Kunsan Xiang

Summary

Affiliation: Shanghai Second Medical University
Country: China

Publications

  1. ncbi [Effects of Trp64Arg mutation in the beta 3-adrenergic receptor gene on body fat, plasma glucose level, lipid profile, insulin secretion and action in Chinese]
    K Xiang
    Department of Endocrinology and Metabolism, Shanghai Sixth People Hospital, Shanghai 200233 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:337-40. 1998
  2. ncbi [The impact of calpain-10 gene combined-SNP variation on type 2 diabetes mellitus and its related metabolic traits]
    K Xiang
    Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai No 6 People Hospital, Shanghai, 200233 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18:426-30. 2001
  3. ncbi [Effects of uncoupling protein 3 gene -55 C-->T variant on lipid metabolism, body fat, its distribution and non-insulin-dependent diabetes mellitus in Chinese]
    Hailian Shen
    Shanghai Diabetes Institute, Shanghai Sixth Hospital, Shanghai, 200233 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:317-21. 2002
  4. ncbi Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24
    Kunsan Xiang
    Shanghai Diabetes Institute, and Department of Endocrinology and Metabolism, Shanghai Jiaotong University No 6 People s Hospital, Shanghai, China
    Diabetes 53:228-34. 2004
  5. pmc Associations of common variants at APLN and hypertension in Chinese subjects with and without diabetes
    Rong Zhang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, 600 Yishan Road Shanghai, 200233, China
    Exp Diabetes Res 2012:917496. 2012
  6. pmc Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, People s Republic of China
    PLoS ONE 5:e15542. 2010
  7. doi Determination of diabetic retinopathy prevalence and associated risk factors in Chinese diabetic and pre-diabetic subjects: Shanghai diabetic complications study
    Can Pang
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai, China
    Diabetes Metab Res Rev 28:276-83. 2012
  8. doi The metabolic syndrome increased risk of cardiovascular events in Chinese--a community based study
    Chen Wang
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai, China
    Int J Cardiol 139:159-65. 2010
  9. ncbi Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population
    Fei Gao
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes, Shanghai, PR China
    Endocr J 56:487-94. 2009
  10. pmc Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    PLoS ONE 5:e11761. 2010

Collaborators

Detail Information

Publications52

  1. ncbi [Effects of Trp64Arg mutation in the beta 3-adrenergic receptor gene on body fat, plasma glucose level, lipid profile, insulin secretion and action in Chinese]
    K Xiang
    Department of Endocrinology and Metabolism, Shanghai Sixth People Hospital, Shanghai 200233 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:337-40. 1998
    ..To ascertain the association of the Trp64Arg mutation in the beta 3-adrenergic receptor (ADRB3) gene with the total body fat and fat distribution, plasma glucose level, lipid profile, insulin secretion and action in Chinese...
  2. ncbi [The impact of calpain-10 gene combined-SNP variation on type 2 diabetes mellitus and its related metabolic traits]
    K Xiang
    Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai No 6 People Hospital, Shanghai, 200233 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18:426-30. 2001
    ..To investigate the impact of calpain-10 gene (CAPN-10) combined single nucleotide polymorphism (SNP) variation on type 2 diabetes mellitus (T2DM) and its related clinical metabolic traits in Chinese...
  3. ncbi [Effects of uncoupling protein 3 gene -55 C-->T variant on lipid metabolism, body fat, its distribution and non-insulin-dependent diabetes mellitus in Chinese]
    Hailian Shen
    Shanghai Diabetes Institute, Shanghai Sixth Hospital, Shanghai, 200233 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:317-21. 2002
    ..To investigate the relationship of UCP3 gene -55 C-->T variant with lipid metabolism, body fat, its distribution and non-insulin-dependent diabetes mellitus(NIDDM) in Chinese...
  4. ncbi Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24
    Kunsan Xiang
    Shanghai Diabetes Institute, and Department of Endocrinology and Metabolism, Shanghai Jiaotong University No 6 People s Hospital, Shanghai, China
    Diabetes 53:228-34. 2004
    ....
  5. pmc Associations of common variants at APLN and hypertension in Chinese subjects with and without diabetes
    Rong Zhang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, 600 Yishan Road Shanghai, 200233, China
    Exp Diabetes Res 2012:917496. 2012
    ..The aim of the study was to investigate the association between the common variants of apelin gene (APLN) and hypertension, which was reported recently in a Chinese Han population with and without diabetes...
  6. pmc Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, People s Republic of China
    PLoS ONE 5:e15542. 2010
    ..In the current study, we aimed to evaluate the association between these loci and traits related to glucose metabolism in the Chinese...
  7. doi Determination of diabetic retinopathy prevalence and associated risk factors in Chinese diabetic and pre-diabetic subjects: Shanghai diabetic complications study
    Can Pang
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai, China
    Diabetes Metab Res Rev 28:276-83. 2012
    ..Hence, we investigated the prevalence of and risk factors associated with retinopathy in diabetic and pre-diabetic subjects from Chinese communities...
  8. doi The metabolic syndrome increased risk of cardiovascular events in Chinese--a community based study
    Chen Wang
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai, China
    Int J Cardiol 139:159-65. 2010
    ..The aim of the study was to prospectively evaluate the predictive value of the MetS for CVD events in Chinese population by different MetS definitions...
  9. ncbi Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population
    Fei Gao
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Medicine Center for Diabetes, Shanghai, PR China
    Endocr J 56:487-94. 2009
    ..In conclusion, the SNP-1308G/T (rs1917760) genotypes of DsbA-L gene might participate in insulin secretion and body fat distribution. It is possible that polymorphisms of DsbA-L gene associated with metabolic diseases...
  10. pmc Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    PLoS ONE 5:e11761. 2010
    ..The current study aimed to replicate this association in the Chinese population and further analyze their effects on biphasic insulin secretion...
  11. pmc Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population
    Congrong Wang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China
    Diabetes 58:1023-7. 2009
    ..We therefore investigated common variants across the HNF1beta gene in a Chinese population...
  12. ncbi Co-inheritance of specific genotypes of HSPG and ApoE gene increases risk of type 2 diabetic nephropathy
    Limei Liu
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, China
    Mol Cell Biochem 254:353-8. 2003
    ..In addition, we find that co-inheritance of T/E2 confers a higher risk of type 2 diabetes mellitus progression to diabetic nephropathy in Chinese...
  13. doi Serum fibroblast growth factor 21 is associated with adverse lipid profiles and gamma-glutamyltransferase but not insulin sensitivity in Chinese subjects
    Huating Li
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai 200233, China
    J Clin Endocrinol Metab 94:2151-6. 2009
    ..This study investigated the association of serum FGF21 levels with insulin secretion and sensitivity, as well as circulating parameters of lipid metabolism and hepatic enzymes in Chinese subjects...
  14. pmc Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose tolerance
    Shan Jiang
    Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    BMC Med Genet 13:22. 2012
    ..In the current study, we aimed to test the impacts of APPL2 genetic variants on obesity in a Chinese population with normal glucose tolerance...
  15. doi Prevalence and risk factors of albuminuria and chronic kidney disease in Chinese population with type 2 diabetes and impaired glucose regulation: Shanghai diabetic complications study (SHDCS)
    Weiping Jia
    Department of Endocrinology and Metabolism, Shanghai Clinical Center of Diabetes, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
    Nephrol Dial Transplant 24:3724-31. 2009
    ..We aimed to determine the prevalence of albuminuria and chronic kidney disease (CKD) in Chinese subjects with diabetes and pre-diabetes and the risk factors for kidney disease...
  16. pmc PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    PLoS ONE 4:e7643. 2009
    ..In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism...
  17. ncbi High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China
    Huating Li
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    J Hepatol 58:557-63. 2013
    ..We investigated the prospective association of FGF21 with NAFLD development in a 3-year prospective study involving a population-based cohort comprising 808 Chinese subjects...
  18. doi Phenotypic heterogeneity in Chinese patients with hepatocyte nuclear factor-1β mutations
    Congrong Wang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, China
    Diabetes Res Clin Pract 95:119-24. 2012
    ..The aim of this study was to investigate clinical spectrum of hepatocyte nuclear factor-1β (HNF-1β) mutation in Chinese diabetic patients with renal dysfunction and/or structure abnormalities...
  19. ncbi Functional characterization of insulin receptor gene mutations contributing to Rabson-Mendenhall syndrome - phenotypic heterogeneity of insulin receptor gene mutations
    Shan Jiang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai, 200233, China
    Endocr J 58:931-40. 2011
    ..In conclusion, INSR mutations associated with RMS were identified. Moreover, the A1028V mutation associated with a decrease in expression of INSR potentially accounts for loss of function of the INSR...
  20. pmc CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients
    Cheng Hu
    Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    Diabetes 60:3085-9. 2011
    ..The aim of this study was to test the effects of single nucleotide polymorphisms (SNPs) from these four loci on diabetic nephropathy and retinopathy in Chinese type 2 diabetic patients...
  21. ncbi Ala45Thr variation in neuroD1 gene is associated with early-onset type 2 diabetes with or without diabetic pedigree in Chinese
    Limei Liu
    Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai JiaoTong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai 200233, China
    Mol Cell Biochem 290:199-204. 2006
    ....
  22. pmc Lack of association between genetic polymorphisms within DUSP12 - ATF6 locus and glucose metabolism related traits in a Chinese population
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, PR China
    BMC Med Genet 12:3. 2011
    ..Studies in Pima Indian, Caucasians and African Americans identified several SNPs in DUSP12 and ATF6, located in chromosome 1q21-q23, were associated with type 2 diabetes...
  23. pmc Glycated haemoglobin A1c for diagnosing diabetes in Chinese population: cross sectional epidemiological survey
    Yuqian Bao
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai 200233, China
    BMJ 340:c2249. 2010
    ..To evaluate haemoglobin A1c (HbA(1c)) in diagnosing diabetes and identify the optimal HbA(1c) threshold to be used in Chinese adults...
  24. doi A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population
    Rong Zhang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    Hypertens Res 34:645-8. 2011
    ..17, P = 0.0011) and diastolic blood pressure (β = -1.75, P = 0.0010) in men. A common variant on CYP4A11 was associated with blood pressure in a Chinese population. Future studies are needed to confirm our findings...
  25. doi Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
    Huating Li
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    J Hepatol 53:934-40. 2010
    ..This study investigated the association of FGF21 with nonalcoholic fatty liver disease (NAFLD) in Chinese patients...
  26. doi Optimal waist circumference cutoffs for abdominal obesity in Chinese
    Yuqian Bao
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    Atherosclerosis 201:378-84. 2008
    ..To determine the appropriate cutoffs for visceral fat area (VFA) measured by magnetic resonance imaging linking to risk of the metabolic syndrome (MetS) and the corresponding waist circumference in Chinese...
  27. ncbi [The UCSNP44 variation of calpain 10 gene on NIDDM1 locus and its impact on plasma glucose levels in type 2 diabetic patients]
    Yanqing Wang
    Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai No 6 People Hospital, Shanghai 200233, China
    Zhonghua Yi Xue Za Zhi 82:613-6. 2002
    ..To study the contribution of single nucleotide polymorphism-UCSNP44 at calpain-10 gene (CAPN-10) on NIDDM1 locus to type 2 diabetes mellitus (T2DM) in Chinese...
  28. ncbi Association of serum retinol-binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes
    Weiping Jia
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai 200233, China
    J Clin Endocrinol Metab 92:3224-9. 2007
    ..The purpose of this study was to investigate the relationship between serum RBP4 and regional fat distribution in Chinese subjects with and without type 2 diabetes...
  29. doi Polymorphic variations in manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1), and catalase (CAT) contribute to elevated plasma triglyceride levels in Chinese patients with type 2 diabetes or diabetic cardiovascular disease
    Hong Chen
    Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai JiaoTong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai 200233, China
    Mol Cell Biochem 363:85-91. 2012
    ..018) or non-TT+CC+CC genotypes (2.00 ± 0.18 vs. 1.65 ± 0.19 mmol/l, P = 0.070). The common MnSOD, GPX1, and CAT TT+CC+CC genotype may contribute to hypertriglyceridemia in Chinese patients with type 2 diabetes or diabetic CVD...
  30. pmc Risk factors for overweight and obesity, and changes in body mass index of Chinese adults in Shanghai
    Xuhong Hou
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai 200233, PR China
    BMC Public Health 8:389. 2008
    ..The aims of this study were to firstly assess the baseline prevelences and the risk factors for overweight and obesity, and secondly to detect the changes of body mass index (BMI) over a follow-up period in Chinese adults in Shanghai...
  31. ncbi A novel mutation, Ser159Pro in the NeuroD1/BETA2 gene contributes to the development of diabetes in a Chinese potential MODY family
    Limei Liu
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai, China
    Mol Cell Biochem 303:115-20. 2007
    ..To investigate the role of the mutation in early-onset diabetes, we studied its transcriptional activity on human insulin gene and clinical characteristics of the family with the mutation...
  32. ncbi The heparan sulfate proteoglycan gene polymorphism: association with type 2 diabetic nephropathy in Chinese
    Limei Liu
    Shanghai Diabetes Institute, Shanghai No 6 People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Mol Cell Biochem 245:121-6. 2003
    ..29-3.38), respectively, as compared to non-carriers. The T allele of the HSPG gene BamHI polymorphism located in intron 6 may be a risk factor for the development of renal insufficiency in type 2 diabetes mellitus for Chinese...
  33. doi Mitochondrial DNA mutations in diabetes mellitus patients in Chinese Han population
    Suijun Wang
    Department of Endocrinology and Metabolism, Henan Provincial People s Hospital, Zhengzhou University, Zhengzhou, Henan 450003, China
    Gene 531:472-5. 2013
    ..Mutations of mitochondrial DNA are associated with diabetes mellitus (DM). The present case-control study aimed to investigate the mutations of mitochondrial DNA in DM patients of Chinese Han ethnicity...
  34. doi Association between an increment of 30-minute postchallenge plasma glucose and urine albumin excretion exists in postmenopausal women but not in premenopausal women
    Ding Li
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated to Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    Menopause 18:1303-8. 2011
    ....
  35. doi Fenofibrate reduces serum retinol-binding protein-4 by suppressing its expression in adipose tissue
    Haiya Wu
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, 600 Yishan RD, Shanghai 200233, China
    Am J Physiol Endocrinol Metab 296:E628-34. 2009
    ....
  36. ncbi Glycemic variability and its responses to intensive insulin treatment in newly diagnosed type 2 diabetes
    Jian Zhou
    Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai, China
    Med Sci Monit 14:CR552-8. 2008
    ..This study investigated the characteristics of BG variability in type 2 diabetic patients and the effect of intensive treatment...
  37. pmc An evaluation of the performance of HapMap SNP data in a Shanghai Chinese population: analyses of allele frequency, linkage disequilibrium pattern and tagging SNPs transferability on chromosome 1q21-q25
    Cheng Hu
    Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai, 200233, China
    BMC Genet 9:19. 2008
    ....
  38. ncbi Serum retinol binding protein 4 and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus
    Haiya Wu
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, 600 Yishan Road, Shanghai 200233, China
    Diabetes Res Clin Pract 79:185-90. 2008
    ..The study demonstrates that retinol binding protein 4 might contribute to the pathogenesis of nonalcoholic fatty liver disease...
  39. doi The Leu72Met polymorphism of the GHRL gene prevents the development of diabetic nephropathy in Chinese patients with type 2 diabetes mellitus
    Langen Zhuang
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, 600 Yishan Road, Shanghai, 200233, China
    Mol Cell Biochem 387:19-25. 2014
    ..001). The GHRL Leu72Met polymorphism may help to maintain normal renal function and may protect against the development of DN by reducing albuminuria and improving renal function in Chinese patients with type 2 diabetes...
  40. pmc Serum Proteome Changes in Healthy Subjects with Different Genotypes of NOS1AP in the Chinese Population
    Feng Jiang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, 600 Yishan Road, Shanghai 200233, China
    J Diabetes Res 2013:357630. 2013
    ..05). The protein profiling changes between the genotypes of rs12742393 indicated that this SNP might play a role in the development of type 2 diabetes...
  41. doi Serum C-reactive protein and risk of cardiovascular events in middle-aged and older chinese population
    Shan Jiang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    Am J Cardiol 103:1727-31. 2009
    ..58; confidence interval 1.08 to 2.31). In conclusion, the results of our study suggest that elevated hs-CRP (>or=2.0 mg/L) is an effective predictor of CVD in a Chinese population...
  42. ncbi [Evaluation of abdominal visceral obesity from anthropometric parameters using receiver operating characteristic curves]
    Weiping Jia
    Shanghai Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai 200233, China
    Zhonghua Liu Xing Bing Xue Za Zhi 23:20-3. 2002
    ..To evaluate the best cut-off point, sensitivity and specificity of body mass index (BMI), waist circumference (WC) and Waist-to-hip ratio (WHR) in predicting of abdominal visceral obesity...
  43. doi A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population
    C Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai, 200233, People s Republic of China
    Diabetologia 52:451-6. 2009
    ..The aim of this study was to investigate the effect of common variants of G6PC2 on type 2 diabetes and related clinical features in a Chinese population...
  44. doi Effect of RBP4 gene variants on circulating RBP4 concentration and type 2 diabetes in a Chinese population
    C Hu
    Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    Diabet Med 25:11-8. 2008
    ..The aim of this study was to determine the relationship between genetic variants of the RBP4 gene, circulating RBP4 concentrations and phenotypes related to glucose and lipid metabolism in the Chinese population...
  45. doi Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population
    C Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai, People s Republic of China
    Diabetologia 52:1322-5. 2009
    ..Recent genome-wide association studies in East Asian populations reported that single nucleotide polymorphisms (SNPs) in KCNQ1 are associated with type 2 diabetes. The aim of this study was to validate this finding in a Chinese population...
  46. ncbi Peroxisome proliferator-activated receptor (PPAR) delta genetic polymorphism and its association with insulin resistance index and fasting plasma glucose concentrations in Chinese subjects
    C Hu
    Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai, China
    Diabet Med 23:1307-12. 2006
    ..We investigated the association between the polymorphism (-87T/C) of the human PPARD gene and phenotypes related to body weight, insulin sensitivity, glucose and lipid metabolism in Chinese subjects...
  47. doi Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes
    Limei Liu
    Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, 600 Yishan Road, Shanghai, 200233, China
    Diabetologia 56:2609-18. 2013
    ..To investigate the molecular aetiology, we identified and characterised whether mutations in the KCNJ11 gene are responsible for these families...
  48. ncbi [Dyslipidaemia and insulin resistance in Chinese in Shanghai]
    Y Bao
    Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, Shanghai Diabetes Research Institute, Shanghai 200233, China
    Zhonghua Nei Ke Za Zhi 40:299-302. 2001
    ..3) Both body fat (BMI, WHR) and triglycerides were independent risk factors accounting for HOMA-IR. CONCLUSION: Hypertriglycerides could be regarded as an independent risk factor for insulin resistance...
  49. ncbi Relationship between the renin-angiotensin system genes and diabetic nephropathy in the Chinese
    S Wu
    Department of Endocrinology and Metabolism, Diabetes Research Laboratory and Medical Genetics Research Laboratory, Shanghai Sixth People s Hospital, Shanghai Second Medical University, Shanghai 200233, China
    Chin Med J (Engl) 113:437-41. 2000
    ..To clarify whether genetic variants of the renin-angiotensin system (RAS) contribute to the development of diabetic nephropathy (DN) in the Chinese...
  50. doi Identification of waist circumference cutoffs for abdominal obesity in the Chinese population: a 7.8-year follow-up study in the Shanghai urban area
    Y Ye
    Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    Int J Obes (Lond) 33:1058-62. 2009
    ..To identify the appropriate visceral adipose tissue (VAT) cutoff values for the diagnosis of abdominal obesity in predicting diabetes and the corresponding waist circumference in the Chinese population...
  51. ncbi Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Diabetes 55:2541-8. 2006
    ..These data exclude USF1 as a major contributor to type 2 diabetes susceptibility and the basis for the chromosome 1q linkage. They reveal only limited evidence for replication of USF1 effects on continuous metabolic traits...
  52. doi Diagnostic strategy to improve the efficiency of screening diabetes--ROC analysis for fasting plasma glucose
    Junxi Lu
    Diabetes Res Clin Pract 80:e14-5. 2008