Affiliation: Shanghai Institutes for Biological Sciences
Su P, Chen S, Zheng Y, Zhou H, Yan C, Yu F, et al
. Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis. J Immunol. 2016;197:1054-64 pubmed publisher
Sha W, Mitoma H, Hanabuchi S, Bao M, Weng L, Sugimoto N, et al
. Human NLRP3 inflammasome senses multiple types of bacterial RNAs. Proc Natl Acad Sci U S A. 2014;111:16059-64 pubmed publisher
..Therefore, human and murine macrophages may have evolved to recognize bacterial cytosolic RNA differently during bacterial infections. ..
Mao K, Chen S, Wang Y, Zeng Y, Ma Y, Hu Y, et al
. Î²-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes. J Immunol. 2015;194:1867-73 pubmed publisher
..Taken together, our results indicate that Î²-arrestin1 plays a critical role in the assembly and activation of two major canonical inflammasomes, and it may provide a new therapeutic target for inflammatory diseases. ..
Yan S, Zhang Y, Sun B. The function and potential drug targets of tumour-associated Tregs for cancer immunotherapy. Sci China Life Sci. 2019;: pubmed publisher
..In this review, we focus on the regulatory mechanisms of Tregs, including intrinsic and extrinsic factors within the tumour microenvironment, and we address potential drug targets on Tregs for immunotherapy. ..
Sun B, Zhang Y. Overview of orchestration of CD4+ T cell subsets in immune responses. Adv Exp Med Biol. 2014;841:1-13 pubmed publisher
..In this chapter, we will have a broad overview of all Th cell subsets, including Th1, Th2, Th17, Treg, Tfh, as well as Th9 and Th22. ..
Yu F, Sharma S, Jankovic D, Gurram R, Su P, Hu G, et al
. The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination. J Exp Med. 2018;215:1813-1821 pubmed publisher
..Thus, our results demonstrate that transcription factor Bhlhe40 is a molecular switch for determining the fate of inflammatory and antiinflammatory Th1 cells. ..
Xie D, Liu Z, Li Z, Ji Y, Chen J, Sun B. Differential expression of neutrophilic granule proteins between Th1 and Th2 cells. Acta Biochim Biophys Sin (Shanghai). 2007;39:67-72 pubmed
..GFP-NGP fusion proteins overexpressed in HeLa cells were localized to the cytoplasm. These results suggest NGP is a novel marker distinguishing Th2 from Th1 cells and maybe a novel cytokine secreted by Th2 cells. ..
Hu W, Zhang H, Han Q, Li L, Chen Y, Xia N, et al
. A Vero-cell-adapted vaccine donor strain of influenza A virus generated by serial passages. Vaccine. 2015;33:374-81 pubmed publisher
..Thus, our work describes the generation of a Vero-adapted, high-yield PR8-4mut virus that may serve as a promising candidate for an influenza-vaccine donor virus. ..
Zhang H, Han Q, Ping X, Li L, Chang C, Chen Z, et al
. A single NS2 mutation of K86R promotes PR8 vaccine donor virus growth in Vero cells. Virology. 2015;482:32-40 pubmed publisher
..Because the NS2(K86R) mutation does not increase PR8 virulence in either mice or embryonated eggs, the PR8-NS2(K86R) virus could serve as a promising vaccine donor strain in Vero cells. ..