Z Chen

Summary

Affiliation: Shanghai Jiao Tong University
Country: China

Publications

  1. ncbi Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB
    Z G Han
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, 201203 Shanghai, China
    J Biol Chem 274:35741-8. 1999
  2. ncbi [Studies on complex chromosomal translocation and their relevance to clinical prognosis in acute promyelocytic leukemia]
    X Su
    Shanghai Institute of Hematology and Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:198-201. 1998
  3. ncbi [Chinese Human Genome Project--opportunity and challenge]
    Z Chen
    Shanghai Human Genome Center, Shanghai Institute of Hematology and Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:195-7. 1998
  4. pmc Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
    S J Chen
    Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, China
    J Clin Invest 91:2260-7. 1993
  5. ncbi Localization of the chromosome 15 breakpoints and expression of multiple PML-RAR alpha transcripts in acute promyelocytic leukemia: a study of 28 Chinese patients
    J P Geng
    Laboratory of Molecular Biology, Rui Jin Hospital, Shanghai Second Medical University, China
    Leukemia 7:20-6. 1993
  6. pmc Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes
    M Yu
    Key Laboratory of Genome Research, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, 200025, People s Republic of China
    Proc Natl Acad Sci U S A 94:7406-11. 1997
  7. doi Overexpression of Csk-binding protein contributes to renal cell carcinogenesis
    X Feng
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Oncogene 28:3320-31. 2009
  8. doi Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries
    B Chen
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 26:1608-16. 2012
  9. pmc Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia
    Z Chen
    Shanghai Institute of Haematology, Rui Jin Hospital, Shanghai Second Medical University, China
    EMBO J 12:1161-7. 1993
  10. doi Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1
    P Wang
    1 Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    Oncogene 33:514-24. 2014

Collaborators

Detail Information

Publications98

  1. ncbi Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB
    Z G Han
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, 201203 Shanghai, China
    J Biol Chem 274:35741-8. 1999
    ..The results indicated that ZNF255 might be a conditional transactivator, whereas ZNF253 and ZNF191 displayed a suppressive effect on the transcription in yeast and/or mammalian systems...
  2. ncbi [Studies on complex chromosomal translocation and their relevance to clinical prognosis in acute promyelocytic leukemia]
    X Su
    Shanghai Institute of Hematology and Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:198-201. 1998
    ..To study the relationship between the complex chromosome translocation in acute promyelocytic leukemia(APL, M3) and clinical therapy and prognosis...
  3. ncbi [Chinese Human Genome Project--opportunity and challenge]
    Z Chen
    Shanghai Human Genome Center, Shanghai Institute of Hematology and Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15:195-7. 1998
    ....
  4. pmc Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
    S J Chen
    Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, China
    J Clin Invest 91:2260-7. 1993
    ....
  5. ncbi Localization of the chromosome 15 breakpoints and expression of multiple PML-RAR alpha transcripts in acute promyelocytic leukemia: a study of 28 Chinese patients
    J P Geng
    Laboratory of Molecular Biology, Rui Jin Hospital, Shanghai Second Medical University, China
    Leukemia 7:20-6. 1993
    ..The primary structure of a 1.4 kb DNA segment flanking the 5' part of the PML gene and that of the bcr3 cluster (2.1 kb) were also established...
  6. pmc Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes
    M Yu
    Key Laboratory of Genome Research, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, 200025, People s Republic of China
    Proc Natl Acad Sci U S A 94:7406-11. 1997
    ..A synergistic induction of RIG-G expression in NB4 cells by combined treatment with ATRA and IFNs suggests that a collaboration exists between their respective signaling pathways...
  7. doi Overexpression of Csk-binding protein contributes to renal cell carcinogenesis
    X Feng
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Oncogene 28:3320-31. 2009
    ..These results provided new insights into the function of Cbp in modulating RhoA activation, by which Cbp might contribute to renal cell carcinogenesis...
  8. doi Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries
    B Chen
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 26:1608-16. 2012
    ..69% vs 4-11%). In general, it seems that Chinese ALL patients bear more adverse prognostic factors than their Western counterparts do...
  9. pmc Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia
    Z Chen
    Shanghai Institute of Haematology, Rui Jin Hospital, Shanghai Second Medical University, China
    EMBO J 12:1161-7. 1993
    ....
  10. doi Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1
    P Wang
    1 Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    Oncogene 33:514-24. 2014
    ..Our findings suggest a previously unidentified molecular mechanism involved in the progression and metastasis of pancreatic cancer. ..
  11. doi How to manage acute promyelocytic leukemia
    J Q Mi
    State Key Laboratory for Medical Genomics and Department of Hematology, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 26:1743-51. 2012
    ....
  12. ncbi Desferrioxamine induces leukemic cell differentiation potentially by hypoxia-inducible factor-1 alpha that augments transcriptional activity of CCAAT/enhancer-binding protein-alpha
    Y Jiang
    Department of Pathophysiology, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University SSMU, Shanghai, China
    Leukemia 19:1239-47. 2005
    ..Taken together, these results provided novel evidence for a role of HIF-1 alpha in AML cell differentiation, and suggested that C/EBP alpha might be a downstream effector for HIF-1 alpha-mediated differentiation...
  13. doi K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer
    H Chen
    Department of Hepatobiliary and Pancreatic Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Eur J Surg Oncol 36:657-62. 2010
    ..To determine the prognostic value of K-ras mutations in plasma DNA of unresectable pancreatic cancer patients...
  14. doi The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis
    Q L Zhang
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 23:1507-14. 2009
    ....
  15. doi Newly diagnosed acute lymphoblastic leukemia in China (II): prognosis related to genetic abnormalities in a series of 1091 cases
    J Q Mi
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 26:1507-16. 2012
    ....
  16. pmc RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell
    M Mao
    Key Laboratory of Human Genome Research and Shangai Institute of Hematology, Shanghai, China
    Proc Natl Acad Sci U S A 93:5910-4. 1996
    ..It seems that so far RIG-E is the closest human homolog of the LY-6 family. Expression of RIG-E is not restricted to myeloid differentiation, because it is also present in thymocytes and in a number of other tissues at different levels...
  17. ncbi Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation
    Q Zhao
    State Key Lab for Human Genome Research SKLHGR, Shanghai Institute of Hematology, Ruijin Hospital, Samuel Waxman Cancer Research Foundation Laboratory of Shanghai Second Medical University SSMU, Shanghai, China
    Leukemia 18:285-92. 2004
    ..Taken together, we suggested a crosstalk between ATRA-induced cytosolic pathway and nuclear pathway in APL cell differentiation...
  18. doi Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype
    J Jiang
    China Novartis Institutes for BioMedical Research, Shanghai, China
    Oncogene 31:671-82. 2012
    ..In conclusion, the results from this study provide new insights into the gastric tumorigenic process and offer potential implications for the development of anticancer drugs as well as therapeutic treatment of gastric cancers...
  19. ncbi Genomic sequence and expression analyses of human chromatin assembly factor 1 p150 gene
    H Dong
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Zhangjiang High Tech Park, Shanghai 201203, P R China
    Gene 264:187-96. 2001
    ..Tissue-correlated alternative splicing forms of the transcript was initially identified by EST clustering analysis, then confirmed by RT-PCR which resulted more splicing forms than computational prediction...
  20. ncbi Analysis of hypermutation of the 5' noncoding region in the BCL-6 gene
    L Wang
    Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Chin Med J (Engl) 114:286-90. 2001
    ..CONCLUSIONS: The 5' regulatory region of the BCL-6 gene undergoes frequent somatic hypermutation during lymphomagenesis and the identification of BCL-6 gene hypermutations provides a molecular marker for confirmatory diagnosis of B-NHL...
  21. doi The effects of proteasome inhibitor bortezomib on a P-gp positive leukemia cell line K562/A02
    S Lu
    Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China
    Int J Lab Hematol 32:e123-31. 2010
    ..Bortezomib shows a promising effect for the treatment of refractory/relapsed leukemia, but it does not improve the effect of anthracycline to MDR leukemia cells...
  22. pmc Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver
    X R Xu
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou-Jing Road, Shanghai 201203, China
    Proc Natl Acad Sci U S A 98:15089-94. 2001
    ..Notably, the altered transcriptome profiles in HCC could be correlated to a number of chromosome regions with amplification or loss of heterozygosity, providing one of the underlying causes of the transcription anomaly of HCC...
  23. ncbi Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha
    Y Huang
    Department of Pathophysiology of Basic Medical College, Shanghai Second Medical University, Shanghai, China
    Leukemia 17:2065-73. 2003
    ....
  24. doi Knockdown of zinc finger protein X-linked inhibits prostate cancer cell proliferation and induces apoptosis by activating caspase-3 and caspase-9
    H Jiang
    Department of Urology, Huashan Hospital, Fudan University, Shanghai, China
    Cancer Gene Ther 19:684-9. 2012
    ..Moreover, inhibition of ZFX-induced cell apoptosis by activating caspase-1, -3 and -9. In conclusion, ZFX represents the prominent role in the progression of prostate cancer and may be a promising therapy target for prostate cancer...
  25. ncbi Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation
    L Q Jiang
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Oncogene 25:5495-506. 2006
    ....
  26. ncbi Effects of RNA interference on CD80 and CD86 expression in bone marrow-derived murine dendritic cells
    X Gu
    Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China
    Scand J Immunol 64:588-94. 2006
    ..This approach is a useful tool by which costimulatory molecules of DC can be studied as well as a potential therapeutic option for allograft rejection...
  27. ncbi Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12 cells
    Z Chen
    Department of Neurobiology, The Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, China
    Neuroscience 104:593-8. 2001
    ..Therefore, it is inferred that similar intracellular signaling components are used by distinct growth factors toward a common biological effect...
  28. ncbi Molecular response in acute promyelocytic leukemia: a direct comparison of regular and real-time RT-PCR
    Y F Liu
    Department of Hematology, State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Jiaotong University School of Medicine, Jiaotong University, Shanghai, China
    Leukemia 20:1393-9. 2006
    ....
  29. ncbi Arsenic trioxide and acute promyelocytic leukemia: clinical and biological
    Z Chen
    Shanghai Institute of Hematology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, 197 Rui Jin Road II, 200025 Shanghai, People s Republic of China
    Curr Top Microbiol Immunol 313:129-44. 2007
    ..Indeed, arsenic trioxide combined with all-trans retinoic acid shows a synergistic effect. Mechanistically, arsenic targets the key leukemogenic protein PML-RARalpha, setting up a new example of molecular target-based cancer therapy...
  30. ncbi Invasive neuroendocrine carcinoma of the breast: a prognostic research of 107 Chinese patients
    Y Zhang
    Department of Pathology, Fudan University, Shanghai, China
    Neoplasma 60:215-22. 2013
    ..NEC of the breast is a distinct type of neoplasm with higher malignancy. Novel therapies such as the endocrine therapy should be explored and studies with larger case number and longer follow-up will be needed...
  31. ncbi High expression of nuclear factor of activated T cells in Chinese primary non-small cell lung cancer tissues
    K Zhang
    State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, China
    Int J Biol Markers 22:221-5. 2007
    ..This research was the first to investigate NFAT protein expression in primary non-small cell lung cancer (NSCLC) tissues from Chinese patients...
  32. ncbi Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries
    B Chen
    State Key Lab for Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, China
    Leukemia 19:767-75. 2005
    ....
  33. ncbi African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes
    Y Ke
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, China
    Science 292:1151-3. 2001
    ..Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia...
  34. ncbi Chronic morphine treatment inhibits oxytocin release from the supraoptic nucleus slices of rats
    J Li
    Department of Neurobiology, Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, China
    Neurosci Lett 300:54-8. 2001
    ..These results indicated that the neurons within SON could develop dependence on morphine in vitro, and these effects might be exerted via mu-opioid receptor in oxytocin neurons of the SON...
  35. doi Isolation of Photobacterium sp. LuB-1 and its application in rapid assays for chemical toxicants in water
    Y Hong
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Lett Appl Microbiol 51:308-12. 2010
    ..To isolate marine bacteria with strong bioluminescence in a wide range of NaCl concentration, especially at low salt conditions...
  36. doi AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2
    B Jiao
    State Key Laboratory of Medical Genomics, Institute of Health Sciences, Shanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences and Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Leukemia 23:1598-604. 2009
    ..0072 and P=0.0076, respectively). Taken together, these data suggest that AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) AML-M2...
  37. ncbi Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer
    J Gao
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
    Gene Ther 13:1587-94. 2006
    ..Our study suggests that targeting at the Hh signaling pathway may be an effective novel gene therapeutic strategy alone or in combination with other agents for the treatment of pancreatic cancer...
  38. ncbi Development of universal influenza vaccines based on influenza virus M and NP genes
    M Zheng
    Shanghai Institute of Biological Products, Shanghai, 200052, China
    Infection 42:251-62. 2014
    ..Therefore, developing a universal influenza vaccine (UIV) that induces broad-spectrum and long-term immunity has become a major trend in influenza vaccine research and development...
  39. ncbi Chemerin suppresses murine allergic asthma by inhibiting CCL2 production and subsequent airway recruitment of inflammatory dendritic cells
    L Zhao
    Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China
    Allergy 69:763-74. 2014
    ..However, the effect of chemerin in allergic asthma has not yet been explored. We sought to investigate the role of chemerin in the murine model of allergic asthma and explore the underlying mechanism...
  40. ncbi Pharmaco-induced erections for penile color-duplex ultrasound: oral PDE5 inhibitors or intracavernosal injection?
    Y Yang
    Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Int J Impot Res 24:191-5. 2012
    ....
  41. ncbi Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants
    J H Tong
    Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, Shanghai Second Medical University, China
    Oncogene 7:311-6. 1992
    ..The variation of chromosome breakpoints within the MYL gene may explain size heterogeneity previously observed in some MYL-RARA fusion transcripts expressed in APL cells...
  42. ncbi Diagnostic value and complications of fine needle aspiration for primary liver cancer and its influence on the treatment outcome-a study based on 3011 patients in China
    P Wang
    Department of Hepatobiliary and Pancreatic Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Eur J Surg Oncol 34:541-6. 2008
    ..To determine the diagnostic value and major complications of fine-needle aspiration (FNA) for primary liver cancer (PLC) and its influence on the treatment outcome and prognosis...
  43. ncbi Arg485Lys polymorphism of factor V increases the risk of coronary artery disease in a Chinese population
    W Le
    Department of Cardiology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Chin Med J (Engl) 113:963-6. 2000
    ..To explore the relationship between genetic variation in coagulation factor V and the occurrence of coronary arterial disease (CAD)...
  44. ncbi Arsenic trioxide, a therapeutic agent for APL
    T D Zhang
    The First Hospital affiliated to Harbin Medical University, 23 You Zheng Road, Nangang District, Harbin, 150001, PR China
    Oncogene 20:7146-53. 2001
    ..1 approximately 2.0 microM) induces degradation of a key leukemogenic protein, PML-RARalpha, as well as the wild-type PML, thus setting up a good example of targeting therapy for human cancers...
  45. ncbi [Expression of extraneuronal monoamine transporter gene and DNA repair gene vis-à-vis with antitumor efficacy of SarCNU in human tumor xenografts]
    Z Chen
    Cancer Institute, Tumor Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China
    Zhonghua Zhong Liu Za Zhi 23:122-4. 2001
    ..While DNA repair decreases SarCNU's activity by repairing damaged DNA, EMT appears to enhance its antitumor efficacy...
  46. ncbi [Molecular cloning and sequencing of outer capsid protein gene of rice dwarf virus and its expression in Escherichia coli]
    R Lu
    National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871
    Wei Sheng Wu Xue Bao 39:305-14. 1999
    ..RDV S2 partial and full-length sequences were then cloned into expression vector pET-11d & pTrcHisC. SDS-PAGE and Western blot proved that amino- and carborn-termini of P2 were successfully expressed in E. coli...
  47. ncbi Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells
    X Cai
    National Key Laboratory for Medicinal Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, People s Republic of China
    Leukemia 17:1333-7. 2003
    ..In conclusion, our results strongly support that there is a tight link between As(2)O(3)-induced apoptosis and mitotic arrest, the latter being one of common mechanisms for As(2)O(3)-induced apoptosis in cancer cells...
  48. ncbi Cloning and characterization of murine endothelial constitutive nitric oxide synthase
    K Gnanapandithen
    Department of Medicine, St Michael s Hospital, University of Toronto, Canada
    Biochim Biophys Acta 1308:103-6. 1996
    ..DNA sequence analysis indicates a 1202 amino acid protein showing significant sequence identity with human as well as bovine ecNOS...
  49. pmc A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist
    W Xu
    ZymoGenetics Inc, Seattle, WA 98102, USA
    Proc Natl Acad Sci U S A 98:9511-6. 2001
    ..Because IL-22 induces the expression of acute phase reactants, IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses...
  50. ncbi Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19403, USA
    J Biol Chem 275:15254-64. 2000
    ..These results indicate that HDAC8 is a novel member of the histone deacetylase family, which may play a role in the development of a broad range of tissues and potentially in the etiology of cancer...
  51. ncbi Molecular cloning, sequencing, functional analysis and expression in E. coli of major core protein gene (S3) of rice dwarf virus Chinese isolate
    F Zhang
    National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, P R of China
    Acta Virol 41:161-8. 1997
    ..The full length cDNA sequence failed to be expressed in E. coli, but the partial sequence was successfully expressed there as confirmed by the Western blot analysis. Further analysis of RDV P3 is under way...
  52. ncbi Cloning and characterization of the murine homologue of the rat/human MRC OX-2 gene
    Z Chen
    The Toronto Hospital, Dept Surgery, University of Toronto, Ontario, Canada
    Biochim Biophys Acta 1362:6-10. 1997
    ..Several clones were identified which, on DNA sequence analysis, predicted a 218 amino acid protein showing significant homology with the rat and human MRC OX-2 gene product...
  53. ncbi Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family
    H Wang
    Department of Molecular Biology, Max Planck Institute für Biochemie, Germany
    Oncogene 12:2555-62. 1996
    ..A potential role of PCP-2 in cell-cell recognition and adhesion is supported by its co-localization with cell adhesion molecules, such as catenin and E-cadherin, at sites of cell-cell contact...
  54. ncbi Treatment of acute promyelocytic leukemia with arsenic compounds: in vitro and in vivo studies
    Z Chen
    Shanghai Institute of Hematology, Rui Jin Hospital, People's Republic of China
    Semin Hematol 38:26-36. 2001
    ....
  55. ncbi Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)
    P Goyette
    Department of Human Genetics, McGill University Health Center, Montreal, Quebec, Canada H3H 1P3
    Mamm Genome 9:652-6. 1998
    ..The mouse genomic clones will be helpful in designing constructs for gene targeting and generation of mouse models for MTHFR deficiency...
  56. pmc Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing
    J Kim
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 95:12364-9. 1998
    ..Thus, certain biochemical properties, although not the specificity of the tissue in which the gene is expressed, have been conserved through the evolution of the Gcm gene family...
  57. ncbi Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle
    Z Chen
    St Vincent s Institute of Medical Research, St Vincent s Hospital, 41 Victoria Parade, Fitzroy, Vic, Australia
    FEBS Lett 460:343-8. 1999
    ..Sequence analysis revealed that glycogen synthase, a known AMPK substrate, co-immunoprecipitated with the AMPK alpha2beta2gamma1 complex...
  58. ncbi Genomic organization and promoter characterization of the rat cyclin B1 gene
    J H Trembley
    Department of Medicine, University of Minnesota Medical School, Box 36 UMHC, 420 Delaware St S E, 55455, Minneapolis, MN, USA
    Gene 255:93-104. 2000
    ..Our results suggest that an E-Box and/or CCAAT binding sites are important for transcription, and that there may be negative regulatory elements present between 1800 and 1100bp upstream of the translation start site...
  59. ncbi Murine lymphotactin: gene structure, post-translational modification and inhibition of expression by CD28 costimulation
    D Hautamaa
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455, USA
    Cytokine 9:375-82. 1997
    ....
  60. ncbi Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein
    Y Xin
    State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, 200433, People s Republic of China
    Genomics 74:408-13. 2001
    ..Sequence comparison of the cDNAs and their corresponding genomic sequences shows that GABARAP, GABARAPL1, and GABARAPL2 are composed of four exons each, while GABARAPL3 is distributed only at one exon...
  61. ncbi Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2)
    B Vulevic
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cancer Res 61:3339-47. 2001
    ..Furthermore, the presence of a lipocalin signature motif in the ABCA2 sequence suggests a possible broad role for this protein in the transport of steroids, lipids, and related molecules...
  62. ncbi Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage
    Y Shen
    Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, PR China
    Leukemia 15:735-41. 2001
    ..2865 and 0.7146, respectively). In conclusion, we demonstrated that low-dose As2O3 had the same effect as the conventional dosage and the mechanism of low-dose arsenic seemed to primarily induce differentiation of APL cells...
  63. ncbi Expression of Rap1GAP in human myeloid disease following microarray selection
    X Qi
    Leukemia Research Division, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, First Affiliated Hospital, Soochow University, Suzhou, China
    Genet Mol Res 7:379-87. 2008
    ..01). We propose that over-expression of RAP1GAP gene may play a role in the pathogenesis of MDS...
  64. ncbi Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed
    K A Brayton
    Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907
    J Biol Chem 269:5313-21. 1994
    ..Expression of a luciferase reporter from the GPAT promoter was approximately 3-4-fold higher than from the AIRC promoter. The GPAT gene was mapped to the q12 region of chromosome 4...
  65. ncbi Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain
    Z Chen
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9041, USA
    J Biol Chem 274:28803-7. 1999
    ..These results suggest that TAO proteins lie in stress-sensitive kinase cascades and define a mechanism by which these kinases may organize downstream targets...
  66. ncbi Glutamine stimulates translation of uncoupling protein 2mRNA
    C Hurtaud
    BIOTRAM UPR9078, CNRS, Universite Paris Descartes, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, 75730 Paris, France
    Cell Mol Life Sci 64:1853-60. 2007
    ....
  67. ncbi Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice
    Z Chen
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genes Dev 8:2293-301. 1994
    ..Although transcription of a number of muscle-specific genes believed to be TEF-1 targets appears normal, the defect in cardiogenesis is likely attributable to diminished transcription of one or several cardiac-specific genes...
  68. ncbi Sequence of the genome of lactate dehydrogenase-elevating virus: heterogenicity between strains P and C
    G A Palmer
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455, USA
    Virology 209:637-42. 1995
    ..All functional motifs of the ORF 1a and ORF 1b proteins were conserved. The ORF 1a protein possesses 11 potential transmembrane segments that flank the serine protease domain...
  69. ncbi JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia
    E Duprez
    Institut National de la Sante et de la Recherche Medical, INSERM U301, Centre G, Hayem, Hopital Saint Louis, Paris, France
    Oncogene 14:1563-70. 1997
    ..We hypothesise that this novel nuclear factor may act as a transcription factor, or a coregulator, involved in either cell growth control and/or maturation...
  70. ncbi Genes differentially expressed with malignant transformation and metastatic tumor progression of murine squamous cell carcinoma
    G Dong
    Tumor Biology Section, Head and Neck Surgery Branch, NIDCD NIH, Bethesda, Maryland 20892 1419, USA
    J Cell Biochem Suppl 28:90-100. 1997
    ....
  71. ncbi Brain capillary endothelial cells express MBEC1, a protein that is related to the Clostridium perfringens enterotoxin receptors
    Z Chen
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Lab Invest 78:353-63. 1998
    ..Our research thus provides a new molecule for further study of the function of normal and abnormal blood-brain barrier as well as of other specialized endothelia and epithelia...
  72. pmc PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors
    Z Chen
    Shanghai Institute of Hematology, Samuel Waxman Cancer Research Foundation Laboratory of Shanghai Second Medical University, Rui Jin Hospital, China
    Proc Natl Acad Sci U S A 91:1178-82. 1994
    ..These abnormal transactivation properties observed in retinoic acid-sensitive myeloid cells strongly implicate the PLZF-RAR alpha fusion proteins in the molecular pathogenesis of APL...
  73. ncbi Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development
    M Fuchs
    Department of Molecular Biology, Max Planck Institut fur Biochemie, Martinsried, Germany
    Mech Dev 70:91-109. 1998
    ..Based on our results and previous reports we discuss MAM-PTPases as a new class of morphoregulatory molecules...
  74. ncbi A chloroplast DNA deletion located in RNA polymerase gene rpoC2 in CMS lines of sorghum
    Z Chen
    Department of Soil and Crop Sciences, Texas A and M University, College Station 77843 2474
    Mol Gen Genet 236:251-9. 1993
    ..Further studies designed to determine whether or not the deletion is involved in CMS of sorghum are underway...
  75. ncbi Telomerase activity in Kaposi's sarcoma, squamous cell carcinoma, and basal cell carcinoma
    Z Chen
    American Registry of Pathology, Washington, District of Columbia 20306, USA
    Exp Biol Med (Maywood) 226:753-7. 2001
    ..All KS as well as two other skin carcinoma samples revealed positive telomerase activity. Our finding supports telomerase's role in tumor cell immortality and suggests the true neoplastic nature of KS...
  76. pmc Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation
    S J Chen
    Unité INSERM U 301 and SDI CNRS no 159541, CNRS, Hopital Saint Louis, Paris, France
    Nucleic Acids Res 17:7631-42. 1989
    ..In the second leukemia, the breakpoints are not located in Alu sequences, but such repeats are found in their vicinity. The implications of these findings are discussed...
  77. ncbi Hornerin gene was involved in a case of acute myeloid leukemia transformed from myelodysplastic syndrome with t(1;2)(q21;q37)
    L Wang
    Leukemia 20:2184-7. 2006
  78. ncbi Feasibility and clinical significance of real-time quantitative RT-PCR assay of PML-RARalpha fusion transcript in patients with acute promyelocytic leukemia
    B W Gu
    Shanghai Institute of Hematology, Key Laboratory of Human Genome Research, Ministry of Public Health and Shanghai Municipality, Rui-Jin Hospital, Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, P.R. China
    Hematol J 2:330-40. 2001
    ....
  79. ncbi Treatment of acute promyelocytic leukemia with arsenic trioxide: clinical and basic studies
    W L Zhao
    Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Second Medical University, People's Republic of China
    Leuk Lymphoma 42:1265-73. 2001
    ..Importantly, at both concentrations, As2O3 can degrade PML (promyelocytic leukemia) -RAR alpha (retinoic acid receptor), an oncoprotein that has a central role in leukemogenesis...
  80. ncbi [In vitro effect of lovastatin on NB4 promyelocytic leukemia cells]
    F Guo
    First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, China
    Zhonghua Xue Ye Xue Za Zhi 22:584-8. 2001
    ..Inhibition of p21Ras protein isoprenylation is considered to be the major mechanism of LOV affecting NB4 cells...
  81. ncbi [Cloning of liver cancer-related gene HCCA2 and association of that gene with liver cancer]
    Z Wang
    International Co-operation Lab on Cellular Signal Transduction, The East Hospital of Hepatobiliary Surgery, The Second Military Medical University, Shanghai 200438, China
    Zhonghua Yi Xue Za Zhi 81:332-5. 2001
    ..Its expression was associated with the completeness of the tumor envelop and the expression of KI-67 PROTEIN (P < 0.01). CONCLUSION: The novel gene HCCA2 may be related with the infiltration and proliferation of liver cancer...
  82. ncbi Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    J B Sunwoo
    Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 7:1419-28. 2001
    ..We conclude that PS-341 inhibits activation of NF-kappa B pathway components related to cell survival, tumor growth, and angiogenesis in SCC...
  83. ncbi A bicistronic retroviral vector to introduce drug resistance genes into human umbilical cord blood CD34+ cells to improve combination chemotherapy tolerance
    J Wang
    Jiangsu Institute of Hematology, First Affiliated Hospital of Suzhou Medical College, Suzhou 215006, China
    Chin Med J (Engl) 114:25-9. 2001
    ....
  84. ncbi Expression of protease-activated receptor 1 in oral squamous cell carcinoma
    Y Liu
    Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Box 441, 77030, Houston, TX, USA
    Cancer Lett 169:173-80. 2001
    ..Thrombin and TRP also induced matrix metalloproteinase (MMP)-2 and MMP-9 activities in metastatic cells. These results suggest that PAR-1 may contribute to the growth and invasive potential of oral SCC...
  85. pmc Positional cloning of the mouse saccharin preference (Sac) locus
    A A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 26:925-33. 2001
    ..This study provides compelling evidence that Tas1r3 is equivalent to the Sac locus and that the T1R3 receptor responds to sweeteners...
  86. ncbi Estrogen receptor alpha mediated induction of the transforming growth factor alpha gene by estradiol and 4-hydroxytamoxifen in MDA-MB-231 breast cancer cells
    J MacGregor Schafer
    Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Olson Pavilion 8258, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Steroid Biochem Mol Biol 78:41-50. 2001
    ..We conclude that both E(2) and 4-OHT induce TGF alpha by direct interaction of ER alpha with DNA and that ER beta is not involved in the estrogen-like response to 4-OHT in the MDA-MB-231 cells...
  87. ncbi Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2
    Z Chen
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    J Biol Chem 276:16070-5. 2001
    ..Activation of endogenous TAO2 during differentiation of C2C12 myoblasts paralleled activation of p38 but not JNK/SAPK, consistent with the idea that TAO2 is a physiological regulator of p38 under certain circumstances...
  88. ncbi [Study on the chemosensitivity test of human gastric cancer using the MTT assay]
    Z Chen
    Department of General Surgery, First Affiliated Hospital, WCUMS, Chengdu 610041, China
    Hua Xi Yi Ke Da Xue Xue Bao 32:134-5. 2001
    ..On the other hand, the sensitivity was relative to pathology and individual differences. CONCLUSION: The MTT assay is an accurate system for determination of the chemosensitivity of tumor cells...
  89. ncbi Calcium increases apolipoprotein B mRNA editing
    Z Chen
    National Heart, Lung and Blood Institute, Bethesda, Maryland, 20892, USA
    Biochem Biophys Res Commun 277:221-7. 2000
    ..The editing increase by extracellular calcium is not related to alterations of APOBEC-1 mRNA expression. These data suggest that calcium is not only involved in the regulation of apolipoprotein metabolism but also apoB mRNA editing...
  90. ncbi Positional cloning of a cyromazine resistance gene in Drosophila melanogaster
    Z Chen
    Centre for Environmental Stress and Adaptation Research, Department of Genetics, The University of Melbourne, VIC 3010, Australia
    Insect Mol Biol 15:181-6. 2006
    ..In mammals Smg1 phosphorylates P53 in response to DNA damage. This finding supports the hypothesis that cyromazine interferes with nucleic acid metabolism...
  91. ncbi Genomic organization of the JEM-1 (BLZF1) gene on human chromosome 1q24: molecular cloning and analysis of its promoter region
    J H Tong
    Centre G Hayem, I N S E R M U 496, Hopital Saint Louis, 1, avenue Claude Vellefaux, Paris, 75010, France
    Genomics 69:380-90. 2000
    ..Thus, the maximal constitutive promoter activity was assigned to a -432 + 101 region overlapping the TSS. These data support the idea of a constitutive expression of JEM-1, but a negative regulation in APL released by retinoids...
  92. ncbi Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant gamma2 subunit of 5'-AMP-activated protein kinase, to human chromosome 7q36
    T Lang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 220 Handan Road, Shanghai, 200433, People s Republic of China
    Genomics 70:258-63. 2000
    ..The genomic organization of PRKAG2-b was identified by comparing its cDNA sequence with two genomic sequences AC006358 and AC006966, which showed that PRKAG2-b spanned an approximately 80-kb region and was composed of 12 exons...
  93. ncbi Rapid isolation of tissue-specific genes from rat kidney
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Exp Nephrol 9:156-64. 2001
    ..Our results suggested that tissue-specific genes can be rapidly isolated and characterized using PCR-select techniques and this methodology may be generally applicable to isolate specific genes from a variety of tissues...
  94. ncbi Human versus chimpanzee chromosome-wide sequence comparison and its evolutionary implication
    Y Sakaki
    RIKEN, Genomic Sciences Center, Yokohama 230 0045, Japan
    Cold Spring Harb Symp Quant Biol 68:455-60. 2003
  95. ncbi DNA sequence and comparative analysis of chimpanzee chromosome 22
    H Watanabe
    RIKEN, Genomic Sciences Center, Yokohama 230 0045, Japan
    Nature 429:382-8. 2004
    ..The genomic changes after speciation and their biological consequences seem more complex than originally hypothesized...
  96. ncbi A genetic analysis of neural progenitor differentiation
    D H Geschwind
    Neurogenetics Program, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neuron 29:325-39. 2001
    ..This combination of methods demonstrates the power of using custom microarrays derived from RDA-subtracted libraries for both gene discovery and gene expression analysis in the central nervous system...
  97. ncbi Ser(13)-phosphorylated PYY from porcine intestine with a potent biological activity
    Z Chen
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    FEBS Lett 492:119-22. 2001
    ..5 nM compared to 0.15 nM for non-phosphorylated PYY. The finding of phosphorylation of PYY is unusual among hormonal peptides, and emphasizes the importance of direct protein analysis of gene products...
  98. ncbi Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells
    Z Chen
    Saskatoon Cancer Center, Saskatoon, Saskatchewan, Canada
    Int J Cancer 93:539-48. 2001
    ..Therefore, DCs that had phagocytosed apoptotic/necrotic tumor cells appear to offer new strategies in DC cancer vaccines...