699-713. 2009
    ..Together, these data provide insight into the molecular mechanisms for the anti-silencing functions of Rpd3p during the formation of heterochromatin boundaries...
  13. pmc SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation
    Bo O Zhou
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, 320 Yue Yang Road, Shanghai 200031, China
    Mol Cell Biol 30:2391-400. 2010
    ..Our results support a model where SWR1-C resides at the heterochromatin boundary to maintain and amplify antisilencing activity of histone H4 acetylation through incorporating H2A.Z into chromatin...
  14. doi Characterization of the intramolecular G-quadruplex promoting activity of Est1
    Qian Jin Li
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    FEBS Lett 587:659-65. 2013
    ..Therefore, it remains possible that the intramolecular G-quadruplex promoting activity of Est1 is biologically relevant in telomere replication in vivo...
  15. pmc Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication
    Fei Long Meng
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    EMBO J 28:1466-78. 2009
    ..Thus, Sua5p represents a novel ssTG DNA-binding protein and positively regulates the telomere length in vivo...
  16. pmc Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast
    Xin Hua Liao
    Max Planck Junior Research Group in the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
    Biochem J 390:169-76. 2005
    ....
  17. ncbi Characterization of ATPase activity of recombinant human Pif1
    Yu Huang
    Max Planck Junior Research Group at the State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Acta Biochim Biophys Sin (Shanghai) 38:335-41. 2006
    ..Km for ATP for the ATPase activity is approximately 200 microM. As the ATPase activity is essential for hPif1's helicase activity, these results will facilitate the further investigation on hPif1...
  18. pmc The N-terminus of histone H3 is required for de novo DNA methylation in chromatin
    Jia Lei Hu
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Proc Natl Acad Sci U S A 106:22187-92. 2009
    ..These findings establish the N terminus of histone H3 tail with an unmethylated lysine 4 as a chromatin determinant for DNA methylation...
  19. pmc Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae
    Xiao Fen Chen
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS Genet 5:e1000535. 2009
    ..These results suggest that telomere recombination accelerates cellular aging in telomerase-null type II survivors and that telomerase is likely a superior telomere maintenance pathway in sustaining yeast replicative life span...
  20. doi Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation
    Wei Qian
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School of Chinese Academy of Sciences, Shanghai, China
    Cell Res 19:849-63. 2009
    ..These results suggest that Ten1p enhances the telomeric DNA-binding activity of Cdc13p to negatively regulate telomere length...
  21. doi Saccharomyces cerevisiae MHF complex structurally resembles the histones (H3-H4)₂ heterotetramer and functions as a heterotetramer
    Hui Yang
    State Key Laboratory of Molecular Biology and Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Structure 20:364-70. 2012
    ..These results provide, to the best of our knowledge, new mechanistic insights into the function of the MHF complex...
  22. ncbi Immortalization of normal human cytotrophoblast cells by reconstitution of telomeric reverse transcriptase activity
    Yan Ling Wang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Mol Hum Reprod 12:451-60. 2006
    ..The cells will provide an ideal in vitro model for the study of human extravillous trophoblast (EVT) functions and consequently the mechanisms of embryonic implantation and placentation...
  23. doi Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism
    Yuanyuan Chang
    Research Center for Structural Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Biochem J 433:295-302. 2011
    ..Taken together, our structural and biological data provide insights into the molecular basis of the histone demethylase activity and the substrate specificity of Rph1...
  24. pmc Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivors
    Xiao Hong Fu
    The State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 9:e90644. 2014
    ..Our results support the notion that Rad50 and Rad59 are not essential for the maintenance of type II survivors once established. ..