Affiliation: Shanghai Institutes for Biological Sciences
Luo C, Cheng Y, Liu Y, Chen L, Liu L, Wei N, et al
. SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development. Cancer Res. 2017;77:1168-1178 pubmed publisher
..Our findings identify SRSF2 as a key regulator of RNA splicing dysregulation in cancer, with possible clinical implications as a candidate prognostic factor in patients with HCC. Cancer Res; 77(5); 1168-78. Â©2017 AACR. ..
Wei N, Cheng Y, Wang Z, Liu Y, Luo C, Liu L, et al
. SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Rep. 2015;13:1647-57 pubmed publisher
..SRSF10 represses inclusion of PGC1Î± exon 7a and facilitates the production of functional protein. The results highlight the biological significance of SRSF10 and regulated alternative splicing inÂ vivo. ..
Wei N, Feng X, Xie Z, Zhang Y, Feng Y. Long-term di (2-ethylhexyl)-phthalate exposure promotes proliferation and survival of HepG2 cells via activation of NFÎºB. Toxicol In Vitro. 2017;42:86-92 pubmed publisher
..In conclusion, continuous DEHP treatment could promote proliferation of HepG2 cells via activating NFÎºB signaling pathway. ..
Li H, Cheng Y, Wu W, Liu Y, Wei N, Feng X, et al
. SRSF10 regulates alternative splicing and is required for adipocyte differentiation. Mol Cell Biol. 2014;34:2198-207 pubmed publisher
..Taken together, our results identify SRSF10 as an essential regulator for adipocyte differentiation and also provide new insights into splicing control by SRSF10 in lipin1 pre-mRNA splicing. ..
Cheng Y, Luo C, Wu W, Xie Z, Fu X, Feng Y. Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice. Mol Cell Biol. 2016;36:1628-38 pubmed publisher
..Taking these observations together, inactivation of SRSF2 in liver caused dysregulated splicing events and hepatic metabolic disorders, which trigger endoplasmic reticulum stress, oxidative stress, and finally liver failure. ..
Chen L, Luo C, Shen L, Liu Y, Wang Q, Zhang C, et al
. SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing. Cell Rep. 2017;21:3406-3413 pubmed publisher
..Taken together, our findings identify SRSF1 as a key regulator of DBF4B pre-mRNA splicing dysregulation in colon cancer, with possible clinical implications as candidate prognostic factors in cancer patients. ..