Jinhua Wen

Summary

Affiliation: Peking University
Country: China

Publications

  1. doi request reprint Pax6 directly modulate Sox2 expression in the neural progenitor cells
    Jinhua Wen
    Peking University Stem Cell Research Center and Cell Biology Department, Peking University Health Science Center, Beijing, China
    Neuroreport 19:413-7. 2008
  2. pmc PAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation
    Jing Fang
    1 Department of Cell Biology, Peking University Stem Cell Research Center, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
    Stem Cells Dev 23:2297-310. 2014
  3. pmc Lysophosphatidic acid accelerates lung fibrosis by inducing differentiation of mesenchymal stem cells into myofibroblasts
    Na Tang
    Peking University Stem Cell Research Center, Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    J Cell Mol Med 18:156-69. 2014
  4. doi request reprint Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets
    Yuanyuan Chen
    Peking University Stem Cell Research Center, and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China
    Exp Biol Med (Maywood) 238:1259-64. 2013
  5. pmc Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing
    Ting Liu
    Peking University Stem Cell Research Center, Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    PLoS ONE 7:e46934. 2012
  6. doi request reprint Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression
    Ruopeng Feng
    Peking University Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China, 100191
    Biochem J 450:459-68. 2013
  7. ncbi request reprint Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation
    Zhifeng Xiao
    Peking University Stem Cell Research Center and Cell Biology Department, Peking University Health Science Center, Beijing, China
    Cell Res 17:73-9. 2007
  8. doi request reprint GLP-1 analog liraglutide enhances proinsulin processing in pancreatic β-cells via a PKA-dependent pathway
    Liang Wang
    Department of Endocrinology and Metabolism L W, Y L, J Y, H Z, J K, Q T, L Z, R W, T H, Peking University Third Hospital, and Peking University Stem Cell Research Center J W, T H, Peking University Health Science Center, Beijing 100191, China
    Endocrinology 155:3817-28. 2014
  9. doi request reprint Efficient induction of pluripotent stem cells from menstrual blood
    Yang Li
    Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing, China
    Stem Cells Dev 22:1147-58. 2013
  10. doi request reprint High-fat diet induces early-onset diabetes in heterozygous Pax6 mutant mice
    Yuanyuan Chen
    Department of Endocrinology and Metabolism, Peking University Third Hospital, Peking University Stem Cell Research Centre, Peking University Health Science Center, Beijing, China Jiangsu Province Key Lab of Human Functional Genomics, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China
    Diabetes Metab Res Rev 30:467-75. 2014

Collaborators

Detail Information

Publications14

  1. doi request reprint Pax6 directly modulate Sox2 expression in the neural progenitor cells
    Jinhua Wen
    Peking University Stem Cell Research Center and Cell Biology Department, Peking University Health Science Center, Beijing, China
    Neuroreport 19:413-7. 2008
    ..Moreover, neural progenitors isolated from the Pax6(-/-) embryos showed a decreased neurosphere formation as well as proliferation...
  2. pmc PAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation
    Jing Fang
    1 Department of Cell Biology, Peking University Stem Cell Research Center, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
    Stem Cells Dev 23:2297-310. 2014
    ..Therefore, we propose a novel PAX6-miR-124 pathway that controls ES cell migration. Our findings may provide important information for studies on ES cell differentiation and embryonic development. ..
  3. pmc Lysophosphatidic acid accelerates lung fibrosis by inducing differentiation of mesenchymal stem cells into myofibroblasts
    Na Tang
    Peking University Stem Cell Research Center, Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    J Cell Mol Med 18:156-69. 2014
    ..Collectively, the above findings not only further validate LPA1 as a drug target in the treatment of pulmonary fibrosis but also elucidate a novel pathway in which BMSCs contribute to the pathologic process...
  4. doi request reprint Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets
    Yuanyuan Chen
    Peking University Stem Cell Research Center, and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China
    Exp Biol Med (Maywood) 238:1259-64. 2013
    ..The results provide new insights into the mechanism of truncated PAX6 in regulating the functions of the pancreas and endocrine system. ..
  5. pmc Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing
    Ting Liu
    Peking University Stem Cell Research Center, Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    PLoS ONE 7:e46934. 2012
    ..As a protein cleaving enzyme, in addition to its expression, the activity of PC1/3 is closely related to its function. We therefore hypothesize that Pax6 mutation alters the activity of PC1/3, which affects proinsulin processing...
  6. doi request reprint Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression
    Ruopeng Feng
    Peking University Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China, 100191
    Biochem J 450:459-68. 2013
    ..In short, we have found a novel Sox2/survivin pathway that regulates NSC survival and homoeostasis, thus revealing a new mechanism of brain development, neurological degeneration and such aging-related disorders...
  7. ncbi request reprint Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation
    Zhifeng Xiao
    Peking University Stem Cell Research Center and Cell Biology Department, Peking University Health Science Center, Beijing, China
    Cell Res 17:73-9. 2007
    ..Collectively, this study may provide insight into the mechanisms by which microenvironmental niche signals regulate NSCs...
  8. doi request reprint GLP-1 analog liraglutide enhances proinsulin processing in pancreatic β-cells via a PKA-dependent pathway
    Liang Wang
    Department of Endocrinology and Metabolism L W, Y L, J Y, H Z, J K, Q T, L Z, R W, T H, Peking University Third Hospital, and Peking University Stem Cell Research Center J W, T H, Peking University Health Science Center, Beijing 100191, China
    Endocrinology 155:3817-28. 2014
    ..Our study provides a new mechanism for improvement of pancreatic β-cell function by the GLP-1-based therapy...
  9. doi request reprint Efficient induction of pluripotent stem cells from menstrual blood
    Yang Li
    Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing, China
    Stem Cells Dev 22:1147-58. 2013
    ..These cells were able to differentiate into various cell types of all 3 germ layers both in vitro and in vivo. Therefore, MenSCs may be a preferred candidate for generation of iPSCs...
  10. doi request reprint High-fat diet induces early-onset diabetes in heterozygous Pax6 mutant mice
    Yuanyuan Chen
    Department of Endocrinology and Metabolism, Peking University Third Hospital, Peking University Stem Cell Research Centre, Peking University Health Science Center, Beijing, China Jiangsu Province Key Lab of Human Functional Genomics, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China
    Diabetes Metab Res Rev 30:467-75. 2014
    ..In this study, we aimed to develop a novel diabetic model imitating human type 2 diabetes by exposing Pax6(m/+) mice to high-fat diet and to explore the underlying mechanism of diabetes in this model...
  11. pmc Genome-wide analysis of human microRNA stability
    Yang Li
    Department of Cell Biology, Stem Cell Research Center, Peking University School of Basic Medical Sciences, 38 Xueyuan Road, Beijing 100191, China
    Biomed Res Int 2013:368975. 2013
    ..Together, our results provided an extensive description of the global landscape, dynamics, and distinct mode of human miRNA stability, which provide help in investigating their functions in physiology and pathophysiology. ..
  12. ncbi request reprint Cartilage-derived morphogenetic protein-1 promotes the differentiation of mesenchymal stem cells into chondrocytes
    Xiaowen Bai
    Peking University Stem Cell Research Center, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    Biochem Biophys Res Commun 325:453-60. 2004
    ..This study may provide an improved induction approach using MSCs for repairing damaged cartilage...
  13. ncbi request reprint Repeated streptozotocin injections cause early onset of glomerulosclerosis in mice
    Shinya Mizuno
    Division of Molecular Regenerative Medicine, Department of Molecular Regenerative Medicine, Osaka University, Suita, Japan
    Exp Anim 53:175-80. 2004
    ..Our results provide an animal tool to elucidate the molecular mechanisms of DN, for example to investigate vascular pathology in diabetic glomerular diseases...
  14. ncbi request reprint Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice
    Jinhua Wen
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Cancer Gene Ther 11:419-30. 2004
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