Lin Lu

Summary

Affiliation: Peking University
Country: China

Publications

  1. ncbi request reprint A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:1604-11. 2004
  2. ncbi request reprint Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving
    Jeffrey W Grimm
    Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:742-7. 2003
  3. ncbi request reprint Central amygdala ERK signaling pathway is critical to incubation of cocaine craving
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nat Neurosci 8:212-9. 2005
  4. pmc Activation of group II metabotropic glutamate receptors in the nucleus accumbens shell attenuates context-induced relapse to heroin seeking
    Jennifer M Bossert
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:2197-209. 2006
  5. ncbi request reprint Systemic and central amygdala injections of the mGluR2/3 agonist LY379268 attenuate the expression of incubation of sucrose craving in rats
    Jamie L Uejima
    Neurobiology of Relapse Section, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 22124, USA
    Behav Brain Res 181:292-6. 2007
  6. ncbi request reprint Drug abuse in China: past, present and future
    Lin Lu
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Cell Mol Neurobiol 28:479-90. 2008
  7. pmc Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving
    Lin Lu
    National Institute on Drug Dependence, Peking University, Beijing, China
    Biol Psychiatry 66:137-45. 2009
  8. doi request reprint Traditional medicine in the treatment of drug addiction
    Lin Lu
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 35:1-11. 2009
  9. doi request reprint Conditioned place preference induced by licit drugs: establishment, extinction, and reinstatement
    Yu Liu
    National Institute on Drug Dependence, Peking University, Beijing, China
    ScientificWorldJournal 8:1228-45. 2008
  10. doi request reprint Stereotactic neurosurgical treatment of drug addiction
    Lin Lu
    National Institute on Drug Dependence, Peking University, 38, Xue Yuan Road, Beijing 100083, China
    Am J Drug Alcohol Abuse 35:391-3. 2009

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:1604-11. 2004
    ..These data suggest that BDNF-mediated neuroadaptations in mesolimbic areas are involved in the persistent cocaine seeking induced by exposure to drug cues after withdrawal...
  2. ncbi request reprint Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving
    Jeffrey W Grimm
    Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:742-7. 2003
    ..Time-dependent increases in BDNF levels may lead to synaptic modifications that underlie enhanced responsiveness to cocaine cues after prolonged withdrawal periods...
  3. ncbi request reprint Central amygdala ERK signaling pathway is critical to incubation of cocaine craving
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nat Neurosci 8:212-9. 2005
    ..Results suggest that the incubation of cocaine craving is mediated by time-dependent increases in the responsiveness of the central amygdala ERK pathway to cocaine cues...
  4. pmc Activation of group II metabotropic glutamate receptors in the nucleus accumbens shell attenuates context-induced relapse to heroin seeking
    Jennifer M Bossert
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:2197-209. 2006
    ..0 microg) 1.5 mm dorsal from the NAc core into the caudate-putamen were ineffective. Results suggest an important role of glutamate transmission in the NAc shell in context-induced reinstatement of heroin seeking...
  5. ncbi request reprint Systemic and central amygdala injections of the mGluR2/3 agonist LY379268 attenuate the expression of incubation of sucrose craving in rats
    Jamie L Uejima
    Neurobiology of Relapse Section, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 22124, USA
    Behav Brain Res 181:292-6. 2007
    ..These findings suggest that central amygdala glutamate plays an important role in the incubation of reward craving after withdrawal from both drug and non-drug rewards...
  6. ncbi request reprint Drug abuse in China: past, present and future
    Lin Lu
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Cell Mol Neurobiol 28:479-90. 2008
    ..With continuous application of these therapies and managements that have been proved to be effective in harm reduction in the western countries, we believe that drug abuse and its related problems in China will be brought under control...
  7. pmc Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving
    Lin Lu
    National Institute on Drug Dependence, Peking University, Beijing, China
    Biol Psychiatry 66:137-45. 2009
    ..Here, we studied the role of glial cell line-derived neurotrophic factor (GDNF) in incubation of cocaine craving because, like BDNF, GDNF provides trophic support to midbrain dopamine neurons...
  8. doi request reprint Traditional medicine in the treatment of drug addiction
    Lin Lu
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 35:1-11. 2009
    ..To evaluate clinical trials and neurochemical mechanisms of the action of traditional herbal remedies and acupuncture for treating drug addiction...
  9. doi request reprint Conditioned place preference induced by licit drugs: establishment, extinction, and reinstatement
    Yu Liu
    National Institute on Drug Dependence, Peking University, Beijing, China
    ScientificWorldJournal 8:1228-45. 2008
    ..Finally, we draw on findings from pharmacological studies and discuss the neurotransmitters and neurohormones underlying CPP produced by ethanol, nicotine, and caffeine...
  10. doi request reprint Stereotactic neurosurgical treatment of drug addiction
    Lin Lu
    National Institute on Drug Dependence, Peking University, 38, Xue Yuan Road, Beijing 100083, China
    Am J Drug Alcohol Abuse 35:391-3. 2009
    ..Stereotactic neurosurgery is a well-developed and accepted treatment for movement disorders like Parkinson's disease...
  11. ncbi request reprint [Neurobiological mechanisms and interventions in drug craving after withdrawal]
    Lin Lu
    National Institute on Drug Dependence, Peking University, Beijing 100191, China
    Beijing Da Xue Xue Bao 41:282-4. 2009
    ..Our findings have provided evidence for effective inventions on preventing relapse after abstinence in addicts...
  12. ncbi request reprint Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine craving
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Biol Psychiatry 61:591-8. 2007
    ....
  13. ncbi request reprint Role of ERK in cocaine addiction
    Lin Lu
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Trends Neurosci 29:695-703. 2006
    ..Pharmacological manipulations that decrease the extent to which cocaine and cocaine cues induce ERK activity might therefore be considered as potential treatments for cocaine addiction...
  14. pmc Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory
    Yan qin Li
    National Institute on Drug Dependence, Peking University, Beijing 100191, China
    J Neurosci 31:5436-46. 2011
    ..Results indicate that PKMζ activity in accumbens core is a critical cellular substrate for the maintenance of memories of relapse-provoking reward cues during prolonged abstinence periods...
  15. doi request reprint Time-dependent neuroendocrine alterations and drug craving during the first month of abstinence in heroin addicts
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 35:267-72. 2009
    ..Heroin use and withdrawal cause abnormality in the endocrine system. However, the time course of neuroendocrine alterations in heroin addicts during pharmacologically unassisted withdrawal is still unclear...
  16. pmc A memory retrieval-extinction procedure to prevent drug craving and relapse
    Yan xue Xue
    National Institute on Drug Dependence, Peking University, Beijing, China
    Science 336:241-5. 2012
    ..The memory retrieval-extinction procedure is a promising nonpharmacological method for decreasing drug craving and relapse during abstinence...
  17. pmc Central amygdala extracellular signal-regulated kinase signaling pathway is critical to incubation of opiate craving
    Yan qin Li
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    J Neurosci 28:13248-57. 2008
    ..Additionally, this "incubation of morphine craving" is mediated by acute activation of central amygdala ERK pathway...
  18. doi request reprint Circadian alteration in neurobiology during protracted opiate withdrawal in rats
    Su Xia Li
    National Institute on Drug Dependence, Peking University, Beijing, China
    J Neurochem 115:353-62. 2010
    ....
  19. pmc PI3K/Akt signaling pathway in the basolateral amygdala mediates the rapid antidepressant-like effects of trefoil factor 3
    Hai shui Shi
    National Institute on Drug Dependence, Peking University, Beijing, China
    Neuropsychopharmacology 37:2671-83. 2012
    ..These findings suggest a novel neuropeptide system target in the development of new antidepressants...
  20. doi request reprint Increased Cdk5/p35 activity in the dentate gyrus mediates depressive-like behaviour in rats
    Wei Li Zhu
    National Institute on Drug Dependence, Peking University, Beijing, China
    Int J Neuropsychopharmacol 15:795-809. 2012
    ....
  21. doi request reprint Glycogen synthase kinase 3β in the nucleus accumbens core is critical for methamphetamine-induced behavioral sensitization
    Chun Mei Xu
    National Institute on Drug Dependence, Peking University, Beijing, China
    J Neurochem 118:126-39. 2011
    ....
  22. doi request reprint Diurnal variation in cue-induced responses among protracted abstinent heroin users
    Zhen Yu Ren
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Pharmacol Biochem Behav 91:468-72. 2009
    ..The present study was to examine whether there was a variation in drug-related cue reactivity across the diurnal cycle among recently abstinent opiate addicts...
  23. doi request reprint Glycogen synthase kinase 3beta in the nucleus accumbens core mediates cocaine-induced behavioral sensitization
    Chun Mei Xu
    National Institute on Drug Dependence, Peking University, Beijing, China
    J Neurochem 111:1357-68. 2009
    ....
  24. ncbi request reprint Conditioned drug reward enhances subsequent spatial learning and memory in rats
    Hai Feng Zhai
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38, Xue Yuan Road, Haidian District, Beijing 100083, China
    Psychopharmacology (Berl) 195:193-201. 2007
    ..A context that is repeatedly paired with reinforcing drugs will acquire secondary reinforcing properties (conditioned reward). However, the effects of conditioned reward on spatial learning are unknown...
  25. pmc Stress enhances retrieval of drug-related memories in abstinent heroin addicts
    Li Yan Zhao
    National Institute on Drug Dependence, Peking University, Beijing, China
    Neuropsychopharmacology 35:720-6. 2010
    ..The potential of beta-adrenergic blockade to reduce or block stress-induced enhancement of drug-related memory retrieval may be relevant to preventing stress-induced relapse in abstinent heroin addicts...
  26. doi request reprint Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers
    Yu Liu
    National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Beijing 100083, China
    Drug Alcohol Depend 101:42-52. 2009
    ..The partial dopamine D(2) receptor agonist aripiprazole has recently been tested as a treatment for stimulant and alcohol dependence in both animal and clinical studies...
  27. doi request reprint Nucleus accumbens core mammalian target of rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats
    Xi Wang
    National Institute on Drug Dependence, Peking University, Beijing 100191, China
    J Neurosci 30:12632-41. 2010
    ..These findings indicate that cue-induced reinstatement of cocaine seeking is mediated by activation of the mTOR signaling pathway in the NAc core...
  28. doi request reprint Glycogen synthase kinase 3β in the basolateral amygdala is critical for the reconsolidation of cocaine reward memory
    Ping Wu
    National Institute on Drug Dependence, Peking University, Beijing, China
    J Neurochem 118:113-25. 2011
    ..These results indicate that GSK-3β activity in the BLA mediates the reconsolidation of cocaine cue memories...
  29. doi request reprint Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala
    Xiao Yi Wang
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
    J Neurosci 28:5602-10. 2008
    ..These results show that stress blocks reconsolidation of a drug-related memory, and this effect is mediated by activation of GRs in the BLA...
  30. doi request reprint Drug-related cues exacerbate decision making and increase craving in heroin addicts at different abstinence times
    Gui Bin Wang
    National Institute on Drug Dependence, Peking University, Beijing, 100191, China
    Psychopharmacology (Berl) 221:701-8. 2012
    ..Impulsive decision making may contribute to relapse through a poorly considered assessment of the consequences of drug use. Drug cues robustly increase subjective craving, which is frequently associated with relapse...
  31. doi request reprint A morphine/heroin vaccine with new hapten design attenuates behavioral effects in rats
    Qian Qian Li
    National Institute on Drug Dependence, Peking University, Beijing, China
    J Neurochem 119:1271-81. 2011
    ..These results suggest that immunization with a novel vaccine is an effective means of inducing a morphine-specific antibody response that is able to attenuate the behavioral and psychoactive effects of heroin...
  32. doi request reprint Circadian alteration in neurobiology during 30 days of abstinence in heroin users
    Su Xia Li
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Biol Psychiatry 65:905-12. 2009
    ..However, there are no published studies of changes in expression of clock genes or of other neuropeptides related to circadian-rhythm regulation, which may influence relapse susceptibility...
  33. doi request reprint A comparative clinical study of the effects of the traditional Chinese medicine Jinniu capsules and lofexidine on acute heroin withdrawal symptoms
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 34:792-800. 2008
    ..In this randomized multicenter clinical trial we evaluated the efficacy and safety of Jinniu capsules used to treat the symptoms of heroin withdrawal, as compared with lofexidine...
  34. doi request reprint Effects of acute combined serotonin and dopamine depletion on cue-induced drinking intention/desire and cognitive function in patients with alcohol dependence
    Hong Qiang Sun
    National Institute on Drug Dependence, Peking University, Beijing 100191, China
    Drug Alcohol Depend 124:200-6. 2012
    ..However, no study of the effects of acute CMD has been previously conducted. Therefore, we investigated whether the attenuation of serotonin and dopamine synthesis changes cue-induced alcohol craving in recently abstinent alcoholics...
  35. pmc Clonidine improved laboratory-measured decision-making performance in abstinent heroin addicts
    Xiao Li Zhang
    National Institute on Drug Dependence, Peking University, Beijing, China
    PLoS ONE 7:e29084. 2012
    ..The present study investigated the effects of clonidine, which decreased norepinephrine release through presynaptic alpha-2 receptor activation, on the impaired decision-making performance in abstinent heroin addicts...
  36. doi request reprint Role of calcineurin in the VTA in rats behaviorally sensitized to methamphetamine
    Jun Wang
    National Institute on Drug Dependence, Peking University, 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China
    Psychopharmacology (Berl) 220:117-28. 2012
    ..Calcineurin has been suggested to participate in psychostimulant-induced sensitization, but the underlying neurobiological mechanism is poorly understood...
  37. pmc A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory
    Zhen Yu Ren
    Pharmacy Department, Peking University Third Hospital, Beijing, China
    Neuropsychopharmacology 38:778-90. 2013
    ..These findings suggest that ubiquitin-proteasome system-dependent protein degradation is critical for retrieval-induced memory destabilization...
  38. doi request reprint Drug addiction in China
    Lin Lu
    National Institute on Drug Dependence, Peking University, Beijing, China
    Ann N Y Acad Sci 1141:304-17. 2008
    ..Although the new trends of drug addiction in China pose great public health challenges, these government interventions are likely to successfully stem the problem of drug abuse in the future...
  39. doi request reprint Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats
    Yan qin Li
    National Institute on Drug Dependence, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, China
    Psychopharmacology (Berl) 199:245-53. 2008
    ..While many manipulations used to study these consequences alter mother-infant interactions, the effects of sibling interactions are less well characterized...
  40. doi request reprint Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Eur J Pharmacol 615:108-12. 2009
    ..Our findings suggested that rapamycin merits outpatient clinical trials as a potential pharmacotherapy for relapse prevention from drug-related cue induced craving...
  41. ncbi request reprint A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking
    Jennifer M Bossert
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:10726-30. 2004
    ..Results indicate that glutamate transmission in the VTA plays an important role in contextual cue-induced relapse to heroin seeking...
  42. ncbi request reprint Cocaine seeking over extended withdrawal periods in rats: time dependent increases of responding induced by heroin priming over the first 3 months
    Lin Lu
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 176:109-14. 2004
    ..Using a rat relapse model, recent studies reported time dependent increases in cocaine seeking induced by re-exposure to cocaine cues, but not cocaine itself, over withdrawal periods of up to 3 months...
  43. pmc Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Pharmacol Biochem Behav 92:603-7. 2009
    ..The purpose of this double-blind, placebo-controlled study was to assess the effect of a single intramuscular dose of TTX on cue-induced craving and anxiety in abstinent heroin addicts...
  44. ncbi request reprint Cocaine seeking over extended withdrawal periods in rats: different time courses of responding induced by cocaine cues versus cocaine priming over the first 6 months
    Lin Lu
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 176:101-8. 2004
    ..Here, we studied cocaine seeking induced by re-exposure to cocaine cues or cocaine itself over an extended withdrawal period of 6 months...
  45. doi request reprint Harm reduction for injecting opiate users: an update and implications in China
    Maja Meise
    National Institute on Drug Dependence, Peking University, Beijing, China
    Acta Pharmacol Sin 30:513-21. 2009
    ..The main focus of the review is on the definition and the practical aspects of harm reduction; it includes a brief introduction of Chinese harm-reduction efforts and their implications...
  46. doi request reprint Green tea polyphenols produce antidepressant-like effects in adult mice
    Wei Li Zhu
    National Institute on Drug Dependence, Peking University, 38 Xue Yuan Road, Beijing 100191, China zhu
    Pharmacol Res 65:74-80. 2012
    ..The present study demonstrated that GTP exerts antidepressant-like effects in a mouse behavioral models of depression, and the mechanism may involve inhibition of the hypothalamic-pituitary-adrenal axis...
  47. ncbi request reprint Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 85:1604-13. 2003
    ..Cocaine self-administration produces long-lasting molecular neuroadaptations in the VTA and accumbens that may underlie cocaine relapse during periods of abstinence...
  48. ncbi request reprint Differential long-term neuroadaptations of glutamate receptors in the basolateral and central amygdala after withdrawal from cocaine self-administration in rats
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute on Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Neurochem 94:161-8. 2005
    ..These results indicate that cocaine self-administration and subsequent withdrawal induces long-lasting and differential neuroadaptations in basolateral and central amygdala glutamate receptors...
  49. doi request reprint Blockade of cue- and drug-induced reinstatement of morphine-induced conditioned place preference with intermittent sucrose intake
    Haifeng Zhai
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Pharmacol Biochem Behav 90:404-8. 2008
    ..Our findings suggest that offering non-drug rewards could be a valuable approach to maintain abstinence and preventing relapse in drug addicts...
  50. doi request reprint Effects of stress on decision-making deficits in formerly heroin-dependent patients after different durations of abstinence
    Xiao Li Zhang
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Psychiatry 168:610-6. 2011
    ....
  51. doi request reprint Inhibition of nuclear factor-κB impairs reconsolidation of morphine reward memory in rats
    Jianli Yang
    National Institute on Drug Dependence, Peking University, Beijing 100191, China
    Behav Brain Res 216:592-6. 2011
    ..These results indicate that SN50 disrupts morphine-related memory reconsolidation by inhibiting NF-κB, and this effect can be reversed by inhibiting histone acetylation...
  52. doi request reprint Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus
    Wen gao Jiang
    National Institute on Drug Dependence, Peking University, 38, Xue Yuan Road, Beijing 100191, China
    Brain Res 1399:25-32. 2011
    ....
  53. ncbi request reprint Incubation of cocaine craving after withdrawal: a review of preclinical data
    Lin Lu
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 47:214-26. 2004
    ..4. Incubation of cocaine craving after withdrawal is associated with increases in the levels of brain-derived neurotrophic factor (BDNF) in mesolimbic dopamine areas...
  54. ncbi request reprint PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Eur J Pharmacol 579:160-6. 2008
    ..Our findings suggest that chronic opioid use induces long-lasting striatum dopamine neuron impairment, and prolonged withdrawal from opioids can benefit the recovery of impaired dopamine neurons in the brain...
  55. doi request reprint Psychosocial stress enhances non-drug-related positive memory retrieval in male abstinent heroin addicts
    Li Yan Zhao
    National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Beijing 100083, China
    Neurosci Lett 485:16-20. 2010
    ..Our findings will provide richer information in understanding dysregulation of their emotional memory processing under stress and hopefully provide insight into designing improved treatments for drug addiction...
  56. ncbi request reprint Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys
    Su qing Chen
    Departments of Neuropharmacology and Clinical Pharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Acta Pharmacol Sin 28:473-83. 2007
    ..The aim of the study was to determine if clonidine administered during morphine withdrawal in rhesus monkeys produces long-lasting effects on withdrawal symptoms and alters the effects of subsequently taken drugs of abuse...
  57. doi request reprint Effects of scopolamine and ketamine on reconsolidation of morphine conditioned place preference in rats
    Haifeng Zhai
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing, China
    Behav Pharmacol 19:211-6. 2008
    ....
  58. ncbi request reprint Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers
    Jie Shi
    Department of Clinical Pharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Pharmacol Biochem Behav 87:141-5. 2007
    ..PA symptoms have rarely been compared between drug-free and methadone-maintained former heroin users after similar lengths of heroin abstinence...
  59. doi request reprint Role of melanin-concentrating hormone in the nucleus accumbens shell in rats behaviourally sensitized to methamphetamine
    Li Li Sun
    National Institute on Drug Dependence, Peking University, B38 Xue Yuan Road, Haidian, Beijing, China
    Int J Neuropsychopharmacol 16:1767-80. 2013
    ..Our study suggests that MCH might be a potential target for the treatment of Meth addiction. ..
  60. doi request reprint High prevalence of HIV, syphilis and HCV, and low methadone maintenance treatment in a migrant population in Beijing
    Dongliang Li
    Chaoyang District Centre for Disease Control and Prevention, Beijing, China
    J Addict Med 6:311-7. 2012
    ....
  61. ncbi request reprint The cystine-glutamate transporter in the accumbens: a novel role in cocaine relapse
    Lin Lu
    Behavioral Neuroscience Branch, IRP, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Trends Neurosci 27:74-6. 2004
    ..These data also suggest the cystine-glutamate transporter as a novel target for medication that could prevent cocaine relapse...
  62. doi request reprint Morphine withdrawal produces circadian rhythm alterations of clock genes in mesolimbic brain areas and peripheral blood mononuclear cells in rats
    Su Xia Li
    National Institute on Drug Dependence, Peking University, Beijing, China
    J Neurochem 109:1668-79. 2009
    ..These findings indicate that withdrawal from chronic morphine treatment resulted in desynchronization from the SCN rhythm, with blunting of rPER1 and rPER2 expression in reward-related neurocircuits and PBMCs...
  63. pmc A meta-analysis of acupuncture combined with opioid receptor agonists for treatment of opiate-withdrawal symptoms
    Ting Ting Liu
    National Institute on Drug Dependence, Peking University, Hai Dian District, Beijing, China
    Cell Mol Neurobiol 29:449-54. 2009
    ..One limitation of this meta-analysis is the poor quality of the methodology of some included trials. High-quality studies are needed to confirm findings regarding the side effects and medication dosage...
  64. pmc Psychosocial stress after reactivation of drug-related memory impairs later recall in abstinent heroin addicts
    Li Yan Zhao
    National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Beijing 100083, China
    Psychopharmacology (Berl) 203:599-608. 2009
    ..Here we presumed that stress after memory reactivation can effectively inhibit drug-related memory by disrupting its reconsolidation in abstinent heroin addicts...
  65. ncbi request reprint Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications
    Jennifer M Bossert
    Behavioral Neuroscience Branch, IRP NIDA NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Pharmacol 526:36-50. 2005
    ....
  66. doi request reprint Effects of sleep deprivation on retrieval and reconsolidation of morphine reward memory in rats
    Hai shui Shi
    National Institute on Drug Dependence, Peking University, Beijing 100191, China
    Pharmacol Biochem Behav 98:299-303. 2011
    ..Our findings suggest that sleep plays a critical role in morphine reward memory reconsolidation, and sleep deprivation may be a potential non-pharmacotherapy for the management of relapse associated with drug-related memory...
  67. pmc A meta-analysis of Chinese herbal medicine in treatment of managed withdrawal from heroin
    Ting Ting Liu
    National Institute on Drug Dependence, Peking University, Hai Dian District, Beijing, China
    Cell Mol Neurobiol 29:17-25. 2009
    ..Our meta-analysis suggests that Chinese herbal medicine is an effective and safety treatment for heroin detoxification. And more work is needed to determine the specific effects of specific forms of Chinese herbal medicine...
  68. ncbi request reprint Effects of stress during reactivation on rewarding memory
    Mei Zhao
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing
    Neuroreport 18:1153-6. 2007
    ....
  69. doi request reprint Effects of β-adrenergic receptor blockade on drug-related memory reconsolidation in abstinent heroin addicts
    Li Yan Zhao
    National Institute on Drug Dependence, Peking University, 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China
    Drug Alcohol Depend 118:224-9. 2011
    ..In this study, we investigated whether propranolol impairs the drug-related memory by disrupting the reconsolidation process in heroin addicts...
  70. ncbi request reprint Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats
    Yan qin Li
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Behav Brain Res 186:138-42. 2008
    ..EPSD on PN1 improved, but on PN7 impaired performance of the spatial learning task in adult female rats. However, EPSD did not have any effect on the spatial learning ability in adult male rats...
  71. ncbi request reprint Traditional Chinese medicine in treatment of opiate addiction
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Acta Pharmacol Sin 27:1303-8. 2006
    ..Given that TCM is effective in the prevention of relapse and causes fewer side effects, it may be used widely in the treatment of opiate addiction...
  72. doi request reprint Addiction research centres and the nurturing of creativity. The Chinese National Institute on Drug Dependence, Peking University: past, present and future
    Xi Wang
    National Institute on Drug Dependence, Peking University, Beijing, China
    Addiction 105:1525-30. 2010
    ..In the future, NIDD will continue to engage in various aspects of drug addiction research and will enter the field of brain function...
  73. doi request reprint Family support and employment as predictors of smoking cessation success: a randomized, double-blind, placebo-controlled trial of nicotine sublingual tablets in chinese smokers
    Hong Qiang Sun
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 35:183-8. 2009
    ..The purpose of this study is to assess social support and demographic factors that influence the success of smoking cessation aided with sublingual nicotine tablets in a Han Chinese population...
  74. doi request reprint Effects of polyinosinic-polycytidylic acid (Poly I:C) on naloxone-precipitated withdrawal in morphine-dependent mice
    Lei Chen
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38, Xueyuan Road, Haidian District, Beijing 100191, China
    Neurosci Lett 487:341-4. 2011
    ..Our findings suggest that Poly I:C-induced immune challenge has no effects on acute physical opioid withdrawal symptoms but facilitates depression-like behavior...
  75. pmc Serum cortisol secretion during heroin abstinence is elevated only nocturnally
    Su Xia Li
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 34:321-8. 2008
    ..The abstinent heroin-dependent participants had significantly higher plasma cortisol levels nocturnally suggesting a loss of diurnal variation in these heroin subjects...
  76. ncbi request reprint Recent trends in drug abuse in China
    Yu Xia Fang
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Acta Pharmacol Sin 27:140-4. 2006
    ..However, changing the public's attitudes toward drug abusers and breaking the link between drug use and HIV spread are equally important...
  77. ncbi request reprint Drug-induced alterations in the extracellular signal-regulated kinase (ERK) signalling pathway: implications for reinforcement and reinstatement
    Haifeng Zhai
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38, Xue Yuan Road, Hai Dian District, Beijing, 100083, China
    Cell Mol Neurobiol 28:157-72. 2008
    ....
  78. pmc Abnormal pain response in pain-sensitive opiate addicts after prolonged abstinence predicts increased drug craving
    Zhen Yu Ren
    National Institute on Drug Dependence, Peking University, Haidian District, Beijing, China
    Psychopharmacology (Berl) 204:423-9. 2009
    ..Opiate use can also produce abnormal pain perception. We predicted that for opiate addicts (OAs), there may be an association between these two major features of addiction (drug craving and abnormal pain responses)...
  79. ncbi request reprint Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a review
    Lin Lu
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurosci Biobehav Rev 27:457-91. 2003
    ..The broader implications of the data reviewed here for future research and for the treatment of opiate and psychostimulant addiction are briefly discussed...
  80. ncbi request reprint Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine
    Qing Rong Liu
    Molecular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program NIDA IRP, NIH, Department of Health and Human Services DHHS, Box 5180, Baltimore, MD 21224, USA
    Brain Res 1067:1-12. 2006
    ..These data suggest a role of specific BDNF promoter regions and regulatory sequences in stimulant-induced alterations in BDNF expression, and in the alterations that changed BDNF expression is likely to confer in the brain...
  81. doi request reprint HIV and STIs in clients and female sex workers in mining regions of Gejiu City, China
    Jun Jie Xu
    National Center for AIDS STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Sex Transm Dis 35:558-65. 2008
    ..To investigate HIV/sexually transmitted infections (STIs) among female sex workers (FSWs) and clients in a mining region of China...
  82. pmc A meta-analysis of retention in methadone maintenance by dose and dosing strategy
    Yan Ping Bao
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 35:28-33. 2009
    ..To estimate, via meta-analysis, the influence of different methadone dose ranges and dosing strategies on retention rates in methadone maintenance treatment (MMT)...
  83. ncbi request reprint The reinstatement model of drug relapse: history, methodology and major findings
    Yavin Shaham
    Behavioral Neuroscience Branch, NIDA IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:3-20. 2003
    ....
  84. doi request reprint Exploratory analysis of the association between new-type drug use and sexual transmission of HIV in China
    Zhongwei Jia
    School of Public Health and Family Medicine, Capital Medical University, Beijing, China
    Am J Drug Alcohol Abuse 36:130-3. 2010
    ..These observations suggest that ATS use may have contributed to the rapid increase in sexual transmission of HIV in China...
  85. pmc Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China
    Yong Zhang
    Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, People s Republic of China
    PLoS Med 3:e443. 2006
    ..However, the molecular epidemiology of HIV-1 in Yunnan has not been fully characterized...
  86. ncbi request reprint [Analysis for epidemic trend of acquired immunodeficiency syndrome in Yunnan Province of China]
    Lin Lu
    The Department of AIDS STD, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China
    Zhonghua Yu Fang Yi Xue Za Zhi 38:309-12. 2004
    ..To understand epidemiologic characteristics and changes in epidemic trend of human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) in different areas and populations of Yunnan Province...
  87. ncbi request reprint Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats
    Jishi Wang
    Department of Pharmacology, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China
    Psychopharmacology (Berl) 185:19-28. 2006
    ..However, the brain sites involved in the effect of CP-154,526 on footshock-induced reinstatement of opiate seeking are unknown...
  88. ncbi request reprint Comparison of drug abuse in Germany and China
    Ingo Ilja Michels
    Office of the Federal Drug Commissioner, Federal Ministry of Health, Berlin 10117, Germany
    Acta Pharmacol Sin 28:1505-18. 2007
    ..We recommend more dialogue and collaboration between Germany and China...
  89. doi request reprint Methadone maintenance treatment of heroin abuse in China
    Lin Lu
    Am J Drug Alcohol Abuse 34:127-31. 2008
  90. pmc 3MATRIX and 3MOTIF: a protein structure visualization system for conserved sequence motifs
    Steven P Bennett
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Nucleic Acids Res 31:3328-32. 2003
    ..Important properties of motifs such as sequence conservation and solvent accessible surface area are also displayed in the visualizations, using carefully chosen color shading schemes...
  91. ncbi request reprint Modification of hippocampal neurogenesis and neuroplasticity by social environments
    Lin Lu
    National Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, 138 Yi Xue Yuan Road, 200032, Shanghai, China
    Exp Neurol 183:600-9. 2003
    ..These findings demonstrated that social environments can modify neurogenesis and synaptic plasticity in adult hippocampal regions, which is associated with alterations in spatial learning and memory...
  92. ncbi request reprint [Study on subcretin in 8 minorities of Yunnan province]
    Shan Shan Wang
    Yunnan Provincal Health and Anti epidemic Center, Kunming 650022, China
    Zhonghua Liu Xing Bing Xue Za Zhi 24:26-9. 2003
    ..To estimate the prevalence of subcretins in 8 minorities of Yunnan province and to provide scientific basis for public health policy-making, as well as for prevention and control of iodine deficiency disorders...
  93. ncbi request reprint Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes
    Lin Lu
    Institute of Mental Health, West China University of Medical Sciences, Chengdu, China Medical Center of Fudan University, Shanghai, China
    J Neurochem 84:1378-86. 2003
    ..These results suggest that the CRF receptor antagonist, particularly the CRF receptor subtype 1 antagonist, might be of some value in the treatment of cocaine addiction and cocaine-related behavioral disorders...
  94. ncbi request reprint Role of withdrawal in reinstatement of morphine-conditioned place preference
    Lin Lu
    National Laboratory of Medical Neurobiology and Pharmacology Research Center, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
    Psychopharmacology (Berl) 181:90-100. 2005
    ..However, the role of withdrawal in relapse has not yet been systemically investigated in the reinstatement model...
  95. doi request reprint Cannabinoid CB(1) receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats
    Fangqiong Li
    School of Pharmacology and the Affiliated Hospital of Guiyang Medical College, Guiyang, China
    Eur J Pharmacol 589:122-6. 2008
    ..Since the reinstatement effects of ketamine administration were inhibited by rimonabant, these findings suggest that a cannabinoid CB(1) receptor antagonist may be useful in preventing relapse to ketamine abuse...
  96. ncbi request reprint BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuropsychopharmacology 33:2200-5. 2008
    ..Our results suggest that variation in the BDNF gene may be a risk factor for weight gain in male patients with schizophrenia on long-term antipsychotic treatment, and decreased BDNF levels may be associated with weight gain in females...
  97. ncbi request reprint Reactivation of cocaine conditioned place preference induced by stress is reversed by cholecystokinin-B receptors antagonist in rats
    Lin Lu
    Kailuan Mental Health Center, Tangshan 063001, China
    Brain Res 954:132-40. 2002
    ..CCK-B receptor antagonists might be of some value in the treatment and prevention of relapse to stress-induced to drug craving following long-term detoxification...
  98. pmc Expansion of HIV/AIDS in China: lessons from Yunnan Province
    Yan Xiao
    National Center for AIDS STD Control and Prevention, Chinese Center for Disease Control and Prevention, Room 502, No 42 Dongjing Road, Xuanwu District, Beijing 100050, China
    Soc Sci Med 64:665-75. 2007
    ....
  99. doi request reprint The changing face of HIV in China
    Lin Lu
    Yunnan Center for Disease Control and Prevention, Yunnan, People s Republic of China
    Nature 455:609-11. 2008
    ..HIV has advanced from high-risk groups such as intravenous drug users to some in the general population, according to comprehensive new data from the south of China. What needs to be done to halt its spread?..
  100. ncbi request reprint Circulating endothelial progenitor cells, C-reactive protein and severity of coronary stenosis in Chinese patients with coronary artery disease
    Hai ya Wang
    Shanghai Key Laboratory of Vascular Biology at Ruijin Hospital and Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, P R China
    Hypertens Res 30:133-41. 2007
    ..Given the important role of EPCs in neovascularization of ischemic tissue, a decrease in the number and activity of EPCs may contribute to the impaired vascularization in patients with CAD...
  101. doi request reprint Increased glycated albumin and decreased esRAGE concentrations are associated with in-stent restenosis in Chinese diabetic patients
    Lin Lu
    Department of Cardiology, Rui Jin Hospital, Institute of Cardiovascular Diseases, Jiaotong University School of Medicine, Shanghai, People s Republic of China
    Clin Chim Acta 396:33-7. 2008
    ..We investigated the impact of glycated albumin (GA) and endogenous secretory receptor for advanced glycation end products (esRAGE) and RAGE polymorphisms on occurrence of in-stent restenosis (ISR) in Chinese patients with type 2 diabetes...