Genomes and Genes

Species

Xinshan Ye

Summary

Affiliation: Peking University
Country: China

Publications

  1. Xiao A, Zheng X, Song C, Gui Y, Huo C, Ye X. Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing N-acetyl modified STn derivatives as anticancer vaccines. Org Biomol Chem. 2016;14:7226-37 pubmed publisher
  2. Luo H, Niu Y, Jin X, Cao X, Yao X, Ye X. Indolo-quinoline boron difluoride dyes: synthesis and spectroscopic properties. Org Biomol Chem. 2016;14:4185-8 pubmed publisher
    ..The synthetic complexes could be used as new fluorescent dyes. ..
  3. Yu Y, Xiong D, Ye X. 2-Trifluoromethylthiolation of glycals. Org Biomol Chem. 2016;14:6403-6 pubmed publisher
    ..These trifluoromethylthiolated carbohydrates may benefit the development of carbohydrate-based drugs. ..
  4. Gao X, Yang H, Xu Y, Xiong Y, Wang G, Ye X, et al. Iminosugar derivative WGN-26 suppresses acute allograft rejection via inhibiting the IFN-γ/p-STAT1/T-bet signaling pathway. Int Immunopharmacol. 2014;23:688-95 pubmed publisher
  5. Huo C, Zheng X, Xiao A, Liu C, Sun S, Lv Z, et al. Synthetic and immunological studies of N-acyl modified S-linked STn derivatives as anticancer vaccine candidates. Org Biomol Chem. 2015;13:3677-90 pubmed publisher
  6. Xiong D, Zhu J, Han M, Luo H, Wang C, Yu Y, et al. Rapid probing of sialylated glycoproteins in vitro and in vivo via metabolic oligosaccharide engineering of a minimal cyclopropene reporter. Org Biomol Chem. 2015;13:3911-7 pubmed publisher
    ..This is the first reported metabolic labelling of cyclopropene-modified sugars in vivo. Therefore, Ac4ManNCp is a powerful probe for efficient and rapid MOE and it may find wide applications in the labelling of glycans. ..
  7. Liu Y, Li X, Xiong D, Yu B, Pu X, Ye X. Synthetic phenylethanoid glycoside derivatives as potent neuroprotective agents. Eur J Med Chem. 2015;95:313-23 pubmed publisher
    ..Compounds 5, 6, 8 may hold the potential as promising neuroprotective agents and new lead compounds for the treatment of neurodegenerative diseases or cerebral ischemia. ..
  8. Zheng X, Yang F, Zheng M, Huo C, Zhang Y, Ye X. Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen. Org Biomol Chem. 2015;13:6399-406 pubmed publisher
  9. Yang X, Xiong D, Song C, Tai G, Ye X. Synthesis of N-dialkylphosphoryl iminosugar derivatives and their immunosuppressive activities. Org Biomol Chem. 2015;13:9364-8 pubmed publisher
    ..The disclosure of the structure-activity relationships may benefit the structural modifications of iminosugars to find new types of immunosuppressive agents. ..

More Information

Publications16

  1. Liu C, Zheng X, Ye X. Broadly Neutralizing Antibody-Guided Carbohydrate-Based HIV Vaccine Design: Challenges and Opportunities. ChemMedChem. 2016;11:357-62 pubmed publisher
    ..Herein we summarize recent studies into the design of carbohydrate-based HIV vaccines and some valuable experiences gained in work with other bnAb-based HIV vaccines. ..
  2. Song C, Sun S, Huo C, Li Q, Zheng X, Tai G, et al. Synthesis and immunological evaluation of N-acyl modified Tn analogues as anticancer vaccine candidates. Bioorg Med Chem. 2016;24:915-20 pubmed publisher
    ..Moreover, the elicited antisera against antigen 6-CRM197 reacted strongly with the Tn-positive tumor cells, implying the potential of this glycoconjugate as an anticancer vaccine. ..
  3. Bai X, Niu Y, Zhu J, Yang A, Wu Y, Ye X. A new GLP-1 analogue with prolonged glucose-lowering activity in vivo via backbone-based modification at the N-terminus. Bioorg Med Chem. 2016;24:1163-70 pubmed publisher
    ..This modification strategy will benefit the development of GLP-1-based anti-diabetic drugs. ..
  4. Sun S, Zheng X, Huo C, Song C, Li Q, Ye X. Synthesis and Evaluation of Glycoconjugates Comprising N-Acyl-Modified Thomsen-Friedenreich Antigens as Anticancer Vaccines. ChemMedChem. 2016;11:1090-6 pubmed publisher
    ..In particular, the N-monofluoroacetyl-modified TF conjugate 4-CRM197 showed the strongest complement-dependent cytotoxicity effect against 4T1 cells, implying the potential of this glycoconjugate as an anticancer vaccine. ..
  5. Sun L, Wu X, Xiong D, Ye X. Stereoselective Koenigs-Knorr Glycosylation Catalyzed by Urea. Angew Chem Int Ed Engl. 2016;55:8041-4 pubmed publisher
    ..Moreover, the low ?-stereoselectivity of glycosylations observed when using perbenzylated glucosyl donors can be greatly improved by the addition of tri-(2,4,6-trimethoxyphenyl)phosphine (TTMPP). ..
  6. Yang A, Li D, Chi L, Ye X. Validation, Identification, and Biological Consequences of the Site-specific O-GlcNAcylation Dynamics of Carbohydrate-responsive Element-binding Protein (ChREBP). Mol Cell Proteomics. 2017;16:1233-1243 pubmed publisher
    ..This work is a detailed study of ChREBP O-GlcNAcylation and highlights the biological consequences of the site-specific O-GlcNAcylation dynamics of ChREBP. ..
  7. Liu H, Song C, Niu Y, Li T, Li Q, Ye X. Synthesis and biological evaluation of N-arylated-lactam-type iminosugars as potential immunosuppressive agents. Org Biomol Chem. 2017;15:5912-5919 pubmed publisher
    ..These results may be beneficial to the discovery of new iminosugar derivatives as immunosuppressive agents. ..