Ping Xu

Summary

Affiliation: Shanghai Jiaotong University
Country: China

Publications

  1. ncbi request reprint Pseudomonas stutzeri as a novel biocatalyst for pyruvate production from DL-lactate
    Jianrong Hao
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, PR China
    Biotechnol Lett 29:105-10. 2007
  2. pmc PSP: rapid identification of orthologous coding genes under positive selection across multiple closely related prokaryotic genomes
    Fei Su
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, P, R, China
    BMC Genomics 14:924. 2013
  3. pmc Rationally re-designed mutation of NAD-independent L-lactate dehydrogenase: high optical resolution of racemic mandelic acid by the engineered Escherichia coli
    Tianyi Jiang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China
    Microb Cell Fact 11:151. 2012
  4. doi request reprint Recent developments in biodesulfurization of fossil fuels
    Ping Xu
    Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People s Republic of China
    Adv Biochem Eng Biotechnol 113:255-74. 2009
  5. doi request reprint Biotechnological routes to pyruvate production
    Ping Xu
    Key Laboratory of Microbial Metabolism, Ministry of Education, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Biosci Bioeng 105:169-75. 2008
  6. pmc Genome sequence of Bacillus pumilus S-1, an efficient isoeugenol-utilizing producer for natural vanillin
    Fei Su
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:6400-1. 2011
  7. pmc Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Sci Rep 2:377. 2012
  8. pmc A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    J Biol Chem 286:39179-87. 2011
  9. pmc Genome sequence of Sphingomonas elodea ATCC 31461, a highly productive industrial strain of gellan gum
    Zhonghui Gai
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:7015-6. 2011
  10. pmc The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5
    Zhonghui Gai
    MOE Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 5:e10018. 2010

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Pseudomonas stutzeri as a novel biocatalyst for pyruvate production from DL-lactate
    Jianrong Hao
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, PR China
    Biotechnol Lett 29:105-10. 2007
    ..Both NAD(+)-independent D-lactate dehydrogenase and NAD(+)-independent L-lactate dehydrogenase were found for the first time in the bioconversion of lactate to pyruvate based on the enzyme activity assay and proteomic analysis...
  2. pmc PSP: rapid identification of orthologous coding genes under positive selection across multiple closely related prokaryotic genomes
    Fei Su
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, P, R, China
    BMC Genomics 14:924. 2013
    ..Genes with significant positive selection may play key roles in bacterial adaption to different environmental pressures. However, selection pressure analyses are computationally intensive and awkward to configure...
  3. pmc Rationally re-designed mutation of NAD-independent L-lactate dehydrogenase: high optical resolution of racemic mandelic acid by the engineered Escherichia coli
    Tianyi Jiang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China
    Microb Cell Fact 11:151. 2012
    ..However, this enzyme showed rather low activity towards aromatic 2-hydroxycarboxylic acids...
  4. doi request reprint Recent developments in biodesulfurization of fossil fuels
    Ping Xu
    Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People s Republic of China
    Adv Biochem Eng Biotechnol 113:255-74. 2009
    ..Genetic technology was also used to improve sulfur removal efficiencies. In this review, we summarize recent progress mainly in China on petroleum biodesulfurization...
  5. doi request reprint Biotechnological routes to pyruvate production
    Ping Xu
    Key Laboratory of Microbial Metabolism, Ministry of Education, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Biosci Bioeng 105:169-75. 2008
    ..In this review, we summarize recent developments related to pyruvate production by biotechnological systems, with emphasis on the enzymatic synthesis of pyruvate from the cheaper substrate lactate...
  6. pmc Genome sequence of Bacillus pumilus S-1, an efficient isoeugenol-utilizing producer for natural vanillin
    Fei Su
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:6400-1. 2011
    ..The genome of B. pumilus S-1 contains the epoxide hydrolase and six candidate monooxygenases that make it possible to explore the mechanism involved in conversion of isoenguenol to vanillin in the B. pumilus strain...
  7. pmc Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Sci Rep 2:377. 2012
    ..The deletion of gene hpo showed that this gene is essential for nicotine degradation. This study defines the mechanism of nicotine degradation...
  8. pmc A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    J Biol Chem 286:39179-87. 2011
    ..This study demonstrates the importance of the newly discovered enzyme HspB, which is crucial for nicotine degradation by the Pseudomonas strain...
  9. pmc Genome sequence of Sphingomonas elodea ATCC 31461, a highly productive industrial strain of gellan gum
    Zhonghui Gai
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:7015-6. 2011
    ..However, the genes involved in the biosynthesis, regulation, and modification of gellan gum have not been fully characterized. Here we describe the draft genome sequence of stain ATCC 31461 and major findings from its annotation...
  10. pmc The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5
    Zhonghui Gai
    MOE Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 5:e10018. 2010
    ..Usually, this process is mediated by mobile genetic elements such as plasmids, transposons, and insertion sequences...
  11. pmc Genome sequence of Rhodococcus erythropolis XP, a biodesulfurizing bacterium with industrial potential
    Fei Tao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Bacteriol 193:6422-3. 2011
    ..erythropolis XP (7,229,582 bp). The biodesulfurizing genes dszABC are located on a plasmid, while the flavin reductase gene dszD is located on the chromosome...
  12. pmc Characterization of two Streptomyces enzymes that convert ferulic acid to vanillin
    Wenwen Yang
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 8:e67339. 2013
    ..The catalytic efficiency (kcat/Km) value of Fcs was 193.4 mM(-1) s(-1) for ferulic acid. The characterization of Fcs and Ech may be helpful for further research in the field of enzymatic engineering and metabolic regulation...
  13. doi request reprint Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside
    Duoduo Chen
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China
    Mol Microbiol 87:1237-44. 2013
    ..The isomerase probably uses this breathing motion to prevent the solvent from entering the active site and prohibit unproductive side reactions from happening...
  14. pmc Genome sequence of Xanthomonas campestris JX, an industrially productive strain for Xanthan gum
    Fei Tao
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai, People s Republic of China
    J Bacteriol 194:4755-6. 2012
    ..0-Mb assembly of its genome sequence. We have annotated 12 coding sequences (CDSs) responsible for xanthan gum biosynthesis, 346 CDSs encoding carbohydrate metabolism, and 69 CDSs related to virulence, defense, and plant disease...
  15. pmc Genome sequence of a novel nicotine-degrading strain, Pseudomonas geniculata N1
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:3553-4. 2012
    ..51-Mb assembly of its genome, which is the first sequence of the P. geniculata group. The sequence contains the genes related to nicotine catabolism and may provide insights into its molecular mechanism for N-heterocyclic degradation...
  16. pmc Genome sequence of Pseudomonas putida strain B6-2, a superdegrader of polycyclic aromatic hydrocarbons and dioxin-like compounds
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:6789-90. 2011
    ..Here, we present a 6.24-Mb draft genome sequence of B6-2, which could provide further insights into the biodegradative mechanisms of a diverse range of chemical compounds...
  17. pmc Structural basis for the recognition of Asef by adenomatous polyposis coli
    Zhenyi Zhang
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, China
    Cell Res 22:372-86. 2012
    ..Our structures thus elucidate the molecular mechanism of Asef recognition by APC, as well as provide a potential target for pharmaceutical intervention against cancers...
  18. pmc Genome sequence of Sphingobium yanoikuyae XLDN2-5, an efficient carbazole-degrading strain
    Zhonghui Gai
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Bacteriol 193:6404-5. 2011
    ..Here, we describe the draft genome sequence of strain XLDN2-5, which may provide important clues as to how it recruited exogenous genes to establish pathways to degrade the xenobiotics...
  19. pmc Genome sequences of Pseudomonas luteola XLDN4-9 and Pseudomonas stutzeri XLDN-R, two efficient carbazole-degrading strains
    Xiaorui Liu
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:5701-2. 2012
    ..Here we present 4.63- and 4.70-Mb assemblies of their genomes. Their annotated key genes for carbazole catabolism are similar, which may provide further insights into the molecular mechanism of carbazole degradation in Pseudomonas...
  20. pmc Genome sequence of Pseudomonas putida Idaho, a unique organic-solvent-tolerant bacterium
    Fei Tao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Bacteriol 193:7011-2. 2011
    ..Here, we announce its first draft genome sequence (6,363,067 bp). We annotated 192 coding sequences (CDSs) responsible for aromatic compound metabolism, 40 CDSs encoding phospholipid synthesis, and 212 CDSs related to stress response...
  21. pmc Genome sequence of the thermophilic strain Bacillus coagulans XZL4, an efficient pentose-utilizing producer of chemicals
    Fei Su
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:6398-9. 2011
    ..Here we present a 2.8-Mb assembly of its genome. Simple and efficient carbohydrate metabolism systems, especially the transketolase/transaldolase pathway, make it possible to convert pentose sugars to products at high levels...
  22. pmc Genome sequence of the thermophilic strain Bacillus coagulans 2-6, an efficient producer of high-optical-purity L-lactic acid
    Fei Su
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 193:4563-4. 2011
    ..The frameshift mutation at the start of the d-lactate dehydrogenase sequence might be responsible for the production of high-optical-purity l-lactic acid...
  23. pmc Genome sequence of a nicotine-degrading strain of Arthrobacter
    Yuxiang Yao
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:5714-5. 2012
    ..Nicotine catabolism genes of the nicotine-degrading plasmid pAO1 were predicted, but plasmid function genes were not found. These results will help to better illustrate the molecular mechanism of nicotine degradation by Arthrobacter...
  24. doi request reprint Microbial transformation of benzothiophenes, with carbazole as the auxiliary substrate, by Sphingomonas sp. strain XLDN2-5
    Zhonghui Gai
    Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Microbiology 154:3804-12. 2008
    ..However, the formation of the high-molecular-mass products, such as benzo[b]naphtho[1,2-d]thiophene, should be considered in the biodegradation of benzothiophenes...
  25. doi request reprint Novel organic solvent-responsive expression vectors for biocatalysis: application for development of an organic solvent-tolerant biodesulfurizing strain
    Fei Tao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Bioresour Technol 102:9380-7. 2011
    ..5 mM DBT. These results suggested that use of the constructed organic solvent-responsive expression vectors can facilitate the biphasic biocatalysis involving organic solvents...
  26. doi request reprint Physiological and Biochemical Characterization of a Novel Nicotine-Degrading Bacterium Pseudomonas geniculata N1
    Yanghui Liu
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 9:e84399. 2014
    ..The identified metabolites were different from those generated by Pseudomonas putida strains. The analysis also highlighted the bacterial metabolic diversity in relation to nicotine degradation by different Pseudomonas strains. ..
  27. doi request reprint Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-dose chemotherapeutic drugs
    Shenghai Zhang
    Experimental Research Center, First People s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Invest Ophthalmol Vis Sci 53:2675-84. 2012
    ..However, one of the major limitations of this approach is the vector's low transduction efficiency. This study is designed to increase AAV2 transduction efficiency in vitro and in vivo...
  28. pmc Iron(II)-dependent dioxygenase and N-formylamide deformylase catalyze the reactions from 5-hydroxy-2-pyridone to maleamate
    Yuxiang Yao
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Sci Rep 3:3235. 2013
    ..This study provides a better understanding of 2,5-DHP catabolism. ..
  29. pmc Engineering of cofactor regeneration enhances (2S,3S)-2,3-butanediol production from diacetyl
    Yu Wang
    1 State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China 2 State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Sci Rep 3:2643. 2013
    ..The biocatalytic process presented should be a promising route for biotechnological production of NADH-dependent microbial metabolites. ..
  30. pmc One-pot bio-synthesis: N-acetyl-D-neuraminic acid production by a powerful engineered whole-cell catalyst
    Fei Tao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Sci Rep 1:142. 2011
    ..The results highlight the promise of large-scale Neu5Ac synthesis and point at a potential of our approach as a general strategy to improve whole-cell biocatalysis...
  31. pmc Genome sequence of the thermophile Bacillus coagulans Hammer, the type strain of the species
    Fei Su
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:6294-5. 2012
    ..Genomic analyses based on the sequence may provide insights into the phylogeny of the species and help to elucidate characteristics of the poorly studied strains of Bacillus coagulans...
  32. pmc Carotenoids play a positive role in the degradation of heterocycles by Sphingobium yanoikuyae
    Xiaorui Liu
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 7:e39522. 2012
    ..Carotenoids can serve as membrane-integrated antioxidants, protecting cells from oxidative stress...
  33. pmc Genome sequence of the welan gum-producing strain Sphingomonas sp. ATCC 31555
    Xiaoyu Wang
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:5989-90. 2012
    ..Here we present a 4.0-Mb assembly of its genome sequence. We have annotated 10 coding sequences (CDSs) responsible for the welan gum biosynthesis and 55 CDSs related to monosaccharide metabolism...
  34. pmc Genome sequence of Pseudomonas putida S12, a potential platform strain for industrial production of valuable chemicals
    Fei Tao
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:5985-6. 2012
    ..Here, we present a 6.28-Mb assembly of its genome sequence. We have annotated 32 coding sequences (CDSs) encoding efflux systems of organic compounds and 195 CDSs responsible for the metabolism of aromatic compounds...
  35. pmc Genome sequence of Klebsiella pneumoniae LZ, a potential platform strain for 1,3-propanediol production
    Fei Tao
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, corrected Shanghai, People s Republic of China
    J Bacteriol 194:4457-8. 2012
    ..We annotated 9 coding sequences (CDSs) responsible for glycerol fermentation to 1,3-propanediol, 19 CDSs encoding glycerol utilization, and 134 CDSs related to its virulence and defense...
  36. pmc Genome sequence of Pseudomonas aeruginosa DQ8, an efficient degrader of n-alkanes and polycyclic aromatic hydrocarbons
    Zhonghui Gai
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:6304-5. 2012
    ..Here, we present a 6.8-Mb assembly of its genome sequence. We have annotated 23 coding sequences (CDSs) responsible for catabolism of n-alkanes and PAHs...
  37. pmc Complete genome sequence of the nicotine-degrading Pseudomonas putida strain S16
    Hao Yu
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Bacteriol 193:5541-2. 2011
    ..The genes of enzymes in the core genome and a genomic island encode the proteins responsible for nicotine catabolism...
  38. pmc Chemoenzymatic synthesis of N-acetyl-D-neuraminic acid from N-acetyl-D-glucosamine by using the spore surface-displayed N-acetyl-D-neuraminic acid aldolase
    Chao Gao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Appl Environ Microbiol 77:7080-3. 2011
    ..9 g liter(-1)) was achieved in this study. Thus, displaying a target enzyme on the surface of spores might be an alternative for integration of biocatalytic conversion into chemical synthesis...
  39. pmc Draft genome sequence of Sporolactobacillus inulinus strain CASD, an efficient D-lactic acid-producing bacterium with high-concentration lactate tolerance capability
    Bo Yu
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    J Bacteriol 193:5864-5. 2011
    ..inulinus (2,930,096 bp). The large number of annotated two-component system genes makes it possible to explore the mechanism of extraordinary lactate tolerance of S. inulinus CASD...
  40. pmc Regulatory roles of the PI3K/Akt signaling pathway in rats with severe acute pancreatitis
    Ping Xu
    Department of Gastroenterology, Songjiang Hospital Affiliated the First People s Hospital, Shanghai Jiaotong University, Shanghai, China
    PLoS ONE 8:e81767. 2013
    ..These findings showed that the PI3K/Akt inhibitor wortmannin decreases inflammatory cytokines in SAP rats and suggests its regulatory mechanisms may occur through the suppression on NF-κB and p38MAPK activity. ..
  41. doi request reprint Biotechnological production and applications of N-acetyl-D-neuraminic acid: current state and perspectives
    Fei Tao
    MOE Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Appl Microbiol Biotechnol 87:1281-9. 2010
    ..In this review article, we discuss existing knowledge on the biotechnological production and applications of Neu5Ac and also propose some guidelines for future studies...
  42. pmc Systematic unraveling of the unsolved pathway of nicotine degradation in Pseudomonas
    Hongzhi Tang
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS Genet 9:e1003923. 2013
    ..The proteins and functional pathway identified in the current study represent attractive targets for degradation of environmental toxic compounds. ..
  43. doi request reprint Characterization and biotechnological potential of petroleum-degrading bacteria isolated from oil-contaminated soils
    Zhengzhi Zhang
    MOE Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Bioresour Technol 101:8452-6. 2010
    ..The collection of isolated bacteria might be a useful resource for bioremediation of oil-contaminated soils and biotreatment of oil wastewater...
  44. doi request reprint Pancreatitis-associated ascitic fluid induces proinflammatory cytokine expression in THP-1 cells by inhibiting anti-inflammatory signaling
    Jing Wang
    Department of Gastroenterology, Songjiang Hospital Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Pancreas 42:855-60. 2013
    ..We investigated whether pancreatitis-associated ascitic fluid (PAAF) could induce the expression of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in THP-1 cells and the mechanism(s) involved...
  45. doi request reprint Effects of peroxisome proliferator-activated receptor-γ activation on apoptosis in rats with acute pancreatitis
    Ping Xu
    Department of Gastroenterology, Songjiang Hospital Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, 201600, China
    Dig Dis Sci 58:3516-23. 2013
    ..To investigate the effects and mechanisms of peroxisome proliferator-activated receptor-γ (PPAR-γ) activation on the induction of apoptosis in rats with acute pancreatitis...
  46. pmc Novel nicotine oxidoreductase-encoding gene involved in nicotine degradation by Pseudomonas putida strain S16
    Hongzhi Tang
    Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, People s Republic of China
    Appl Environ Microbiol 75:772-8. 2009
    ....
  47. doi request reprint Efficient conversion of 1,2-butanediol to (R)-2-hydroxybutyric acid using whole cells of Gluconobacter oxydans
    Chao Gao
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Bioresour Technol 115:75-8. 2012
    ..5 g l(-1)) and a high enantiomeric excess (99.7%). The biocatalysis process introduced in this study may provide a technically and economically interesting route for production of (R)-2-HBA...
  48. ncbi request reprint Biotransformation of isoeugenol to vanillin by a newly isolated Bacillus pumilus strain: identification of major metabolites
    Dongliang Hua
    Key Laboratory of Microbial Metabolism, Ministry of Education, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    J Biotechnol 130:463-70. 2007
    ..These findings suggest that isoeugenol is degraded through an epoxide-diol pathway...
  49. doi request reprint Recent advances in biotechnological production of 2-phenylethanol
    Dongliang Hua
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Biotechnol Adv 29:654-60. 2011
    ..Future research should focus on product scale-up and product recovery processes for the industrialization of microbial processes...
  50. pmc Genome sequence of Sphingomonas wittichii DP58, the first reported phenazine-1-carboxylic acid-degrading strain
    Zhiwei Ma
    State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    J Bacteriol 194:3535-6. 2012
    ..Here we present a 5.6-Mb assembly of its genome. This sequence would contribute to the elucidation of the molecular mechanism of PCA degradation to improve the antifungal's effectiveness or remove superfluous PCA...
  51. pmc Cometabolic degradation of dibenzofuran and dibenzothiophene by a newly isolated carbazole-degrading Sphingomonas sp. strain
    Zhonghui Gai
    State Key Laboratory of Microbial Technology, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Appl Environ Microbiol 73:2832-8. 2007
    ..After 40 h of incubation, 90% of DBT was transformed, and CA and DBF were completely removed. These results suggested that strain XLDN2-5 might be useful in the bioremediation of environments contaminated by these compounds...
  52. doi request reprint Genomic analysis of thermophilic Bacillus coagulans strains: efficient producers for platform bio-chemicals
    Fei Su
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P R China
    Sci Rep 4:3926. 2014
    ..Our genomic analysis provides comprehensive insights into the genetic characteristics of B. coagulans and paves the way for improving and extending the uses of this species. ..
  53. doi request reprint Efficient production of l-lactic acid using co-feeding strategy based on cane molasses/glucose carbon sources
    Ke Xu
    State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Bioresour Technol 153:23-9. 2014
    ..1g/Lh and a yield of 0.88g/g. Since cane molasses is a feasible carbon source, the co-feeding fermentation might be a promising alternative for the economical production of l-lactic acid. ..
  54. doi request reprint Frequent down-regulation of hABH2 in gastric cancer and its involvement in growth of cancer cells
    Wei Gao
    Department of Gastroenterology, Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine, Shanghai, China
    J Gastroenterol Hepatol 26:577-84. 2011
    ..Whether hABH2 is involved in this malignancy is unknown. The present study was aimed to investigate the expression profile of hABH2 in gastric cancer and the effect of hABH2 on cancer cell growth...
  55. pmc A prescribed Chinese herbal medicine improves glucose profile and ameliorates oxidative stress in Goto-Kakisaki rats fed with high fat diet
    Lin Wu
    Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China
    PLoS ONE 8:e60262. 2013
    ..However, no differences of serum glucose concentration or OS were observed on week 16. We concluded that QHYH decreased hyperglycemia exacerbated by HFD in GK rats by improving β cell function partly via its antioxidant effect...
  56. doi request reprint A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling
    Xinjian Liu
    State Key Laboratory of Oncogenes and Related Genes, Cancer Institute, Shanghai Jiaotong University, Shanghai, China
    Hum Gene Ther 22:427-37. 2011
    ..We think that our approach is a promising strategy in the treatment of gastrointestinal cancer, warranting further clinical investigation...
  57. doi request reprint [Phenotype analysis and mutant gene location of ventral yellow mouse (VY(Slac))]
    Mei Lian Shi
    Shanghai SLAC Laboratory Animal Co, Ltd, Shanghai, China
    Dongwuxue Yanjiu 33:290-7. 2012
    ..3 Mb region between rs13476833 and rs27310903 on chromosome 2. The preliminary results of our phenotype analysis and gene location provides a solid basis for further identification of this mutant gene...
  58. pmc Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein
    Zhenyi Zhang
    State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    PLoS ONE 6:e23507. 2011
    ..The results provide new insights into the binding mode of a defined C-terminal segment of APC by the PDZ domains of DLG1...
  59. pmc Degradation of carbazole by microbial cells immobilized in magnetic gellan gum gel beads
    Xia Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Appl Environ Microbiol 73:6421-8. 2007
    ....
  60. pmc Microbial desulfurization of gasoline in a Mycobacterium goodii X7B immobilized-cell system
    Fuli Li
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Appl Environ Microbiol 71:276-81. 2005
    ..With this excellent efficiency, strain X7B is considered a good potential candidate for industrial applications for the biodesulfurization of gasoline...
  61. ncbi request reprint Methods for the preparation of a biodesulfurization biocatalyst using Rhodococcus sp
    Cui Qing Ma
    State Key Lab of Microbial Technology of Shandong University, Jinan 250100, PR China
    Chemosphere 65:165-9. 2006
    ..The biocatalyst prepared by this method with the least cost could remove sulfur from hydrodesulfurization (HDS)-treated diesel oil efficiently, providing a total desulfurization percent of 78% and suggesting its cost-effective advantage...
  62. pmc Modeling for gellan gum production by Sphingomonas paucimobilis ATCC 31461 in a simplified medium
    Xia Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Appl Environ Microbiol 72:3367-74. 2006
    ..Based on model prediction, higher gellan gum production (17.71 g liter(-1)) and higher conversion efficiency (57.12%) were obtained in fed-batch fermentation at the same total glucose concentration (30 g liter(-1))...
  63. ncbi request reprint Highly efficient conversion of lactate to pyruvate using whole cells of Acinetobacter sp
    Cui Qing Ma
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China
    Biotechnol Prog 19:1672-6. 2003
    ..About 60% of 800 mM of l-lactate was transformed into pyruvate in 24 h. This reduced conversion rate is probably due to the high substrate inhibition in biotransformation...
  64. pmc Biodesulfurization in biphasic systems containing organic solvents
    Fei Tao
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Appl Environ Microbiol 72:4604-9. 2006
    ..This study is a significant step in the exploration of the biotechnological potential of novel biocatalysts for developing an efficient biodesulfurization process in biphasic reaction mixtures containing toxic organic solvents...
  65. ncbi request reprint Biodesulfurization of DBT in tetradecane and crude oil by a facultative thermophilic bacterium Mycobacterium goodii X7B
    Fuli Li
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, PR China
    J Biotechnol 127:222-8. 2007
    ..The total sulfur level of dibenzothiophene in tetradecane, was reduced by 99%, from 200 to 2 ppm within 24h at 40 degrees C. After 72 h treatment, 59% of the total sulfur content in Liaoning crude oil was removed, from 3600 to 1478 ppm...
  66. ncbi request reprint Microbial transformation of propenylbenzenes for natural flavour production
    Ping Xu
    Institute of Microbiology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, PR China
    Trends Biotechnol 25:571-6. 2007
    ..Future research should focus on metabolic-mechanism characterisation and on optimisation of biotransformation to improve the yields of target products for scale-up and industrial use...
  67. pmc Simultaneous biodetoxification of S, N, and O pollutants by engineering of a carbazole-degrading gene cassette in a recombinant biocatalyst
    Bo Yu
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Appl Environ Microbiol 72:7373-6. 2006
    ..The resultant strain, Rhodococcus erythropolis XPDN, could simultaneously transform the model pollutants dibenzothiophene, carbazole, and dibenzofuran to nontoxic metabolites and may have an application potential for bioremediation...
  68. ncbi request reprint Optimization of an ethanol production medium in very high gravity fermentation
    Fan qiang Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    Biotechnol Lett 29:233-6. 2007
    ..Concentrations of Mg(2+) and peptone were identified as the critical factors: 50 mM Mg(2+) and 1.5% (w/v) peptone in the medium increased the final ethanol titre from 14.2% (v/v) to 17% (v/v) in 48 h...
  69. ncbi request reprint Medium optimization by combination of response surface methodology and desirability function: an application in glutamine production
    Jinshan Li
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, People s Republic of China
    Appl Microbiol Biotechnol 74:563-71. 2007
    ..Compared with OM-1 in validated experiment, similar amounts of glutamine were obtained in OM-2 while the concentration of glutamate and the production cost decreased by 53.6 and 7.1%, respectively...