Jing Fang

Summary

Affiliation: Shanghai Institutes for Biological Sciences
Country: China

Publications

  1. ncbi Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells
    Jing Fang
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 28:713-23. 2007
  2. ncbi Fludarabine reduces survivability of HepG2 cells through VEGF under hypoxia
    Jing Xue
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Arch Biochem Biophys 468:100-6. 2007
  3. pmc pVHL mediates K63-linked ubiquitination of nCLU
    Jing Xue
    The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e35848. 2012
  4. doi Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin
    Qiong Zhou
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai
    Mol Cancer Ther 8:1684-91. 2009
  5. ncbi Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression
    Jing Fang
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 28:858-64. 2007
  6. ncbi Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis
    Beibei Fu
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Cancer Ther 6:220-6. 2007
  7. ncbi Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase
    Xiao Wen Hu
    Key Laboratory of Nutrition and Metabolism, Institute of Nutritional Sciences, Shanghai Institute for Biological Sciences, The Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    Carcinogenesis 29:2369-76. 2008
  8. ncbi Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells
    Ling Zhi Liu
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Free Radic Biol Med 41:1521-33. 2006
  9. pmc Enterolactone inhibits insulin-like growth factor-1 receptor signaling in human prostatic carcinoma PC-3 cells
    Li Hua Chen
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
    J Nutr 139:653-9. 2009
  10. doi The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells
    Xue Bing Li
    The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cancer Lett 309:137-44. 2011

Collaborators

Detail Information

Publications39

  1. ncbi Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells
    Jing Fang
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 28:713-23. 2007
    ..Immunoblotting of the extracts of tumor tissues showed that luteolin inhibited IGF-1R/AKT signaling. Our results provide a new insight into the mechanisms that luteolin is against cancer cells...
  2. ncbi Fludarabine reduces survivability of HepG2 cells through VEGF under hypoxia
    Jing Xue
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Arch Biochem Biophys 468:100-6. 2007
    ..HepG2 cells were much more sensitive to fludarabine treatment under hypoxia than under nomoxia. These results suggest that fludarabine reduces survivability of HepG2 cells via VEGF signaling under hypoxia...
  3. pmc pVHL mediates K63-linked ubiquitination of nCLU
    Jing Xue
    The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e35848. 2012
    ..In summary, our results disclose a novel function of pVHL that mediates K63-linked ubiquitination and identify nCLU as a new target of pVHL...
  4. doi Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin
    Qiong Zhou
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai
    Mol Cancer Ther 8:1684-91. 2009
    ..These findings provide a new sight into the mechanisms that luteolin is against cancer cells, and suggest that molecular targeting of E-cadherin by luteolin may be a useful strategy for treatment of invasive prostate cancers...
  5. ncbi Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression
    Jing Fang
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 28:858-64. 2007
    ..The inhibition of tumor angiogenesis was associated with the decrease of HIF-1 and VEGF in tumor tissues. Taken together, our results show that apigenin suppresses tumor angiogenesis through HIF-1 and VEGF expression...
  6. ncbi Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis
    Beibei Fu
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Cancer Ther 6:220-6. 2007
    ..Taken together, these results suggest that chrysin is a potent inhibitor of HIF-1alpha and provide a new sight into the mechanisms of chrysin against cancers...
  7. ncbi Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase
    Xiao Wen Hu
    Key Laboratory of Nutrition and Metabolism, Institute of Nutritional Sciences, Shanghai Institute for Biological Sciences, The Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    Carcinogenesis 29:2369-76. 2008
    ..These results suggest that molecular targeting of FAK by apigenin might be a useful strategy for chemoprevention and/or chemotherapeutics of ovarian cancers...
  8. ncbi Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells
    Ling Zhi Liu
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Free Radic Biol Med 41:1521-33. 2006
    ..This study also indicates that p70S6K1 and H2O2 are important in tumor angiogenesis. The results of the study could have an important implication in ovarian cancer therapy...
  9. pmc Enterolactone inhibits insulin-like growth factor-1 receptor signaling in human prostatic carcinoma PC-3 cells
    Li Hua Chen
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
    J Nutr 139:653-9. 2009
    ..The finding of this study provides new insights into the molecular mechanisms that enterolactone exerts against prostate cancer...
  10. doi The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells
    Xue Bing Li
    The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cancer Lett 309:137-44. 2011
    ..Our results suggest that EAR2 plays an important role in development of colorectal cancer. The findings also suggest that EAR2 may serve as a potential therapeutic target of colorectal cancer...
  11. ncbi Reactive oxygen species regulate insulin-induced VEGF and HIF-1alpha expression through the activation of p70S6K1 in human prostate cancer cells
    Qiong Zhou
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 28:28-37. 2007
    ..These results provide some useful information for prostate cancer therapy in the future...
  12. pmc PAX2 protein induces expression of cyclin D1 through activating AP-1 protein and promotes proliferation of colon cancer cells
    Hai Sheng Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 287:44164-72. 2012
    ..Taken together, these results suggest that PAX2 promotes proliferation of colon cancer cells through AP-1...
  13. doi PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers
    Xiao Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai China
    Carcinogenesis 33:2228-35. 2012
    ..Collectively, our data reveal for the first time that PAQR3 has a tumor suppressor activity in the development of colorectal cancers...
  14. doi A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression
    Zongmeng Li
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Graduate University of the Chinese Academy of Sciences, Shanghai, China
    Cancer Lett 328:278-84. 2013
    ..The expression of FAM3B-258 in human colorectal adenocarcinomas was positively correlated with Slug. These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug...
  15. doi Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity
    Jing Xue
    Key Laboratory of Nutrition and Metabolisms, Institute of Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai, China
    Gastroenterology 138:606-15. 2010
    ..However, the expression pattern of PHDs in colorectal cancer and the correlation between their expression level and tumorigenesis is unclear...
  16. doi Benzo[a]pyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells
    Dan Meng
    The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, PR China
    Toxicol Lett 184:44-9. 2009
    ..These results suggest that the aryl hydrocarbon receptor plays an important role in B[a]P-induced expression of MMPs and migration and invasion of VSMC. Our findings may reveal a novel role of B[a]P in inducing atherogenesis...
  17. ncbi Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species
    Dan Meng
    The Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Free Radic Biol Med 42:1651-60. 2007
    ..These results suggest that (1) IGF-I induces EGFR activation through production of ROS and ROS-mediated Src activation in VSMCs, and (2) EGFR transactivation is required for IGF-I-induced VSMC proliferation...
  18. doi Prolyl hydroxylase domain protein 3 targets Pax2 for destruction
    Bing Yan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Biochem Biophys Res Commun 409:315-20. 2011
    ..Our results suggest that PHD3 targets Pax2 for destruction. The findings may disclose a mechanism for the regulation of Pax2 expression in cancer cells...
  19. ncbi Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide
    Qiong Zhou
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    FEBS Lett 580:5161-6. 2006
    ..IGF-1 did not induced production of H(2)O(2) in DU145 cells. Our results suggest that transactivation of EGFR by IGF-1 requires basal intracellular H(2)O(2) in DU145 cells...
  20. doi TRAF6 upregulates expression of HIF-1α and promotes tumor angiogenesis
    Heng Sun
    The Key Lab of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Cancer Res 73:4950-9. 2013
    ..Finally, we showed that TRAF6 promoted tumor angiogenesis and growth. Our results reveal how TRAF6 functions to upregulate HIF-1α expression and promote tumor angiogenesis...
  21. doi Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells
    Dan Meng
    The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, People s Republic of China
    Cardiovasc Res 80:299-308. 2008
    ..Knockdown of Nox4 did not affect IGF-I-induced activation of Rac1. IGF-I increased matrix metalloproteinase (MMP)-2 and 9 activity and promoted VSMC migration, which was inhibited by knockdown of Nox4 and inactivation of Rac1...
  22. doi Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1
    Zhao dong Li
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai 200031, China
    FEBS Lett 583:1999-2003. 2009
    ..Apigenin suppressed the expression of Id1 through activating transcription factor 3 (ATF3). Our results may elucidate a new mechanism underlying the inhibitory effects of apigenin on cancer cells...
  23. ncbi Benzo[a]pyrene-3,6-dione inhibited VEGF expression through inducing HIF-1alpha degradation
    Zhao dong Li
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Biochem Biophys Res Commun 357:517-23. 2007
    ....
  24. ncbi Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism
    Dan Meng
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai, 200031, China
    Toxicol Appl Pharmacol 244:291-9. 2010
    ..These findings demonstrate a role for HO-1 in arsenite-mediated angiogenesis in vitro...
  25. pmc The von Hippel-Lindau protein pVHL inhibits ribosome biogenesis and protein synthesis
    Wen Ting Zhao
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 288:16588-97. 2013
    ..We also demonstrate that pVHL suppresses both cap-dependent and cap-independent protein synthesis. Our findings unravel a novel function of pVHL and provide insight into the regulation of ribosome biogenesis by the tumor suppressor pVHL...
  26. doi Activating transcription factor 3 regulates survivability and migration of vascular smooth muscle cells
    Dandan Lv
    Key Laboratory of Nutrition and Metabolism, The Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    IUBMB Life 63:62-9. 2011
    ..In addition, we found that the expression of ATF3 was upregulated in smooth muscle cells in the injured mouse femoral arteries compared with the uninjured control group. These results suggest that ATF3 is relevant to disease physiology...
  27. ncbi TRAF6 is upregulated in colon cancer and promotes proliferation of colon cancer cells
    Heng Sun
    Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Int J Biochem Cell Biol 53:195-201. 2014
    ..Thus, inhibition of TRAF6 may improve the therapeutic treatment of these drugs. Together, our data suggest that TRAF6 promotes proliferation of colon cancer cells and it may serve as a potential target for therapy of colon cancer. ..
  28. pmc Forkhead transcription factor FOXO3a protein activates nuclear factor κB through B-cell lymphoma/leukemia 10 (BCL10) protein and promotes tumor cell survival in serum deprivation
    Zhaodong Li
    Key Laboratory of Nutrition and Metabolism, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 287:17737-45. 2012
    ..Our findings may add another layer to the complexity of the role of FOXO3a in cancer. Therefore, caution should be taken when FOXO3a is employed as a target for cancer therapy...
  29. ncbi Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway
    Li Hua Chen
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Mol Cancer Ther 6:2581-90. 2007
    ..Mechanistic studies suggested roles for Akt, GSK-3beta, MDM2, and p53 in enterolactone-dependent apoptosis. Our findings encourage further studies of enterolactone as a promising chemopreventive agent against prostate cancer...
  30. pmc Research advances at the Institute for Nutritional Sciences at Shanghai, China
    Yan Chen
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Adv Nutr 2:428-39. 2011
    ..This review highlights the major research endeavors undertaken by INS scientists in recent years...
  31. ncbi Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer
    Ling Zhi Liu
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Mol Pharmacol 68:635-43. 2005
    ..Our data suggested that apigenin may inhibit human lung cancer angiogenesis by inhibiting HIF-1alpha and VEGF expression, thus providing a novel explanation for the anticancer action of apigenin...
  32. doi Artificial neural network modeling of dissolved oxygen in the Heihe River, Northwestern China
    Xiaohu Wen
    Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Chunhui Rd 17, Yantai, 264003 Shandong Province, China
    Environ Monit Assess 185:4361-71. 2013
    ..The most effective inputs were determined as pH, NO3-N, NH4-N, and Ca(2+). Cl(-) was found to be least effective variables on the proposed model. The identified ANN model can be used to simulate the water quality parameters...
  33. pmc PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis
    Jing Fang
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Cell Signal 19:2487-97. 2007
    ....
  34. ncbi Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway
    Qiao Meng
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA
    Cell Signal 18:2262-71. 2006
    ..This study demonstrates the important role of the PI3K/AKT/mTOR/p70S6K1 pathway in cell proliferation, migration, and invasion in ovarian cancer cells by using siRNA-mediated gene silencing as a reverse genetic method...
  35. ncbi Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
    Jing Fang
    The Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    FASEB J 19:342-53. 2005
    ..These findings reveal a novel role of apigenin in inhibiting HIF-1 and VEGF expression that is important for tumor angiogenesis and growth, identifying new signaling molecules that mediate this regulation...
  36. ncbi Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling
    Heath D Skinner
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Biol Chem 279:45643-51. 2004
    ..It also indicates the important role of VEGF and HIF-1 in ovarian tumorigenesis and angiogenesis, which is mediated by the PI3K/AKT/HDM2 and AKT/p70S6K1 pathways in ovarian cancer cells...
  37. ncbi A downstream kinase of the mammalian target of rapamycin, p70S6K1, regulates human double minute 2 protein phosphorylation and stability
    Jing Fang
    Department of Microbiology, Immunology and Cell Biology, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Cell Physiol 209:261-5. 2006
    ..Overexpression of p70S6K1 enhanced HDM2 phosphorylation and led to an increase in HDM2 protein turnover. Our results suggest that p70S6K1 regulates turnover of HDM2 protein for cancer development...
  38. ncbi AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway
    Ling Zhi Liu
    Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China
    Cancer Res 67:6325-32. 2007
    ....
  39. ncbi trans-3,4,5'-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells
    Zongxian Cao
    Department of Microbiology, Immunology and Cell Biology, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, USA
    Clin Cancer Res 10:5253-63. 2004
    ..Our data suggested that resveratrol may inhibit human ovarian cancer progression and angiogenesis by inhibiting HIF-1alpha and VEGF expression and thus provide a novel potential mechanism for the anticancer action of resveratrol...