Bin Zhou

Summary

Affiliation: Shanghai Institutes for Biological Sciences
Country: China

Publications

  1. pmc Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart
    Xueying Tian
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 8:e80857. 2013
  2. pmc Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries
    Xueying Tian
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Res 23:1075-90. 2013
  3. pmc Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre alleles
    Bin Zhou
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Circ Res 111:e276-80. 2012
  4. pmc Epicardial epithelial-to-mesenchymal transition in injured heart
    Bin Zhou
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Cell Mol Med 15:2781-3. 2011
  5. pmc Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes
    Bin Zhou
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Mol Cell Cardiol 52:43-7. 2012
  6. pmc Adult mouse epicardium modulates myocardial injury by secreting paracrine factors
    Bin Zhou
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA
    J Clin Invest 121:1894-904. 2011
  7. doi Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells
    Bin Zhou
    Department of Cardiology, Children s Hospital Boston, Boston, MA, USA
    Methods Mol Biol 843:155-68. 2012
  8. pmc Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity
    Qing Ma
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Dev Biol 323:98-104. 2008
  9. doi Ginsenoside Rb1 reverses H2O2-induced senescence in human umbilical endothelial cells: involvement of eNOS pathway
    Ding Hui Liu
    Department of Cardiology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong, China
    J Cardiovasc Pharmacol 59:222-30. 2012
  10. pmc WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways
    Alexander von Gise
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA, USA
    Dev Biol 356:421-31. 2011

Collaborators

Detail Information

Publications29

  1. pmc Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart
    Xueying Tian
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 8:e80857. 2013
    ..In conclusion, main coronary arteries and their orifices form through the recruitment and vascular remodeling of peritruncal endothelial cells in mammalian heart. ..
  2. pmc Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries
    Xueying Tian
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Res 23:1075-90. 2013
    ..Collectively, these data suggested that subepicardial ECs are the major source of intramyocardial coronary arteries in the ventricle wall, and that coronary arteries and veins have a common origin in the developing heart...
  3. pmc Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre alleles
    Bin Zhou
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Circ Res 111:e276-80. 2012
    ..Wt1-Cre-based tools are important reagents for studying epicardial cell fate and gene function...
  4. pmc Epicardial epithelial-to-mesenchymal transition in injured heart
    Bin Zhou
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Cell Mol Med 15:2781-3. 2011
    ..This image supports active involvement of the epicardium in repair and regeneration of infarcted myocardium...
  5. pmc Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes
    Bin Zhou
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Mol Cell Cardiol 52:43-7. 2012
    ..This article is part of a Special Issue entitled 'Possible Editorial'...
  6. pmc Adult mouse epicardium modulates myocardial injury by secreting paracrine factors
    Bin Zhou
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA
    J Clin Invest 121:1894-904. 2011
    ..Our findings indicate that epicardium modulates the cardiac injury response by conditioning the subepicardial environment, potentially offering a new therapeutic strategy for cardiac protection...
  7. doi Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells
    Bin Zhou
    Department of Cardiology, Children s Hospital Boston, Boston, MA, USA
    Methods Mol Biol 843:155-68. 2012
    ..This platform allows further characterization and manipulation of EpiCs and EPDCs for expression studies and functional assays...
  8. pmc Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity
    Qing Ma
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Dev Biol 323:98-104. 2008
    ..These results have important implications for our understanding of cardiac lineage diversification in vivo, and for the interpretation of Cre-based fate maps...
  9. doi Ginsenoside Rb1 reverses H2O2-induced senescence in human umbilical endothelial cells: involvement of eNOS pathway
    Ding Hui Liu
    Department of Cardiology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong, China
    J Cardiovasc Pharmacol 59:222-30. 2012
    ..This study investigated the effects of Rb1, a major ginsenoside in ginseng, on H2O2-induced senescence in primary human umbilical vein endothelial cells (HUVECs)...
  10. pmc WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways
    Alexander von Gise
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA, USA
    Dev Biol 356:421-31. 2011
    ..Collectively, our study shows that Wt1 regulates epicardial EMT and heart development through canonical Wnt, non-canonical Wnt, and retinoic acid signaling pathways...
  11. pmc Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 454:109-13. 2008
    ..These results identify Wt1(+) epicardial cells as previously unrecognized cardiomyocyte progenitors, and lay the foundation for future efforts to harness the cardiogenic potential of these progenitors for cardiac regeneration and repair...
  12. pmc Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Biochem Biophys Res Commun 375:450-3. 2008
    ..Taken together, these results suggest that Nkx2-5 and/or Isl1 cardiac progenitors contribute to proepicardium during heart development...
  13. ncbi Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart
    Xueying Tian
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
    Science 345:90-4. 2014
    ..This mechanism of postnatal coronary vascular growth provides avenues for understanding and stimulating cardiovascular regeneration following injury and disease. ..
  14. pmc Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart
    Bin Zhou
    Department of Cardiology, Children s Hospital Boston and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 119:1462-76. 2009
    ..Loss of the FOG2 or FOG2-GATA4 interaction altered the expression of a panel of angiogenesis-related genes. Collectively, our data indicate that FOG2 regulates adult heart function and coronary angiogenesis...
  15. pmc A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance
    Dharminder Chauhan
    Department of Medical Oncology, The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 22:345-58. 2012
    ..Our preclinical study therefore supports clinical evaluation of USP7 inhibitor, alone or in combination, as a potential MM therapy...
  16. pmc Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart
    Bin Zhou
    Department of Cardiology, Children s Hospital Boston and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 338:251-61. 2010
    ..Abnormalities of this differentiation process may underlie development of some forms of re-entrant atrioventricular tachycardia...
  17. ncbi Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion
    Hui Zhang
    Chinese Academy of Sciences, China
    J Biol Chem . 2014
    ..Together, our results identify a role of YAP1 in regulating EMT through modulation of TGFβ-Smad signaling and through proliferative activity during cardiac cushion development...
  18. pmc Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification
    Pingzhu Zhou
    Department of Cardiology, Boston Children s Hospital, Boston, MA 02115
    Proc Natl Acad Sci U S A 110:15395-400. 2013
    ..Together, these data show that the TRAP strategy and the Rosa26(fsTRAP) allele will be useful tools to probe cell type-specific transcriptomes, study translational regulation, and probe ribosome binding of noncoding RNAs. ..
  19. pmc A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis
    Chaoshe Guo
    Department of Urology, Children s Hospital Boston, and Department of Surgery and Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 121:1585-95. 2011
    ..Together, these findings reveal a Tbx1-Six1/Eya1-Fgf8 genetic pathway that is crucial for mammalian cardiocraniofacial morphogenesis and provide insights into the pathogenesis of human del22q11 syndromes...
  20. pmc Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells
    Ruei Zeng Lin
    Department of Cardiac Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Angiogenesis 15:443-55. 2012
    ..These results validate multiple tissues as potential sources of MSCs for future cell-based vascular therapies...
  21. pmc RNT4 3'-UTR insertion/deletion polymorphisms are not associated with atrial septal defect in Chinese Han population: a brief communication
    Hui Li
    Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China
    DNA Cell Biol 31:1121-4. 2012
    ..The same results were seen in their genotypes. The present study suggests that CAA and TATC insertion/deletion polymorphisms of RNT4 gene may not be a useful marker to predict the susceptibility of ASD in Chinese Han population...
  22. pmc YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy
    Alexander von Gise
    Department of Cardiology and Stem Cell Program, Children s Hospital Boston, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:2394-9. 2012
    ..Activation of Yap1 in postnatal cardiomyocytes may be a useful strategy to stimulate cardiomyocyte expansion in therapeutic myocardial regeneration...
  23. pmc CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy
    Zhan Peng Huang
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, MA 02115, USA
    Circ Res 110:818-30. 2012
    ..Whereas the regulatory pathways that activate cardiac hypertrophy have been well-established, the molecular events that inhibit or repress cardiac hypertrophy are less known...
  24. doi Polymorphisms of presenilin-1 gene associate with dilated cardiomyopathy susceptibility
    Hui Li
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    Mol Cell Biochem 358:31-6. 2011
    ..300, 95% CI 1.013-1.669; P = 0.039). Our data indicate, for the first time, the association of the presenilin-1 gene SNPs with human DCM and the allele A at SNP rs177415 in presenilin-1 gene may increase the risk of DCM...
  25. ncbi [Signal transducer and activator of transcription 4 gene polymorphisms associated with dilated cardiomyopathy in Chinese Han population]
    Kai Fu
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 44:558-62. 2013
    ..To investigate the association between signal transducer and activator of transcription 4 (STAT4) gene polymorphism and dilated cardiomyopathy (DCM)...
  26. pmc In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells
    Dharminder Chauhan
    The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 17:5311-21. 2011
    ..In the present study, we evaluated the efficacy of one such novel orally bioactive proteasome inhibitor MLN9708/MLN2238 in MM using well-established in vitro and in vivo models...
  27. ncbi [Effects of cardiotrophin-1 on differentiation of cardiomyocyte-like cells induced from rat bone marrow mesenchymal stem cells]
    Xin Yun Chen
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 40:85-8. 2009
    ..To investigate the effects of cardiotrophin-1 (CT-1) on differentiation of induced rat bone marrow mesenchymal stem cells (BMMSCs) in vitro with 5-azacytidine (5-aza) for the purpose of elucidation of the cellular biological mechanisms...
  28. ncbi Rb1 protects endothelial cells from hydrogen peroxide-induced cell senescence by modulating redox status
    Ding Hui Liu
    Department of Cardiology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong 510630, China
    Biol Pharm Bull 34:1072-7. 2011
    ..Taken together, our data demonstrate that Rb1 exhibits antioxidant effects and antagonizes H(2)O(2)-induced cellular senescence...
  29. ncbi [Association of TNNT2 gene mutations with idiopathic dilated cardiomyopathy in a Chengdu population]
    Bin Chen
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 39:969-72. 2008
    ..To determine whether cardiac troponin T gene (TNNT2, AY044273) is the virulence gene of idiopathic dilated cardiomyopathy (IDCM) in a Chengdu population...