Zhe Yu Chen

Summary

Affiliation: Shandong University
Country: China

Publications

  1. ncbi request reprint Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
    Zhe Yu Chen
    Department of Psychiatry and Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 24:4401-11. 2004
  2. pmc Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway
    Zhe Yu Chen
    Department of Psychiatry, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:6156-66. 2005
  3. pmc Differential involvement of brain-derived neurotrophic factor in reconsolidation and consolidation of conditioned taste aversion memory
    Yue Wang
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong, People s Republic of China
    PLoS ONE 7:e49942. 2012
  4. pmc Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 314:140-3. 2006
  5. pmc Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants
    Hui Yu
    Department of Neurobiology, Shandong University, Jinan, Shandong, Peoples Republic of China
    J Neurosci 32:4092-101. 2012
  6. doi request reprint RanBPM contributes to TrkB signaling and regulates brain-derived neurotrophic factor-induced neuronal morphogenesis and survival
    Yu Xia Yin
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, China
    J Neurochem 114:110-21. 2010
  7. pmc Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory
    Hui Yu
    Department of Neurobiology, School of Medicine, Shandong University, Jinan, Shandong 250012, China
    J Neurosci 29:4056-64. 2009
  8. pmc Region-specific involvement of BDNF secretion and synthesis in conditioned taste aversion memory formation
    Ling Ma
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, Peoples Republic of China
    J Neurosci 31:2079-90. 2011
  9. ncbi request reprint ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
    Henry K Teng
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:5455-63. 2005
  10. ncbi request reprint Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice
    Wen jing Li
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China
    Brain Res 1347:71-9. 2010

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
    Zhe Yu Chen
    Department of Psychiatry and Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 24:4401-11. 2004
    ....
  2. pmc Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway
    Zhe Yu Chen
    Department of Psychiatry, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:6156-66. 2005
    ....
  3. pmc Differential involvement of brain-derived neurotrophic factor in reconsolidation and consolidation of conditioned taste aversion memory
    Yue Wang
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong, People s Republic of China
    PLoS ONE 7:e49942. 2012
    ....
  4. pmc Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 314:140-3. 2006
    ..A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders...
  5. pmc Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants
    Hui Yu
    Department of Neurobiology, Shandong University, Jinan, Shandong, Peoples Republic of China
    J Neurosci 32:4092-101. 2012
    ....
  6. doi request reprint RanBPM contributes to TrkB signaling and regulates brain-derived neurotrophic factor-induced neuronal morphogenesis and survival
    Yu Xia Yin
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, China
    J Neurochem 114:110-21. 2010
    ..Together, these results suggest that RanBPM may modulate TrkB-mediated downstream signaling and biological functions...
  7. pmc Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory
    Hui Yu
    Department of Neurobiology, School of Medicine, Shandong University, Jinan, Shandong 250012, China
    J Neurosci 29:4056-64. 2009
    ..Importantly, DCS was effective in rescuing this delay in extinction, suggesting that when coupled with behavior therapy, DCS may be an effective treatment option for anxiety disorders in humans with this genetic variant BDNF...
  8. pmc Region-specific involvement of BDNF secretion and synthesis in conditioned taste aversion memory formation
    Ling Ma
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, Peoples Republic of China
    J Neurosci 31:2079-90. 2011
    ..These data suggest that region-specific BDNF release and synthesis temporally regulate different CTA memory phases through activation of TrkB receptors...
  9. ncbi request reprint ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
    Henry K Teng
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:5455-63. 2005
    ..Together with our past findings, these data suggest that the neurotrophin family is capable of modulating diverse biological processes via differential processing of the proneurotrophins...
  10. ncbi request reprint Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice
    Wen jing Li
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China
    Brain Res 1347:71-9. 2010
    ..Together, our results imply that music may provide an effective therapeutic intervention for anxiety disorders in humans with this genetic BDNF(Met) variant...
  11. pmc Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosine kinase receptors and controls depolarization enhanced RET surface insertion
    Xue Zhi Li
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, PR China
    J Biol Chem 287:1932-45. 2012
    ..Finally, we found that the phosphorylation status of the Thr(675) residue influences RET mediated response to GDNF stimulation. In all, these findings provide a novel mechanism for the modulation of RET surface expression...
  12. ncbi request reprint Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes
    Rithwick Rajagopal
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 24:6650-8. 2004
    ..These results indicate that there are alternative modes of activating Trk receptor tyrosine kinases in the absence of neurotrophin binding at the cell surface and that receptor signaling may occur and persist inside of neuronal cells...
  13. pmc Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination
    Kevin G Bath
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Neurosci 28:2383-93. 2008
    ..Through these observations, we have identified novel links between genetic variant BDNF and adult neurogenesis in vivo, which may contribute to significant impairments in olfactory function...
  14. ncbi request reprint Involvement of BDNF signaling transmission from basolateral amygdala to infralimbic prefrontal cortex in conditioned taste aversion extinction
    Jian Xin
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, P R China, and
    J Neurosci 34:7302-13. 2014
    ..Together, these data suggest that BLA-IL circuit regulates CTA memory extinction by identifying BDNF as a key regulator. ..
  15. doi request reprint BDNF-dependent recycling facilitates TrkB translocation to postsynaptic density during LTP via a Rab11-dependent pathway
    Shu Hong Huang
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, PR China
    J Neurosci 33:9214-30. 2013
    ..These findings provide a mechanistic link between Rab11-dependent endocytic recycling and TrkB modulation of synaptic plasticity...
  16. doi request reprint JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1
    Shu Hong Huang
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, People s Republic of China
    J Neurosci 31:10602-14. 2011
    ....
  17. pmc Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1
    Shu Hong Huang
    Department of Neurobiology, Key Laboratory of Medical Neurobiology, School of Medicine, Jinan, Shandong 250012, China
    J Biol Chem 284:15126-36. 2009
    ..These observations provide evidence for differential postendocytic sorting of TrkB-FL and TrkB.T1 receptors to alternate intracellular pathways...
  18. ncbi request reprint GDNF isoform affects intracellular trafficking and secretion of GDNF in neuronal cells
    Yue Wang
    Department of Neurobiology, School of Medicine, Shandong University, No 44 Wenhua Xi Road, Jinan, Shandong 250012, China
    Brain Res 1226:1-7. 2008
    ..To our knowledge, it is reported for the first time that the GDNF Delta 78 isoform has a deficit in GDNF intracellular trafficking and secretion...
  19. doi request reprint Phosphorylation of cofilin regulates extinction of conditioned aversive memory via AMPAR trafficking
    Yue Wang
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, People s Republic of China
    J Neurosci 33:6423-33. 2013
    ....
  20. pmc LIM kinase 1 (LIMK1) interacts with tropomyosin-related kinase B (TrkB) and Mediates brain-derived neurotrophic factor (BDNF)-induced axonal elongation
    Qing Dong
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, China
    J Biol Chem 287:41720-31. 2012
    ..Our findings provided evidence of a novel mechanism for the BDNF-mediated signal transduction leading to axonal elongation...
  21. pmc c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner
    Tao Sun
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, No 4 Wenhua Xi Road, Jinan, Shandong 250012, USA
    J Biol Chem 288:14531-43. 2013
    ..These findings may have important implications for our understanding of neuronal axon elongation during development...
  22. doi request reprint Region-specific involvement of actin rearrangement-related synaptic structure alterations in conditioned taste aversion memory
    Ai Ling Bi
    Department of Neurobiology, Shandong University, Jinan, People s Republic of China
    Learn Mem 17:420-7. 2010
    ..Our results suggest temporal and regional-specific regulation of actin rearrangement-related synaptic structure in different phases of CTA memory...
  23. doi request reprint BDNF Val66Met polymorphism and anxiety/depression symptoms in schizophrenia in a Chinese Han population
    Meng Meng Sun
    Department of Psychiatry, Shandong Mental Health Center, Shandong University, Jinan, Shandong, People s Republic of China
    Psychiatr Genet 23:124-9. 2013
    ....
  24. doi request reprint Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells
    Zong Peng Sun
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong, China
    J Neurochem 117:121-32. 2011
    ..In all, these findings will advance our understanding of the molecular mechanism of CDNF trafficking and secretion...
  25. ncbi request reprint Identification of the key amino acids of glial cell line-derived neurotrophic factor family receptor alpha1 involved in its biological function
    Li Mei Wang
    Department of Neurobiology, The Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    J Biol Chem 279:109-16. 2004
    ..However N152A/N153A or S316A/N317A/S318A mutation in the GFRalpha1 molecule still retained the ability to bind with Ret. These findings suggest that distinct structural elements in GFRalpha1 may be involved in binding to GDNF and Ret...
  26. doi request reprint Transcriptome profiling analysis of the mechanisms underlying the BDNF Val66Met polymorphism induced dysfunctions of the central nervous system
    Dong Dong Wang
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong, 250012, People s Republic of China
    Hippocampus 24:65-78. 2014
    ..These findings will help us further understanding the molecular mechanisms involved in the BDNF(Met) associated behavior and neuroanatomy alternations...
  27. ncbi request reprint Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination
    Juan Carlos Arevalo
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology, and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Neuron 50:549-59. 2006
    ..Our results indicate that Trk neurotrophin receptors are differentially regulated by ubiquitination to modulate the survival of neurons...
  28. pmc Brain-derived neurotrophic factor (BDNF)-induced mitochondrial motility arrest and presynaptic docking contribute to BDNF-enhanced synaptic transmission
    Bo Su
    From the Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, China
    J Biol Chem 289:1213-26. 2014
    ..Together, these data suggest that mitochondrial transport and distribution play essential roles in BDNF-mediated synaptic transmission. ..
  29. pmc A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Biol Cell 16:5761-72. 2005
    ..These results indicate that TrkA receptors, which predominantly recycle in signal-dependent manner, have unique biological properties dictated by its specific endocytic trafficking itinerary...
  30. doi request reprint Association of plasma brain-derived neurotrophic factor and cardiovascular risk factors and prognosis in angina pectoris
    Hong Jiang
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China
    Biochem Biophys Res Commun 415:99-103. 2011
    ..We compared the association of plasma levels of BDNF and C-reactive protein, an established marker, and risk factors of cardiovascular dysfunction and prognosis in patients with angina pectoris...
  31. pmc Neuronal release of proBDNF
    Jianmin Yang
    Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, New York 10065, USA
    Nat Neurosci 12:113-5. 2009
    ..Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB...
  32. doi request reprint BDNF Val66Met polymorphism is associated with unstable angina
    Hong Jiang
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China
    Clin Chim Acta 400:3-7. 2009
    ..The human BDNF Val66Met polymorphism has been shown to be associated with altered susceptibility to neuropsychiatric disorders. However it is unknown whether this polymorphism plays a role in cardiovascular disease...
  33. doi request reprint A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia
    Li Mei Wang
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong, 250012, China
    Eur J Neurosci 37:1669-81. 2013
    ..SIRT1 is a downstream target of p-AMPK signaling induced by RSV in the recurrent ischemic stroke model...
  34. doi request reprint Mechanism underlying activity-dependent insertion of TrkB into the neuronal surface
    Ling Zhao
    Department of Neurobiology, Key Laboratory of Medical Neurobiology, School of Medicine, Shandong University, Shandong, P R China
    J Cell Sci 122:3123-36. 2009
    ..Our studies provide new insights regarding neuronal activity-dependent surface delivery of TrkB receptor, which will advance our understanding of the modulatory role of TrkB in synaptic plasticity...
  35. pmc Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor
    Zhao Geng
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, PR China
    J Biol Chem 286:41871-82. 2011
    ..Together, these findings will advance our understanding of the molecular mechanism underlying GDNF-regulated secretion...
  36. doi request reprint The role of BDNF in depression on the basis of its location in the neural circuitry
    Hui Yu
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Ji nan 250012, China
    Acta Pharmacol Sin 32:3-11. 2011
    ..Here, we present an overview of the current knowledge concerning BDNF actions and associated intracellular signaling in hippocampus, prefrontal cortex, nucleus accumbens (NAc) and amygdala as their relation to depression...
  37. pmc Impact of genetic variant BDNF (Val66Met) on brain structure and function
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Novartis Found Symp 289:180-8; discussion 188-95. 2008
    ..A genetic variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders...
  38. doi request reprint Arginase I attenuates inflammatory cytokine secretion induced by lipopolysaccharide in vascular smooth muscle cells
    Xu Ping Wang
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University, Qilu Hospital, Jinan, China
    Arterioscler Thromb Vasc Biol 31:1853-60. 2011
    ..Arginase I (Arg I) promotes the proliferation of vascular smooth muscle cells; however, the effect of Arg I on inflammation remains unknown. The present study investigated the role of Arg I in inflammation in vitro and in vivo...
  39. doi request reprint Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines
    Hai Ji Sun
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong, P R China
    Mol Med Rep 6:1276-80. 2012
    ..This difference depends on the GDP/GTP-binding form, and inhibition of the Rab23 cycle decreases the expression and nuclear localization of Gli1...
  40. doi request reprint Gypenosides pre-treatment protects the brain against cerebral ischemia and increases neural stem cells/progenitors in the subventricular zone
    Xiao Jing Wang
    Department of Cell Biology, School of Medicine, Shandong University, Jinan, Shandong, People s Republic of China Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong, People s Republic of China
    Int J Dev Neurosci 33:49-56. 2014
    ..These findings provide new evidence for a potential therapy involving GPs for the treatment of stroke. ..
  41. doi request reprint Comparative proteomics analysis of cerebrospinal fluid of patients with Guillain-Barré syndrome
    Yin Rong Yang
    Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong, P R China
    Cell Mol Neurobiol 28:737-44. 2008
    ..These identified proteins may be involved in the pathophysiological process of GBS and call for further studying the role of these proteins in the pathogenesis of the disease...
  42. ncbi request reprint Single-cell characterization of retrograde signaling by brain-derived neurotrophic factor
    Jason P Magby
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    J Neurosci 26:13531-6. 2006
    ....
  43. ncbi request reprint A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1
    Li Mei Wang
    Department of Neurobiology, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, China
    Protein Pept Lett 10:61-72. 2003
    ..The results suggest that the central domain of GFRalpha1 is a crucial determinant for ligand binding. This established a solid basis for further study to find the key amino acid mediating the binding of GDNF and GFRalpha1...