Yan Chen

Summary

Affiliation: Shanghai Institutes for Biological Sciences
Country: China

Publications

  1. pmc PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus
    Xiao Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 62:444-56. 2013
  2. pmc Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population
    Wei Gan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e42010. 2012
  3. pmc High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin 22
    Zheng Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e23737. 2011
  4. pmc Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis
    Xiaolin Luo
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 60:1435-45. 2011
  5. pmc Critical roles of p53 in epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma cells
    Zheng Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 8:e72846. 2013
  6. pmc Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury
    Lu Zhu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e17415. 2011
  7. doi request reprint PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling
    Lingdi Wang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
    Endocrinology 154:4525-35. 2013
  8. pmc Research advances at the Institute for Nutritional Sciences at Shanghai, China
    Yan Chen
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Adv Nutr 2:428-39. 2011
  9. pmc Unraveling the biological functions of Smad7 with mouse models
    Lu Zhu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    Cell Biosci 1:44. 2011
  10. pmc PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus
    Ting Jin
    Key Laboratory of Nutrition and Metabolism, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    Cell Res 22:661-76. 2012

Collaborators

Detail Information

Publications64

  1. pmc PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus
    Xiao Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 62:444-56. 2013
    ..Thus, PAQR3 negatively regulates insulin signaling by shunting cytosolic p110α to the Golgi apparatus while competing with p85 subunit in forming a PI3K complex with p110α...
  2. pmc Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population
    Wei Gan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e42010. 2012
    ..259). In conclusion, our results suggest that genetic variations in CFH and its related genes may contribute to hypertension risk in Chinese Hans...
  3. pmc High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin 22
    Zheng Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e23737. 2011
    ..Taken together, our study not only established a novel mouse model with spontaneous liposarcoma, but also revealed that IL-22 overexpression may collaborate with diet-induced obesity to impact on tumor development in mouse...
  4. pmc Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis
    Xiaolin Luo
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 60:1435-45. 2011
    ..This study determines the molecular mechanism underlying the coupling of hepatic glycogenesis with the fasting-feeding cycle...
  5. pmc Critical roles of p53 in epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma cells
    Zheng Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 8:e72846. 2013
    ..In conclusion, this study reveals that p53 plays a pivotal role in EMT and metastasis of HCC cells via its regulation on β-catenin signaling. ..
  6. pmc Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury
    Lu Zhu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e17415. 2011
    ..Smad7 is an intracellular negative regulator of TGF-β signaling. It is currently unclear whether endogenous Smad7 has an effect on liver function and alcoholic liver damage...
  7. doi request reprint PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling
    Lingdi Wang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
    Endocrinology 154:4525-35. 2013
    ..In conclusion, this study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin signaling. ..
  8. pmc Research advances at the Institute for Nutritional Sciences at Shanghai, China
    Yan Chen
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Adv Nutr 2:428-39. 2011
    ..This review highlights the major research endeavors undertaken by INS scientists in recent years...
  9. pmc Unraveling the biological functions of Smad7 with mouse models
    Lu Zhu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    Cell Biosci 1:44. 2011
    ....
  10. pmc PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus
    Ting Jin
    Key Laboratory of Nutrition and Metabolism, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    Cell Res 22:661-76. 2012
    ..Furthermore, differentiation of PC12 cells is significantly enhanced by overexpression of PAQR10/PAQR11. Collectively, this study uncovers a new paradigm of spatial regulation of Ras signaling in the Golgi apparatus by PAQR10 and PAQR11...
  11. pmc Regulation of G-protein signaling by RKTG via sequestration of the G betagamma subunit to the Golgi apparatus
    Yuhui Jiang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Rd, Shanghai 200031, China
    Mol Cell Biol 30:78-90. 2010
    ..Taken together, our results reveal that RKTG can modulate GPCR signaling through sequestering G betagamma to the Golgi apparatus and thereby attenuating the functions of G betagamma...
  12. doi request reprint Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22
    Ling Yang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Hepatol 53:339-47. 2010
    ..However, it is currently unknown whether IL-22 has an effect on lipid metabolism in the liver...
  13. doi request reprint Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat
    Xiangbo Ruan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Cell Mol Med 15:763-72. 2011
    ..Taken together, our results reveal that ApoA-I has an anti-obesity effect in the mouse and such effect is associated with increases in energy expenditure and UCP1 expression in the brown fat tissue...
  14. doi request reprint PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers
    Xiao Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai China
    Carcinogenesis 33:2228-35. 2012
    ..Collectively, our data reveal for the first time that PAQR3 has a tumor suppressor activity in the development of colorectal cancers...
  15. doi request reprint Progesterone and adipoQ receptor 11 links ras signaling to cardiac development in zebrafish
    Heng Huang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Arterioscler Thromb Vasc Biol 32:2158-70. 2012
    ..The aim of this study was to investigate the physiological functions of PAQR10 and PAQR11...
  16. doi request reprint Identification of the topology and functional domains of PAQR10
    Ting Jin
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
    Biochem J 443:643-53. 2012
    ..Collectively, the results of the present study indicate that Golgi localization is indispensable for PAQR10 to implement its regulatory functions in the Ras signalling cascade...
  17. doi request reprint RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells
    Fengjuan Fan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 29:1157-63. 2008
    ..Collectively, our results suggest that RKTG may play a suppressive role in human melanoma that harbors an oncogenic B-Raf mutation via its antagonistic action on B-Raf...
  18. pmc A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells
    Yifu Qiu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Sci Signal 3:ra7. 2010
    ..Thus, our findings demonstrate that RACK1 functions as a key component in regulating the IRE1alpha signaling pathway in pancreatic beta cells...
  19. pmc A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors
    Yongliang Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 287:37973-85. 2012
    ..Importantly, PIAS1 impaired LXRβ binding to its target DNA sequence. Taken together, our results suggest that PIAS1 may serve as a lipogenic regulator by negatively modulating LXRs in a SUMOylation-independent manner...
  20. pmc Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor-β signaling pathway
    Lu Zhu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 287:39653-63. 2012
    ..Collectively, our studies reveal that Tollip cooperates with Smad7 to modulate intracellular trafficking and degradation of ubiquitinated TβRI, whereby negatively regulates TGF-β signaling pathway...
  21. pmc A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese
    Liang Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes Care 33:1925-32. 2010
    ..We aimed to investigate the association between plasma LBP and metabolic disorders in apparently healthy Chinese...
  22. ncbi request reprint Characterization of the topology and functional domains of RKTG
    Xiaolin Luo
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
    Biochem J 414:399-406. 2008
    ....
  23. pmc The RAS guanyl nucleotide-releasing protein RasGRP1 is involved in lymphatic development in zebrafish
    Heng Huang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 288:2355-64. 2013
    ..Taken together, this finding demonstrates a critical role for RasGRP1 in lymphatic development in zebrafish...
  24. doi request reprint Association of PPP1R3B polymorphisms with blood lipid and C-reactive protein levels in a Chinese population (PPP1R3B C )
    Yongxian Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Diabetes 5:275-81. 2013
    ..The aim of the present study was to investigate whether the PPP1R3B variants are associated with plasma levels of lipids and inflammation factors in Chinese Han...
  25. doi request reprint Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition
    Yuhui Jiang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Cancer Res 71:2959-68. 2011
    ....
  26. ncbi request reprint Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse
    Xiaoduo Xie
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 29:1632-8. 2008
    ..Collectively, our results indicate that RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin...
  27. pmc Spatial regulation of Raf kinase signaling by RKTG
    Lin Feng
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 104:14348-53. 2007
    ..Collectively, our results reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway...
  28. doi request reprint Regulation of glucose homeostasis and lipid metabolism by PPP1R3G-mediated hepatic glycogenesis
    Yongxian Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Mol Endocrinol 28:116-26. 2014
    ..Cumulatively, these data indicate that PPP1R3G plays a critical role in postprandial glucose homeostasis and liver triglyceride metabolism via its regulation on hepatic glycogenesis. ..
  29. pmc Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse
    Rui Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 288:10275-85. 2013
    ..In addition, our data indicate that alterations in the signaling of BMP, TGF-β, and SHH likely underlie the defects in eye development caused by Smad7 deletion...
  30. doi request reprint Acute myeloid leukemia following exposure to benzene more closely resembles de novo than therapy related-disease
    Richard D Irons
    Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China
    Genes Chromosomes Cancer 52:887-94. 2013
    ..These findings are important for further understanding the biological basis of AML, particularly in environmental and occupational settings...
  31. pmc Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals
    Ling Lu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes Care 32:1278-83. 2009
    ..To evaluate the association between 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome in the Chinese population...
  32. doi request reprint Characterization of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Shanghai, China: molecular and cytogenetic characteristics, IgV gene restriction and hypermutation patterns
    Richard D Irons
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Leuk Res 33:1599-603. 2009
    ..IgV(H) gene mutation status was a significant predictor of initial survival in CLL/SLL. However, an influence of karyotype on prognosis was not observed...
  33. pmc In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse
    Xiaolin Luo
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 5:e10149. 2010
    ..Furthermore, the in vivo TGF-beta function specifically in the airway epithelium during lung cancer development has been largely elusive...
  34. doi request reprint Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element
    Xiaolan Sun
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
    FEBS Lett 582:3401-7. 2008
    ..Insulin treatment could induce formation of a protein complex that bound the NIP element. Collectively, our data suggest that a repressive NIP element is involved in the negative regulation of AdipoR1 promoter by insulin...
  35. doi request reprint Integrating WHO 2001-2008 criteria for the diagnosis of Myelodysplastic Syndrome (MDS): a case-case analysis of benzene exposure
    Richard D Irons
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Chem Biol Interact 184:30-8. 2010
    ....
  36. doi request reprint β-Arrestin 1 modulates functions of autoimmune T cells from primary biliary cirrhosis patients
    Zhide Hu
    Department of Laboratory Diagnostic, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China
    J Clin Immunol 31:346-55. 2011
    ..Arrestins (βarr) are multifunctional signaling molecules that are crucial to T cell survival. We hypothesized that βarr plays a critical regulatory function in the autoreactive T cells of PBC patients...
  37. doi request reprint Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation
    Ling Yang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, China
    Eur J Hum Genet 16:759-61. 2008
    ..06), indicating that the C/C genotype may contribute to obesity in certain subpopulation among Chinese under certain environmental settings...
  38. doi request reprint Protection of cerulein-induced pancreatic fibrosis by pancreas-specific expression of Smad7
    Jing He
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
    Biochim Biophys Acta 1792:56-60. 2009
    ..Taken together, these data indicate that inhibition of TGF-beta signaling by Smad7 is able to protect cerulein-induced pancreatic fibrosis in vivo...
  39. doi request reprint A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China
    Sherilyn A Gross
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, 130 Dong an Road, 200032, Shanghai, China
    Int J Hematol 88:165-73. 2008
    ..Precursor T lymphoblastic leukemia/lymphoma, anaplastic large T cell lymphoma, aggressive NK cell leukemia, angioimmunoblastic T cell lymphoma and peripheral T cell lymphoma were prominent subtypes of T cell NHL...
  40. doi request reprint Associations of inflammatory factors with glycaemic status among middle-aged and older Chinese people
    Xingwang Ye
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Clin Endocrinol (Oxf) 70:854-62. 2009
    ..Low-grade chronic inflammation is associated with risk for type 2 diabetes. We investigated the associations between inflammatory factors and glycaemic status in a middle-aged and older Chinese population...
  41. doi request reprint Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes
    Ting Lu
    Department of Endocrinology, Xuhui District Central Hospital, Shanghai, China
    Nutr Res 32:408-12. 2012
    ..In conclusion, our study indicates that cinnamon supplementation is able to significantly improve blood glucose control in Chinese patients with type 2 diabetes...
  42. doi request reprint A case-control study of chronic myelomonocytic leukemia (CMML) in Shanghai, China: evaluation of risk factors for CMML, with special focus on benzene
    Sherilyn A Gross
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Arch Environ Occup Health 67:206-18. 2012
    ..These results do not support an increased risk for developing CMML associated with historical exposures to benzene...
  43. pmc Deficiency of adiponectin protects against ovariectomy-induced osteoporosis in mice
    Fang Wang
    Department of Medical Genetics, E Institutes of Shanghai Universities, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 8:e68497. 2013
    ....
  44. doi request reprint alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract
    Yan Chen
    Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
    Curr Eye Res 35:620-30. 2010
    ..To evaluate whether alpha-lipoic acid (LA) inhibits lens opacity of naphthalene-induced cataract by altering post-translational modifications (PTMs) and protecting the chaperone activity of alpha-crystallins...
  45. pmc Sonic hedgehog initiates cochlear hair cell regeneration through downregulation of retinoblastoma protein
    Na Lu
    Otology Skull Base Surgery Department, Hearing Research Institute, Eye and ENT Hospital of Shanghai Medical School, Fudan University, Shanghai 200031, China
    Biochem Biophys Res Commun 430:700-5. 2013
    ..This study provides an additional route to modulate pRb function with important implications in mammalian hair cell regeneration...
  46. doi request reprint A novel method for detection of mutation in epidermal growth factor receptor
    Jinyin Zhao
    Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
    Lung Cancer 74:226-32. 2011
    ....
  47. ncbi request reprint Endocytosis of adiponectin receptor 1 through a clathrin- and Rab5-dependent pathway
    Qiurong Ding
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, China
    Cell Res 19:317-27. 2009
    ..These data indicate that AdipoR1 is internalized through a clathrin- and Rab5-dependent pathway and that endocytosis may play a role in the regulation of adiponectin signaling...
  48. ncbi request reprint Catalase potentiates retinoic acid-induced THP-1 monocyte differentiation into macrophage through inhibition of peroxisome proliferator-activated receptor gamma
    Qiurong Ding
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences, 294 Tai Yuan Rd, Shanghai 200031, China
    J Leukoc Biol 81:1568-76. 2007
    ..Therefore, these data indicate that catalase is able to potentiate ATRA-induced macrophage differentiation by inhibition of PPARgamma activity, underscoring an important interplay between H(2)O(2), RA, and PPARgamma in macrophages...
  49. pmc Using HSV-TK/GCV suicide gene therapy to inhibit lens epithelial cell proliferation for treatment of posterior capsular opacification
    Yong Xiang Jiang
    Department of Ophthalmology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, China
    Mol Vis 17:291-9. 2011
    ....
  50. doi request reprint Peripheral blood transcriptome sequencing reveals rejection-relevant genes in long-term heart transplantation
    Yan Chen
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China The Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
    Int J Cardiol 168:2726-33. 2013
    ..Recent advances in the high-throughput deep sequencing (HTS) technologies provide new leads in transcriptome analysis...
  51. ncbi request reprint Resistance to activation-induced cell death and elevated FLIPL expression of CD4+ T cells in a polyI:C-induced primary biliary cirrhosis mouse model
    Tingwang Jiang
    Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China
    Clin Exp Med 9:269-76. 2009
    ..The inhibition of FasL and TRAIL expression may also help enhance this anti-apoptotic ability in CD4+ T lymphocytes and contribute to the aggravation of portal area inflammation...
  52. ncbi request reprint Red blood cell distribution width is a potential index to assess the disease activity of systemic lupus erythematosus
    Zhi De Hu
    Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai, PR China Department of Laboratory Diagnosis, Changzheng Hospital, Second Military Medical University, Shanghai, PR China Department of Laboratory Medicine, General Hospital of Ji nan Military Command Region, Ji Nan, PR China
    Clin Chim Acta 425:202-5. 2013
    ..Therefore, the objective of this study was to investigate the correlation between RDW and disease activity of systemic lupus erythematosus (SLE)...
  53. doi request reprint Maternal mosaicism is a significant contributor to discordant sex chromosomal aneuploidies associated with noninvasive prenatal testing
    Yanlin Wang
    Key Laboratory of Molecular Medicine, Ministry of Education, Shanghai Medical College, Fudan University, Shanghai, China
    Clin Chem 60:251-9. 2014
    ..We hypothesized that an altered maternal karyotype may also be an important contributor to discordant SCA NIPT results...
  54. doi request reprint Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing mad expression
    Wenwen Shi
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Neurosci 33:12352-63. 2013
    ..These results together reveal an important and previously unidentified role for Brat in synaptic development and endocytosis mediated by suppression of BMP signaling. ..
  55. pmc An automated microfluidic device for assessment of mammalian cell genetic stability
    Yan Chen
    Department of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China
    Lab Chip 12:3930-5. 2012
    ..The result demonstrates that this platform has the potential for assessment of genetic stability in cancer diagnosis...
  56. doi request reprint Diffuse large B-cell lymphoma in Chinese patients: immunophenotypic and cytogenetic analyses of 124 cases
    Yan Chen
    Department of Pathology, Shanghai Cancer Hospital and Institute, Fudan University School of Medicine, Shanghai, China
    Am J Clin Pathol 133:305-13. 2010
    ..More interestingly, BCL2 expression was associated with gain of chromosome 3/3q in Chinese DLBCL cases, whereas this association was less significant in Western cases...
  57. ncbi request reprint Transcriptomics: advances and approaches
    Zhicheng Dong
    Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China
    Sci China Life Sci 56:960-7. 2013
    ..Here, we discuss the concept, history, and especially the recent advances in this inspiring field of study. ..
  58. doi request reprint High-throughput detection of banana bunchy top virus in banana plants and aphids using real-time TaqMan(®) PCR
    Yan Chen
    Institute of Microbiology, Chinese Academy of Sciences, No 1 West Beichen Road, Chaoyang District, Beijing 100101, China
    J Virol Methods 193:177-83. 2013
    ..966) and for infected leaves (R(2)=0.979). The method developed in this study can quantify BBTV in aphids and plants, even before the appearance of symptoms of banana bunchy top disease...
  59. ncbi request reprint In vitro insulin refolding: characterization of the intermediates and the putative folding pathway
    YueHua Tang
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
    Sci China C Life Sci 50:717-25. 2007
    ....
  60. doi request reprint Expression of monocyte chemoattractant protein-1 and CC chemokine receptor 2 in non-small cell lung cancer and its significance
    Xiao Wei Zhang
    Department of Respiratory Medicine, Huadong Hospital, Fudan University, 221 Yan an West Road, Shanghai, 200040, China
    Cancer Immunol Immunother 62:563-70. 2013
    ..Our data indicate that MCP-1 is overexpressed in NSCLC cells. Its expression in cancer cells is associated with better survival in NSCLC patients...
  61. doi request reprint Ocular delivery of cyclosporine A based on glyceryl monooleate/poloxamer 407 liquid crystalline nanoparticles: preparation, characterization, in vitro corneal penetration and ocular irritation
    Yan Chen
    Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai, China
    J Drug Target 20:856-63. 2012
    ..Liquid crystalline nanoparticles exhibited excellent ocular tolerance in the ocular irritation test. This low-irritant vehicle based on liquid crystalline nanoparticles might be a promising system for effective ocular CsA delivery...
  62. doi request reprint A novel mutation in the MITF may be digenic with GJB2 mutations in a large Chinese family of Waardenburg syndrome type II
    Xukun Yan
    Department of Otolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai 200031, China
    J Genet Genomics 38:585-91. 2011
    ..Thus, a novel compound heterozygous mutation, c.[742_743delAAinsT;746_747delCA] in MITF exon 8 was the key genetic reason for WS2 in this family, and a digenic effect of MITF and GJB2 genes may contribute to deafness of the proband...
  63. ncbi request reprint [Comparison of characteristics of heavy metals in different grain sizes of intertidalite sediment by using grid sampling method]
    Tao Liang
    Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China
    Huan Jing Ke Xue 29:421-7. 2008
    ..Concentration of Sr is affected significantly by the grain size, while concentration of Cr and Ti are affected a little by the grain size...
  64. doi request reprint Adult precursor B lymphoblastic leukemia in Shanghai, China: characterization of phenotype, cytogenetics and outcome for 137 consecutive cases
    Liming Bao
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Int J Hematol 89:431-7. 2009
    ..These findings suggest significant geographic heterogeneity in precursor B-cell ALL which may be of both etiological and therapeutic significance...