Research Topics
Genomes and Genes
| Bin ZhouSummaryAffiliation: Shanghai Institutes for Biological Sciences Country: China Publications
| Collaborators
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Detail Information
Publications
Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heartXueying Tian
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
PLoS ONE 8:e80857. 2013..In conclusion, main coronary arteries and their orifices form through the recruitment and vascular remodeling of peritruncal endothelial cells in mammalian heart. ..- Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteriesXueying Tian
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Cell Res 23:1075-90. 2013..Collectively, these data suggested that subepicardial ECs are the major source of intramyocardial coronary arteries in the ventricle wall, and that coronary arteries and veins have a common origin in the developing heart... - Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre allelesBin Zhou
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Circ Res 111:e276-80. 2012..Wt1-Cre-based tools are important reagents for studying epicardial cell fate and gene function... - Epicardial epithelial-to-mesenchymal transition in injured heartBin Zhou
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
J Cell Mol Med 15:2781-3. 2011..This image supports active involvement of the epicardium in repair and regeneration of infarcted myocardium... - Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytesBin Zhou
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
J Mol Cell Cardiol 52:43-7. 2012..This article is part of a Special Issue entitled 'Possible Editorial'... - Adult mouse epicardium modulates myocardial injury by secreting paracrine factorsBin Zhou
Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA
J Clin Invest 121:1894-904. 2011..Our findings indicate that epicardium modulates the cardiac injury response by conditioning the subepicardial environment, potentially offering a new therapeutic strategy for cardiac protection... 
Isolation and characterization of embryonic and adult epicardium and epicardium-derived cellsBin Zhou
Department of Cardiology, Children s Hospital Boston, Boston, MA, USA
Methods Mol Biol 843:155-68. 2012..This platform allows further characterization and manipulation of EpiCs and EPDCs for expression studies and functional assays...- Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activityQing Ma
Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Dev Biol 323:98-104. 2008..These results have important implications for our understanding of cardiac lineage diversification in vivo, and for the interpretation of Cre-based fate maps... 
Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heartXueying Tian
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
Science 345:90-4. 2014..This mechanism of postnatal coronary vascular growth provides avenues for understanding and stimulating cardiovascular regeneration following injury and disease. ..- Ginsenoside Rb1 reverses H2O2-induced senescence in human umbilical endothelial cells: involvement of eNOS pathwayDing Hui Liu
Department of Cardiology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong, China
J Cardiovasc Pharmacol 59:222-30. 2012..This study investigated the effects of Rb1, a major ginsenoside in ginseng, on H2O2-induced senescence in primary human umbilical vein endothelial cells (HUVECs)... - WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathwaysAlexander von Gise
Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA, USA
Dev Biol 356:421-31. 2011..Collectively, our study shows that Wt1 regulates epicardial EMT and heart development through canonical Wnt, non-canonical Wnt, and retinoic acid signaling pathways... - Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heartBin Zhou
Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 454:109-13. 2008..These results identify Wt1(+) epicardial cells as previously unrecognized cardiomyocyte progenitors, and lay the foundation for future efforts to harness the cardiogenic potential of these progenitors for cardiac regeneration and repair... - Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardiumBin Zhou
Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Biochem Biophys Res Commun 375:450-3. 2008..Taken together, these results suggest that Nkx2-5 and/or Isl1 cardiac progenitors contribute to proepicardium during heart development... - Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heartBin Zhou
Department of Cardiology, Children s Hospital Boston and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 119:1462-76. 2009..Loss of the FOG2 or FOG2-GATA4 interaction altered the expression of a panel of angiogenesis-related genes. Collectively, our data indicate that FOG2 regulates adult heart function and coronary angiogenesis... - A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistanceDharminder Chauhan
Department of Medical Oncology, The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
Cancer Cell 22:345-58. 2012..Our preclinical study therefore supports clinical evaluation of USP7 inhibitor, alone or in combination, as a potential MM therapy... - Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heartBin Zhou
Department of Cardiology, Children s Hospital Boston and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 338:251-61. 2010..Abnormalities of this differentiation process may underlie development of some forms of re-entrant atrioventricular tachycardia... - Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushionHui Zhang
From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
J Biol Chem 289:18681-92. 2014..Together, our results identify a role of YAP1 in regulating EMT through modulation of TGFβ-Smad signaling and through proliferative activity during cardiac cushion development. .. - Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purificationPingzhu Zhou
Department of Cardiology, Boston Children s Hospital, Boston, MA 02115
Proc Natl Acad Sci U S A 110:15395-400. 2013..Together, these data show that the TRAP strategy and the Rosa26(fsTRAP) allele will be useful tools to probe cell type-specific transcriptomes, study translational regulation, and probe ribosome binding of noncoding RNAs. .. - A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesisChaoshe Guo
Department of Urology, Children s Hospital Boston, and Department of Surgery and Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 121:1585-95. 2011..Together, these findings reveal a Tbx1-Six1/Eya1-Fgf8 genetic pathway that is crucial for mammalian cardiocraniofacial morphogenesis and provide insights into the pathogenesis of human del22q11 syndromes... - Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cellsRuei Zeng Lin
Department of Cardiac Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
Angiogenesis 15:443-55. 2012..These results validate multiple tissues as potential sources of MSCs for future cell-based vascular therapies... - RNT4 3'-UTR insertion/deletion polymorphisms are not associated with atrial septal defect in Chinese Han population: a brief communicationHui Li
Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China
DNA Cell Biol 31:1121-4. 2012..The same results were seen in their genotypes. The present study suggests that CAA and TATC insertion/deletion polymorphisms of RNT4 gene may not be a useful marker to predict the susceptibility of ASD in Chinese Han population... - YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophyAlexander von Gise
Department of Cardiology and Stem Cell Program, Children s Hospital Boston, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 109:2394-9. 2012..Activation of Yap1 in postnatal cardiomyocytes may be a useful strategy to stimulate cardiomyocyte expansion in therapeutic myocardial regeneration... - Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI ModelZhiqiang Lin
From the Departments of Cardiology, Boston Children s Hospital Z L, A v G, P Z, F G, Q M, A L Y, J N B, K A G, P R R v G, B Z, J C, D Z W, W T P and Genetics J J, J G S, Harvard Medical School, Boston, MA Department of Pediatric Cardiology and Intensive Care, MHH Hannover Medical School, Hannover, Germany A v G Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands P R R v G Harvard Stem Cell Institute, Harvard University, Cambridge, MA D Z W, W T P and Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China B Z
Circ Res 115:354-63. 2014..Yes-associated protein (YAP), the terminal effector of the Hippo signaling pathway, is crucial for regulating embryonic cardiomyocyte proliferation... - [Signal transducer and activator of transcription 4 gene polymorphisms associated with dilated cardiomyopathy in Chinese Han population]Kai Fu
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China
Sichuan Da Xue Xue Bao Yi Xue Ban 44:558-62. 2013..To investigate the association between signal transducer and activator of transcription 4 (STAT4) gene polymorphism and dilated cardiomyopathy (DCM)... - CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophyZhan Peng Huang
Department of Cardiology, Children s Hospital Boston, Harvard Medical School, MA 02115, USA
Circ Res 110:818-30. 2012..Whereas the regulatory pathways that activate cardiac hypertrophy have been well-established, the molecular events that inhibit or repress cardiac hypertrophy are less known... - Polymorphisms of presenilin-1 gene associate with dilated cardiomyopathy susceptibilityHui Li
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Mol Cell Biochem 358:31-6. 2011..300, 95% CI 1.013-1.669; P = 0.039). Our data indicate, for the first time, the association of the presenilin-1 gene SNPs with human DCM and the allele A at SNP rs177415 in presenilin-1 gene may increase the risk of DCM... - In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cellsDharminder Chauhan
The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Clin Cancer Res 17:5311-21. 2011..In the present study, we evaluated the efficacy of one such novel orally bioactive proteasome inhibitor MLN9708/MLN2238 in MM using well-established in vitro and in vivo models... - [Effects of cardiotrophin-1 on differentiation of cardiomyocyte-like cells induced from rat bone marrow mesenchymal stem cells]Xin Yun Chen
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China
Sichuan Da Xue Xue Bao Yi Xue Ban 40:85-8. 2009..To investigate the effects of cardiotrophin-1 (CT-1) on differentiation of induced rat bone marrow mesenchymal stem cells (BMMSCs) in vitro with 5-azacytidine (5-aza) for the purpose of elucidation of the cellular biological mechanisms... - Rb1 protects endothelial cells from hydrogen peroxide-induced cell senescence by modulating redox statusDing Hui Liu
Department of Cardiology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong 510630, China
Biol Pharm Bull 34:1072-7. 2011..Taken together, our data demonstrate that Rb1 exhibits antioxidant effects and antagonizes H(2)O(2)-induced cellular senescence... - [Association of TNNT2 gene mutations with idiopathic dilated cardiomyopathy in a Chengdu population]Bin Chen
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China
Sichuan Da Xue Xue Bao Yi Xue Ban 39:969-72. 2008..To determine whether cardiac troponin T gene (TNNT2, AY044273) is the virulence gene of idiopathic dilated cardiomyopathy (IDCM) in a Chengdu population...