Research Topics
Genomes and Genes | Chao Yu MiaoSummaryAffiliation: Second Military Medical University Country: China Publications
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Publications
The role of perivascular adipose tissue in vascular smooth muscle cell growthChao Yu Miao
Department of Pharmacology, Second Military Medical University, Shanghai, China
Br J Pharmacol 165:643-58. 2012..LINKED ARTICLES: This article is part of a themed section on Fat and Vascular Responsiveness. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.165.issue-3...
Circulating and local visfatin/Nampt/PBEF levels in spontaneously hypertensive rats, stroke-prone spontaneously hypertensive rats and Wistar-Kyoto ratsPei Wang
Department of Pharmacology, Second Military Medical University, 325 Guo He Road, Shanghai, 200433, China
J Physiol Sci 60:317-24. 2010..Thus, our results may provide useful information for understanding the characteristic of visfatin in hypertensive models, and support the view that visfatin may be a myokine...
The importance of blood pressure variability in rat aortic and left ventricular hypertrophy produced by sinoaortic denervationChao Yu Miao
Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai, China
J Hypertens 20:1865-72. 2002..The main objective was to examine the role of hemodynamics in rat aortic and left ventricular hypertrophy produced by sinoaortic denervation (SAD)...- Arterial baroreflex function in conscious ratsDing feng Su
Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai 200433, China
Acta Pharmacol Sin 23:673-9. 2002..Ketanserin improved the impaired ABR function in SHR. Finally, the possibility to develop a strain of rats with spontaneous deficiency on ABR function is mentioned... - Comparative study of sinoaortic denervated rats and spontaneously hypertensive ratsChao Yu Miao
Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai, China
Am J Hypertens 16:585-91. 2003..Both hypertension and high blood pressure variability (BPV) are involved in cardiovascular damage. This comparative study was designed to explore the possible effects of both of these phenomena on the cardiovascular system... - Two useful methods for evaluating antihypertensive drugs in conscious freely moving ratsDing feng Su
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
Acta Pharmacol Sin 25:148-51. 2004..They were the directly intragastric administration of drugs and modified probability sum test for evaluating the synergism of the combination of two drugs... - Effects of glucose-insulin-potassium on baroreflex sensitivity, left ventricular function and ventricular arrhythmia in the subacute phase of myocardial infarction in ratsJian Guo Liu
Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai 200433, China
Fundam Clin Pharmacol 17:443-8. 2003..It is proposed that reducing ventricular arrhythmia and improving left ventricular function contribute to the effect of GIK on reducing the mortality after MI... - Visfatin is associated with lipid metabolic abnormalities in Lyon hypertensive ratsPei Wang
Department of Pharmacology, Second Military Medical University, Shanghai, China
Clin Exp Pharmacol Physiol 37:894-9. 2010..4. In conclusion, the results of the present study demonstrate that serum visfatin levels in LH rats are elevated and are associated with lipid metabolic abnormalities... - Candesartan inhibits sinoaortic denervation-induced cardiovascular hypertrophy in ratsChao Yu Miao
Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai 200433, China
Acta Pharmacol Sin 23:713-20. 2002..To study the effect of candesartan cilexetil (candesartan), a new AT1 receptor antagonist, on sinoaortic denervation (SAD)-induced cardiovascular hypertrophy and its potential mechanisms in rats... - Angiotensin II and AT1 receptor in hypertrophied ventricles and aortas of sinoaortic-denervated ratsChao Yu Miao
Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai 200433, China
Acta Pharmacol Sin 24:812-8. 2003..The present study was to observe these two factors in the hypertrophied ventricles and aortas of sinoaortic-denervated rats... - Greater hypertrophy in right than left ventricles is associated with pulmonary vasculopathy in sinoaortic-denervated Wistar-Kyoto ratsChao Yu Miao
Department of Pharmacology, Second Military Medical University, Shanghai, China
Clin Exp Pharmacol Physiol 31:450-5. 2004..5. These findings suggest that greater RVH following SAD is associated with pulmonary vasculopathy, but is not secondary to the left ventricular problems or high BPV... - Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathwayPei Wang
Department of Pharmacology, Second Military Medical University, Shanghai, China
Ann Neurol 69:360-74. 2011..However, the role of Nampt in brain and stroke remains to be investigated... - Frequent ventricular premature beats increase blood pressure variability in ratsChao Yu Miao
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
Acta Pharmacol Sin 25:545-53. 2004..The present study was designed to test a hypothesis that nonfatal ventricular arrhythmia such as ventricular premature beats (VPB) is a contributing factor in the elevation of blood pressure variability (BPV)... - 4-Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetesTian Ying Xu
Department of Pharmacology, Second Military Medical University, Shanghai, China
Clin Exp Pharmacol Physiol 37:441-6. 2010.... - Effects of ketanserin on endotoxic shock and baroreflex function in rodentsChong Liu
Department of Pharmacology, Second Military Medical University, Shanghai, China
J Infect Dis 204:1605-12. 2011..The present work tested the hypothesis that restoration of baroreflex function is an effective treatment for lipopolysaccharide (LPS)-induced shock... - Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restrictionPei Wang
Department of Pharmacology, Second Military Medical University, Shanghai, China
Mol Med 17:523-32. 2011..Thus, our results provide the first evidence that the LepRb-STAT3 signaling pathway is involved in the brain FTO downregulation during ER... - Deficiency of NG2+ cells contributes to the susceptibility of stroke-prone spontaneously hypertensive ratsPei Wang
Department of Pharmacology, Second Military Medical University, Shanghai, China
CNS Neurosci Ther 17:327-32. 2011..The purpose of this study is to investigate whether the NG2(+) cells, a class of oligodendrocyte progenitor cells, is involved in the pathophysiology of stroke in stroke-prone spontaneously hypertensive rat (SHR-SP)... - Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotidePei Wang
Department of Pharmacology, Second Military Medical University, 325 Guo He Road, Shanghai 200433, People s Republic of China
Cardiovasc Res 81:370-80. 2009..The present study was to determine whether visfatin is involved in these paracrine actions of PVAT, and if so, to explore the underlying mechanisms... - A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferaseRuo Yu Zhang
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
Anal Biochem 412:18-25. 2011..This HTS system should expedite the discovery of Nampt inhibitors as antitumor drug candidates... - Reduction of blood pressure variability: a new strategy for the treatment of hypertensionDing feng Su
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
Trends Pharmacol Sci 26:388-90. 2005..The reduction of BPV is an important contributory factor of the organ protection provided by some antihypertensive drugs. Thus, reduction of BPV might represent a new strategy for the treatment of hypertension... - Chronic exposure to nicotine enhances insulin sensitivity through α7 nicotinic acetylcholine receptor-STAT3 pathwayTian Ying Xu
Department of Pharmacology, Second Military Medical University, Shanghai, China
PLoS ONE 7:e51217. 2012..Our results contribute not only to the understanding of the pharmacological effects of nicotine, but also to the identifying of new therapeutic targets against insulin resistance... - Loss of AMP-activated protein kinase-α2 impairs the insulin-sensitizing effect of calorie restriction in skeletal musclePei Wang
Department of Pharmacology, Second Military Medical University, Shanghai, China
Diabetes 61:1051-61. 2012..Our results suggest that AMPK may be modulated by CR in a ubiquitylation-dependent manner and acts as a chief dictator for the insulin-sensitizing effects of CR in skeletal muscle... - Visfatin and cardio-cerebro-vascular diseasePei Wang
Department of Pharmacology, Second Military Medical University, Shanghai, China
J Cardiovasc Pharmacol 59:1-9. 2012..This brief review focuses on the current understanding of the complex role of visfatin in the cardio-cerebro-vascular system under normal and pathophysiological conditions... - Blood pressure variability is more important than blood pressure level in determination of end-organ damage in ratsChao Yu Miao
Department of Pharmacology, Second Military Medical University, Shanghai, China
J Hypertens 24:1125-35. 2006..This study was designed to determine how important a novel risk factor of elevated blood pressure variability (BPV) is in the determination of end-organ damage by comparison with the classic risk factor of a high blood pressure (BP) level... - Adipokines in inflammation, insulin resistance and cardiovascular diseaseZhi Yong Li
Department of Pharmacology, Second Military Medical University, Shanghai, China
Clin Exp Pharmacol Physiol 38:888-96. 2011..In particular, we focus on the effects of various adipokines in pathological processes, which may provide an insight into obesity-linked CVD and facilitate the development of new therapeutic strategies... - Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemiaPei Wang
Department of Pharmacology, Second Military Medical University, Shanghai, China
Autophagy 8:77-87. 2012..Our results demonstrate that Nampt promotes neuronal survival through inducing autophagy via regulating TSC2-mTOR-S6K1 signaling pathway in a SIRT1-dependent manner during cerebral ischemia... - A double-edged sword with therapeutic potential: an updated role of autophagy in ischemic cerebral injuryKai Wei
Department of Pharmacology, Second Military Medical University, Shanghai, China
CNS Neurosci Ther 18:879-86. 2012..Moreover, autophagy inhibitor abolished the neuroprotection of ischemic preconditioning, implying a neuroprotective effect of autophagy. To clarify these issues on autophagy in cerebral ischemia, future investigations are warranted... - Hypertonic and isotonic potassium solutions have different effects on vessel contractility resulting in differences in optimal resting tension in rat aortaYun Feng Guan
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
Acta Pharmacol Sin 28:643-50. 2007..To compare high K(+ )-induced contraction and optimal resting tension measured by two commonly used techniques of hypertonic and isotonic K(+ ) in aortas with and without adventitial fat from various age rats...