Xiao Li Tian
Affiliation: Peking University
Ma J, Yang F, Mahida S, Zhao L, Chen X, Zhang M, et al
. TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians. Cardiovasc Res. 2016;109:442-50 pubmed publisher
..Our results provide both genetic and functional evidence to support the contribution of TBX5 gene in the pathogenesis of AF. The potential mechanism of arrhythmia may be due in part to the disturbed expression of ANP and CX40. ..
Yang F, Zhou L, Wang Q, You X, Li Y, Zhao Y, et al
. NEXN inhibits GATA4 and leads to atrial septal defects in mice and humans. Cardiovasc Res. 2014;103:228-37 pubmed publisher
..We identify NEXN as a novel gene for ASD and its function to inhibit GATA4 established a critical regulation of an F-actin binding protein on a transcription factor in cardiac development. ..
Guo J, Li Y, Ren Y, Sun Z, Dong J, Yan H, et al
. Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease. Int J Mol Sci. 2016;17: pubmed publisher
..Thus, mutation Y418H in LRP6 likely contributes to normolipidemic familial CAD via impairing endothelial cell functions and weakening the Wnt3a signaling pathway. ..
Tian X, Li Y. Endothelial cell senescence and age-related vascular diseases. J Genet Genomics. 2014;41:485-95 pubmed publisher
Xu K, Ma L, Li Y, Wang F, Zheng G, Sun Z, et al
. Genetic and Functional Evidence Supports LPAR1 as a Susceptibility Gene for Hypertension. Hypertension. 2015;66:641-6 pubmed publisher
..Together, we show that LPAR1 is a novel susceptibility gene for human essential hypertension and that stress, such as shortage of sleep, increases the susceptibility of patients with risk allele to essential hypertension. ..
Li W, Zheng N, Yuan Q, Xu K, Yang F, Gu L, et al
. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. J Mol Med (Berl). 2016;94:993-1002 pubmed publisher
..NFAT5-mediated expression of CACNA1C is evolutionarily conserved. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. ..
Zhao Y, Yu Y, Shi M, Yang X, Li X, Jiang F, et al
. Association study to evaluate TFPI gene in CAD in Han Chinese. BMC Cardiovasc Disord. 2017;17:188 pubmed publisher
..Genetic variations of the TFPI genes seem to be related with CAD, which likely cooperate with metabolic risk factor (diabetes mellitus) and play critical roles in the pathogenesis of coronary artery disease. ..