Research Topics

Shu Li You


Affiliation: Shanghai Institute of Organic Chemistry
Country: China


  1. Yin Q, Wang S, Liang X, Gao D, Zheng J, You S. Organocatalytic asymmetric chlorinative dearomatization of naphthols. Chem Sci. 2015;6:4179-4183 pubmed publisher
    ..The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation. ..
  2. Liang X, Liu C, Zhang W, You S. Asymmetric fluorinative dearomatization of tryptamine derivatives. Chem Commun (Camb). 2017;53:5531-5534 pubmed publisher
    ..This method is characterized by a simple operation, facile introduction of a fluorine atom in a highly enantioselective manner and construction of two contiguous quaternary stereogenic centers. ..
  3. Zhang X, Liu W, Tu H, You S. Ligand-enabled Ir-catalyzed intermolecular diastereoselective and enantioselective allylic alkylation of 3-substituted indoles. Chem Sci. 2015;6:4525-4529 pubmed publisher
    ..The key to this method is the high level of diastereocontrol enabled by an iridium catalyst derived from a N-aryl phosphoramidite ligand (Me-THQphos, 1c). ..
  4. Wu W, Xu R, Zhang L, You S. Construction of spirocarbocycles via gold-catalyzed intramolecular dearomatization of naphthols. Chem Sci. 2016;7:3427-3431 pubmed publisher
    ..This facile and direct approach furnishes spirocarbocycles in excellent yields under mild conditions. ..
  5. Xu R, Yang P, You S. Pd(0)-Catalyzed intramolecular arylative dearomatization of β-naphthols. Chem Commun (Camb). 2017;53:7553-7556 pubmed publisher
    ..1 mol%. This method offers an efficient access to a series of structurally diverse spirocarbocycles. Preliminary investigation indicates that an enantioselective reaction is feasible in the presence of a chiral phosphoramidite ligand. ..
  6. Wu W, Zhang L, You S. Catalytic asymmetric dearomatization (CADA) reactions of phenol and aniline derivatives. Chem Soc Rev. 2016;45:1570-80 pubmed publisher
    ..In this tutorial review, an up to date summary of recent progress in CADA reactions of phenol and aniline derivatives is presented. ..
  7. Li G, Gu Q, You S. Enantioselective annulation of enals with 2-naphthols by triazolium salts derived from l-phenylalanine. Chem Sci. 2015;6:4273-4278 pubmed publisher
    ..These reactions proceeded with high chemoselectivity and wide substrate scope affording enantioenriched β-arylsplitomicins in good yields with up to 96% ee. ..
  8. Yi J, Tu H, You S. Rh-Catalyzed aminative dearomatization of 2-naphthols. Org Biomol Chem. 2018;16:8700-8703 pubmed publisher
    ..The conditions were compatible with gram-scale reaction, and the product could undergo diverse transformations. ..
  9. Cai Y, Gu Q, You S. Chemoselective N-H functionalization of indole derivatives via the Reissert-type reaction catalyzed by a chiral phosphoric acid. Org Biomol Chem. 2018;16:6146-6154 pubmed publisher
    ..The current method is compatible with gram-scale reaction and the products can undergo versatile chemical transformations. ..

More Information


  1. Zhang X, You S. THQphos in Ir-catalyzed Asymmetric Allylic Substitution Reactions. Chimia (Aarau). 2018;72:589-594 pubmed publisher
    ..In this short review article, an overall introduction on the development of THQphos, involving their original design, preparation, mechanistic studies, applications and features will be described. ..
  2. Liu C, Yin Q, Dai L, You S. Synthesis of pyrroloindolines and furoindolines via cascade dearomatization of indole derivatives with carbenium ion. Chem Commun (Camb). 2015;51:5971-4 pubmed publisher
  3. Zhuo C, Cheng Q, Liu W, Zhao Q, You S. Enantioselective Synthesis of Pyrrole-Based Spiro- and Polycyclic Derivatives by Iridium-Catalyzed Asymmetric Allylic Dearomatization and Controllable Migration Reactions. Angew Chem Int Ed Engl. 2015;54:8475-9 pubmed publisher
    ..Additionally, the novel Ir-complex K1, derived from [Ir(cod)Cl]2 (cod = 1,5-cyclooctadiene) and N-benzhydryl-N-phenyldinaphthophosphoramidite (BHPphos), showed excellent control of both diastereo- and enantioselectivities. ..
  4. Zhuo C, Zhou Y, Cheng Q, Huang L, You S. Enantioselective Construction of Spiroindolines with Three Contiguous Stereogenic Centers and Chiral Tryptamine Derivatives via Reactive Spiroindolenine Intermediates. Angew Chem Int Ed Engl. 2015;54:14146-9 pubmed publisher
    ..In addition, a chiral tryptamine derivative could be easily accessed in good yield with excellent ee value through an unprecedented dearomatization/retro-Mannich/hydrolysis cascade reaction of an indole derivative. ..
  5. Shao W, Li H, Liu C, Liu C, You S. Copper-catalyzed intermolecular asymmetric propargylic dearomatization of indoles. Angew Chem Int Ed Engl. 2015;54:7684-7 pubmed publisher
    ..This method provides a highly efficient synthesis of versatile furoindoline and pyrroloindoline derivatives containing a quaternary carbon stereogenic center and a terminal alkyne moiety with up to 86 % yield and 98 % ee. ..
  6. Liang X, Zheng C, You S. Dearomatization through Halofunctionalization Reactions. Chemistry. 2016;22:11918-33 pubmed publisher
    ..By applying these methods, various valuable halogenated polycyclic molecular architectures have been obtained from readily available starting materials. ..
  7. Liu C, Yi J, Liang X, Xu R, Dai L, You S. Copper(I)-Catalyzed Asymmetric Dearomatization of Indole Acetamides with 3-Indolylphenyliodonium Salts. Chemistry. 2016;22:10813-6 pubmed publisher
    ..The utility of the protocol has been demonstrated by the formal asymmetric synthesis of folicanthine. ..
  8. Ye K, Cheng Q, Zhuo C, Dai L, You S. An Iridium(I) N-Heterocyclic Carbene Complex Catalyzes Asymmetric Intramolecular Allylic Amination Reactions. Angew Chem Int Ed Engl. 2016;55:8113-6 pubmed publisher
    ..Preliminary mechanistic investigations reveal that the C-H activation occurs at the position ortho to the N-aryl group of the ligand. ..
  9. Liu C, Yi J, Zheng Z, Tang Y, Dai L, You S. Enantioselective Synthesis of 3a-Amino-Pyrroloindolines by Copper-Catalyzed Direct Asymmetric Dearomative Amination of Tryptamines. Angew Chem Int Ed Engl. 2016;55:751-4 pubmed publisher
    ..Furthermore, the synthetic value of this method was demonstrated in the total synthesis of (-)-psychotriasine in a highly concise manner. ..
  10. Wang D, Xie M, Guo H, Qu G, Zhang M, You S. Enantioselective Dearomative [3+2] Cycloaddition Reactions of Benzothiazoles. Angew Chem Int Ed Engl. 2016;55:14111-14115 pubmed publisher
    ..With the same catalytic system, a highly efficient kinetic resolution of 2-substituted cyclopropane-1,1-dicarboxylates was also realized. ..
  11. Gao R, Xu Q, Dai L, You S. Pd-catalyzed cascade allylic alkylation and dearomatization reactions of indoles with vinyloxirane. Org Biomol Chem. 2016;14:8044-6 pubmed publisher
  12. Gao R, Xu Q, Zhang B, Gu Y, Dai L, You S. Palladium(0)-Catalyzed Intermolecular Allylic Dearomatization of Indoles by a Formal [4+2] Cycloaddition Reaction. Chemistry. 2016;22:11601-4 pubmed publisher
    ..The reaction between indoles and allyl carbonates bearing a nucleophilic alcohol side-chain proceeds in a cascade fashion, providing bridged indolines in excellent enantioselectivity. ..
  13. Cheng Q, Wang Y, You S. Chemo-, Diastereo-, and Enantioselective Iridium-Catalyzed Allylic Intramolecular Dearomatization Reaction of Naphthol Derivatives. Angew Chem Int Ed Engl. 2016;55:3496-9 pubmed publisher
    ..r., and 99 % ee, thus providing a general method for the dearomatization of naphthols. ..
  14. Wang S, Liu X, Zhao Q, Zheng C, Wang S, You S. Asymmetric Dearomatization of β-Naphthols through a Bifunctional-Thiourea-Catalyzed Michael Reaction. Angew Chem Int Ed Engl. 2015;54:14929-32 pubmed publisher