Zhe Yu Chen

Summary

Affiliation: Shandong University
Country: China

Publications

  1. ncbi request reprint Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
    Zhe Yu Chen
    Department of Psychiatry and Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 24:4401-11. 2004
  2. pmc Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway
    Zhe Yu Chen
    Department of Psychiatry, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:6156-66. 2005
  3. pmc Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 314:140-3. 2006
  4. ncbi request reprint ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
    Henry K Teng
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:5455-63. 2005
  5. pmc Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination
    Kevin G Bath
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Neurosci 28:2383-93. 2008
  6. ncbi request reprint Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes
    Rithwick Rajagopal
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 24:6650-8. 2004
  7. pmc Neuronal release of proBDNF
    Jianmin Yang
    Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, New York 10065, USA
    Nat Neurosci 12:113-5. 2009
  8. ncbi request reprint Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination
    Juan Carlos Arevalo
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology, and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Neuron 50:549-59. 2006
  9. pmc A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Biol Cell 16:5761-72. 2005
  10. pmc Impact of genetic variant BDNF (Val66Met) on brain structure and function
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Novartis Found Symp 289:180-8; discussion 188-95. 2008

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
    Zhe Yu Chen
    Department of Psychiatry and Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 24:4401-11. 2004
    ....
  2. pmc Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway
    Zhe Yu Chen
    Department of Psychiatry, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:6156-66. 2005
    ....
  3. pmc Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 314:140-3. 2006
    ..A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders...
  4. ncbi request reprint ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
    Henry K Teng
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:5455-63. 2005
    ..Together with our past findings, these data suggest that the neurotrophin family is capable of modulating diverse biological processes via differential processing of the proneurotrophins...
  5. pmc Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination
    Kevin G Bath
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Neurosci 28:2383-93. 2008
    ..Through these observations, we have identified novel links between genetic variant BDNF and adult neurogenesis in vivo, which may contribute to significant impairments in olfactory function...
  6. ncbi request reprint Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes
    Rithwick Rajagopal
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 24:6650-8. 2004
    ..These results indicate that there are alternative modes of activating Trk receptor tyrosine kinases in the absence of neurotrophin binding at the cell surface and that receptor signaling may occur and persist inside of neuronal cells...
  7. pmc Neuronal release of proBDNF
    Jianmin Yang
    Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, New York 10065, USA
    Nat Neurosci 12:113-5. 2009
    ..Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB...
  8. ncbi request reprint Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination
    Juan Carlos Arevalo
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology, and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Neuron 50:549-59. 2006
    ..Our results indicate that Trk neurotrophin receptors are differentially regulated by ubiquitination to modulate the survival of neurons...
  9. pmc A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Biol Cell 16:5761-72. 2005
    ..These results indicate that TrkA receptors, which predominantly recycle in signal-dependent manner, have unique biological properties dictated by its specific endocytic trafficking itinerary...
  10. pmc Impact of genetic variant BDNF (Val66Met) on brain structure and function
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Novartis Found Symp 289:180-8; discussion 188-95. 2008
    ..A genetic variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders...
  11. ncbi request reprint Single-cell characterization of retrograde signaling by brain-derived neurotrophic factor
    Jason P Magby
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    J Neurosci 26:13531-6. 2006
    ....
  12. ncbi request reprint A structure-function analysis of glial cell-line-derived neurotrophic factor receptor alpha1
    Li Mei Wang
    Department of Neurobiology, The Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, China
    Protein Pept Lett 10:61-72. 2003
    ..The results suggest that the central domain of GFRalpha1 is a crucial determinant for ligand binding. This established a solid basis for further study to find the key amino acid mediating the binding of GDNF and GFRalpha1...