Jing Yi

Summary

Affiliation: Shanghai Second Medical University
Country: China

Publications

  1. doi request reprint PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase
    Lingna Li
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciencies, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Cell Physiol 217:486-93. 2008
  2. pmc Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90
    Shan Yan
    Department of Biochemistry and Cell Biology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, PR China
    EMBO J 29:3773-86. 2010
  3. ncbi request reprint Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling
    Jing Yi
    Department of Cell Biology, Shanghai Second Medical University, Shanghai, People s Republic of China
    Cancer Res 64:108-16. 2004
  4. ncbi request reprint Apoptosis susceptibility of tumor cells to arsenic trioxide and the inherent cellular level of reactive oxygen species
    Jing Yi
    Laboratory of Cell Biology, Shanghai Second Medical University, Shanghai 200025, China
    Chin Med J (Engl) 115:603-6. 2002
  5. ncbi request reprint Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis
    Jie Yang
    Department of Cell Biology, Shanghai Second Medical University, 280 Chongqing Road, Shanghai 200025, China
    Free Radic Biol Med 37:2027-41. 2004
  6. pmc p16 gene methylation in colorectal cancers associated with Duke's staging
    J Yi
    Department of Cell Biology, Shanghai Second Medical University, 280 Chongqing South Road, Shanghai 200025, China
    World J Gastroenterol 7:722-5. 2001
  7. pmc SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress
    Yan Han
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 285:12906-15. 2010
  8. doi request reprint Mechanisms of verapamil-enhanced chemosensitivity of gallbladder cancer cells to platinum drugs: glutathione reduction and MRP1 downregulation
    Haolu Wang
    Department of General Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, PR China
    Oncol Rep 29:676-84. 2013
  9. pmc The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress
    Ying Wang
    Department of Biochemistry and Molecular Cell Biology, Key Laboratory of the Shanghai Science and Technology Commission for Cancer Microenvironment and Inflammation, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, China
    Acta Pharmacol Sin 33:953-63. 2012
  10. ncbi request reprint Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin, a reactive oxygen species-producing agent
    Yawu Jing
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Free Radic Biol Med 40:2183-97. 2006

Collaborators

  • Hui Li
  • Jie Yang
  • Fei Gao
  • Jian Wang
  • Wei Wang
  • Chao Huang
  • Yang Lu
  • Hao Zhang
  • Ying Wang
  • Ping Zhu
  • Xiao Jing Wang
  • Qi Lin
  • Hua Yang
  • Li Li
  • Min He
  • Jian Hai
  • Rong He
  • Yuying Chen
  • Kai Yang
  • Ming Wang
  • Guiying Shi
  • Hui Cang
  • Xin Xing Li
  • Yu Ying Chen
  • Xuxu Sun
  • Haolu Wang
  • Jing Sang
  • Yan Han
  • Binggang Xiang
  • Gui Ying Shi
  • Qiwei Li
  • Hao Lu Wang
  • Yueping Sun
  • Shan Yan
  • Edward T H Yeh
  • Yong Zuo
  • Yan Bin Zhang
  • Rongying Wang
  • Xin Zhi Huang
  • Jun Cai
  • Xueming Tang
  • Qing Zhang
  • Qingshen Hu
  • Qing shen Hu
  • Yawu Jing
  • Ya Wu Jing
  • Amir Orian
  • Zhaoyuan Hou
  • Aiwu Zhou
  • Xue Ming Tang
  • Xinyi Liu
  • Kejia Liu
  • Jian Zhang
  • Wei Chen
  • Benpeng Zhao
  • Yi Yang
  • Man Mohan
  • Yuzheng Zhao
  • Xie Li
  • Qihong Huang
  • Ming Zhan
  • Hu Zhou
  • Mian Wu
  • Huilin Chu
  • Yanhua Ren
  • Jianrong Xu
  • Ren Ding
  • Hong Zhi Zou
  • Qiang Liu
  • Tao Chen
  • Ying Dong
  • Xinxing Li
  • Qi wei Li
  • Xiao Bin Yin
  • Jie Zhou
  • Kangmin Wang
  • Xunlei Kang
  • Beilei Wang
  • Yanqiong Zou
  • Meng Yuan Kan
  • Zhen An Zhu
  • Hong Zhuan Chen
  • Zhen Yuan
  • Jian Lu
  • Wen Long Ding
  • Zhi Hui Yang
  • Yuanqing Mao
  • Xin Niu
  • Huacheng Wu
  • Ming quan Su

Detail Information

Publications44

  1. doi request reprint PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase
    Lingna Li
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciencies, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Cell Physiol 217:486-93. 2008
    ..PML/RARalpha that bestows NB4 cells various pathological features, paradoxically also endows these cells with the basis for susceptibility to ATO-induced cytotoxcity...
  2. pmc Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90
    Shan Yan
    Department of Biochemistry and Cell Biology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, PR China
    EMBO J 29:3773-86. 2010
    ..In addition, enhanced SENP3/Hsp90 association is found in cancer. These findings provide new mechanistic insight into how cells regulate the SUMO protease in response to oxidative stress...
  3. ncbi request reprint Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling
    Jing Yi
    Department of Cell Biology, Shanghai Second Medical University, Shanghai, People s Republic of China
    Cancer Res 64:108-16. 2004
    ..This result allows us to propose a novel strategy in chemotherapy that uses mild ROS generators to facilitate apoptosis-inducing drugs whose efficacy depends on ROS...
  4. ncbi request reprint Apoptosis susceptibility of tumor cells to arsenic trioxide and the inherent cellular level of reactive oxygen species
    Jing Yi
    Laboratory of Cell Biology, Shanghai Second Medical University, Shanghai 200025, China
    Chin Med J (Engl) 115:603-6. 2002
    ..To explore the association of inherent cellular reactive oxygen species (ROS) levels with susceptibility of the tumor cells to apoptosis induction by arsenic trioxide (As(2)O(3))...
  5. ncbi request reprint Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis
    Jie Yang
    Department of Cell Biology, Shanghai Second Medical University, 280 Chongqing Road, Shanghai 200025, China
    Free Radic Biol Med 37:2027-41. 2004
    ..Taken together, these results suggest an innovative and safe chemotherapeutic strategy that uses natural anthraquinone derivatives as ROS generators to increase the susceptibility of tumor cells to cytotoxic therapeutic agents...
  6. pmc p16 gene methylation in colorectal cancers associated with Duke's staging
    J Yi
    Department of Cell Biology, Shanghai Second Medical University, 280 Chongqing South Road, Shanghai 200025, China
    World J Gastroenterol 7:722-5. 2001
    ..To explore the association of methylation of the CpG island in the promotor of the p16 tumor suppressor gene with the clinicopathological characteristics of the colorectal cancers...
  7. pmc SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress
    Yan Han
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 285:12906-15. 2010
    ..These results reveal an important role of SENP3 and the SUMOylation status of PML in the regulation of cell proliferation under oxidative stress...
  8. doi request reprint Mechanisms of verapamil-enhanced chemosensitivity of gallbladder cancer cells to platinum drugs: glutathione reduction and MRP1 downregulation
    Haolu Wang
    Department of General Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, PR China
    Oncol Rep 29:676-84. 2013
    ..Our data demonstrate that verapamil may be used as a safe chemosensitizer for platinum drugs in the treatment of GBC. It functions by ROS and ATP-binding cassette transporter-related mechanisms...
  9. pmc The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress
    Ying Wang
    Department of Biochemistry and Molecular Cell Biology, Key Laboratory of the Shanghai Science and Technology Commission for Cancer Microenvironment and Inflammation, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, China
    Acta Pharmacol Sin 33:953-63. 2012
    ..To investigate the mechanisms underlying the biphasic redox regulation of hypoxia-inducible factor-1 (HIF-1) transcriptional activity under different levels of oxidative stress caused by reactive oxidative species (ROS)...
  10. ncbi request reprint Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin, a reactive oxygen species-producing agent
    Yawu Jing
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Free Radic Biol Med 40:2183-97. 2006
    ..NF-kappaB binding and transactivation were inhibited in these tumors. These data help in the understanding of the mechanisms by which manipulation of cellular redox and NF-kappaB activation may enhance chemotherapy...
  11. ncbi request reprint [Emodin sensitizes HeLa cell to arsenic trioxide induced apoptosis via the reactive oxygen species-mediated signaling pathways]
    Jie Yang
    Department of Cell Biology, Shanghai Second Medical University, Shanghai 200025, China
    Shi Yan Sheng Wu Xue Bao 36:465-75. 2003
    ..The study elucidated that emodin sensitize HeLa cells via generation of ROS which result in enhancement of apoptosis signaling pathway and inhibition of survival signaling pathway...
  12. pmc SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation
    Chao Huang
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    EMBO J 28:2748-62. 2009
    ..In vivo nude mouse xenografts overexpressing SENP3 are more angiogenic. Taken together, our results identify SENP3 as a redox sensor that regulates HIF-1 transcriptional activity under oxidative stress through the de-SUMOylation of p300...
  13. doi request reprint Emodin enhances sensitivity of gallbladder cancer cells to platinum drugs via glutathion depletion and MRP1 downregulation
    Wei Wang
    Renji Hospital, Shanghai Jiao Tong University School of Medicine, China
    Biochem Pharmacol 79:1134-40. 2010
    ..In conclusion, emodin can work as an adjunct to enhance the anticancer effect of platinum drugs in gallbladder cancer cells via ROS-related mechanisms...
  14. doi request reprint Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression
    Wei Wang
    Division of General Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 S Dongfang Road, Shanghai 200127, PR China
    Oncol Rep 26:1143-8. 2011
    ..Further experiments proved that emodin potentiated the antitumor effects of CDDP in vivo by downregulating the expression of survivin without causing detectable toxic effects on normal tissues...
  15. doi request reprint Cyclic AMP-dependent regulation of differentiation of rat C6 glioma cells by panaxydol
    Jian Hai
    Department of Neurosurgery, Tongji Hospital, Tongji University, Shanghai, China
    Neurol Res 31:274-9. 2009
    ..However, the molecular mechanism underlying this differentiation remains unknown. We sought to investigate the role of cyclic adenosine monophosphate (cAMP) in cellular differentiation induced by panaxydol...
  16. pmc Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis
    Jun Cai
    Departments of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Neoplasia 10:41-51. 2008
    ..In conclusion, activation of RhoA is required for the maintenance of anoikis resistance phenotype of gastric cancer cells, and oxidative stress might be a therapeutic strategy for the inhibition of RhoA in cancer cells...
  17. ncbi request reprint Dicoumarol alters cellular redox state and inhibits nuclear factor kappa B to enhance arsenic trioxide-induced apoptosis
    Ya Wu Jing
    Department of Cell Biology, Shanghai Second Medical University, Shanghai 200025, China
    Acta Biochim Biophys Sin (Shanghai) 36:235-42. 2004
    ..It was suggested that dicoumarol in combination with anthraquinones might be a novel strategy to expand the chemotherapeutic spectrum of As2O3 by means of interfering the cellular redox state...
  18. ncbi request reprint Gene expression alteration during redox-dependent enhancement of arsenic cytotoxicity by emodin in HeLa cells
    Xiao Jing Wang
    Department of Cell Biology, Shanghai Second Medical University, 280 Chongqing Road, Shanghai 200025, China
    Cell Res 15:511-22. 2005
    ..These data suggest that based on the cytotoxicity of As2O3, emodin mobilize every genomic resource through which the As2O3-induced apoptosis is facilitated...
  19. ncbi request reprint Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: the mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1
    Xin Zhi Huang
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cancer Biol Ther 7:468-75. 2008
    ..In conclusions, emodin, as a novel small inhibitor of HIF-1, may be recognized an effective adjunctive to improve efficacy of cytotoxic drugs in prostate cancer cells with over-activated HIF-1 and potent MDR...
  20. pmc The sensitivity of digestive tract tumor cells to As2O3 is associated with the inherent cellular level of reactive oxygen species
    Fei Gao
    Department of Cell Biology, Shanghai Second Medical University, Shanghai 200025 China
    World J Gastroenterol 8:36-9. 2002
    ..To explore the correlation of the inherent cellular ROS level with the susceptibility of the digestive tract tumor cells to apoptosis inducted by As2O3...
  21. ncbi request reprint The cell cycle related apoptotic susceptibility to arsenic trioxide is associated with the level of reactive oxygen species
    Fei Gao
    Department of Cell Biology, Shanghai Second Medical University, Shanghai 200025, China
    Cell Res 14:81-5. 2004
    ..These results suggested that different ROS level in different cell cycle phases of NB4 cells might determine the selective induction of G2/M apoptosis and the cells' susceptibility to apoptosis by As2O3...
  22. ncbi request reprint [Ascorbic acid enhances the apoptosis of U937 cells induced by arsenic trioxide in combination with DMNQ and its mechanism]
    Fei Gao
    Laboratory of Cell Biology, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Xue Ye Xue Za Zhi 23:9-11. 2002
    ..To investigate whether ascorbic acid could enhance the efficacy of arsenic trioxide (As(2)O(3)) combined with 2, 3-dimethoxy-1, 4-naphthoquinone (DMNQ) in inducing the apoptosis of leukemia cell line U937 and its possible mechanism...
  23. pmc Emodin as an effective agent in targeting cancer stem-like side population cells of gallbladder carcinoma
    Xin Xing Li
    Division of General Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Stem Cells Dev 22:554-66. 2013
    ..Our results suggest that emodin is an effective agent targeting cancer stem-like SP cells of gallbladder carcinoma, either alone or acts as a chemotherapy enhancer...
  24. doi request reprint Characterization of cancer stem-like cells derived from a side population of a human gallbladder carcinoma cell line, SGC-996
    Xin Xing Li
    Division of General Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
    Biochem Biophys Res Commun 419:728-34. 2012
    ..Hence, these results collectively suggest that SP cells are progenitor/stem-like cells and ABCG2 might be a candidate marker for SP cells in human gallbladder cancer...
  25. doi request reprint SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent manner
    Jing Sang
    Department of Biochemistry and Molecular Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Biochem J 435:489-98. 2011
    ..This revealed for the first time that the expression of SUMO2 and SUMO3 is regulated differently by ROS. These findings may enhance our understanding about the regulation of SUMOylation and also shed light on the functions of Sp1...
  26. ncbi request reprint Cancer cell killing via ROS: to increase or decrease, that is the question
    Jie Wang
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cancer Biol Ther 7:1875-84. 2008
    ..In clinical setting individualized choice of an optimal ROS-manipulation therapy may require accurate and convenient measurements for ROS as well as "redox signaling signature" for prediction of efficacy and systemic toxicity...
  27. doi request reprint Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1
    Yong Zuo
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Cell Res 19:449-57. 2009
    ..This mechanism may facilitate apoptosome formation and caspase-9 activation under oxidative stress...
  28. ncbi request reprint NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells
    Jie Wang
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Leuk Res 32:429-36. 2008
    ..Therefore, increasing the NADPH oxidase activity may be a novel mechanism to enhance cytotoxicity induced by anticancer agents...
  29. ncbi request reprint The Susceptibility of Leukemia Cells to Arsenic Trioxide-induced Apoptosis is Determined by Cellular Reactive Oxygen Species Level
    Fei Gao
    Department of Cell Biology, Shanghai Second Medical University, Shanghai 200025, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 33:585-589. 2001
    ..Catalase reversed the effect of DMNQ on NB4 and U937 cells. It was concluded that the susceptibility of leukemia cells to arsenic trioxide-induced apoptosis is determined by ROS level in the cells...
  30. ncbi request reprint The endogenous reactive oxygen species promote NF-kappaB activation by targeting on activation of NF-kappaB-inducing kinase in oral squamous carcinoma cells
    Yumei Wang
    Department of Cell Biology, Key Laboratory of the Education Ministry of China for Cell Differentiation and Apoptosis, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Free Radic Res 41:963-71. 2007
    ..In addition, the data are useful to explain why the altered intracellular microenvironment related to redox state may influence biological behaviours of cancer cells...
  31. doi request reprint Autografts and xenografts of skin fibroblasts delivering BMP-2 effectively promote orthotopic and ectopic osteogenesis
    Rongying Wang
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, The Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Anat Rec (Hoboken) 292:777-86. 2009
    ..The success of bone regeneration in calvaria defects induced by the autologous hBMP-2-modified skin fibroblasts provides evidence that fibroblasts could be effectively used in ex vivo gene therapy for local bone repair...
  32. doi request reprint Suppression of growth of pancreatic cancer cell and expression of vascular endothelial growth factor by gene silencing with RNA interference
    Jian Wang
    Division of General Surgery, Renji Hospital, Shanghai, China
    J Dig Dis 9:228-37. 2008
    ..To explore the anti-angiogenesis and tumor cell growth suppressive effects resulted from gene silencing by RNAi in BxPC-3 human pancreatic cancer cells...
  33. ncbi request reprint Growth inhibition and induction of differentiation by panaxydol in rat C6 glioma cells
    Jian Hai
    Department of Neurosurgery, Tongji Hospital, Tongji University, Shanghai, China
    Neurol Res 30:99-105. 2008
    ..In this study, we aimed to investigate the effects of panaxydol on growth inhibition and its mechanisms in C6 rat glioma cells...
  34. doi request reprint Upregulation of LAPTM4B-35 promotes malignant transformation and tumorigenesis in L02 human liver cell line
    Li Li
    Department of Cell Biology, Health Science Center, Peking University, Beijing, China
    Anat Rec (Hoboken) 294:1135-42. 2011
    ..These findings suggest that overexpression of LAPTM4B-35 may play a critical role in hepatocarcinogenesis and therefore, may be a therapeutic target for HCC...
  35. pmc SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation
    Ming Wang
    Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
    Protein Cell 7:63-77. 2016
    ..These results provided a new explanation for the enrichment of the Sp1 protein in various cancers, and revealed a regulation of SUMO2/3 conjugated proteins whose levels may be tightly controlled by SENP3 and RNF4. ..
  36. ncbi request reprint Detection of aberrant p16 methylation in the serum of colorectal cancer patients
    Hong Zhi Zou
    Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Clin Cancer Res 8:188-91. 2002
    ..This study was designed to detect aberrant p16 promoter methylation in the serum of patients with colorectal cancer (CRC) and to explore the possibility of using this assay in early detection or as a prognostic marker of CRC patients...
  37. doi request reprint Redox sensing by proteins: oxidative modifications on cysteines and the consequent events
    Ying Wang
    Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Department of Biochemistry and Molecular Cell Biology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Antioxid Redox Signal 16:649-57. 2012
    ..It remains elusive how proteins are modulated, rather than simply damaged, by ROS and then mediate the diverse cellular responses...
  38. pmc Phenylethyl isothiocyanate reverses cisplatin resistance in biliary tract cancer cells via glutathionylation-dependent degradation of Mcl-1
    Qiwei Li
    Department of Biliary Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    Oncotarget 7:10271-82. 2016
    ..Hence, our results provide support that dietary intake of watercress may help reverse CDDP resistance in BTC patients. ..
  39. pmc A redox mechanism underlying nucleolar stress sensing by nucleophosmin
    Kai Yang
    Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China
    Nat Commun 7:13599. 2016
    ..This study elucidates a redox mechanism for the nucleolar stress sensing and may help the development of therapeutic strategies...
  40. doi request reprint Neuroprotective effects of N-stearoyltyrosine on transient global cerebral ischemia in gerbils
    Yan Bin Zhang
    Department of Pharmacy, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China
    Brain Res 1287:146-56. 2009
    ....
  41. ncbi request reprint [The expression of laminin in the intermingled skin transplantation of allograft and autograft]
    Ren Ding
    Shanghai Burn Institute, Ruijin Hospital, Shanghai Second Medical University, Shanghai, P R China 200025
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 16:36-8. 2002
    ..To explore the healing mechanism of full-thickness wound treating by the intermingled skin transplantation of large sheet allograft with autograft through studying the expression of laminin (LN)...
  42. pmc Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development
    Jing Yi
    Institute of Developmental Biology and Molecular Medicine, School of Life Sciences, Fudan University, Shanghai, PR China
    Dev Dyn 239:2005-13. 2010
    ..However, ERK activation did not appear to be affected in mutant ECs, suggesting that SUR-8 may act in an ERK-independent pathway to regulate AVC development...
  43. ncbi request reprint Guided selection of an anti-gamma-seminoprotein human Fab for antibody directed enzyme prodrug therapy of prostate cancer
    Qing Zhang
    Department of Clinical Laboratory, Xijing Hospital, Fourth Military Medical University, Xi an 710032, People s Republic of China
    Cancer Immunol Immunother 56:477-89. 2007
    ..In this study we have achieved humanization of the anti-gamma-seminoprotein E(4)B(7) murine mAb by guided selection...
  44. ncbi request reprint Induction of apoptosis in rat C6 glioma cells by panaxydol
    Jian Hai
    Department of Neurosurgery, Tongji Hospital, Tongji University, 389 Xin Cun Road, Shanghai 200065, China
    Cell Biol Int 31:711-5. 2007
    ..In conclusion, panaxydol has profound effects on growth and apoptosis of C6 cells, suggesting that panaxydol may be a potential candidate for the treatment of malignant gliomas...