Genomes and Genes


Zhuan Zhou


Affiliation: Peking University
Country: China


  1. Shang S, Zhu F, Liu B, Chai Z, Wu Q, Hu M, et al. Intracellular TRPA1 mediates Ca2+ release from lysosomes in dorsal root ganglion neurons. J Cell Biol. 2016;215:369-381 pubmed
    ..Thus, in addition to working via Ca2+ influx, TRPA1 channels trigger vesicle release in sensory neurons by releasing Ca2+ from lysosome-like organelles. ..
  2. Kang X, Xu H, Teng S, Zhang X, Deng Z, Zhou L, et al. Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo. Proc Natl Acad Sci U S A. 2014;111:15804-9 pubmed publisher
    ..Thus, pNSC-DAn grafts release and reuptake dopamine in the striatum in vivo and alleviate PD symptoms in rats, providing proof-of-concept for human clinical translation. ..
  3. Zhang Q, Liu B, Wu Q, Liu B, Li Y, Sun S, et al. Differential Co-release of Two Neurotransmitters from a Vesicle Fusion Pore in Mammalian Adrenal Chromaffin Cells. Neuron. 2019;102:173-183.e4 pubmed publisher
    ..These findings strongly imply that, in contrast to sub-quantal CA release in chromaffin cells, fast synaptic transmission without transmitter-matrix binding is mediated exclusively via quantal release in neurons. ..
  4. Wu Q, Zhang Q, Liu B, Li Y, Wu X, Kuo S, et al. Dynamin 1 Restrains Vesicular Release to a Subquantal Mode In Mammalian Adrenal Chromaffin Cells. J Neurosci. 2019;39:199-211 pubmed publisher
    ..The present work with dyn1-KO mice further confirms that Ca2+-dependent transmitter release is mainly via subquantal mode, suggesting that subquantal release could be also important in other types of cells. ..
  5. Xu H, Zuo P, Wang S, Zhou L, Sun X, Hu M, et al. Striatal dopamine release in a schizophrenia mouse model measured by electrochemical amperometry in vivo. Analyst. 2015;140:3840-5 pubmed publisher
  6. He L, Zhang Q, Wang L, Dai J, Wang C, Zheng L, et al. Muscarinic inhibition of nicotinic transmission in rat sympathetic neurons and adrenal chromaffin cells. Philos Trans R Soc Lond B Biol Sci. 2015;370: pubmed publisher
    ..The time dependence suggests that MiI may provide a novel mechanism for post-synaptic adaptation in all cells/neurons and synapses expressing both types of AChRs. ..
  7. Zhu F, Wu Q, Li J, Grycel K, Liu B, Sun X, et al. A single dose of cocaine potentiates glutamatergic synaptic transmission onto locus coeruleus neurons. Cell Calcium. 2017;67:11-20 pubmed publisher
    ..These results reveal that LC-NE serves as an initial target of drug intake. ..
  8. Chai Z, Wang C, Huang R, Wang Y, Zhang X, Wu Q, et al. CaV2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons. Neuron. 2017;96:1317-1326.e4 pubmed publisher
    ..2-SNARE "voltage-gating fusion pore" as a novel pathway co-existing with the canonical "Ca2+-gating fusion pore" pathway for neurotransmitter release following action potentials in primary sensory neurons. ..
  9. Wang C, Kang X, Zhou L, Chai Z, Wu Q, Huang R, et al. Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology. Nat Commun. 2018;9:81 pubmed publisher
    ..Thus, PD-like neurotoxicity induced by parkin dysfunction requires synaptotagmin-11 accumulation in SNpc dopaminergic neurons. ..