Ping Xu

Summary

Affiliation: Shanghai Jiaotong University
Country: China

Publications

  1. pmc The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5
    Zhonghui Gai
    MOE Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 5:e10018. 2010
  2. pmc Carotenoids play a positive role in the degradation of heterocycles by Sphingobium yanoikuyae
    Xiaorui Liu
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 7:e39522. 2012
  3. pmc Systematic unraveling of the unsolved pathway of nicotine degradation in Pseudomonas
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS Genet 9:e1003923. 2013
  4. pmc Iron(II)-dependent dioxygenase and N-formylamide deformylase catalyze the reactions from 5-hydroxy-2-pyridone to maleamate
    Yuxiang Yao
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Sci Rep 3:3235. 2013
  5. pmc Genomic analysis of thermophilic Bacillus coagulans strains: efficient producers for platform bio-chemicals
    Fei Su
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P R China
    Sci Rep 4:3926. 2014
  6. pmc Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Sci Rep 2:377. 2012
  7. pmc One-pot bio-synthesis: N-acetyl-D-neuraminic acid production by a powerful engineered whole-cell catalyst
    Fei Tao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Sci Rep 1:142. 2011
  8. pmc Non-sterilized fermentative production of polymer-grade L-lactic acid by a newly isolated thermophilic strain Bacillus sp. 2-6
    Jiayang Qin
    Tianjin Industrial Biotechnology R and D Center, Chinese Academy of Sciences, Tianjin, People s Republic of China
    PLoS ONE 4:e4359. 2009
  9. pmc Acetoin catabolism and acetylbutanediol formation by Bacillus pumilus in a chemically defined medium
    Zijun Xiao
    Center for Bioengineering and Biotechnology, China University of Petroleum, Qingdao, People s Republic of China
    PLoS ONE 4:e5627. 2009
  10. pmc Escherichia coli transcription termination factor NusA: heat-induced oligomerization and chaperone activity
    Kun Li
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Science, Beijing 100101, People s Republic of China
    Sci Rep 3:2347. 2013

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. pmc The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5
    Zhonghui Gai
    MOE Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 5:e10018. 2010
    ..Usually, this process is mediated by mobile genetic elements such as plasmids, transposons, and insertion sequences...
  2. pmc Carotenoids play a positive role in the degradation of heterocycles by Sphingobium yanoikuyae
    Xiaorui Liu
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 7:e39522. 2012
    ..Carotenoids can serve as membrane-integrated antioxidants, protecting cells from oxidative stress...
  3. pmc Systematic unraveling of the unsolved pathway of nicotine degradation in Pseudomonas
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS Genet 9:e1003923. 2013
    ..The proteins and functional pathway identified in the current study represent attractive targets for degradation of environmental toxic compounds. ..
  4. pmc Iron(II)-dependent dioxygenase and N-formylamide deformylase catalyze the reactions from 5-hydroxy-2-pyridone to maleamate
    Yuxiang Yao
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Sci Rep 3:3235. 2013
    ..This study provides a better understanding of 2,5-DHP catabolism. ..
  5. pmc Genomic analysis of thermophilic Bacillus coagulans strains: efficient producers for platform bio-chemicals
    Fei Su
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P R China
    Sci Rep 4:3926. 2014
    ..Our genomic analysis provides comprehensive insights into the genetic characteristics of B. coagulans and paves the way for improving and extending the uses of this species. ..
  6. pmc Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Sci Rep 2:377. 2012
    ..The deletion of gene hpo showed that this gene is essential for nicotine degradation. This study defines the mechanism of nicotine degradation...
  7. pmc One-pot bio-synthesis: N-acetyl-D-neuraminic acid production by a powerful engineered whole-cell catalyst
    Fei Tao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Sci Rep 1:142. 2011
    ..The results highlight the promise of large-scale Neu5Ac synthesis and point at a potential of our approach as a general strategy to improve whole-cell biocatalysis...
  8. pmc Non-sterilized fermentative production of polymer-grade L-lactic acid by a newly isolated thermophilic strain Bacillus sp. 2-6
    Jiayang Qin
    Tianjin Industrial Biotechnology R and D Center, Chinese Academy of Sciences, Tianjin, People s Republic of China
    PLoS ONE 4:e4359. 2009
    ..Optically pure L-lactic acid is essential for polymerization of PLA. The high fermentation cost of L-lactic acid is another limitation for PLA polymers to compete with conventional plastics...
  9. pmc Acetoin catabolism and acetylbutanediol formation by Bacillus pumilus in a chemically defined medium
    Zijun Xiao
    Center for Bioengineering and Biotechnology, China University of Petroleum, Qingdao, People s Republic of China
    PLoS ONE 4:e5627. 2009
    ..This study aimed to provide a new way for bacterial production of an acetylated diol, i.e. acetylbutanediol (ABD, 3,4-dihydroxy-3-methylpentan-2-one), by acetoin metabolism...
  10. pmc Escherichia coli transcription termination factor NusA: heat-induced oligomerization and chaperone activity
    Kun Li
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Science, Beijing 100101, People s Republic of China
    Sci Rep 3:2347. 2013
    ..However, it remains to be further investigated whether NusA has the same function under normal physiological conditions. ..
  11. pmc Enzyme-nanoporous gold biocomposite: excellent biocatalyst with improved biocatalytic performance and stability
    Xia Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    PLoS ONE 6:e24207. 2011
    ..Applications involving biomolecules, such as enzymes, antibodies, and other proteins as well as whole cells, are often hampered by their unstable nature at extremely high temperature and in organic solvents...
  12. pmc Transcription elongation factor GreA has functional chaperone activity
    Kun Li
    National Engineering Laboratory for Industrial Enzymes, Institute of Microbiology, Chinese Academy of Science, Beijing, People s Republic of China
    PLoS ONE 7:e47521. 2012
    ..Bacterial GreA is an indispensable factor in the RNA polymerase elongation complex. It plays multiple roles in transcriptional elongation, and may be implicated in resistance to various stresses...
  13. pmc PSP: rapid identification of orthologous coding genes under positive selection across multiple closely related prokaryotic genomes
    Fei Su
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, P, R, China
    BMC Genomics 14:924. 2013
    ..Genes with significant positive selection may play key roles in bacterial adaption to different environmental pressures. However, selection pressure analyses are computationally intensive and awkward to configure...
  14. ncbi request reprint Recent developments in biodesulfurization of fossil fuels
    Ping Xu
    Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People s Republic of China
    Adv Biochem Eng Biotechnol 113:255-74. 2009
    ..Genetic technology was also used to improve sulfur removal efficiencies. In this review, we summarize recent progress mainly in China on petroleum biodesulfurization...
  15. doi request reprint Biotechnological routes to pyruvate production
    Ping Xu
    Key Laboratory of Microbial Metabolism, Ministry of Education, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Biosci Bioeng 105:169-75. 2008
    ..In this review, we summarize recent developments related to pyruvate production by biotechnological systems, with emphasis on the enzymatic synthesis of pyruvate from the cheaper substrate lactate...
  16. pmc Efficient 2,3-butanediol production from cassava powder by a crop-biomass-utilizer, Enterobacter cloacae subsp. dissolvens SDM
    Ailong Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    PLoS ONE 7:e40442. 2012
    ..2,3-Butanediol (BD) is considered as one of the key platform chemicals used in a variety of industrial applications. It is crucial to find an efficient sugar-utilizing strain and feasible carbon source for the economical production of BD...
  17. doi request reprint Efficient production of L-lactic acid from corncob molasses, a waste by-product in xylitol production, by a newly isolated xylose utilizing Bacillus sp. strain
    Limin Wang
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People s Republic of China
    Bioresour Technol 101:7908-15. 2010
    ..4 g l⁻¹) in fed-batch fermentation. This study provides an encouraging means of producing L-lactic acid from lignocellulosic resource such as the low-cost corncob molasses...
  18. doi request reprint Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-dose chemotherapeutic drugs
    Shenghai Zhang
    Experimental Research Center, First People s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Invest Ophthalmol Vis Sci 53:2675-84. 2012
    ..However, one of the major limitations of this approach is the vector's low transduction efficiency. This study is designed to increase AAV2 transduction efficiency in vitro and in vivo...
  19. pmc Orotate phosphoribosyltransferase from Corynebacterium ammoniagenes lacking a conserved lysine
    Xing Wang
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    J Bacteriol 189:9030-6. 2007
    ..The Km value for OMP is much larger than those of other organisms. These differences may be due to the absence of Lys 73, which is present in the active sites of other OPRTases and is known to interact with OMP and PRPP...
  20. ncbi request reprint Membrane-bound L- and D-lactate dehydrogenase activities of a newly isolated Pseudomonas stutzeri strain
    Cuiqing Ma
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    Appl Microbiol Biotechnol 77:91-8. 2007
    ..Combining activity staining and previous proteomic analysis, the results suggest that there are two separate enzymes in P. stutzeri SDM, which play an important role in converting lactate to pyruvate...
  21. pmc Rationally re-designed mutation of NAD-independent L-lactate dehydrogenase: high optical resolution of racemic mandelic acid by the engineered Escherichia coli
    Tianyi Jiang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China
    Microb Cell Fact 11:151. 2012
    ..However, this enzyme showed rather low activity towards aromatic 2-hydroxycarboxylic acids...
  22. pmc A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16
    Hongzhi Tang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Appl Environ Microbiol 74:1567-74. 2008
    ..DNA sequence analysis of this 936-bp fragment reveals that the deduced amino acid shows no similarity with any protein of known function...
  23. pmc Simultaneous biodetoxification of S, N, and O pollutants by engineering of a carbazole-degrading gene cassette in a recombinant biocatalyst
    Bo Yu
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Appl Environ Microbiol 72:7373-6. 2006
    ..The resultant strain, Rhodococcus erythropolis XPDN, could simultaneously transform the model pollutants dibenzothiophene, carbazole, and dibenzofuran to nontoxic metabolites and may have an application potential for bioremediation...
  24. pmc A novel whole-cell biocatalyst with NAD+ regeneration for production of chiral chemicals
    Zijun Xiao
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    PLoS ONE 5:e8860. 2010
    ....
  25. pmc Degradation of carbazole by microbial cells immobilized in magnetic gellan gum gel beads
    Xia Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Appl Environ Microbiol 73:6421-8. 2007
    ....
  26. pmc Lactate utilization is regulated by the FadR-type regulator LldR in Pseudomonas aeruginosa
    Chao Gao
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    J Bacteriol 194:2687-92. 2012
    ..L-Lactate and D-lactate interfered with the DNA-binding activity of LldR. Thus, L-iLDH and D-iLDH were expressed when the operon was induced in the presence of L-lactate or D-lactate...
  27. doi request reprint Production of (2S,3S)-2,3-butanediol and (3S)-acetoin from glucose using resting cells of Klebsiella pneumonia and Bacillus subtilis
    Zhen Liu
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Bioresour Technol 102:10741-4. 2011
    ..Using this approach, 12.5 g l(-1) (2S,3S)-2,3-BD and 56.7 g l(-1) (3S)-AC were produced. Stereoisomeric purity of (2S,3S)-2,3-BD and enantiomeric excess of (3S)-AC was 96.9 and 96.2%, respectively...
  28. doi request reprint An efficient method for N-acetyl-D-neuraminic acid production using coupled bacterial cells with a safe temperature-induced system
    Yinan Zhang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, People s Republic of China
    Appl Microbiol Biotechnol 86:481-9. 2010
    ..Our Neu5Ac biosynthetic process is favorable compared with natural product extraction, chemical synthesis, or even many other biocatalysis processes...
  29. ncbi request reprint Characterization of environmentally friendly nicotine degradation by Pseudomonas putida biotype A strain S16
    Shu Ning Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    Microbiology 153:1556-65. 2007
    ..These findings provide new insights into the microbial metabolism of nicotine and the environmentally friendly route of nicotine degradation...
  30. pmc Genome sequence of the lactate-utilizing Pseudomonas aeruginosa strain XMG
    Chao Gao
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    J Bacteriol 194:4751-2. 2012
    ..Besides the lactate utilization mechanism of the strain, the genome sequence may also provide other useful information related to P. aeruginosa, such as identifying genes involved in virulence, drug resistance, and aromatic catabolism...
  31. doi request reprint Characterization and biotechnological potential of petroleum-degrading bacteria isolated from oil-contaminated soils
    Zhengzhi Zhang
    MOE Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Bioresour Technol 101:8452-6. 2010
    ..The collection of isolated bacteria might be a useful resource for bioremediation of oil-contaminated soils and biotreatment of oil wastewater...
  32. pmc Genome sequence of Rhodococcus erythropolis XP, a biodesulfurizing bacterium with industrial potential
    Fei Tao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Bacteriol 193:6422-3. 2011
    ..erythropolis XP (7,229,582 bp). The biodesulfurizing genes dszABC are located on a plasmid, while the flavin reductase gene dszD is located on the chromosome...
  33. pmc Cometabolic degradation of dibenzofuran and dibenzothiophene by a newly isolated carbazole-degrading Sphingomonas sp. strain
    Zhonghui Gai
    State Key Laboratory of Microbial Technology, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Appl Environ Microbiol 73:2832-8. 2007
    ..After 40 h of incubation, 90% of DBT was transformed, and CA and DBF were completely removed. These results suggested that strain XLDN2-5 might be useful in the bioremediation of environments contaminated by these compounds...
  34. doi request reprint A novel microbial habitat of alkaline black liquor with very high pollution load: microbial diversity and the key members in application potentials
    Chunyu Yang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, PR China
    Bioresour Technol 101:1737-44. 2010
    ..The worldwide problem of black liquor treatment and renewable resource utilization would benefit from these microorganisms in application potentials...
  35. doi request reprint Production of (3S)-acetoin from diacetyl by using stereoselective NADPH-dependent carbonyl reductase and glucose dehydrogenase
    Chao Gao
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, PR China
    Bioresour Technol 137:111-5. 2013
    ..Under the optimal conditions, 12.2 g l(-1) (3S)-AC was produced from 14.3 g l(-1) DA in 75 min. Because DA can be biotechnological produced, the two-enzymes coupling system might be a promising alternative for the (3S)-AC production...
  36. pmc Genome sequence of the thermophilic strain Bacillus coagulans 2-6, an efficient producer of high-optical-purity L-lactic acid
    Fei Su
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:4563-4. 2011
    ..The frameshift mutation at the start of the d-lactate dehydrogenase sequence might be responsible for the production of high-optical-purity l-lactic acid...
  37. pmc Genome sequence of Bacillus pumilus S-1, an efficient isoeugenol-utilizing producer for natural vanillin
    Fei Su
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:6400-1. 2011
    ..The genome of B. pumilus S-1 contains the epoxide hydrolase and six candidate monooxygenases that make it possible to explore the mechanism involved in conversion of isoenguenol to vanillin in the B. pumilus strain...
  38. ncbi request reprint Biodesulfurization of DBT in tetradecane and crude oil by a facultative thermophilic bacterium Mycobacterium goodii X7B
    Fuli Li
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, PR China
    J Biotechnol 127:222-8. 2007
    ..The total sulfur level of dibenzothiophene in tetradecane, was reduced by 99%, from 200 to 2 ppm within 24h at 40 degrees C. After 72 h treatment, 59% of the total sulfur content in Liaoning crude oil was removed, from 3600 to 1478 ppm...
  39. pmc A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    J Biol Chem 286:39179-87. 2011
    ..This study demonstrates the importance of the newly discovered enzyme HspB, which is crucial for nicotine degradation by the Pseudomonas strain...
  40. ncbi request reprint Biotransformation of isoeugenol to vanillin by a newly isolated Bacillus pumilus strain: identification of major metabolites
    Dongliang Hua
    Key Laboratory of Microbial Metabolism, Ministry of Education, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Biotechnol 130:463-70. 2007
    ..These findings suggest that isoeugenol is degraded through an epoxide-diol pathway...
  41. pmc Chemoenzymatic synthesis of N-acetyl-D-neuraminic acid from N-acetyl-D-glucosamine by using the spore surface-displayed N-acetyl-D-neuraminic acid aldolase
    Chao Gao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Appl Environ Microbiol 77:7080-3. 2011
    ..9 g liter(-1)) was achieved in this study. Thus, displaying a target enzyme on the surface of spores might be an alternative for integration of biocatalytic conversion into chemical synthesis...
  42. doi request reprint Efficient production of L-lactic acid from cassava powder by Lactobacillus rhamnosus
    Limin Wang
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People s Republic of China
    Bioresour Technol 101:7895-901. 2010
    ..5 g/l) in SSF batch fermentation. This is the highest L-lactic acid concentration reported, from cassava source, and it provides an efficient L-lactic acid production process with cheap raw bioresources, such as cassava powder...
  43. pmc Biodesulfurization in biphasic systems containing organic solvents
    Fei Tao
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Appl Environ Microbiol 72:4604-9. 2006
    ..This study is a significant step in the exploration of the biotechnological potential of novel biocatalysts for developing an efficient biodesulfurization process in biphasic reaction mixtures containing toxic organic solvents...
  44. pmc The surfactant tween 80 enhances biodesulfurization
    Jinhui Feng
    State Key Laboratory of Microbial Technology of Shandong University, Jinan 250100, People s Republic of China
    Appl Environ Microbiol 72:7390-3. 2006
    ..Tween 80 was shown to decrease the product concentration associated with the cells, reducing product inhibition...
  45. doi request reprint Kinetics of D-lactic acid production by Sporolactobacillus sp. strain CASD using repeated batch fermentation
    Bo Zhao
    Institute of Microbiology, Chinese Academy of Sciences, Beijing, People s Republic of China
    Bioresour Technol 101:6499-505. 2010
    ..From a kinetic point of view, two-reactor fermentation system was shown to be an alternative for conventional one-reactor repeated batch operation...
  46. doi request reprint New metabolites in dibenzofuran cometabolic degradation by a biphenyl-cultivated Pseudomonas putida strain B6-2
    Qinggang Li
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Environ Sci Technol 43:8635-42. 2009
    ..Because benzofuran derivatives may have biological, pharmacological, and toxic properties, the elucidation of this new pathway should be significant from both biotechnological and environmental views...
  47. doi request reprint Enantioselective oxidation of racemic lactic acid to D-lactic acid and pyruvic acid by Pseudomonas stutzeri SDM
    Chao Gao
    State Key Laboratory of Microbial Technology, Shandong University, Shandananlu 27, Jinan 250100, People s Republic of China
    Bioresour Technol 100:1878-80. 2009
    ..Co-production of d-lactic acid and pyruvic acid by enantioselective oxidation of racemic lactic acid is technically feasible...
  48. pmc Novel nicotine oxidoreductase-encoding gene involved in nicotine degradation by Pseudomonas putida strain S16
    Hongzhi Tang
    Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, People s Republic of China
    Appl Environ Microbiol 75:772-8. 2009
    ....
  49. pmc Engineering of cofactor regeneration enhances (2S,3S)-2,3-butanediol production from diacetyl
    Yu Wang
    1 State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China 2 State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Sci Rep 3:2643. 2013
    ..The biocatalytic process presented should be a promising route for biotechnological production of NADH-dependent microbial metabolites. ..
  50. doi request reprint Synthesis and characterization of polyamidoamine dendrimer-coated multi-walled carbon nanotubes and their application in gene delivery systems
    Bifeng Pan
    Department of Bio Nano Science and Engineering, National Key Laboratory of Nano Micro Fabrication Technology, Institute of Micro Nano Science and Technology, Shanghai Jiaotong University, Shanghai, People s Republic of China
    Nanotechnology 20:125101. 2009
    ..The intracellular gene transport and uptake via dMNTs should be generic for the mammalian cell lines. The dMNTs have potentials in applications such as gene or drug delivery for cancer therapy and molecular imaging...
  51. doi request reprint Enhanced 2,3-butanediol production by Klebsiella pneumoniae SDM
    Cuiqing Ma
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, People s Republic of China
    Appl Microbiol Biotechnol 82:49-57. 2009
    ..21 g/l h was obtained by the constant residual glucose concentration feeding strategy. To the best of our knowledge, these results were new records on BD fermentation...
  52. pmc Characterization of a novel metagenome-derived 6-phospho-β-glucosidase from black liquor sediment
    Chunyu Yang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    Appl Environ Microbiol 79:2121-7. 2013
    ..This functional identification may provide insights into the specificity of 6-phospho-β-glycosidases in GH1 and be useful for designing further directed evolution...
  53. pmc Genome sequence of Klebsiella pneumoniae LZ, a potential platform strain for 1,3-propanediol production
    Fei Tao
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, corrected Shanghai, People s Republic of China
    J Bacteriol 194:4457-8. 2012
    ..We annotated 9 coding sequences (CDSs) responsible for glycerol fermentation to 1,3-propanediol, 19 CDSs encoding glycerol utilization, and 134 CDSs related to its virulence and defense...
  54. doi request reprint Both FMNH2 and FADH2 can be utilized by the dibenzothiophene monooxygenase from a desulfurizing bacterium Mycobacterium goodii X7B
    Jingchen Li
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Bioresour Technol 100:2594-9. 2009
    ..The results suggest that DszC should be reclassified as an FMNH(2) and FADH(2) both-utilizing monooxygenase component and the flavins should be controlled at properly reduced levels to obtain optimal biodesulfurization results...
  55. pmc Genome sequence of Pseudomonas stutzeri SDM-LAC, a typical strain for studying the molecular mechanism of lactate utilization
    Tianyi Jiang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    J Bacteriol 194:894-5. 2012
    ..Here we present a 4.2-Mb assembly of its genome. The annotated four adjacent genes form a lactate utilization operon, which could provide further insights into the molecular mechanism of lactate utilization...
  56. pmc Characterization of two Streptomyces enzymes that convert ferulic acid to vanillin
    Wenwen Yang
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 8:e67339. 2013
    ..The catalytic efficiency (kcat/Km) value of Fcs was 193.4 mM(-1) s(-1) for ferulic acid. The characterization of Fcs and Ech may be helpful for further research in the field of enzymatic engineering and metabolic regulation...
  57. ncbi request reprint NSSR1 is regulated in testes development and cryptorchidism and promotes the exon 5-included splicing of CREB transcripts
    Ping jie Xiao
    Laboratory of Genomic Physiology and State Key Laboratory of Medical Neurobiology, School of Life Sciences and Shanghai Medical College, Fudan University, Shanghai, China
    Mol Reprod Dev 74:1363-72. 2007
    ..The findings for the first time provide the evidence indicating the potential importance of NSSR1 in testes development, spermatogenesis and cryptorchidism...
  58. pmc NAD-independent L-lactate dehydrogenase is required for L-lactate utilization in Pseudomonas stutzeri SDM
    Chao Gao
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    PLoS ONE 7:e36519. 2012
    ..Various Pseudomonas strains can use L-lactate as their sole carbon source for growth. However, the L-lactate-utilizing enzymes in Pseudomonas have never been identified and further studied...
  59. pmc Genome sequence of Sphingomonas elodea ATCC 31461, a highly productive industrial strain of gellan gum
    Zhonghui Gai
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:7015-6. 2011
    ..However, the genes involved in the biosynthesis, regulation, and modification of gellan gum have not been fully characterized. Here we describe the draft genome sequence of stain ATCC 31461 and major findings from its annotation...
  60. doi request reprint Kinetic resolution of 2-hydroxybutanoate racemic mixtures by NAD-independent L-lactate dehydrogenase
    Chao Gao
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Bioresour Technol 102:4595-9. 2011
    ..193 M). Using a simple ion exchange process with the macroporous anion exchange resin D301, D-2-hydroxybutanoate was separated from the biotransformation system with a high recovery of 84.7%...
  61. doi request reprint Highly efficient production of D-lactate by Sporolactobacillus sp. CASD with simultaneous enzymatic hydrolysis of peanut meal
    Limin Wang
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People s Republic of China
    Appl Microbiol Biotechnol 89:1009-17. 2011
    ....
  62. doi request reprint Repeated open fermentative production of optically pure L-lactic acid using a thermophilic Bacillus sp. strain
    Bo Zhao
    Institute of Microbiology, Chinese Academy of Sciences, Beijing, People s Republic of China
    Bioresour Technol 101:6494-8. 2010
    ..In this study, repeated open operation was shown to be feasible for optically pure L-lactic acid production, and new light shed on the roles of viable and unviable cells in repeated batch fermentation...
  63. doi request reprint Biocatalytic production of (2S,3S)-2,3-butanediol from diacetyl using whole cells of engineered Escherichia coli
    Lixiang Li
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, PR China
    Bioresour Technol 115:111-6. 2012
    ..1 g l(-1) and 26.8 g l(-1) in batch and fed-batch conversions, respectively. Thus, the process might be a promising alternative for the production of (2S,3S)-2,3-BD...
  64. pmc Genome sequence of Pseudomonas putida strain B6-2, a superdegrader of polycyclic aromatic hydrocarbons and dioxin-like compounds
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:6789-90. 2011
    ..Here, we present a 6.24-Mb draft genome sequence of B6-2, which could provide further insights into the biodegradative mechanisms of a diverse range of chemical compounds...
  65. doi request reprint Metabolic versatility of halotolerant and alkaliphilic strains of Halomonas isolated from alkaline black liquor
    Chunyu Yang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Bioresour Technol 101:6778-84. 2010
    ..0-11.0 and NaCl concentrations of 0-15%. The metabolic versatility of these Halomonas strains even under extreme pH and salinity conditions makes them promising agents for bioremediation and industrial processes...
  66. ncbi request reprint Structural insights into the specific recognition of N-heterocycle biodenitrogenation-derived substrates by microbial amide hydrolases
    Geng Wu
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    Mol Microbiol 91:1009-21. 2014
    ..Our work thus provides a thorough elucidation of the molecular mechanism through which amide hydrolases accomplish substrate-specific recognition in the microbial N-heterocycles biodenitrogenation pathway...
  67. doi request reprint Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside
    Duoduo Chen
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China
    Mol Microbiol 87:1237-44. 2013
    ..The isomerase probably uses this breathing motion to prevent the solvent from entering the active site and prohibit unproductive side reactions from happening...
  68. pmc Genome sequence of Xanthomonas campestris JX, an industrially productive strain for Xanthan gum
    Fei Tao
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai, People s Republic of China
    J Bacteriol 194:4755-6. 2012
    ..0-Mb assembly of its genome sequence. We have annotated 12 coding sequences (CDSs) responsible for xanthan gum biosynthesis, 346 CDSs encoding carbohydrate metabolism, and 69 CDSs related to virulence, defense, and plant disease...
  69. pmc Genome sequence of a novel nicotine-degrading strain, Pseudomonas geniculata N1
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:3553-4. 2012
    ..51-Mb assembly of its genome, which is the first sequence of the P. geniculata group. The sequence contains the genes related to nicotine catabolism and may provide insights into its molecular mechanism for N-heterocyclic degradation...
  70. pmc Structural basis for the recognition of Asef by adenomatous polyposis coli
    Zhenyi Zhang
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, China
    Cell Res 22:372-86. 2012
    ..Our structures thus elucidate the molecular mechanism of Asef recognition by APC, as well as provide a potential target for pharmaceutical intervention against cancers...
  71. pmc Genome sequence of Sphingobium yanoikuyae XLDN2-5, an efficient carbazole-degrading strain
    Zhonghui Gai
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Bacteriol 193:6404-5. 2011
    ..Here, we describe the draft genome sequence of strain XLDN2-5, which may provide important clues as to how it recruited exogenous genes to establish pathways to degrade the xenobiotics...
  72. pmc Genome sequences of Pseudomonas luteola XLDN4-9 and Pseudomonas stutzeri XLDN-R, two efficient carbazole-degrading strains
    Xiaorui Liu
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:5701-2. 2012
    ..Here we present 4.63- and 4.70-Mb assemblies of their genomes. Their annotated key genes for carbazole catabolism are similar, which may provide further insights into the molecular mechanism of carbazole degradation in Pseudomonas...
  73. pmc Genome sequence of Pseudomonas putida Idaho, a unique organic-solvent-tolerant bacterium
    Fei Tao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Bacteriol 193:7011-2. 2011
    ..Here, we announce its first draft genome sequence (6,363,067 bp). We annotated 192 coding sequences (CDSs) responsible for aromatic compound metabolism, 40 CDSs encoding phospholipid synthesis, and 212 CDSs related to stress response...
  74. pmc Genome sequence of the thermophilic strain Bacillus coagulans XZL4, an efficient pentose-utilizing producer of chemicals
    Fei Su
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:6398-9. 2011
    ..Here we present a 2.8-Mb assembly of its genome. Simple and efficient carbohydrate metabolism systems, especially the transketolase/transaldolase pathway, make it possible to convert pentose sugars to products at high levels...
  75. pmc Genome sequence of a nicotine-degrading strain of Arthrobacter
    Yuxiang Yao
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:5714-5. 2012
    ..Nicotine catabolism genes of the nicotine-degrading plasmid pAO1 were predicted, but plasmid function genes were not found. These results will help to better illustrate the molecular mechanism of nicotine degradation by Arthrobacter...
  76. ncbi request reprint Microbial transformation of benzothiophenes, with carbazole as the auxiliary substrate, by Sphingomonas sp. strain XLDN2-5
    Zhonghui Gai
    Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Microbiology 154:3804-12. 2008
    ..However, the formation of the high-molecular-mass products, such as benzo[b]naphtho[1,2-d]thiophene, should be considered in the biodegradation of benzothiophenes...
  77. doi request reprint Novel organic solvent-responsive expression vectors for biocatalysis: application for development of an organic solvent-tolerant biodesulfurizing strain
    Fei Tao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Bioresour Technol 102:9380-7. 2011
    ..5 mM DBT. These results suggested that use of the constructed organic solvent-responsive expression vectors can facilitate the biphasic biocatalysis involving organic solvents...
  78. pmc Glycerol dehydrogenase plays a dual role in glycerol metabolism and 2,3-butanediol formation in Klebsiella pneumoniae
    Yu Wang
    From the State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Biol Chem 289:6080-90. 2014
    ..Revelation of the dual role of DhaD could further the understanding of mechanisms responsible for enzyme evolution through promiscuity, and guide metabolic engineering methods of glycerol metabolism. ..
  79. pmc Physiological and biochemical characterization of a novel nicotine-degrading bacterium Pseudomonas geniculata N1
    Yanghui Liu
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 9:e84399. 2014
    ..The identified metabolites were different from those generated by Pseudomonas putida strains. The analysis also highlighted the bacterial metabolic diversity in relation to nicotine degradation by different Pseudomonas strains. ..
  80. pmc Genome sequence of the thermophile Bacillus coagulans Hammer, the type strain of the species
    Fei Su
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:6294-5. 2012
    ..Genomic analyses based on the sequence may provide insights into the phylogeny of the species and help to elucidate characteristics of the poorly studied strains of Bacillus coagulans...
  81. pmc Genome sequence of Pseudomonas putida S12, a potential platform strain for industrial production of valuable chemicals
    Fei Tao
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:5985-6. 2012
    ..Here, we present a 6.28-Mb assembly of its genome sequence. We have annotated 32 coding sequences (CDSs) encoding efflux systems of organic compounds and 195 CDSs responsible for the metabolism of aromatic compounds...
  82. pmc Genome sequence of the welan gum-producing strain Sphingomonas sp. ATCC 31555
    Xiaoyu Wang
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:5989-90. 2012
    ..Here we present a 4.0-Mb assembly of its genome sequence. We have annotated 10 coding sequences (CDSs) responsible for the welan gum biosynthesis and 55 CDSs related to monosaccharide metabolism...
  83. pmc Genome sequence of Pseudomonas aeruginosa DQ8, an efficient degrader of n-alkanes and polycyclic aromatic hydrocarbons
    Zhonghui Gai
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:6304-5. 2012
    ..Here, we present a 6.8-Mb assembly of its genome sequence. We have annotated 23 coding sequences (CDSs) responsible for catabolism of n-alkanes and PAHs...
  84. pmc Complete genome sequence of the nicotine-degrading Pseudomonas putida strain S16
    Hao Yu
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Bacteriol 193:5541-2. 2011
    ..The genes of enzymes in the core genome and a genomic island encode the proteins responsible for nicotine catabolism...
  85. pmc Draft genome sequence of Sporolactobacillus inulinus strain CASD, an efficient D-lactic acid-producing bacterium with high-concentration lactate tolerance capability
    Bo Yu
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    J Bacteriol 193:5864-5. 2011
    ..inulinus (2,930,096 bp). The large number of annotated two-component system genes makes it possible to explore the mechanism of extraordinary lactate tolerance of S. inulinus CASD...
  86. doi request reprint An unusual repressor controls the expression of a crucial nicotine-degrading gene cluster in Pseudomonas putida S16
    Lijuan Wang
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China
    Mol Microbiol 91:1252-69. 2014
    ..The transcriptional regulation of nicotine degradation in Pseudomonas highlights a new level of complexity in prokaryotic transcriptional regulation. ..
  87. pmc Regulatory roles of the PI3K/Akt signaling pathway in rats with severe acute pancreatitis
    Ping Xu
    Department of Gastroenterology, Songjiang Hospital Affiliated the First People s Hospital, Shanghai Jiaotong University, Shanghai, China
    PLoS ONE 8:e81767. 2013
    ..These findings showed that the PI3K/Akt inhibitor wortmannin decreases inflammatory cytokines in SAP rats and suggests its regulatory mechanisms may occur through the suppression on NF-κB and p38MAPK activity. ..
  88. doi request reprint Biotechnological production and applications of N-acetyl-D-neuraminic acid: current state and perspectives
    Fei Tao
    MOE Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Appl Microbiol Biotechnol 87:1281-9. 2010
    ..In this review article, we discuss existing knowledge on the biotechnological production and applications of Neu5Ac and also propose some guidelines for future studies...
  89. doi request reprint Pancreatitis-associated ascitic fluid induces proinflammatory cytokine expression in THP-1 cells by inhibiting anti-inflammatory signaling
    Jing Wang
    Department of Gastroenterology, Songjiang Hospital Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Pancreas 42:855-60. 2013
    ..We investigated whether pancreatitis-associated ascitic fluid (PAAF) could induce the expression of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in THP-1 cells and the mechanism(s) involved...
  90. doi request reprint Effects of peroxisome proliferator-activated receptor-γ activation on apoptosis in rats with acute pancreatitis
    Ping Xu
    Department of Gastroenterology, Songjiang Hospital Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, 201600, China
    Dig Dis Sci 58:3516-23. 2013
    ..To investigate the effects and mechanisms of peroxisome proliferator-activated receptor-γ (PPAR-γ) activation on the induction of apoptosis in rats with acute pancreatitis...
  91. doi request reprint Efficient conversion of 1,2-butanediol to (R)-2-hydroxybutyric acid using whole cells of Gluconobacter oxydans
    Chao Gao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Bioresour Technol 115:75-8. 2012
    ..5 g l(-1)) and a high enantiomeric excess (99.7%). The biocatalysis process introduced in this study may provide a technically and economically interesting route for production of (R)-2-HBA...
  92. doi request reprint Recent advances in biotechnological production of 2-phenylethanol
    Dongliang Hua
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Biotechnol Adv 29:654-60. 2011
    ..Future research should focus on product scale-up and product recovery processes for the industrialization of microbial processes...
  93. pmc Genome sequence of Sphingomonas wittichii DP58, the first reported phenazine-1-carboxylic acid-degrading strain
    Zhiwei Ma
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:3535-6. 2012
    ..Here we present a 5.6-Mb assembly of its genome. This sequence would contribute to the elucidation of the molecular mechanism of PCA degradation to improve the antifungal's effectiveness or remove superfluous PCA...
  94. doi request reprint Efficient production of l-lactic acid using co-feeding strategy based on cane molasses/glucose carbon sources
    Ke Xu
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Bioresour Technol 153:23-9. 2014
    ..1g/Lh and a yield of 0.88g/g. Since cane molasses is a feasible carbon source, the co-feeding fermentation might be a promising alternative for the economical production of L-lactic acid...
  95. doi request reprint [Phenotype analysis and mutant gene location of ventral yellow mouse (VY(Slac))]
    Mei Lian Shi
    Shanghai SLAC Laboratory Animal Co, Ltd, Shanghai, China
    Dongwuxue Yanjiu 33:290-7. 2012
    ..3 Mb region between rs13476833 and rs27310903 on chromosome 2. The preliminary results of our phenotype analysis and gene location provides a solid basis for further identification of this mutant gene...
  96. doi request reprint A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling
    Xinjian Liu
    State Key Laboratory of Oncogenes and Related Genes, Cancer Institute, Shanghai Jiaotong University, Shanghai, China
    Hum Gene Ther 22:427-37. 2011
    ..We think that our approach is a promising strategy in the treatment of gastrointestinal cancer, warranting further clinical investigation...