Yi Zhu

Summary

Affiliation: Peking University
Country: China

Publications

  1. ncbi request reprint Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells
    Yi Liu
    Division of Biomedical Sciences, University of California at Riverside, Riverside, CA 92521 0121, USA
    Circulation 110:1128-33. 2004
  2. pmc Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells
    Xiaomei Qin
    Institute of Cardiovascular Science and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, 100083, PR China
    Cardiovasc Res 74:506-14. 2007
  3. pmc Upregulation of Scavenger Receptor BI by Hepatic Nuclear Factor 4α through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism in Liver
    Yi Zhang
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Beijing 100191, China
    PPAR Res 2011:164925. 2011
  4. ncbi request reprint Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR)
    Yi Zhu
    Department of Physiology, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Health Science Center, Peking University, Beijing 100083, China
    Cardiovasc Res 68:425-32. 2005
  5. doi request reprint LIF maintains progenitor phenotype of endothelial progenitor cells via Krüppel-like factor 4
    Xiaoxia Li
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, 100191 China
    Microvasc Res 84:270-7. 2012
  6. pmc AMPK potentiates hypertonicity-induced apoptosis by suppressing NFκB/COX-2 in medullary interstitial cells
    Qifei Han
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    J Am Soc Nephrol 22:1897-911. 2011
  7. ncbi request reprint Laminar shear stress regulates liver X receptor in vascular endothelial cells
    Minjia Zhu
    Department of Physiology and Pathophysiology, Peking University, Health Sciences Center, Beijing, China 100083
    Arterioscler Thromb Vasc Biol 28:527-33. 2008
  8. doi request reprint Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae
    Chenglai Fu
    Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Peking University Health Science Center, Beijing 100091, China
    Biochim Biophys Acta 1801:702-10. 2010
  9. doi request reprint Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice
    Xiaomei Qin
    Institute of Cardiovascular Science and Key Laboratory of Cardiovascular Science of Ministry of Education, Peking University Health Science Center, Beijing, China
    Hepatology 48:432-41. 2008
  10. pmc Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs
    Xuefen Xie
    Department of Physiology and Pathophysiology, Peking University, Health Sciences Center, Beijing 100083, China
    Mol Endocrinol 23:434-43. 2009

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells
    Yi Liu
    Division of Biomedical Sciences, University of California at Riverside, Riverside, CA 92521 0121, USA
    Circulation 110:1128-33. 2004
    ..We studied the activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) in ECs in response to laminar flow and the associated antiinflammatory effect...
  2. pmc Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells
    Xiaomei Qin
    Institute of Cardiovascular Science and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, 100083, PR China
    Cardiovasc Res 74:506-14. 2007
    ..Stearoyl-CoA desaturase-1 (SCD1), which catalyzes the biosynthesis of monounsaturated fatty acids, affects the lipid composition and fluidity of the cell membrane. Thus, we examined the effect of laminar flow on SCD1 expression in ECs...
  3. pmc Upregulation of Scavenger Receptor BI by Hepatic Nuclear Factor 4α through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism in Liver
    Yi Zhang
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Beijing 100191, China
    PPAR Res 2011:164925. 2011
    ..In conclusion, HNF4α regulates cholesterol metabolism in rat by modulating the expression of SR-BI in the liver, in which the upregulation of PPARγ was involved...
  4. ncbi request reprint Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR)
    Yi Zhu
    Department of Physiology, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Health Science Center, Peking University, Beijing 100083, China
    Cardiovasc Res 68:425-32. 2005
    ..This report describes the effect of copper-catalyzed oxLDL on the regulation of ABCA1 in human endothelial cells (ECs)...
  5. doi request reprint LIF maintains progenitor phenotype of endothelial progenitor cells via Krüppel-like factor 4
    Xiaoxia Li
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, 100191 China
    Microvasc Res 84:270-7. 2012
    ..We investigated the effect of leukemia inhibitory factor (LIF) combined with vascular endothelial growth factor (VEGF) on EPCs and the potential roles of Krüppel-like transcription factors (KLFs)...
  6. pmc AMPK potentiates hypertonicity-induced apoptosis by suppressing NFκB/COX-2 in medullary interstitial cells
    Qifei Han
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    J Am Soc Nephrol 22:1897-911. 2011
    ..Furthermore, this study raises safety concerns for the development of AMPK activators as anti-diabetic drugs, especially for patients prone to dehydration...
  7. ncbi request reprint Laminar shear stress regulates liver X receptor in vascular endothelial cells
    Minjia Zhu
    Department of Physiology and Pathophysiology, Peking University, Health Sciences Center, Beijing, China 100083
    Arterioscler Thromb Vasc Biol 28:527-33. 2008
    ..The liver X receptors (LXRs) regulate a set of genes involved in lipid metabolism and reverse cholesterol transport. We investigated the mechanism by which shear stress regulates LXR in vascular endothelial cells (ECs)...
  8. doi request reprint Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae
    Chenglai Fu
    Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Peking University Health Science Center, Beijing 100091, China
    Biochim Biophys Acta 1801:702-10. 2010
    ..Thus, our study suggests a molecular basis underlying the synergistic effects of hypercholesterolemia and inflammation in atherogenesis...
  9. doi request reprint Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice
    Xiaomei Qin
    Institute of Cardiovascular Science and Key Laboratory of Cardiovascular Science of Ministry of Education, Peking University Health Science Center, Beijing, China
    Hepatology 48:432-41. 2008
    ..Furthermore, overexpression of PPARdelta by intravenous infection with the PPARdelta adenovirus induced the expression of Insig-1, suppressed SREBP-1 activation, and, consequently, ameliorated hepatic steatosis in obese db/db mice...
  10. pmc Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs
    Xuefen Xie
    Department of Physiology and Pathophysiology, Peking University, Health Sciences Center, Beijing 100083, China
    Mol Endocrinol 23:434-43. 2009
    ..These findings also provide new insights into diabetes-associated complications such as fatty liver disease...
  11. doi request reprint Increased stability of phosphatase and tensin homolog by intermedin leading to scavenger receptor A inhibition of macrophages reduces atherosclerosis in apolipoprotein E-deficient mice
    Xiao Yan Dai
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, PR China
    J Mol Cell Cardiol 53:509-20. 2012
    ..Thus, intermedin inhibited atherosclerosis in apoE(-/-) mice. Increased stability of PTEN by intermedin leads to SR-A inhibition in macrophages, which ameliorates foam-cell formation and atherosclerosis in apoE(-/-) mice...
  12. doi request reprint Induction of MIF expression by oxidized LDL via activation of NF-kappaB in vascular smooth muscle cells
    Lihong Chen
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Atherosclerosis 207:428-33. 2009
    ..Taken together, our results revealed that MIF expression can be induced by oxLDL in VSMCs via a NF-kappaB dependent manner, which may contribute to the pathogenesis of atherosclerosis...
  13. pmc Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile
    Huaixin Dang
    Department of Physiology and Pathophysiology, Health Science Center, Institute of Cardiovascular Research, Peking University, Beijing, China
    J Biol Chem 284:6218-26. 2009
    ..Thus, down-regulation of OSC may account for a novel mechanism underlying the LXR-mediated lipid metabolism in the liver of mice fed an HF diet...
  14. pmc A novel mechanism of γ/δ T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase β chain
    Yi Fu
    Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Peking University Health Sciences Center, Beijing, China
    Circ Res 108:410-7. 2011
    ..Endothelial dysfunction, affected by imposed flow, is one of the earliest events leading to atherogenesis. The involvement of γ/δ T lymphocytes in endothelial dysfunction under flow is largely unknown...
  15. pmc Inhibition of soluble epoxide hydrolase attenuates high-fat-diet-induced hepatic steatosis by reduced systemic inflammatory status in mice
    Yan Liu
    Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Peking University Health Science Center, Beijing, China
    PLoS ONE 7:e39165. 2012
    ..sEH may be a therapeutic target for HF-diet-induced hepatic steatosis in inhibiting systemic inflammation...
  16. doi request reprint Hyperhomocysteinemia exaggerates adventitial inflammation and angiotensin II-induced abdominal aortic aneurysm in mice
    Ziyi Liu
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
    Circ Res 111:1261-73. 2012
    ..A number of epidemiological studies have suggested an association of hyperhomocysteinemia (HHcy) and abdominal aortic aneurysm (AAA), but discrepancies exist. In addition, we lack direct evidence supporting a causal role...
  17. pmc Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake
    Geyang Xu
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China
    Endocrinology 150:3637-44. 2009
    ..mTOR is therefore a gastric fuel sensor whose activity is linked to the regulation of energy intake through ghrelin...
  18. pmc Transcription factor Krüppel-like factor 2 plays a vital role in endothelial colony forming cells differentiation
    Yimeng Song
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
    Cardiovasc Res 99:514-24. 2013
    ..However, the mechanisms underlying transcriptional regulation of ECFC differentiation still remain largely elusive. Here, we investigated the role of transcription factor Krüppel-like factor 2 (KLF2) in the regulation of ECFC function...
  19. doi request reprint Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2
    Yaoyao Du
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, People s Republic of China
    Circ Res 108:917-28. 2011
    ..We recently reported that cartilage oligomeric matrix protein (COMP) is pivotal for maintaining the homeostasis of vascular smooth muscle cells (VSMCs). Whether COMP affects the process of vascular calcification is unknown...
  20. doi request reprint PGC-1alpha attenuates neointimal formation via inhibition of vascular smooth muscle cell migration in the injured rat carotid artery
    Aijuan Qu
    Dept of Physiology and Pathophysiology, School of Basic Medical Science, Peking Univ, Beijing 100191, China
    Am J Physiol Cell Physiol 297:C645-53. 2009
    ..These data strongly suggest that PGC-1alpha inhibits VSMC migration and neointimal formation after vascular injury in rats, mainly by upregulating the expression of the mitochondrial antioxidant enzyme SOD-2...
  21. ncbi request reprint ROS and NF-kappaB but not LXR mediate IL-1beta signaling for the downregulation of ATP-binding cassette transporter A1
    Min Chen
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing 100083, People s Republic of China
    Am J Physiol Cell Physiol 292:C1493-501. 2007
    ....
  22. pmc Prostaglandin E2 promotes endothelial differentiation from bone marrow-derived cells through AMPK activation
    Zhenjiu Zhu
    Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    PLoS ONE 6:e23554. 2011
    ..Therefore, by promoting the differentiation and migration of BMCs, PGE2 reinforced their neovascularization by binding to the receptor of EP4 in an AMPK-dependent manner. PGE2 may have clinical value in ischemic heart disease...
  23. doi request reprint Activation of peroxisome proliferator-activated receptor-γ downregulates soluble epoxide hydrolase in cardiomyocytes
    Wei Pang
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Beijing, China
    Clin Exp Pharmacol Physiol 38:358-64. 2011
    ..4. Our results suggest that the protective role of PPARγ activation in AngII-induced cardiac hypertrophy is, at least in part, through downregulating sEH...
  24. doi request reprint Upregulation of a disintegrin and metalloproteinase with thrombospondin motifs-7 by miR-29 repression mediates vascular smooth muscle calcification
    Yaoyao Du
    Department of Physiology and Pathophysiology, Basic Medical College of Peking University, Beijing 100191, China
    Arterioscler Thromb Vasc Biol 32:2580-8. 2012
    ..We characterized the COMP-degrading metalloproteinase, a disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7). Here, we tested whether ADAMTS-7 facilitates vascular calcification...
  25. doi request reprint Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin
    Li Wang
    Department of Physiology and Pathophysiology, Basic Medical College of Peking University, Beijing 100191, People s Republic of China
    Circ Res 106:514-25. 2010
    ..However, how normal VSMCs maintain the differentiated state is less understood...
  26. ncbi request reprint Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis
    Jing Dai
    Department of Physiology and Pathophysiology, School of Basic Medical Science, Peking University, Beijing 100083, People s Republic of China
    Free Radic Biol Med 41:1566-77. 2006
    ....
  27. doi request reprint Intermedin1-53 attenuates vascular smooth muscle cell calcification by inhibiting endoplasmic reticulum stress via cyclic adenosine monophosphate/protein kinase A pathway
    Jin Rui Chang
    Department of Physiology and Pathophysiology, School of Basic Medical Science, Peking University Health Science Center, Beijing 100191, China
    Exp Biol Med (Maywood) 238:1136-46. 2013
    ..In conclusion, IMD1-53 attenuated VSMC calcification by inhibiting ER stress through cAMP/PKA signalling...
  28. doi request reprint Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the Forkhead box 1 signaling pathway
    Jing Li
    Department of Physiology and Pathophysiology, Beijing, China
    Hepatology 53:1906-16. 2011
    ..Moreover, FOXO1 overexpression increased PANDER expression in cultured hepatocytes and mouse livers...
  29. doi request reprint Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries
    Zhihui Tang
    Institute of Cardiovascular Science, Peking University Health Science Center, Beijing 100083, China
    Circulation 118:764-72. 2008
    ..In the present study, we examined the role of c-Cbl tyrosine phosphorylation in vascular injury...
  30. doi request reprint Homocysteine upregulates resistin production from adipocytes in vivo and in vitro
    Yin Li
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
    Diabetes 57:817-27. 2008
    ..We aimed to determine whether Hcy can induce insulin resistance by directly regulating the expression and secretion of resistin from adipose tissue...
  31. doi request reprint Liver X receptor agonist alleviated high glucose-induced endothelial progenitor cell dysfunction via inhibition of reactive oxygen species and activation of AMP-activated protein kinase
    Xiaoxia Li
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Microcirculation 19:547-53. 2012
    ..However, the effect of LXR agonists on endothelial progenitor cell (EPC) function is largely unknown. Here, we explored the effect of the LXR agonist TO901317 (TO) on EPC biology and the underlying mechanisms...
  32. pmc Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy
    Ding Ai
    Department of Physiology and Pathophysiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences, Health Science Center, Ministry of Education, Peking University, Beijing 100083, China
    Proc Natl Acad Sci U S A 106:564-9. 2009
    ..Thus, pharmacological inhibition of sEH would be a useful approach to prevent and treat Ang II-induced cardiac hypertrophy...
  33. ncbi request reprint [Expression and role of soluble epoxide hydrolase in renal tissue of two kidneys one clip hypertension rats model]
    Yue Juan Pan
    Department of Nephrology, Peking University Third Hospital, Beijing 100191, China
    Beijing Da Xue Xue Bao 43:820-6. 2011
    ..To investigate renal expression of soluble epoxide hydrolase (sEH) in 2-kidney-1-clip rats and explore the role of sEH in renal arterial stenosis hypertensive development...
  34. ncbi request reprint JNK-AP-1 pathway involved in interleukin-1beta-induced calcitonin gene-related peptide secretion in human type II alveolar epithelial cells
    Wenjing Li
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences Reference Laboratory of Education Ministry on Molecular Cardiology, Health Science Center, Peking University, Beijing 100083, PR China
    Peptides 28:1252-9. 2007
    ....
  35. doi request reprint Deficiency of cartilage oligomeric matrix protein causes dilated cardiomyopathy
    Yaqian Huang
    Department of Physiology and Pathophysiology, Basic Medical College of Peking University, Peking University, Beijing, 100191, People s Republic of China
    Basic Res Cardiol 108:374. 2013
    ..Additionally, COMP directly bonded to the extracellular β-tail domain of integrin β1, prevented integrin β1 ubiquitination/degradation, and maintained the cardiac homeostasis. COMP-integrin β1 axis is a potential target of DCM. ..
  36. doi request reprint Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway
    Han Xiao
    Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100191, China
    Cardiovasc Res 87:504-13. 2010
    ..The mechanism of the cardioprotective action of metformin is incompletely understood. We determined the role of metformin in cardiac fibrosis and investigated the mechanism...
  37. pmc Regulation of gastric hormones by systemic rapamycin
    Geyang Xu
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
    Peptides 31:2185-92. 2010
    ..05), but had no effect on somatostatin production (165.2±25.07 pg/ml vs. 178.9±29.14 pg/ml, p=0.73). Gastric mTOR is a gastric sensor whose activity is linked to the differential regulation of gastric hormone production and release...
  38. pmc Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo
    Ding Ai
    Department of Physiology and Pathophysiology, Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Peking University, Beijing 100083, China
    Proc Natl Acad Sci U S A 104:9018-23. 2007
    ..Blocking Ang II binding to Ang II receptor 1 by losartan abolished the sEH induction. Thus, AP-1 activation is involved in the transcriptional up-regulation of sEH by Ang II in ECs, which may contribute to Ang II-induced hypertension...
  39. doi request reprint Intermedin inhibits macrophage foam-cell formation via tristetraprolin-mediated decay of CD36 mRNA
    Xiao Yan Dai
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, P R China
    Cardiovasc Res 101:297-305. 2014
    ..Here, we studied the role of IMD in CD36-mediated macrophage foam-cell formation...
  40. doi request reprint Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein
    Yan Cai
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
    Cardiovasc Res 85:864-73. 2010
    ..Here, we investigated the expression of the novel peptide intermedin (IMD) in the vasculature, tested its ability to prevent VC in vivo and in vitro, and examined the mechanism involved...
  41. ncbi request reprint Insights into cholesterol efflux in vascular endothelial cells
    Xuefen Xie
    Department of Physiology and Pathophysiology, Peking University Health Sciences Center, Beijing 100083, China
    Cardiovasc Hematol Disord Drug Targets 7:127-34. 2007
    ..Such a cholesterol efflux pathway could provide insight into the efficient removal of excess cellular cholesterol in preventing atherogenesis...
  42. doi request reprint Globular adiponectin inhibits angiotensin II-induced nuclear factor kappaB activation through AMP-activated protein kinase in cardiac hypertrophy
    Cheng Wang
    Key Laboratory of Molecular Cardiovascular Sciences, Department of Physiology and Pathophysiology, Peking University Health Science Center, Ministry of Education, Beijing, China
    J Cell Physiol 222:149-55. 2010
    ..When AMPK was inhibited, the suppressive effect of gAd on ANP mRNA expression was reduced. Our data indicate that gAd inhibits cardiac hypertrophic signaling through AMPK mediated suppression of NF-kappaB activation...
  43. pmc Ca2+/calmodulin-dependent protein kinase kinase β phosphorylation of Sirtuin 1 in endothelium is atheroprotective
    Liang Wen
    Department of Physiology and Pathophysiology, Peking University Health Sciences Center, Beijing 100191, China
    Proc Natl Acad Sci U S A 110:E2420-7. 2013
    ..The results suggest that the CaMKKβ-SIRT1 axis in ECs is mechanosensitive, antioxidative, and anti-inflammatory. ..
  44. pmc Liver kinase B1 is required for thromboxane receptor-dependent nuclear factor-κB activation and inflammatory responses
    Jinlong He
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Arterioscler Thromb Vasc Biol 33:1297-305. 2013
    ..The aims of the present study were to determine the contributions of NF-κB activation to TPr-triggered vascular inflammation and elucidate the mechanism(s) underlying TPr activation of NF-κB...
  45. doi request reprint Targeted disruption of the prostaglandin E2 E-prostanoid 2 receptor exacerbates vascular neointimal formation in mice
    Sen Zhu
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Arterioscler Thromb Vasc Biol 31:1739-47. 2011
    ..The PGE(2) receptor E-prostanoid 2 (EP2) is involved in the proliferation and migration of various cell types. We aimed to determine the role of EP2 in the pathogenesis of neointimal formation after vascular injury...
  46. pmc AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells
    Xiaoxia Li
    Department of Physiology and Pathophysiology, Key Laboratory of Cardiovascular Science of Ministry of Education, Peking University Health Science Center, Beijing, China
    Arterioscler Thromb Vasc Biol 28:1789-95. 2008
    ..We investigated the role of AMP-activated protein kinase (AMPK) in EPC differentiation and functions...
  47. pmc Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats
    Yunfeng Zhou
    Department of Physiology and Pathophysiology, Peking University Health Science Center, 38 Xueyuan Rd, Beijing, China
    Am J Physiol Renal Physiol 295:F662-71. 2008
    ..Activation of SREBP-1 transcription factor may represent an underlying molecular mechanism of hyperlipidemia in NS...
  48. ncbi request reprint Cholesterol loading increases the translocation of ATP synthase beta chain into membrane caveolae in vascular endothelial cells
    Tengke Wang
    Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100083, China
    Biochim Biophys Acta 1761:1182-90. 2006
    ..Thus, the ectopic localization of ATPS-beta may participate in the energy balance of cells in response to the change in intracellular cholesterol levels...
  49. pmc 8,9-Epoxyeicosatrienoic acid inhibits antibody production of B lymphocytes in mice
    Yanxiang Gao
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People s Republic of China
    PLoS ONE 7:e40258. 2012
    ..Furthermore, germinal center formation was impaired by 8,9-EET in mice in vivo. 8,9-EET may inhibit B-cell function in vitro and in vivo, which suggests a new therapeutic strategy for diseases with excess B cell activation...
  50. pmc Inactivation of the E-prostanoid 3 receptor attenuates the angiotensin II pressor response via decreasing arterial contractility
    Lihong Chen
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Haidian District, Beijing, China
    Arterioscler Thromb Vasc Biol 32:3024-32. 2012
    ..The present studies aimed at elucidating the role of prostaglandin E(2) receptor subtype 3 (E-prostanoid [EP] 3) in regulating blood pressure...
  51. doi request reprint Opposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosis
    Lijuan Li
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    PLoS ONE 9:e94092. 2014
    ..Thus, compared with pharmacological inhibition of sEH, EPHX2 deletion caused the shift in arachidonic acid metabolism, which may led to pathological cardiac remodeling, especially cardiac fibrosis. ..
  52. doi request reprint Virus-induced gene silencing in eggplant (Solanum melongena)
    Haiping Liu
    Laboratory of Fruit Biology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
    J Integr Plant Biol 54:422-9. 2012
    ..In conclusion, four genes, PDS, Chl H, Su (Sulfur), CLA1, were down-regulated significantly by VIGS, indicating that the VIGS system can be successfully applied in eggplant and is a reliable tool for the study of gene function...
  53. ncbi request reprint Hydrogen sulfide downregulates the aortic L-arginine/nitric oxide pathway in rats
    Bin Geng
    Institute of Cardiovascular Research, First Hospital of Peking Univ, Beijing xishuku St 8, 100034
    Am J Physiol Regul Integr Comp Physiol 293:R1608-18. 2007
    ..Taken together, our findings suggest that H(2)S downregulates the vascular l-Arg/NOS/NO pathway in vitro and in vivo, and the K(ATP) channel could be involved in the regulatory mechanism of H(2)S...
  54. ncbi request reprint Ectopic ATP synthase in endothelial cells: a novel cardiovascular therapeutic target
    Yi Fu
    Department of Physiology and Pathophysiology Peking University Health Science Center 38 Xueyuan Road, Haidian District, Beijing 100191, China
    Curr Pharm Des 16:4074-9. 2010
    ..Through these functions, ectopic ATP synthase on ECs is considered a potential and novel therapeutic target for atherosclerosis, hypertension and lipid disorders...
  55. ncbi request reprint [Renal over expression of soluble epoxide hydrolase in rat with hypertension induced by high-salt]
    Qian Wang
    Department of Nephrology, Peking University Third Hospital, and Department of Physiology and Pathophysiology, Peking University School of Basic Medicine, Beijing 100191, China
    Beijing Da Xue Xue Bao 42:126-30. 2010
    ..To investigate the role of renal expression of soluble epoxide hydrolase in high-salt induced hypertensive rat model...
  56. doi request reprint Proteomic analysis of endothelial lipid rafts reveals a novel role of statins in antioxidation
    Ming Xia Gu
    Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Peking University Health Science Center, Beijing, 100191, China
    J Proteome Res 11:2365-73. 2012
    ....
  57. ncbi request reprint Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells
    Yanbo Fan
    Institute of Cardiovascular Science and Key Laboratory of Molecular Cardiovascular Science, Peking University Health Science Center, Beijing 100083, China
    Arterioscler Thromb Vasc Biol 28:315-21. 2008
    ..The role of peroxisome proliferator-activated receptor-delta (PPAR-delta) in endothelial activation remains poorly understood. In this study, we investigated the anti-inflammatory effect of PPAR-delta and the mechanism involved...
  58. ncbi request reprint [Soluble epoxide hydrolase and lipid metabolism]
    Xin Xin Ma
    Department of Physiology and Pathophysiology, Peking University Health Sciences Center, Beijing 100191, China
    Sheng Li Ke Xue Jin Zhan 41:267-71. 2010
    ..Here we review the progress on the aspects of the different enzyme activity of the two terminals of sEH and the mechanisitic study on the regulation of lipid metabolism by sEH...
  59. ncbi request reprint Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice
    Jinyu Wang
    Institute of Cardiovascular Sciences, Peking University Health Science Center, 38 Xueyuan Road, Hai Dian District, 100083, Beijing, China
    Arterioscler Thromb Vasc Biol 27:197-203. 2007
    ..In this study the role of LPL in atherogenesis in endothelial-intact carotid arteries was assessed in genetically hyperlipidemic LPL- and ApoE-deficient mice...
  60. doi request reprint The regulation mode of RIN transcription factor involved in ethylene biosynthesis in tomato fruit
    Ling Li
    College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
    J Sci Food Agric 91:1822-8. 2011
    ....
  61. ncbi request reprint [Effect of Pongamia pinnata root flavonoids on the quality of ulcer healing and expression of EGF and TGF-alpha in the rat model of gastric ulcer induced by acetic acid]
    Ke Yun Liu
    Department of Physiology, School of Medicine, Hubei Institute for Nationalities, Enshi 445000, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 28:435-8. 2012
    ..To observe the effects and mechanisms of Pongamia pinnata root flavonoids (PRF) on the experimental gastric ulcer induced by acetic acid and to study the mechanism of PRF on the quality of ulcer healing...
  62. ncbi request reprint Calcitonin gene-related peptide inhibits interleukin-1beta-induced endogenous monocyte chemoattractant protein-1 secretion in type II alveolar epithelial cells
    Wenjing Li
    Department of Physiology and Pathophysiology, School of Basic Medical Science, Peking University, Xue Yuan Road No 38, Beijing 100083, People s Republic of China
    Am J Physiol Cell Physiol 291:C456-65. 2006
    ..Thus increased endogenous CGRP secretion in lung inflammatory disease might eliminate the excessive response by elevating the cAMP level through inhibiting the ROS-NF-kappaB-MCP-1 pathway...
  63. ncbi request reprint Native LDL upregulation of ATP-binding cassette transporter-1 in human vascular endothelial cells
    Hailing Liao
    Division of Biomedical Sciences, University of California, Riverside 92521, USA
    Arterioscler Thromb Vasc Biol 22:127-32. 2002
    ..Overexpression of ABCA1 in these cells prevents overloading of cholesterol by increasing the efflux of cholesterol. Thus, ABCA1 plays an important role in the homeostasis of cholesterol in the vascular endothelium...
  64. ncbi request reprint Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection
    Tzong Shyuan Lee
    Division of Biomedical Sciences, University of California, Riverside, CA 92521 0121, USA
    Circulation 110:1296-302. 2004
    ..Here, we studied whether heme oxygenase-1 (HO-1), an important cytoprotective molecule, is induced by simvastatin and the role of HO-1 in the pleiotropic effects of simvastatin...
  65. ncbi request reprint Liver X receptor-alpha mediates cholesterol efflux in glomerular mesangial cells
    Jing Wu
    Division of Nephrology, S 3223 MCN, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Physiol Renal Physiol 287:F886-95. 2004
    ..These data suggest that LXRalpha may be a potential therapeutic target for treating lipid-related renal glomerular disease...
  66. ncbi request reprint Shear stress activation of SREBP1 in endothelial cells is mediated by integrins
    Yi Liu
    Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, USA
    Arterioscler Thromb Vasc Biol 22:76-81. 2002
    ..These results demonstrate that integrin signaling plays a critical role in the modulation of SREBP in ECs in response to shear stress...
  67. ncbi request reprint Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism
    Lingfang Zeng
    Division of Biomedical Sciences, University of California, Riverside, Riverside, California 92521, USA
    J Biol Chem 279:48801-7. 2004
    ..Thus, this SREBP-regulated mechanism may control the efflux of cholesterol, which is a newly defined function of SREBP2 in ECs in addition to its role in cholesterol uptake and biosynthesis...
  68. ncbi request reprint Low density lipoprotein induces eNOS translocation to membrane caveolae: the role of RhoA activation and stress fiber formation
    Yi Zhu
    Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA
    Biochim Biophys Acta 1635:117-26. 2003
    ..In conclusion, a high level of LDL increases the movement of eNOS to membrane caveolae via the increased stress fibers. The RhoA-mediated pathway may play a crucial role in this process in vascular ECs...
  69. ncbi request reprint Inhibitory effect of quercetin on proliferation of human microvascular endothelial cells in vitro
    Pan Sheng Fan
    Department of Pharmacology, Institute of Chinese Materia Medica, Soochow University, Suzhou 215007, China
    Acta Pharmacol Sin 24:1231-4. 2003
    ..To investigate the role of quercetin (Que) in the proliferation of cultured human skin microvascular endothelial cells (MVEC)...
  70. pmc Mutational analysis of the signal-sensing domain of ResE histidine kinase from Bacillus subtilis
    Avanti Baruah
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Bacteriol 186:1694-704. 2004
    ..This suggests that the extracytoplasmic region could contribute to amplification of ResE activity leading to the robust activation of genes required for anaerobic metabolism in B. subtilis...
  71. ncbi request reprint [Effects of quercetin on platelet-endothelial cell adhesion and their expression of adhesion molecules]
    Zhong qin Liang
    Department of Pharmacology, Suzhou University Medical College, Suzhou, 215007 China
    Yao Xue Xue Bao 38:574-7. 2003
    ..To observe the effect of quercetin (Que) on the adhesion of platelets to cultured endothelial cells and adhesion molecule expression by human umbilical vein endothelial cells (HUVEC) and platelets...
  72. ncbi request reprint Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis
    Rui hai Zhou
    Division of Biomedical Sciences, University of California, Riverside Riverside 92521 0121, USA
    Circ Res 95:471-8. 2004
    ..SREBP inhibition also markedly suppressed VEGF-induced angiogenesis in chick embryos. In summary, this study identifies SREBPs as the key molecules in regulating angiogenesis in response to VEGF...
  73. ncbi request reprint Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase
    Yi Zhu
    Department of Human Ontogeny and Childhood Development, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan
    J Med Dent Sci 50:41-6. 2003
    ....
  74. ncbi request reprint [Effect of electroacupuncture of "Hegu" (LI 4)-"Taichong" (LR 3) on colonic nitric oxide synthase and glutathione peroxidase activity and nitric oxide content in depression rats]
    Xue Kuan Huang
    College of Chinese Medicine, Chongqing Medical University, Chongqing 401331, China
    Zhen Ci Yan Jiu 33:183-5. 2008
    ....
  75. pmc ATF6 modulates SREBP2-mediated lipogenesis
    Lingfang Zeng
    Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521 0121, USA
    EMBO J 23:950-8. 2004
    ..As a functional consequence, the lipogenic effect of SREBP2(N) in liver cells was suppressed by ATF6(N). Our results provide a novel mechanism by which ATF6 antagonizes SREBP2 to regulate the homeostasis of lipid and glucose...
  76. ncbi request reprint Effects of hypoxia on promoter of telomerase reverse transcriptase and cell cycle distribution in neonatal rat cardiac myocytes
    Shun Lin Xu
    Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Chin Med J (Engl) 118:409-11. 2005
  77. ncbi request reprint [Activities of circulating endothelial progenitor cells in patients with in-stent restenosis]
    Li Cheng Lei
    Department of Cardiology, First Hospital of Peking University, Beijing 100034, China
    Zhonghua Yi Xue Za Zhi 87:3394-8. 2007
    ..To observe the number and activities of circulating endothelial progenitor cells (EPCs) in patients with in-stent restenosis...
  78. pmc Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium
    Dongsheng Zhang
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267 0529, USA
    J Mol Cell Cardiol 44:281-92. 2008
    ..CXCR4 over-expression led to enhance in vivo mobilization and engraftment of MSCs into ischemic area where these cells promoted neomyoangiogenesis and alleviated early signs of left ventricular remodeling...
  79. ncbi request reprint Multiple genomic alterations on 21q22 predict various TMPRSS2/ERG fusion transcripts in human prostate cancers
    Wennuan Liu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Genes Chromosomes Cancer 46:972-80. 2007
    ....
  80. ncbi request reprint Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers
    Zhi ling Sun
    Department of Pancreas Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Biochim Biophys Acta 1774:764-71. 2007
    ..These results indicate that cyclin I and GDI2 may be potential molecular targets for pancreatic cancer diagnostics and therapeutics...
  81. pmc Characterization of ResDE-dependent fnr transcription in Bacillus subtilis
    Hao Geng
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Bacteriol 189:1745-55. 2007
    ....
  82. ncbi request reprint Statins activate AMP-activated protein kinase in vitro and in vivo
    Wei Sun
    Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521 0121, USA
    Circulation 114:2655-62. 2006
    ..We therefore studied whether statins can activate AMPK, and if so, whether the activated AMPK regulates nitric oxide (NO) production and angiogenesis mediated by endothelial NO synthase, a substrate of AMPK in vascular endothelial cells...
  83. ncbi request reprint [Progress in the study of ATP-binding cassette transporter A1]
    Min Jia Zhu
    Sheng Li Ke Xue Jin Zhan 36:337-40. 2005
  84. pmc The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase
    Yi Liu
    Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 102:16747-52. 2005
    ..Blocking PPARgamma by GW9662 abolished the EET/AUDA-mediated antiinflammatory effect, which indicates that PPARgamma is an effector of EETs...
  85. ncbi request reprint Adenovirus-mediated overexpression of novel mutated IkappaBalpha inhibits nuclear factor kappaB activation in endothelial cells
    Lin Fu Zhou
    Department of Respiratory Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
    Chin Med J (Engl) 118:1422-8. 2005
    ....
  86. ncbi request reprint [The study on platelet-derived growth factor and proliferating cell nuclear antigen antisense oligodeoxynucleotides together inhibiting the stenosis of transplanted vascular]
    Zhong Jun Wu
    The Organ Grafting Center, First Affiliated Hospital, Zhejiang University, Hangzhou 310012, China
    Zhonghua Wai Ke Za Zhi 43:426-9. 2005
    ..To study the effect of platelet-derived growth factor (PDGF) and proliferating cell nuclear antigen (PCNA) antisense oligodeoxynucleotides (AODN) together on inhibiting the proliferation of the stenosis of transplanted vascular...
  87. ncbi request reprint Novel anti-oxidative role of calreticulin in protecting A549 human type II alveolar epithelial cells against hypoxic injury
    Lingyun Jia
    Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People s Republic of China
    Am J Physiol Cell Physiol 294:C47-55. 2008
    ....