Affiliation: Shanghai Second Medical University
Liu F, Zhou Q, Zhou J, Sun H, Wang Y, Zou X, et al
. 14-3-3Ï„ promotes surface expression of Cav2.2 (Î±1B) Ca2+ channels. J Biol Chem. 2015;290:2689-98 pubmed publisher
..2 channels in transfected tsA-201 cells and neurons. Altogether, our findings reveal a previously unidentified regulatory function of 14-3-3 proteins in promoting the surface expression of Cav2.2 Î±1B channels. ..
Wang Y, Gao Y, Tian Q, Deng Q, Wang Y, Zhou T, et al
. TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain. Nat Commun. 2018;9:1529 pubmed publisher
..These data suggest that TRPV1 SUMOylation is essential for the development of inflammatory thermal hyperalgesia, through a mechanism that involves sensitization of the channel response specifically to thermal stimulation. ..
Wang Y, Wang Y, Zhang H, Gao Y, Huang C, Zhou A, et al
. Sequential posttranslational modifications regulate PKC degradation. Mol Biol Cell. 2016;27:410-20 pubmed publisher
..These findings provide a molecular explanation for the activation-induced down-regulation of PKC proteins. ..
Li Y, Liu X, Wu Y, Xu Z, Li H, Griffith L, et al
. Intracellular regions of the Eag potassium channel play a critical role in generation of voltage-dependent currents. J Biol Chem. 2011;286:1389-99 pubmed publisher
..Synthesis and assembly of Eag at high temperature disrupt the ability of these domains to carry out their function. These results suggest an important role of the intracellular regions in the generation of Eag currents. ..