Affiliation: Shanghai Jiaotong University
- Shen R, Jia R, Liu W, Lin Q, Hai Y, He Z. The Function and Regulation of BMP6 in Various Kinds of Stem Cells. Curr Pharm Des. 2015;21:3634-43 pubmed
- Yang H, Liu Y, Hai Y, Guo Y, Yang S, Li Z, et al. Efficient Conversion of Spermatogonial Stem Cells to Phenotypic and Functional Dopaminergic Neurons via the PI3K/Akt and P21/Smurf2/Nolz1 Pathway. Mol Neurobiol. 2015;52:1654-1669 pubmed publisher..Collectively, this study could provide sufficient neural cells from SSCs for applications in the treatment of PD and offers novel insights into mechanisms underlying neural system development from the line of germ cells. ..
- Zhi E, Li P, Chen H, Xu P, Zhu X, Zhu Z, et al. Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects. Genes (Basel). 2016;7: pubmed..5%). Decreased KIFC1 expression was mainly observed in the testes of patients with globozoospermia at the spermatid stage, which may be useful for counseling and management of such patients. ..
- Sun M, Yuan Q, Niu M, Wang H, Wen L, Yao C, et al. Efficient generation of functional haploid spermatids from human germline stem cells by three-dimensional-induced system. Cell Death Differ. 2018;25:747-764 pubmed publisher..This study thus provides invaluable human male gametes for treating male infertility. ..
- Wang H, Yuan Q, Niu M, Zhang W, Wen L, Fu H, et al. Transcriptional regulation of P63 on the apoptosis of male germ cells and three stages of spermatogenesis in mice. Cell Death Dis. 2018;9:76 pubmed publisher..This study could provide novel targets for the diagnosis and treatment of male infertility. ..
- Wang H, Yuan Q, Niu M, Wen L, Fu H, Zhou F, et al. Gene Silencing of Human Sertoli Cells Utilizing Small Interfering RNAs. Methods Mol Biol. 2018;1748:191-202 pubmed publisher..In summary, siRNAs can effectively and specifically knock down targeting genes at both transcriptional and translational levels utilizing RNAi in human Sertoli cells. ..
- Wang H, Wen L, Yuan Q, Sun M, Niu M, He Z. Establishment and applications of male germ cell and Sertoli cell lines. Reproduction. 2016;152:R31-40 pubmed publisher..We further highlight the essential applications of these cell lines in basic research and translation medicine. ..
- Yang S, Yuan Q, Niu M, Hou J, Zhu Z, Sun M, et al. BMP4 promotes mouse iPS cell differentiation to male germ cells via Smad1/5, Gata4, Id1 and Id2. Reproduction. 2017;153:211-220 pubmed
- Yao C, Yuan Q, Niu M, Fu H, Zhou F, Zhang W, et al. Distinct Expression Profiles and Novel Targets of MicroRNAs in Human Spermatogonia, Pachytene Spermatocytes, and Round Spermatids between OA Patients and NOA Patients. Mol Ther Nucleic Acids. 2017;9:182-194 pubmed publisher..This study thus sheds novel insights into epigenetic regulation of human normal spermatogenesis and the etiology of azoospermia, and it could offer new targets for molecular therapy to treat male infertility. ..