Research Topics
Genomes and Genes
| Cheng HuSummaryAffiliation: Shanghai Jiaotong University Country: China Publications
| Collaborators
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Detail Information
Publications
Impact of marker density on the accuracy of association mappingWeihua Zhang
Section of Cancer Genetics, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK
BMC Proc 1:S166. 2007..We also demonstrated that SNP selection based on equal LD distance outperforms that based on equal physical distance or SNP tagging. Furthermore, ignoring rare SNPs diminished the ability to detect rare causal variants...- Association mapping of susceptibility loci for rheumatoid arthritisTai Yue Kuo
Human Genetics Division, Duthie Building Mailpoint 808, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
BMC Proc 1:S15. 2007..SNP selection based on equal linkage disequilibrium (LD) distance generally produced higher accuracy than that based on equal kilobase distance or tagging... - An evaluation of the performance of HapMap SNP data in a Shanghai Chinese population: analyses of allele frequency, linkage disequilibrium pattern and tagging SNPs transferability on chromosome 1q21-q25Cheng Hu
Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai, 200233, China
BMC Genet 9:19. 2008.... 
[Association of variants in APPL1 gene with body fat and its distribution in Chinese patients with type 2 diabetic mellitus]Qi chen Fang
Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Department of Endocrinology and Metabolism, Sixth People s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China
Zhonghua Yi Xue Za Zhi 88:369-73. 2008..To investigate the impact of single nucleotide polymorphisms (SNPs) in APPL1 gene on body fat and its distribution...- Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the ChineseCheng Hu
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, People s Republic of China
PLoS ONE 5:e15542. 2010..In the current study, we aimed to evaluate the association between these loci and traits related to glucose metabolism in the Chinese... 
[No association of vascular endothelial growth factor A gene rs9369425 polymorphism with glucose metabolism in Chinese Han population]Rong Zhang
Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai, 200233 PR China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:457-9. 2010..To investigate the relationship between the vascular endothelial growth factor A gene (VEGFA) rs9369425 single nucleotide polymorphism (SNP) and type 2 diabetes in Chinese Han population...- Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretionCheng Hu
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
PLoS ONE 5:e11761. 2010..The current study aimed to replicate this association in the Chinese population and further analyze their effects on biphasic insulin secretion... - [Relationship between adiponectin receptor 1 gene -3881T/C variant and glucose metabolism in the Chinese]Cheng Hu
Shanghai Clinical Medicine Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated No 6 People s Hospital, Shanghai, 200233 PR China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:27-30. 2007..To investigate the relationship between adiponectin receptor 1 gene (ADIPOR1) single nucleotide polymorphism (SNP) and glucose metabolism and insulin resistance in the Chinese... - Association of a SLC30A8 genetic variant with monotherapy of repaglinide and rosiglitazone effect in newly diagnosed type 2 diabetes patients in ChinaFeng Jiang
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
Biomed Environ Sci 25:23-9. 2012..To investigate a potential relationship between Solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 variant and efficacy of rosiglitazone or repaglinide in treating newly diagnosed Chinese type 2 diabetes patients... - A common genetic variant of FCN3/CD164L2 is associated with essential hypertension in a Chinese populationJingyi Lu
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, PR China
Clin Exp Hypertens 34:377-82. 2012..We found that a common variant of FCN3/CD164L2 is associated with hypertension in our Chinese population. More studies with larger sample size are needed to confirm this finding... - [Association of -6735T-->C variant of glucokinase-associated dual-specificity phosphatase 12 gene with type 2 diabetes in Chinese]Fei Gao
Shanghai Clinical Medicine Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated No 6 People s Hospital, Shanghai 200233, China
Zhonghua Yi Xue Za Zhi 88:2250-3. 2008..To investigate the impact of glucokinase-associated dual-specificity phosphatase 12 gene (DUSP12) single nucleotide polymorphism (SNP) on type 2 diabetes mellitus in Chinese... - [Study on the status of metabolic syndrome in familial type 2 diabetes pedigrees]Xiao Jing Ma
Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism of Shanghai Jiaotong University Affiliated Sixth People s Hospital, Shanghai 200233, China
Zhonghua Liu Xing Bing Xue Za Zhi 29:745-8. 2008..To investigate the prevalence of metabolic syndrome (MS) and its components in type 2 diabetes mellitus pedigrees... - Effects of ABCA1 variants on rosiglitazone monotherapy in newly diagnosed type 2 diabetes patientsJie Wang
Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai 200233, China
Acta Pharmacol Sin 29:252-8. 2008.... - [The effect of single nucleotide polymorphism SNP + 45 of the adiponectin gene on the rosiglitazone maleate response in patients with type 2 diabetes]Hua Zhang
Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated No 6 People s Hospital, Shanghai 200233, China
Zhonghua Yi Xue Za Zhi 87:2390-3. 2007..To investigate the effect of single nucleotide polymorphism (SNP) + 45 of the adiponectin (ADIPOQ) gene on the response to therapy with rosiglitazone maleate in patients with type 2 diabetes... - A variation in NOS1AP gene is associated with repaglinide efficacy on insulin resistance in type 2 diabetes of ChineseWen Qin
Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai 200233, China
Acta Pharmacol Sin 31:450-4. 2010..To investigate a potential association between SNP rs10494366 in the neural nitric oxide synthase adaptor protein (NOS1AP) and efficacy of repaglinide (an insulin secretagogue) in newly diagnosed Shanghai Chinese type 2 diabetes patients... - [Comparison of the application of three diagnostic criteria of metabolic syndrome in familial type 2 diabetic pedigrees]Xiao Jing Ma
Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism of Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai 200233, China
Zhonghua Yu Fang Yi Xue Za Zhi 43:489-94. 2009.... - PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese populationCheng Hu
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
PLoS ONE 4:e7643. 2009..In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism... - Lack of association between genetic polymorphisms within DUSP12 - ATF6 locus and glucose metabolism related traits in a Chinese populationCheng Hu
Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, PR China
BMC Med Genet 12:3. 2011..Studies in Pima Indian, Caucasians and African Americans identified several SNPs in DUSP12 and ATF6, located in chromosome 1q21-q23, were associated with type 2 diabetes... - [Scanning the HNF4A gene mutation from Chinese pedigrees with early- and/or multiple-onset diabetes]Rong Zhang
Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated No 6 People s Hospital, Shanghai Diabetes Clinical Center, Shanghai 200233, P R China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:406-9. 2006..To screen the mutation of hepatocyte nuclear factor 4 alpha gene (HNF4A) in Chinese pedigrees with early and/or multiplex-onset diabetes in Shanghai and nearby area... - Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese populationCongrong Wang
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China
Diabetes 58:1023-7. 2009..We therefore investigated common variants across the HNF1beta gene in a Chinese population... - [An analysis method to apply linkage disequilibrium maps to association study]Cheng Hu
Shanghai Clinical Medicine Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated No 6 People s Hospital, Shanghai, 200233 PR China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:495-8. 2007..To apply linkage disequilibrium (LD) maps to associations studies with high throughput single nucleotide polymorphisms (SNPs)... - [Study on prevalence and risk factors of fatty liver of patients with type 2 diabetes]Jian Zhou
Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Sixth People s Hospital, Jiaotong University, Shanghai Diabetes Institute, Shanghai 200233, China
Zhonghua Yi Xue Za Zhi 87:2249-52. 2007..To study the prevalence and risk factors of nonalcoholic fatty liver (NAFL) of patients with type 2 diabetes... - A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese populationRong Zhang
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
Hypertens Res 34:645-8. 2011..17, P = 0.0011) and diastolic blood pressure (β = -1.75, P = 0.0010) in men. A common variant on CYP4A11 was associated with blood pressure in a Chinese population. Future studies are needed to confirm our findings... - Association of apelin genetic variants with type 2 diabetes and related clinical features in Chinese HansRong Zhang
Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai 200233, China
Chin Med J (Engl) 122:1273-6. 2009..The plasma levels of apelin increased in obese patients and diabetic subjects. This study aimed to investigate the effects of apelin genetic variants on type 2 diabetes and related quantitative traits... - Glycated haemoglobin A1c for diagnosing diabetes in Chinese population: cross sectional epidemiological surveyYuqian Bao
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai 200233, China
BMJ 340:c2249. 2010..To evaluate haemoglobin A1c (HbA(1c)) in diagnosing diabetes and identify the optimal HbA(1c) threshold to be used in Chinese adults... - Phenotypic heterogeneity in Chinese patients with hepatocyte nuclear factor-1β mutationsCongrong Wang
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, China
Diabetes Res Clin Pract 95:119-24. 2012..The aim of this study was to investigate clinical spectrum of hepatocyte nuclear factor-1β (HNF-1β) mutation in Chinese diabetic patients with renal dysfunction and/or structure abnormalities... - Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose toleranceShan Jiang
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
BMC Med Genet 13:22. 2012..In the current study, we aimed to test the impacts of APPL2 genetic variants on obesity in a Chinese population with normal glucose tolerance... - CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patientsCheng Hu
Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
Diabetes 60:3085-9. 2011..The aim of this study was to test the effects of single nucleotide polymorphisms (SNPs) from these four loci on diabetic nephropathy and retinopathy in Chinese type 2 diabetic patients... - Association of KCNJ11 and ABCC8 genetic polymorphisms with response to repaglinide in Chinese diabetic patientsYa yi He
Department of Endocrinology and Metabolism, The Sixth People s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
Acta Pharmacol Sin 29:983-9. 2008..The aim of this study was to investigate the association of KCNJ11 E23K and ABCC8 exon16-3T/C with the therapeutic effect of repaglinide in patients with type 2 diabetes... - Glycemic variability and its responses to intensive insulin treatment in newly diagnosed type 2 diabetesJian Zhou
Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai, China
Med Sci Monit 14:CR552-8. 2008..This study investigated the characteristics of BG variability in type 2 diabetic patients and the effect of intensive treatment... - [Study on prevalence of latent autoimmune diabetes in adults and its relationship with metabolic syndrome]Jian Zhou
Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology Metabolism of Shanghai Jiaotong University Affiliated Sixth People s Hospital, Shanghai 200233, China
Zhonghua Yi Xue Za Zhi 89:1250-4. 2009..To investigate the prevalence, clinical features of latent autoimmune diabetes in adults (LADA) from phenotypic type 2 diabetic patients and the relationship between LADA and metabolic syndrome (MS)... - [Genetic characteristics of familial type 2 diabetes pedigrees: a preliminary analysis of 4468 persons from 715 pedigrees]Xiao Jing Ma
Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism of Shanghai Jiaotong University Affiliated Sixth People s Hospital, Shanghai 200233, China
Zhonghua Yi Xue Za Zhi 88:2541-3. 2008..To analyze the inheritance character of type 2 diabetes mellitus (T2DM) pedigrees... - [Relationship between blood glucose variability and microalbuminuria in type 2 diabetic patients with well-controlled glycosylated hemoglobin]Jian Zhou
Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Sixth People s Hospital Affiliated to Jiaotong University, Shanghai Diabetes Institute, Shanghai 200233, China
Zhonghua Yi Xue Za Zhi 88:2977-81. 2008..To investigate the relationship between the blood glucose variability and microalbuminuria (MAU) in type 2 diabetic patients with well-controlled glycosylated hemoglobin (HbA1c) and the influencing factors of blood glucose variability... - Precise microdeletion detection of Prader-Willi Syndrome with array comparative genome hybridizationXin yu Shao
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China
Biomed Environ Sci 23:194-8. 2010..Our study was designed to precisely detect the microdeletions, which accounts for 65%-70% of the PWS... - Association of a common haplotype of hepatocyte nuclear factor 1alpha with type 2 diabetes in Chinese populationCong Rong Wang
Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai, China
Biomed Environ Sci 20:41-6. 2007..To analyze the association of variants of hepatocyte nuclear factor-1alpha (HNF-1alpha) gene with type 2 diabetes in Chinese population... - [The reference values of glycemic parameters for continuous glucose monitoring and its clinical application]Jian Zhou
Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, The Sixth People s Hospital, Affiliated to Jiaotong University, Shanghai 200233, China
Zhonghua Nei Ke Za Zhi 46:189-92. 2007..To establish reference values of glycemic parameters for continuous glucose monitoring in Chinese... - [Association between melanocortin 4 receptor gene polymorphisms and obesity]Rong Zhang
Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated No 6 People s Hospital, Shanghai 200233, China
Zhonghua Yi Xue Za Zhi 87:96-9. 2007..To investigate the association between the polymorphisms of melanocortin-4 receptor (MC4R) gene and obesity... - Cancer incidence and mortality in patients with type 2 diabetes treated with human insulin: a cohort study in shanghaiYunjuan Gu
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital Shanghai Diabetes Institute Shanghai Clinical Centre of Diabetes, Shanghai, China Department of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
PLoS ONE 8:e53411. 2013..The aim was to investigate the association between human insulin and cancer incidence and mortality in Chinese patients with type 2 diabetes... - Genetic advances of type 2 diabetes in Chinese populationsWeihui Yu
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Shanghai, China
J Diabetes 4:213-20. 2012..Despite many advances in the field of risk prediction and pharmacogenetics, the pace of clinical application of these findings is rather slow. As a result, more studies into the practical utility of these findings remain necessary...