Research Topics
Genomes and Genes
| Yan ChenSummaryAffiliation: Shanghai Institutes for Biological Sciences Country: China Publications
| Collaborators
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Detail Information
Publications
PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatusXiao Wang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
Diabetes 62:444-56. 2013..Thus, PAQR3 negatively regulates insulin signaling by shunting cytosolic p110α to the Golgi apparatus while competing with p85 subunit in forming a PI3K complex with p110α...- Research advances at the Institute for Nutritional Sciences at Shanghai, ChinaYan Chen
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Adv Nutr 2:428-39. 2011..This review highlights the major research endeavors undertaken by INS scientists in recent years... - Unraveling the biological functions of Smad7 with mouse modelsLu Zhu
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Cell Biosci 1:44. 2011.... - Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesisXiaolin Luo
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
Diabetes 60:1435-45. 2011..This study determines the molecular mechanism underlying the coupling of hepatic glycogenesis with the fasting-feeding cycle... - PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatusTing Jin
Key Laboratory of Nutrition and Metabolism, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Cell Res 22:661-76. 2012..Furthermore, differentiation of PC12 cells is significantly enhanced by overexpression of PAQR10/PAQR11. Collectively, this study uncovers a new paradigm of spatial regulation of Ras signaling in the Golgi apparatus by PAQR10 and PAQR11... - Regulation of G-protein signaling by RKTG via sequestration of the G betagamma subunit to the Golgi apparatusYuhui Jiang
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Rd, Shanghai 200031, China
Mol Cell Biol 30:78-90. 2010..Taken together, our results reveal that RKTG can modulate GPCR signaling through sequestering G betagamma to the Golgi apparatus and thereby attenuating the functions of G betagamma... 
Progesterone and adipoQ receptor 11 links ras signaling to cardiac development in zebrafishHeng Huang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
Arterioscler Thromb Vasc Biol 32:2158-70. 2012..The aim of this study was to investigate the physiological functions of PAQR10 and PAQR11...- Identification of the topology and functional domains of PAQR10Ting Jin
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
Biochem J 443:643-53. 2012..Collectively, the results of the present study indicate that Golgi localization is indispensable for PAQR10 to implement its regulatory functions in the Ras signalling cascade... - Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor-β signaling pathwayLu Zhu
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
J Biol Chem 287:39653-63. 2012..Collectively, our studies reveal that Tollip cooperates with Smad7 to modulate intracellular trafficking and degradation of ubiquitinated TβRI, whereby negatively regulates TGF-β signaling pathway... - Characterization of the topology and functional domains of RKTGXiaolin Luo
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
Biochem J 414:399-406. 2008.... - Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injuryLu Zhu
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
PLoS ONE 6:e17415. 2011..Smad7 is an intracellular negative regulator of TGF-β signaling. It is currently unclear whether endogenous Smad7 has an effect on liver function and alcoholic liver damage... - PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancersXiao Wang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai China
Carcinogenesis 33:2228-35. 2012..Collectively, our data reveal for the first time that PAQR3 has a tumor suppressor activity in the development of colorectal cancers... - High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin 22Zheng Wang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
PLoS ONE 6:e23737. 2011..Taken together, our study not only established a novel mouse model with spontaneous liposarcoma, but also revealed that IL-22 overexpression may collaborate with diet-induced obesity to impact on tumor development in mouse... - A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cellsYifu Qiu
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Sci Signal 3:ra7. 2010..Thus, our findings demonstrate that RACK1 functions as a key component in regulating the IRE1alpha signaling pathway in pancreatic beta cells... - A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptorsYongliang Zhang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
J Biol Chem 287:37973-85. 2012..Importantly, PIAS1 impaired LXRβ binding to its target DNA sequence. Taken together, our results suggest that PIAS1 may serve as a lipogenic regulator by negatively modulating LXRs in a SUMOylation-independent manner... - Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transitionYuhui Jiang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
Cancer Res 71:2959-68. 2011.... - Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fatXiangbo Ruan
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
J Cell Mol Med 15:763-72. 2011..Taken together, our results reveal that ApoA-I has an anti-obesity effect in the mouse and such effect is associated with increases in energy expenditure and UCP1 expression in the brown fat tissue... - Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22Ling Yang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
J Hepatol 53:339-47. 2010..However, it is currently unknown whether IL-22 has an effect on lipid metabolism in the liver... - A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy ChineseLiang Sun
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
Diabetes Care 33:1925-32. 2010..We aimed to investigate the association between plasma LBP and metabolic disorders in apparently healthy Chinese... - Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouseXiaoduo Xie
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Carcinogenesis 29:1632-8. 2008..Collectively, our results indicate that RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin... - RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cellsFengjuan Fan
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Carcinogenesis 29:1157-63. 2008..Collectively, our results suggest that RKTG may play a suppressive role in human melanoma that harbors an oncogenic B-Raf mutation via its antagonistic action on B-Raf... - Characterization of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Shanghai, China: molecular and cytogenetic characteristics, IgV gene restriction and hypermutation patternsRichard D Irons
Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
Leuk Res 33:1599-603. 2009..IgV(H) gene mutation status was a significant predictor of initial survival in CLL/SLL. However, an influence of karyotype on prognosis was not observed... - Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individualsLing Lu
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
Diabetes Care 32:1278-83. 2009..To evaluate the association between 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome in the Chinese population... - Integrating WHO 2001-2008 criteria for the diagnosis of Myelodysplastic Syndrome (MDS): a case-case analysis of benzene exposureRichard D Irons
Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
Chem Biol Interact 184:30-8. 2010.... - β-Arrestin 1 modulates functions of autoimmune T cells from primary biliary cirrhosis patientsZhide Hu
Department of Laboratory Diagnostic, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China
J Clin Immunol 31:346-55. 2011..Arrestins (βarr) are multifunctional signaling molecules that are crucial to T cell survival. We hypothesized that βarr plays a critical regulatory function in the autoreactive T cells of PBC patients... - In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouseXiaolin Luo
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China
PLoS ONE 5:e10149. 2010..Furthermore, the in vivo TGF-beta function specifically in the airway epithelium during lung cancer development has been largely elusive... - The RAS guanyl nucleotide-releasing protein RasGRP1 is involved in lymphatic development in zebrafishHeng Huang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China
J Biol Chem 288:2355-64. 2013..Taken together, this finding demonstrates a critical role for RasGRP1 in lymphatic development in zebrafish... - Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese populationWei Gan
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
PLoS ONE 7:e42010. 2012..259). In conclusion, our results suggest that genetic variations in CFH and its related genes may contribute to hypertension risk in Chinese Hans... - A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, ChinaSherilyn A Gross
Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, 130 Dong an Road, 200032, Shanghai, China
Int J Hematol 88:165-73. 2008..Precursor T lymphoblastic leukemia/lymphoma, anaplastic large T cell lymphoma, aggressive NK cell leukemia, angioimmunoblastic T cell lymphoma and peripheral T cell lymphoma were prominent subtypes of T cell NHL... - A Case-Control Study of Chronic Myelomonocytic Leukemia (CMML) in Shanghai, China: Evaluation of Risk Factors for CMML, With Special Focus on BenzeneSherilyn A Gross
a Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
Arch Environ Occup Health 67:206-18. 2012..These results do not support an increased risk for developing CMML associated with historical exposures to benzene... - Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein elementXiaolan Sun
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
FEBS Lett 582:3401-7. 2008..Insulin treatment could induce formation of a protein complex that bound the NIP element. Collectively, our data suggest that a repressive NIP element is involved in the negative regulation of AdipoR1 promoter by insulin... - Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulationLing Yang
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, China
Eur J Hum Genet 16:759-61. 2008..06), indicating that the C/C genotype may contribute to obesity in certain subpopulation among Chinese under certain environmental settings... - Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetesTing Lu
Department of Endocrinology, Xuhui District Central Hospital, Shanghai, China
Nutr Res 32:408-12. 2012..In conclusion, our study indicates that cinnamon supplementation is able to significantly improve blood glucose control in Chinese patients with type 2 diabetes... - A novel method for detection of mutation in epidermal growth factor receptorJinyin Zhao
Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
Lung Cancer 74:226-32. 2011.... - Protection of cerulein-induced pancreatic fibrosis by pancreas-specific expression of Smad7Jing He
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
Biochim Biophys Acta 1792:56-60. 2009..Taken together, these data indicate that inhibition of TGF-beta signaling by Smad7 is able to protect cerulein-induced pancreatic fibrosis in vivo... - Using HSV-TK/GCV suicide gene therapy to inhibit lens epithelial cell proliferation for treatment of posterior capsular opacificationYong Xiang Jiang
Department of Ophthalmology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, China
Mol Vis 17:291-9. 2011.... - Resistance to activation-induced cell death and elevated FLIPL expression of CD4+ T cells in a polyI:C-induced primary biliary cirrhosis mouse modelTingwang Jiang
Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China
Clin Exp Med 9:269-76. 2009..The inhibition of FasL and TRAIL expression may also help enhance this anti-apoptotic ability in CD4+ T lymphocytes and contribute to the aggravation of portal area inflammation... - Associations of inflammatory factors with glycaemic status among middle-aged and older Chinese peopleXingwang Ye
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
Clin Endocrinol (Oxf) 70:854-62. 2009..Low-grade chronic inflammation is associated with risk for type 2 diabetes. We investigated the associations between inflammatory factors and glycaemic status in a middle-aged and older Chinese population... - Endocytosis of adiponectin receptor 1 through a clathrin- and Rab5-dependent pathwayQiurong Ding
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, China
Cell Res 19:317-27. 2009..These data indicate that AdipoR1 is internalized through a clathrin- and Rab5-dependent pathway and that endocytosis may play a role in the regulation of adiponectin signaling... - An automated microfluidic device for assessment of mammalian cell genetic stabilityYan Chen
Department of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China
Lab Chip 12:3930-5. 2012..The result demonstrates that this platform has the potential for assessment of genetic stability in cancer diagnosis... 
Catalase potentiates retinoic acid-induced THP-1 monocyte differentiation into macrophage through inhibition of peroxisome proliferator-activated receptor gammaQiurong Ding
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences, 294 Tai Yuan Rd, Shanghai 200031, China
J Leukoc Biol 81:1568-76. 2007..Therefore, these data indicate that catalase is able to potentiate ATRA-induced macrophage differentiation by inhibition of PPARgamma activity, underscoring an important interplay between H(2)O(2), RA, and PPARgamma in macrophages...- Diffuse large B-cell lymphoma in Chinese patients: immunophenotypic and cytogenetic analyses of 124 casesYan Chen
Department of Pathology, Shanghai Cancer Hospital and Institute, Fudan University School of Medicine, Shanghai, China
Am J Clin Pathol 133:305-13. 2010..More interestingly, BCL2 expression was associated with gain of chromosome 3/3q in Chinese DLBCL cases, whereas this association was less significant in Western cases... - alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataractYan Chen
Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
Curr Eye Res 35:620-30. 2010..To evaluate whether alpha-lipoic acid (LA) inhibits lens opacity of naphthalene-induced cataract by altering post-translational modifications (PTMs) and protecting the chaperone activity of alpha-crystallins... - Spatial regulation of Raf kinase signaling by RKTGLin Feng
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
Proc Natl Acad Sci U S A 104:14348-53. 2007..Collectively, our results reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway... - Ocular delivery of cyclosporine A based on glyceryl monooleate/poloxamer 407 liquid crystalline nanoparticles: preparation, characterization, in vitro corneal penetration and ocular irritationYan Chen
Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai, China
J Drug Target 20:856-63. 2012..Liquid crystalline nanoparticles exhibited excellent ocular tolerance in the ocular irritation test. This low-irritant vehicle based on liquid crystalline nanoparticles might be a promising system for effective ocular CsA delivery... - A novel mutation in the MITF may be digenic with GJB2 mutations in a large Chinese family of Waardenburg syndrome type IIXukun Yan
Department of Otolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai 200031, China
J Genet Genomics 38:585-91. 2011..Thus, a novel compound heterozygous mutation, c.[742_743delAAinsT;746_747delCA] in MITF exon 8 was the key genetic reason for WS2 in this family, and a digenic effect of MITF and GJB2 genes may contribute to deafness of the proband... - [Comparison of characteristics of heavy metals in different grain sizes of intertidalite sediment by using grid sampling method]Tao Liang
Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China
Huan Jing Ke Xue 29:421-7. 2008..Concentration of Sr is affected significantly by the grain size, while concentration of Cr and Ti are affected a little by the grain size... - Adult precursor B lymphoblastic leukemia in Shanghai, China: characterization of phenotype, cytogenetics and outcome for 137 consecutive casesLiming Bao
Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
Int J Hematol 89:431-7. 2009..These findings suggest significant geographic heterogeneity in precursor B-cell ALL which may be of both etiological and therapeutic significance...