Zuping He


Affiliation: Shanghai Jiaotong University
Country: China


  1. Tian R, Yao C, Yang C, Zhu Z, Li C, Zhi E, et al. Fibroblast growth factor-5 promotes spermatogonial stem cell proliferation via ERK and AKT activation. Stem Cell Res Ther. 2019;10:40 pubmed publisher
    ..The distinct RNA profiles between Sertoli cells from SCOS and OA patients were identified using RNA-Seq. Also, FGF5, a growth factor that downregulated in SCOS Sertoli cells, could promote SSCs proliferation via ERK and AKT activation. ..
  2. Fu H, Zhou F, Yuan Q, Zhang W, Qiu Q, Yu X, et al. miRNA-31-5p Mediates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells via Targeting JAZF1 and Cyclin A2. Mol Ther Nucleic Acids. 2018;14:90-100 pubmed publisher
    ..This study thus offers a novel insight into the molecular mechanisms underlying the fate determinations of human SSCs and might provide novel targets for molecular therapy of male infertility. ..
  3. Yang C, Yao C, Tian R, Zhu Z, Zhao L, Li P, et al. miR-202-3p Regulates Sertoli Cell Proliferation, Synthesis Function, and Apoptosis by Targeting LRP6 and Cyclin D1 of Wnt/╬▓-Catenin Signaling. Mol Ther Nucleic Acids. 2018;14:1-19 pubmed publisher
    ..This study thus provides a novel insight into fate determinations of human Sertoli cells and niche of human testis. ..
  4. Zhou F, Yuan Q, Zhang W, Niu M, Fu H, Qiu Q, et al. MiR-663a Stimulates Proliferation and Suppresses Early Apoptosis of Human Spermatogonial Stem Cells by Targeting NFIX and Regulating Cell Cycle. Mol Ther Nucleic Acids. 2018;12:319-336 pubmed publisher
    ..This study thus provides novel insights into the molecular mechanisms underlying human spermatogenesis, and it could offer novel targets for treating male infertility and other human diseases. ..
  5. Fu H, Zhang W, Yuan Q, Niu M, Zhou F, Qiu Q, et al. PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT Pathways. Mol Ther Nucleic Acids. 2018;12:769-786 pubmed publisher
    ..This study provides data on novel gene regulation and networks underlying the fate of human SSCs, and it offers new molecular targets for human SSCs in translational medicine. ..
  6. Yang S, Ping P, Ma M, Li P, Tian R, Yang H, et al. Generation of haploid spermatids with fertilization and development capacity from human spermatogonial stem cells of cryptorchid patients. Stem Cell Reports. 2014;3:663-75 pubmed publisher
    ..This study thus provides an invaluable source of autologous male gametes for treating male infertility in azoospermia patients. ..
  7. Guo Y, Liu L, Sun M, Hai Y, Li Z, He Z. Expansion and long-term culture of human spermatogonial stem cells via the activation of SMAD3 and AKT pathways. Exp Biol Med (Maywood). 2015;240:1112-22 pubmed publisher
    ..This study could provide sufficient cells of SSCs for their basic research and clinic applications in reproductive and regenerative medicine. ..
  8. Guo Y, Hai Y, Yao C, Chen Z, Hou J, Li Z, et al. Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation. Cell Commun Signal. 2015;13:20 pubmed publisher
    ..This study could provide adequate human Sertoli cells for reproductive and regenerative medicine. ..
  9. Zhang Z, Gong Y, Guo Y, Hai Y, Yang H, Yang S, et al. Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin E. Cell Commun Signal. 2013;11:67 pubmed publisher
    ..This study thus provides an invaluable source of mature hepatocytes for treating liver-related diseases and drug toxicity screening and offers novel insights into mechanisms of liver development and cell reprogramming. ..

More Information


  1. request reprint
    Shen R, Jia R, Liu W, Lin Q, Hai Y, He Z. The Function and Regulation of BMP6 in Various Kinds of Stem Cells. Curr Pharm Des. 2015;21:3634-43 pubmed
  2. Yang H, Liu Y, Hai Y, Guo Y, Yang S, Li Z, et al. Efficient Conversion of Spermatogonial Stem Cells to Phenotypic and Functional Dopaminergic Neurons via the PI3K/Akt and P21/Smurf2/Nolz1 Pathway. Mol Neurobiol. 2015;52:1654-1669 pubmed publisher
    ..Collectively, this study could provide sufficient neural cells from SSCs for applications in the treatment of PD and offers novel insights into mechanisms underlying neural system development from the line of germ cells. ..
  3. Zhi E, Li P, Chen H, Xu P, Zhu X, Zhu Z, et al. Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects. Genes (Basel). 2016;7: pubmed
    ..5%). Decreased KIFC1 expression was mainly observed in the testes of patients with globozoospermia at the spermatid stage, which may be useful for counseling and management of such patients. ..
  4. Sun M, Yuan Q, Niu M, Wang H, Wen L, Yao C, et al. Efficient generation of functional haploid spermatids from human germline stem cells by three-dimensional-induced system. Cell Death Differ. 2018;25:747-764 pubmed publisher
    ..This study thus provides invaluable human male gametes for treating male infertility. ..
  5. Wang H, Yuan Q, Niu M, Zhang W, Wen L, Fu H, et al. Transcriptional regulation of P63 on the apoptosis of male germ cells and three stages of spermatogenesis in mice. Cell Death Dis. 2018;9:76 pubmed publisher
    ..This study could provide novel targets for the diagnosis and treatment of male infertility. ..
  6. Wang H, Yuan Q, Niu M, Wen L, Fu H, Zhou F, et al. Gene Silencing of Human Sertoli Cells Utilizing Small Interfering RNAs. Methods Mol Biol. 2018;1748:191-202 pubmed publisher
    ..In summary, siRNAs can effectively and specifically knock down targeting genes at both transcriptional and translational levels utilizing RNAi in human Sertoli cells. ..
  7. Wang H, Wen L, Yuan Q, Sun M, Niu M, He Z. Establishment and applications of male germ cell and Sertoli cell lines. Reproduction. 2016;152:R31-40 pubmed publisher
    ..We further highlight the essential applications of these cell lines in basic research and translation medicine. ..
  8. request reprint
    Yang S, Yuan Q, Niu M, Hou J, Zhu Z, Sun M, et al. BMP4 promotes mouse iPS cell differentiation to male germ cells via Smad1/5, Gata4, Id1 and Id2. Reproduction. 2017;153:211-220 pubmed
  9. Yao C, Yuan Q, Niu M, Fu H, Zhou F, Zhang W, et al. Distinct Expression Profiles and Novel Targets of MicroRNAs in Human Spermatogonia, Pachytene Spermatocytes, and Round Spermatids between OA Patients and NOA Patients. Mol Ther Nucleic Acids. 2017;9:182-194 pubmed publisher
    ..This study thus sheds novel insights into epigenetic regulation of human normal spermatogenesis and the etiology of azoospermia, and it could offer new targets for molecular therapy to treat male infertility. ..