Affiliation: Shanghai Institute of Applied Physics
- Single-molecule imaging of DNA polymerase I (Klenow fragment) activity by atomic force microscopyJ Chao
Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
Nanoscale 8:5842-6. 2016..Upon completion of these actions, a double-stranded DNA molecule was formed. Furthermore, the direction of KF activities was captured and then confirmed by shifting the KF binding sites on the template DNA. ..
- Enzymatic digestion of single DNA molecules anchored on nanogold-modified surfacesJunhong Lu
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P, O, Box 800 204, Shanghai, 201800, China
Nanoscale Res Lett 4:1029-34. 2009..We demonstrate that by using Dip-Pen Nanolithography, individual DNA molecules attached to modified mica surfaces can be efficiently digested by DNase I...
- In situ monitoring of single molecule binding reactions with time-lapse atomic force microscopy on functionalized DNA origamiNa Wu
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China
Nanoscale 3:2481-4. 2011..Single streptavidin molecules bound to specifically biotinyated DNA origami were simply counted as a function of time to obtain a direct measure of the binding rate...
- A cancer protein microarray platform using antibody fragments and its clinical applicationsShiping Song
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
Mol Biosyst 3:151-8. 2007..More importantly, clinical applications of our F(ab')2 microarray platform for upwards of 100 patient serum samples clearly show its potential in cancer diagnostics...