Genomes and Genes


Guangwen Cao


Affiliation: Second Military Medical University
Country: China


  1. Wang S, Du X, Han X, Yang F, Zhao J, Li H, et al. Influence of socioeconomic events on cause-specific mortality in urban Shanghai, China, from 1974 to 2015: a population-based longitudinal study. CMAJ. 2018;190:E1153-E1161 pubmed publisher
    ..Decreased cause-specific mortality followed improvements in public health, medical infrastructure and pollution control, but not for cancer or diabetes, likely because of exposure to new risk factors. ..
  2. request reprint
    Xie J, Gao Q, Yang D, Liu T, Cao G. [Associations of signal transducer and activators of transcription 3 polymorphism with the susceptibility to hepatitis B virus-related hepatocellular carcinoma]. Zhonghua Yu Fang Yi Xue Za Zhi. 2014;48:517-20 pubmed
    ..71, 95%CI: 0.40-1.26; OR = 0.90, 95%CI: 0.68-1.19, respectively). STAT3 -1096G/C polymorphism was not associated with the susceptibility to HCC for the HBV-infected subjects without HCC. ..
  3. Zhang Q, Ji X, Hou X, Lu F, Du Y, Yin J, et al. Effect of functional nuclear factor-kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma. Ann Oncol. 2014;25:2413-9 pubmed publisher
    ..The host-virus interactions are important in identifying HBV-infected subjects who are more likely to develop HCC. ..
  4. Ji X, Zhang Q, Li B, Du Y, Yin J, Liu W, et al. Impacts of human leukocyte antigen DQ genetic polymorphisms and their interactions with hepatitis B virus mutations on the risks of viral persistence, liver cirrhosis, and hepatocellular carcinoma. Infect Genet Evol. 2014;28:201-9 pubmed publisher
    ..80 (95% CI, 1.02-7.66) in genotype C HBV-infected subjects. Conclusively, the HLA-DQ polymorphisms affect the risks of LC and HCC differently in chronic HBV-infected subjects, possibly via interacting with the HBV mutations. ..
  5. Li S, Qian X, Yuan Z, Sun X, Li C, Tang X, et al. Molecular epidemiology of measles virus infection in Shanghai in 2000-2012: the first appearance of genotype D8. Braz J Infect Dis. 2014;18:581-90 pubmed publisher
    ..We suggest that Shanghai Center for Disease Control laboratories should strengthen their approaches to monitor measles cases to prevent further spread of imported strains. ..
  6. Yin J, Wang J, Pu R, Xin H, Li Z, Han X, et al. Hepatitis B Virus Combo Mutations Improve the Prediction and Active Prophylaxis of Hepatocellular Carcinoma: A Clinic-Based Cohort Study. Cancer Prev Res (Phila). 2015;8:978-88 pubmed publisher
    ..To prevent HCC, patients infected with HBV carrying A1762T/G1764A or C1653T, but not T1753V, should be given priority of receiving antiviral treatments. ..
  7. Ni H, Yang F, Li Y, Liu W, Jiao S, Li Z, et al. Apodemus agrarius is a potential natural host of severe fever with thrombocytopenia syndrome (SFTS)-causing novel bunyavirus. J Clin Virol. 2015;71:82-8 pubmed publisher
    ..agrarius shared great sequence homologies to those isolated from the patients living in nearby villages. The present study indicated that A. agrarius might be a natural host of SFTSV in East China. ..
  8. Reagan A, Gu X, Hauck S, Ash J, Cao G, Thompson T, et al. Retinal Caveolin-1 Modulates Neuroprotective Signaling. Adv Exp Med Biol. 2016;854:411-8 pubmed publisher
    ..Thus, Cav-1 modulates neuroprotective signaling by regulating the endogenous production of neuroprotective factors. ..
  9. Liu Y, Tan X, Liu W, Chen X, Hou X, Shen D, et al. Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma. Chin J Cancer. 2018;37:2 pubmed publisher
    ..038). FSTL1 plays a tumor suppression role possibly via repressing the NF-?B and HIF-2? signaling pathways. To increase FSTL1 expression might be a candidate therapeutic strategy for metastatic ccRCC. ..

More Information


  1. Mara T, Ma L, Wang S, Wang L, Yang F, Song J, et al. The prevalence rates of major chronic diseases in retired and in-service Chinese military officers (2000-2016): a meta-analysis. Mil Med Res. 2018;5:4 pubmed publisher
    ..Medical intervention should be enforced on the prevention of cerebrovascular diseases in those working in cold areas in the north, as well as hypertension and heart diseases in retirees. ..
  2. Rajakaruna S, Liu W, Ding Y, Cao G. Strategy and technology to prevent hospital-acquired infections: Lessons from SARS, Ebola, and MERS in Asia and West Africa. Mil Med Res. 2017;4:32 pubmed publisher
    ..We also recommend that health authorities invest in training healthcare workers for disease outbreak response, as their preparedness is essential to reducing disaster risk. ..